Publications

Cuevas-Rios, G., Abou-Assale, T., Wissfeld, J., Bungartz, A., Hofmann, J., Langmann, T., Neumann, H. (2024)
Decreased sialylation elicits complement-related microglia response and bipolar cell loss in the mouse retina
Glia, 1-18. doi: 10.1002/glia.24613

Wißfeld, J., Abou Assale, T., Cuevas-Rios, G., Liao, H., Neumann, H. (2024)
Therapeutic potential to target sialylation and SIGLECs in neurodegenerative and psychiatric diseases
Front. Neurol. Dementia and Neurodegenerative Diseases, Volume 15 - 2024. doi: 10.3389/fneur.2024.1330874

Abou-Assale, T., Künzel, T., Schink, T., Shahraz, A., Neumann, H., Klaus, C. (2023)
6’-Sialyllactose ameliorates the ototoxic effects of the aminoglycoside antibiotics neomycin in susceptible mice
Front. Immunol. Sec. Inflammation Volume 14 - 2023. doi: 10.3389/fimmu.2023.1264060.

Mathews, M., Wißfeld, J., Flitsch, L.J., Shahraz, A., Semkova, V., Breitkreuz, Y., Neumann, H., Brüstle, O. (2023)
Reenacting neuroectodermal exposure of hematopoietic progenitors enables scalable production of cryopreservable iPSC-derived human microglia
Stem Cell Rev Rep. 19:455-474. doi: 10.1007/s12015-022-10433-w.

Müller-Miny, L., Thiel, K., Meinert, S., Hahn, T., Kircher, T., Nenadić, I., Krug, A., Hufschmidt, F., Liao, H., Neumann, H., Dannlowski, U., Lünemann, J.D. (2023)
Association of polysialic acid serum levels with schizophrenia spectrum and bipolar disorder-related structural brain changes and hospitalization
Sci Rep. 13:2085. doi: 10.1038/s41598-023-29242-3.

Paolicelli, R.C., Sierra, A.,…, Neumann, H., …Wyss-Coray, T. (2022)
Microglia states and nomenclature: A field at its crossroads
Neuron. 110: 3458-3483. doi.org/10.1016/j.neuron.2022.10.020

Shahraz, A., Lin, Y., Mbroh, J., Winkler, J., Liao, H., Lackmann, M., Bungartz, A., Zipfel, P.F., Skerka, C., Neumann, H. (2022)
Low molecular weight polysialic acid binds to properdin and reduces the activity of the alternative complement pathway
Scientific Reports 12:5818. doi.org/10.1038/s41598-022-09407-2

Wißfeld, J., Nozaki, I., Mathews, M., Raschka, T., Ebeling, C., Hornung, V., Brüstle, O., Neumann, H. (2021)
Deletion of Alzheimer's disease-associated CD33 results in an inflammatory human microglia phenotype
Glia. 69:1393-1412. doi: 10.1002/glia.23968.

Lünemann J.D., von Gunten, S., Neumann, H. (2021)
Targeting sialylation to treat central nervous system diseases
Trends Pharmacol Sci. 42:998-1008. doi: 10.1016/j.tips.2021.09.002.

Liao, H., Winkler, J., Wißfeld, J., Shahraz, A., Klaus, C., Neumann, H. (2021)
Low molecular weight polysialic acid prevents lipopolysaccharide-induced inflammatory dopaminergic neurodegeneration in humanized SIGLEC11 transgenic mice
Glia. 69:2845–2862. doi.org/10.1002/glia.24073

Wißfeld, J., Mathews, M., Mossad, O., Picardi, P., Cinti, A., Redaelli, L., Pradier, L., Brüstle, O., Neumann, H. (2021)
Reporter cell assay for human CD33 validated by specific antibodies and human iPSC-derived microglia
Sci Rep. 11:13462. doi.org/10.1038/s41598-021-92434-2

Shahraz, A., Wißfeld, J., Ginolhac, A., Mathews, M., Sinkkonen, L., Neumann, H. (2021)
Phagocytosis-related NADPH oxidase 2 subunit gp91phox contributes to neurodegeneration after repeated systemic challenge with lipopolysaccharides
Glia. 69:137-150. doi: 10.1002/glia.23890.

