Teaching/Seminars for Students

The Institute of Reconstructive Neurobiology (IRN) is located in the LIFE & BRAIN building. As part of the Medical Faculty, IRN offers seminars and courses in stem cell biology, neural development and regeneration for the following study programs:

Humanmedizin
Molecular Biomedicine
Master of Neuroscience
Master of Medical Immunosciences and Infection
Graduate School BIGS Neuroscience
SciMed

Students from related sciences (e.g. Biology) are welcome.

IRN - Logos Teaching

The Institute further offers three lecture series in the summer semester:

Stem Cell Biology

(accepted for Wahlfach I Humanmedizin, Molecular Biomedicine)

Coordination: Prof. O. Brüstle
SS 19, Mon 17.30-19.00; Room EG.612 LIFE & BRAIN, weekly

  • 01.04.19 – Kick-off & Pluripotent Stem Cells and Reprogramming (Michael Peitz)
  • 08.04.19 – Lineage Decisions in the Early Embryo (Hubert Schorle)
  • 15.04.19 – Genome Editing and Disease Modeling (Michael Peitz)
  • 22.04.19 – Ostermontag – no lecture
  • 29.04.19 – Neural Stem Cells (Oliver Brüstle)
  • 06.05.19 – Germ Cells (Lena Lüke & Liudmila Zhaunova)
  • 13.05.19 – Tumor Stem Cells (Andreas Till)
  • 20.05.19 – Direct Cell Fate Conversion (Lea Flitsch)
  • 27.05.19 – Stem Cells and Cardiovascular Repair (Wilhelm Röll)
  • 03.06.19 – Self-Organisation und Organoids (Vira Iefremova)
  • 10.06.19 – Pfingstferien – no lecture
  • 17.06.19 – Hematopoietic Stem Cells (Tobias Holderried)
  • 24.06.19 – Stem Cells in Ophthalmology (Tim Krohne)
  • 01.07.19 – Stem Cells in the Digestive Tract (Andreas Till)
  • 08.07.19 – 1. Exam (17:30 h, großer Seminarraum)
  • 02.10.19 – 2. Exam (10 h, großer Seminarraum)

Final schedule of lecture | Learning objective


Developmental Neurobiology, Stem Cells and Neuroregeneration

(accepted for Wahlfach I Humanmedizin, Master of Neuroscience, Master of Medical Immunosciences and Infection, Master of Molecular Biotechnology)

Coordination: Prof. O. Brüstle
SS 19 Wed 17.15 – 18.45; Room EG. 612 LIFE & BRAIN, weekly

  • 03.04.19 – Kick-off & From Neurulation to Early Patterning of the Nervous System (Sandra Blaess)
  • 10.04.19 – Molecular and Cellular Aspects of Cortical Development (Oliver Brüstle)
  • 17.04.19 – Fate Instruction and Regional Determination (Sandra Blaess)
  • 24.04.19 – Glia Cells and Myelin (Julia Fischer)
  • 01.05.19 – Tag der Arbeit – no lecture
  • 08.05.19 – Stem Cell Niches and Recruitment into the CNS (Julia Fischer)
  • 15.05.19 – Dies Academicus – no lecture
  • 22.05.19 – Circuit Formation and Repair (Sandra Blaess)
  • 29.05.19 – Self-Organization and 3D Cultures (Vira Iefremova)
  • 05.06.19 – In vitro Models of Neural Development and Disease Models (Michael Peitz)
  • 12.06.19 – Pfingstferien – no lecture
  • 19.06.19 – Principles of Neural Cell Replacement (Oliver Brüstle)
  • 26.06.19 – Stem Cells and Neural Crest (Anja Nitzsche)
  • 03.07.19 – Neural Cancer Stem Cells (Andreas Till)
  • 10.07.19 – 1. Exam Master Students (17:15 h bis 18:45 h)
  • 02.10.19 – 2. Exam Master Students (10:00 h bis 11:30 h)

Final schedule of lecture | Learning objective


Cellular Neurobiology of Disease

(accepted for Wahlfach I Humanmedizin, Master of Neuroscience, Master Medical Immunosciences and Infection, Master of Molecular Biotechnology)

