Teaching/Seminars for Students » Institute of Reconstructive Neurobiology

Teaching/Seminars for Students

The Institute of Reconstructive Neurobiology (IRN) is located in the LIFE & BRAIN building. As part of the Medical Faculty, IRN offers seminars and courses in stem cell biology, neural development and regeneration for the following study programs:

Humanmedizin
Molecular Biomedicine
Master of Neuroscience
Master of Molecular Cell Biology
Master of Medical Immunosciences and Infection
Graduate School BIGS Neuroscience
SciMed

Students from related sciences (e.g. Biology) are welcome.

IRN - Logos Teaching

The Institute further offers three lecture series in the summer semester:

Lecture Series Stem Cell Biology

(accepted for Wahlfach I Humanmedizin, Bachelor Molecular Biomedicine)

Coordination: Prof. O. Brüstle
SS 23, Mon 17.30-19.00; EG Room 612/76 LIFE & BRAIN, weekly

03.04.23 Kick-off & Pluripotent Stem Cells and Reprogramming (Michael Peitz)
10.04.23 Ostermontag – no lecture
17.04.23 The Role of Transcription Factors in Stem Cell Specification (Sandra Blaess and Lea Flitsch)
24.04.23 Neural Stem Cells (Oliver Brüstle)
01.05.23 Tag der Arbeit – no lecture
08.05.23 Genome Editing and Disease Modeling (Michael Peitz)
15.05.23 Direct Cell Fate Conversion (Lea Flitsch)
22.05.23 Self-Organisation und 3D Cultures (Christina Au Yeung)
29.05.23 Pfingstferien – no lecture
05.06.23 Using Stem Cell Paradigms to Unravel Early Lineage Decisions (Hubert Schorle)
12.06.23 Germ Cells (Lena Arévalo)
19.06.23 Stem Cells in Ophthalmology (Volker Busskamp)
26.06.23 Stem Cells and Cardiovascular Repair (Wilhelm Röll)
03.07.23 Stem Cells and Neural Crest (Pascal Röderer)

Written exam Bachelor students
10.07.23 1. Exam: 17:30 h
xx.xx.23 2. Exam: to be announced

Exam medical students
Graded oral presentation of a recent high-impact publication
Date group 1: to be announced
Date group 2: to be announced

Preliminary Program| Learning objective


Lecture Series Developmental Neurobiology, Stem Cells and Disease

(accepted for Wahlfach I Humanmedizin, Master of Neuroscience, Master of Molecular Cell Biology, Master of Medical Immunosciences and Infection)

Coordination: Prof. O. Brüstle
SS 23 Wed 17.15 – 18.45; EG Room 612/76 LIFE & BRAIN, weekly

05.04.23 Kick-off & From Neurulation to Early Patterning of the Nervous System (Sandra Blaess)
12.04.23 Fate Instruction and Regional Determination (Sandra Blaess)
19.04.23 Stem Cells in the Adult Brain (Hideaki Matsumura)
26.04.23 Molecular and Cellular Aspects of Cortical Development (Oliver Brüstle)
03.05.23 Developmental Neurotoxicity (Mohamad Hajo)
10.05.23 Glia Cells and Myelin (Pascal Röderer)
17.05.23 Cell Fate Specification for Retinal Repair (Volker Busskamp)
24.05.23 Dies Academicus – no lecture
31.05.23 Pfingstferien – no lecture
07.06.23 Circuit Formation and Repair (Sandra Blaess)
14.06.23 Neurodevelopment, Stem Cells and Psychiatric Disease (Tamara Krutenko)
21.06.23 In vitro Models of Neural Development and Neurodegeneration (Michael Peitz)
28.06.23 Principles of Neural Cell Replacement (Oliver Brüstle)
05.07.23 Neural Cancer Stem Cells (Andreas Till)
12.07.23 Self-Organization and 3D Cultures (Christina Au Yeung)

Exam medical students
Graded oral presentation of a recent high-impact publication
Date group 1: to be announced
Date group 1: to be announced

Exam Master Neuroscience
Oral presentation of results at the end of the practical course

Exam for all other Master students
Recognition as a guest student is always possible, graded oral examination upon request (only limited student number, on first come, first served basis)

Preliminary Program | Learning objective


Lectue Series Cellular Neurobiology of Disease

(accepted for Wahlfach I Humanmedizin, Master of Neuroscience, Master Medical Immunosciences and Infection, Master of Molecular Cell Biology)

Coordination: Prof. H. Neumann
SS 23, Wed 8.00 – 9.45; Room EG.612/76 LIFE & BRAIN, weekly

05.04.23 – Cytology of neurons and axonal transport
12.04.23 – Cell adhesion and migration
19.04.23 – Guidance molecules
26.04.23 – Microglia and neuroinflammation
03.05.23 – Neurotrophic factors and cytokines
10.05.23 – Neurodegeneration
17.05.23 – Neuro-Ophthalmology
24.05.23 – Dies academicus – no lecture
31.05.23 – Pfingstferien – no lecture
07.06.23 – Neuroregeneration
14.06.23 – Glyconeurobiology
21.06.23 – Neuroimmunology
28.06.23 – Exam
05.07.23 – No lecture
12.07.23 – Exam