Ibach, M., Mathews, M., Linnartz-Gerlach, B., Theil, S., Kumar, S., Feederle, R., Brüstle, O., Neumann, H., Walter, J. (2021)
A reporter cell system for the triggering receptor expressed on myeloid cells 2 reveals differential effects of disease-associated variants on receptor signaling and activation by antibodies against the stalk region
Glia. 69:1126-1139. doi: 10.1002/glia.23953

Wedekind, H., Kats, E., Weiss, A-C., Thiesler, H., Klaus, C., Kispert, A., Horstkorte, R., Neumann, H., Weinhold, B., Münster-Kühnel, A., Abeln, M. (2021)
Gne deletion in mice leads to lethal intracerebral hemorrhage during embryonic development
Glycobiology. 31:1478–1489. doi.org/10.1093/glycob/cwab069

Klaus, C., Liao, H., Allendorf, D.H., Brown, G.C., Neumann, H. (2021)
Sialylation acts as a checkpoint for innate immune responses in the central nervous system
Glia. 69:1619-1636. doi: 10.1002/glia.23945.

Liao, H., Klaus, C., Neumann, H. (2020)
Control of innate immunity by sialic acids in the nervous tissue
Int J Mol Sci. 21:E5494. doi: 10.3390/ijms21155494.

Klaus, C., Hansen, N.J., Ginolhac, A., Gérard, D., Gnanapragassam, V., Horstkorte, R., Rossdam, Ch., Buettner, F., Sauter, T., Sinkkonen, L., Neumann, H., Linnartz-Gerlach, B. (2020)
Reduced sialylation triggers homeostatic synapse and neuronal loss in middle-aged mice
Neurobiology of Aging. 88:91-107. doi.org/10.1016/j.neurobiolaging.2020.01.008.

Boßmann, D., Bartling, B., de Vries, I., Winkler, J., Neumann, H., Lammers, F., Beutel, S., Scheper, T. (2019)
Charged aerosol detector HPLC as a characterization and quantification application of biopharmaceutically relevant polysialic acid from E. coli K1
J Chromatogr A. 1599:85-94. doi: 10.1016/j.chroma.2019.03.069

Mukherjee, S., Klaus, C., Pricop-Jeckstadt, M., Miller, J.A., Struebing, F.L. (2019)
A microglial signature directing human aging and neurodegeneration-related gene networks
Front Neurosci. 13:2. doi: 10.3389/fnins.2019.00002

Linnartz-Gerlach, B., Bodea, L.G., Klaus, C., Ginolhac, A., Halder, R., Sinkkonen, L., Walter, J., Colonna, M., Neumann, H. (2019)
TREM2 triggers microglial density and age-related neuronal loss
Glia. 67:539-550. doi: 10.1002/glia.23563

Fülle, L., Offermann, N., Hansen, J.N., Breithausen, B., Erazo, A.B., Schanz, O., Radau, L., Gondorf, F., Knöpper, K., Alferink, J., Abdullah, Z., Neumann, H., Weighardt, H., Henneberger, C., Halle, A., Förster, I. (2018)
CCL17 exerts a neuroimmune modulatory function and is expressed in hippocampal neurons
Glia. 66:2246-2261. doi: 10.1002/glia.23507

Garcia-Reitboeck, P., Phillips, A., Piers, T.M., Villegas-Llerena, C., Butler, M., Mallach, A., Rodrigues, C., Arber, C.E., Heslegrave, A., Zetterberg, H., Neumann, H., Neame, S., Houlden, H., Hardy, J., Pocock, J.M. (2018)
Human induced pluripotent stem cell-derived microglia-like cells harboring TREM2 missense mutations show specific deficits in phagocytosis
Cell Rep. 24:2300-2311. doi: 10.1016/j.celrep.2018.07.094

de Vries, I., Schreiber, S., Boßmann, D., Hellmann, Z., Kopatz, J., Neumann, H., Beutel, S. (2018)
Single-use membrane adsorbers for endotoxin removal and purification of endogenous polysialic acid from Escherichia coli K1
Biotechnol Rep (Amst). 17:110-116. doi: 10.1016/j.btre.2018.02.001