Coordination: Prof. H. Neumann
SS 19, Wed 8.00 – 9.45; Room EG.612 LIFE & BRAIN, weekly

  • 03.04.19 – Cytology of neurons and axonal transport
  • 10.04.19 – Cell adhesion and migration
  • 17.04.19 – Guidance molecules
  • 24.04.19 – Microglia and neuroinflammation
  • 08.05.19 – Neurotrophic factors and cytokines
  • 22.05.19 – Neurodegeneration
  • 29.05.19 – Neuroregeneration
  • 05.06.19 – Neuro-Ophthalmology
  • 12.06.19 – Glyconeurobiology
  • 19.06.19 – Neuroimmunology
  • 26.06.19 – Exam
  • 10.07.19 – Exam

Practical Course ‘From Bench to Bedside’ for the Study Program ‘Molecular Biomedicine’

General information:
• 1 week (4.-8.11.2019), 10:00 to 17:00 h
• Course rooms at the Institute of Reconstructive Neurobiology, Life & Brain Building, 4th floor

This four week practical course (elective module A) for the Study Program Molecular Biomedicine is conducted in cooperation with the LIMES Institute, the Laboratory of Molecular Developmental Biology, the Institute of Pathology and the Institute of Human Genetics.
The fourth week, carried out at IRN, is focused on ‘Programming Stem Cells for Neurological Disease Modeling and Therapy Development’. It provides information on the development of the central nervous system, insight into targeted differentiation of stem cells into neural subtypes and know-how on the generation of 3D cortical-like organoids. Particular focus is put on methods of reprogramming into iPS cells, direct conversion into neural cells and the use of these in vitro generated cells for disease modeling.


Practical Course ‘Developmental Neurobiology, Stem Cells and Neuroregeneration’ for the Study Program ‘Master of Neuroscience’

General information:
• 2 weeks (16.-27.9.2019), 10:00 to 17:00 h
• Course rooms at the Institute of Reconstructive Neurobiology, Life & Brain Building, 4th floor

Together with the lecture series Developmental Neurobiology, Stem Cells and Neuroregeneration, this course is part of the elective module WPM 7 of the study program Master of Neuroscience.
During this practical course students gain insights into the development of the central nervous system, learn about reprogramming strategies and obtain knowledge in the biomedical applications of iPS cells in disease modeling. Besides the use of differentiation protocols and cell culture techniques for PSCs and PSC-derived neural cells, students acquire experience in surface marker-based flow cytometry for quality control of pluripotent cells. They design gRNAs for CRISPR/Cas9 and use assays to evaluate genome editing efficiency. Furthermore, students prepare embryonic tissue for 3D imaging analysis, perform immunohistochemistry on adult mouse brain sections and analyze the specimens using advanced microscope techniques. In addition, students work on 3D cortical-like organoids and get to know the principles of image-based analyses of cellular (patho-)phenotypes. With a focus on industrial applications of iPS cells, students perform automated detection, harvesting and deposition of hiPSC clones using the CellCelectorTM. (This description is only an extract from the contents of the practical course).


Practical Course ‘Neural Stem Cells’ for the Study Program ‘Master of Neuroscience’ (WPP 3)

General information:
• 8 weeks (7.1.-1.3.2019), 09:00 to 17:00
• Project-based lab work at the Institute of Reconstructive Neurobiology, Life & Brain Building, 4th floor

In this 8-week internship, students work on a small research project. Supervised by an experienced postdoc, students gain knowledge on neural stem cell biology, acquire hands-on experience in controlled differentiation and characterization of stem cells and learn about reprogramming strategies as well as the therapeutic use of pluripotent stem cell-derived neural cells for central nervous system diseases.
Depending on the available project, the main focus lies on:

• Neurodevelopmental genetics
• Cell programming
• Neural fate determination
• Direct conversion into neurons and glia
• Stem cell-based disease modeling
• Genetic modification of stem cells
• Generation of 3D organoids
• Image-based phenotype analysis
• Industrial applications of stem cells

Internships

Internships for students in the fields of medicine, biology, biochemistry and related disciplines are offered upon request. Please contact our office or the individual group leaders for further information.