Practical Course ‘From Bench to Bedside’ for the Study Program ‘Molecular Biomedicine’

General information:
• 1 week (07.-11.11.2022, to be confirmed), 10:00 to 17:00 h
• Course rooms at the Institute of Reconstructive Neurobiology, Life & Brain Building, 4th floor

This four week practical course (elective module A) for the Study Program Molecular Biomedicine is conducted in cooperation with the LIMES Institute, the Laboratory of Molecular Developmental Biology, the Institute of Pathology and the Institute of Human Genetics.
The fourth week, carried out at IRN, is focused on ‘Programming Stem Cells for Neurological Disease Modeling and Therapy Development’. It provides information on the development of the central nervous system, insight into targeted differentiation of stem cells into neural subtypes and know-how on the generation of 3D cortical-like organoids. Particular focus is put on methods of reprogramming into iPS cells, direct conversion into neural cells and the use of these in vitro generated cells for disease modeling.


Practical Course ‘Developmental Neurobiology, Stem Cells and Disease’ for the Study Program ‘Master of Neuroscience’

General information:
• 2 weeks (29.08.-09.09.2022), 10:00 to 17:00 h
• Course rooms at the Institute of Reconstructive Neurobiology, Life & Brain Building, 4th floor

Together with the lecture series Developmental Neurobiology, Stem Cells and Neuroregeneration, this course is part of the elective module WPM 7 of the study program Master of Neuroscience.
During this practical course students gain insight into the molecular mechanisms underlying the development of the central nervous system in mouse and human. They learn about tools used in mouse genetics and cell programming strategies applied in human stem cell biology. In particular, they acquire knowledge on the generation of iPS cells and their genetic modification via genome editing.
After successful participation, attendees should know when to apply these tools for experimentally addressing questions relating to mouse developmental biology, human stem cell biology and genome editing. (Bloom taxonomy: application).
Key skills qualifications:
Attendees perform immunohistochemistry and RNA in situ hybridization on mouse brain sections and analyze the specimens using advanced microscopy techniques. In addition, students get insight into transcription factor based fate programming, learn to establish 3D cultures and get to know the principles of image-based analyses of cellular phenotypes. A particular focus will be on the development of a project plan to address research questions in the area of neurodevelopment and/or stem cell biology. In this context the possibilities but also limitations of the applied techniques will be discussed with tutors and lectures.


Practical Course ‘Molecular Tools for Stem and Developmental Biology’ for the Study Program ‘Master of Molecular Cell Biology’

General information
• 2 weeks (29.08.-09.09.2022), 10:00 to 17:00 h
• Course rooms at the Institute of Reconstructive Neurobiology, Life & Brain Building, 4th floor

This course is an elective module (EM-22) of the study program Master of Molecular Cell Biology.
During this practical course students gain insight into the molecular mechanisms underlying the development of the central nervous system in mouse and human. They learn about tools used in mouse genetics and cell programming strategies applied in human stem cell biology. In particular, they acquire knowledge on the generation of iPS cells and their genetic modification via genome editing.
After successful participation, attendees should know when to apply these tools for experimentally addressing questions relating to mouse developmental biology, human stem cell biology and genome editing.
Key skills qualifications:
Attendees perform immunohistochemistry and RNA in situ hybridization on mouse brain sections and analyze the specimens using advanced microscopy techniques. In addition, students get insight into transcription factor based fate programming, learn to establish 3D cultures and get to know the principles of image-based analyses of cellular phenotypes. A particular focus will be on the development of a project plan to address research questions in the area of neurodevelopment and/or stem cell biology. In this context the possibilities but also limitations of the applied techniques will be discussed with tutors and lectures.


Practical Course ‘Neural Stem Cells’ for the Study Program ‘Master of Neuroscience’ (WPP 3)

General information:
• 8 weeks (Jan – March 2024), 09:00 to 17:00
• Project-based lab work at the Institute of Reconstructive Neurobiology, Life & Brain Building, 4th floor

In this 8-week internship, students work on a small research project. Supervised by an experienced postdoc, students gain knowledge on neural stem cell biology, acquire hands-on experience in controlled differentiation and characterization of stem cells and learn about reprogramming strategies as well as the therapeutic use of pluripotent stem cell-derived neural cells for central nervous system diseases.
Depending on the available project, the main focus lies on:

• Neurodevelopmental genetics
• Cell programming
• Neural fate determination
• Direct conversion into neurons and glia
• Stem cell-based disease modeling
• Genetic modification of stem cells
• Generation of 3D organoids
• Image-based phenotype analysis
• Industrial applications of stem cells

Internships

Internships for students in the fields of medicine, biology, biochemistry and related disciplines are offered upon request. Please contact our office or the individual group leaders for further information.

Institute of Reconstructive Neurobiology

University of Bonn
LIFE & BRAIN Center
Venusberg-Campus 1
Building 76
D-53105 Bonn/Germany

How to find us

Phone +49 (0)228 - 6885 - 500
Fax +49 (0)228 - 6885 - 501
Email

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