Micklisch, S., Lin, Y., Jacob, S., Karlstetter, M., Dannhausen, K., Dasari, P., von der Heide, M., Dahse, H.M., Schmölz, L., Grassmann, F., Alene, M., Fauser, S., Neumann, H., Lorkowski, S., Pauly, D., Weber, B.H., Joussen, A.M., Langmann, T., Zipfel, P.F., Skerka, C. (2017)
Age-related macular degeneration associated polymorphism rs10490924 in ARMS2 results in deficiency of a complement activator.
J Neuroinflammation. 2017 Jan 5;14(1):4. doi: 10.1186/s12974-016-0776-3.

Karlstetter, M., Kopatz, J., Aslanidis, A., Shahraz, A., Caramoy, A., Linnartz-Gerlach, B., Lin, Y., Lückoff, A., Fauser, S., Düker, K., Claude, J., Wang, Y., Ackermann, J., Schmidt, T., Hornung, V., Skerka, C., Langmann, T., Neumann, H. (2017)
Polysialic acid blocks mononuclear phagocyte reactivity, inhibits complement activation, and protects from vascular damage in the retina
EMBO Mol Med. 9:154-166. doi: 10.15252/emmm.201606627

Kemmerling, N., Wunderlich, P., Theil, S., Linnartz-Gerlach, B., Hersch, N., Hoffmann, B., Heneka, M.T., de Strooper, B., Neumann, H., Walter, J. (2017)
Intramembranous processing by γ-secretase regulates reverse signaling of ephrin-B2 in migration of microglia
Glia. 65:1103-1118. doi: 10.1002/glia.23147

de Vries, I., Busse, C., Kopatz, J., Neumann, H., Beutel, S., Scheper, T. (2017)
Polysialic acid production using Escherichia coli K1 in a disposable bag reactor
Engineering in Life Sciences 17:723-731

Shahraz, A., Kopatz, J., Mathy, R., Kappler, J., Winter, D., Kapoor, S., Schütza, V., Scheper, T., Gieselmann, V., Neumann, H. (2015)
Anti-inflammatory activity of low molecular weight polysialic acid on human macrophages.
Sci Rep. 2015 Nov 19;5:16800. doi: 10.1038/srep16800.

Hallmann, K., Kudin, A.P., Zsurka, G., Kornblum, C., Reimann, J., Stüve, B., Waltz, S., Hattingen, E., Thiele, H., Nürnberg, P., Rüb, C., Voos, W., Kopatz, J., Neumann, H., Kunz, W.S. (2016)
Loss of the smallest subunit of cytochrome c oxidase, COX8A, causes Leigh-like syndrome and epilepsy
Brain. 2016 Feb;139(Pt 2):338-45. doi: 10.1093/brain/awv357. Epub 2015 Dec 17.

Werneburg, S., Buettner, F.F., Erben, L., Mathews, M., Neumann, H., Mühlenhoff, M., Hildebrandt H. (2016)
Polysialylation and lipopolysaccharide-induced shedding of E-selectin ligand-1 and neuropilin-2 by microglia and THP-1 macrophages
Glia. 2016 Aug;64(8):1314-30. doi: 10.1002/glia.23004. Epub 2016 May 9.

Beins, E., Ulas, T., Ternes, S., Neumann, H., Schultze, J.L., Zimmer, A. (2016)
Characterization of inflammatory markers and transcriptome profiles of differentially activated embryonic stem cell-derived microglia
Glia. 2016 Jun;64(6):1007-20. doi: 10.1002/glia.22979. Epub 2016 Mar 9.

Linnartz-Gerlach, B., Schuy, C., Shahraz, A., Tenner, A.J., Neumann, H. (2016)
Sialylation of neurites inhibits complement-mediated macrophage removal in a human macrophage-neuron co-culture system
Glia. 2016 Jan;64(1):35-47. doi: 10.1002/glia.22901. Epub 2015 Aug 10

Aslanidis, A., Karlstetter, M., Scholz, R., Fauser, S., Neumann, H., Fried, C., Pietsch, M., Langmann, T. (2015)
Activated microglia/macrophage whey acidic protein (AMWAP) inhibits NFκB signaling and induces a neuroprotective phenotype in microglia
J Neuroinflamm. 2015 Apr 19;12(1):77. doi: 10.1186/s12974-015-0296-6.

Clarner, T., Janssen, K., Nellessen, L., Stangel, M., Skripuletz, T., Krauspe, B., Hess, F.M., Denecke, B., Beutner, C., Linnartz-Gerlach, B., Neumann, H., Vallières, L., Amor, S., Ohl, K., Tenbrock, K., Beyer, C., Kipp, M. (2015)
CXCL10 triggers early microglial activation in the cuprizone model
J Immunol. 2015 Apr 1;194(7):3400-13. doi: 10.4049/jimmunol.1401459. Epub 2015 Feb 27.

Bodea, L.G., Wang, Y., Linnartz-Gerlach, B., Kopatz, J., Sinkkonen, L., Musgrove, R., Kaoma, T., Muller, A., Vallar, L., Di Monte, D.A., Balling, R., Neumann, H. (2014)
Neurodegeneration by activation of the microglial complement-phagosome pathway
J Neurosci 34(25):8546-56. doi: 10.1523/JNEUROSCI.5002-13.2014.

Linnartz-Gerlach, B., Kopatz J., Neumann H. (2014)
Siglec functions of microglia
Glycobiology 24(9):794-799. doi: 10.1093/glycob/cwu044. Review

Linnartz-Gerlach, B., Mathews, M., Neumann, H. (2014)
Sensing the neuronal glycocalyx by glial sialic acid binding immunoglobulin-like lectins
Neuroscience 275C:113-124. doi: 10.1016/j.neuroscience.2014.05.061. Review

Karlstetter, M., Nothdurfter, C., Aslanidis, A., Moeller, K., Horn, F., Scholz, R., Neumann, H., Weber, B.H.F., Rupprecht, R., Langmann, T. (2014)
Translocator protein (18 kDa) (TSPO) is expressed on reactive retinal microglia and modulates microglial inflammation and phagocytosis
J Neuroinflamm 11:3. doi: 10.1186/1742-2094-11-3.

Glas, M., Coch, C., Trageser, D., Simon, M., Koch, P., Mertens, J., Quandel, T., Lüdenbach, B., Daßler, J., Lünskens, R., Reinartz, R., Wieland, A., Eisenreich, R., Höfer, H.,, Keller, M., von Lehe, M., Pusch, A., Schlee, M., Neumann, H., Fimmers, R., Herrlinger, U., Brüstle, O., Besch, R., Hartmann, G., Scheffler, B. (2013)
Targeting the cytosolic innate immune receptors RIG-I and MDA5 effectively counteracts cancer cell heterogeneity in glioblastoma
Stem Cells 31(6):1064-1074

Neumann, H., Daly, M.J. (2013)
Variant TREM2 as risk factor for Alzheimer's disease
N Engl J Med 368(2):182-184

Zhang, B.*, Gaiteri, C.*, Bodea, L.G.*, Wangm Z,*, McElwee, J., Podtelezhnikov, A.A., Zhang, C., Xie, T., Tran, L., Dobrin, R., Fluder, E., Clurman, B., Melquist, S., Narayanan, M., Suver, C., Shah, H., Mahajan, M., Gillis, T., Mysore, J., MacDonald, M.E., Lamb, J.R., Bennett, D.A., Molony, C., Stone, D.J., Gudnason, V., Myers, A.J., Schadt, E.E., Neumann, H., Zhu, J., Emilsson, V. (2013)
Integrated systems approach identifies genetic nodes and networks in late-onset Alzheimer’s disease
Cell 153(3):707-720

Neumann, H., Wekerle, H. (2013)
Brain microglia: Watchdogs with pedigree
Nat Neurosci 16(3):253-255

Claude, J., Linnartz-Gerlach, B., Kudinm A.P., Kunz, W.S.,Neumann, H. (2013)
Microglial CD33-related Siglec-E inhibits neurotoxicity by preventing the phagocytosis associated oxidative burst
J Neurosci 33(46):18270-18276

Linnartz, B., Neumann, H. (2013)
Microglial activatory (immunoreceptor tyrosine-based activation motif)- and inhibitory (immunoreceptor tyrosine-based inhibition motif)-signaling receptors for recognition of the neuronal glycocalyx
Glia 61(1):37-46

Kopatz, J.*, Beutner, C.*, Welle, K., Bodea, L.G., Reinhardt, J., Claude, J., Linnartz-Gerlach, B., Neumann, H. (2013)
Siglec-h on activated microglia for recognition and engulfment of glioma cells
Glia 61(7):1122-1133

Beutner, C.*, Linnartz-Gerlach, B.*, Schmidt, S.V., Beyer, M., Mallmann, M.R., Staratschek-Jox, A., Schultze, J.L., Neumann, H. (2013)
Unique transcriptome signature of mouse microglia
Glia 61(9):1429-1442

Wunderlich, P., Glebov, K., Kemmerling, N., Tien, N.T., Neumann, H., Walter, J. (2013)
Sequential proteolytic processing of the triggering receptor expressed on myeloid cells-2 (TREM2) by ectodomain shedding and γ-secretase dependent intramembranous cleavage
J Biol Chem 288(46):33027-33036

Sieber, M.W., Jaenisch, N., Brehm, M., Guenther, M., Linnartz-Gerlach, B., Neumann, H., Witte, O.W., Frahm, C. (2013)
Attenuated inflammatory response in Triggering receptor expressed on myeloid cells 2 (TREM2) knock-out mice following stroke
PLoS ONE 8(1): e52982

Sierra, A., Abiega, O., Shahraz, A., Neumann, H. (2013)
Janus-faced microglia: beneficial and detrimental consequences of microglial phagocytosis
Front Cell Neurosci 2013;7:6. doi: 10.3389/fncel.2013.00006.

Beutner, C., Lepperhof, V., Dann, A., Linnartz-Gerlach, B., Litwak, S., Napoli, I., Prinz, M., Neumann, H. (2013)
Engineered stem cell-derived microglia as therapeutic vehicle for experimental autoimmune encephalomyelitis
Gene Therapy 20(8):797-806

Hucke, S., Floßdorf, J., Grützke, B., Dunay, I.R., Frenzel, K., Jungverdorben, J., Linnartz, B., Mack, M., Peitz, M., Brüstle, O., Kurts, C., Klockgether, T., Neumann, H., Prinz, M., Knolle, P., Klotz, L. (2012)
Licensing of myeloid cells promotes central nervous system autoimmunity and is controlled by PPARγ
Brain 135(Pt 5):1586-1605

Linnartz, B., Kopatz, J., Tenner, A.J., Neumann, H. (2012)
Sialic acid on the neuronal glycocalyx prevents complement C1 binding and complement receptor-3 mediated removal by microglia
J Neurosci 32(3):946-952

Linnartz, B., Bodea, L., Neumann, H. (2012)
Microglial carbohydrate binding receptors for neural repair
Cell Tissue Res 349(1):215-227

Roy, K., Beutner, C., Neumann, H. (2011)
Perspectives of stem cell-derived microglia for medicine.
In: Embryonic stem cells - Recent advances in pluripotent stem cell-based regenerative medicine, ISBN 978-953-307-198-5, Edited by: Craig Atwood, Publisher: InTech, April 2011

Beutner, C., Roy, K., Linnartz, B., Napoli, I., Neumann, H. (2010)
Generation of microglial cells from mouse embryonic stem cells
Nat Protoc 5(9):1481-1494

Kierdorf, K., Wang, Y., Neumann, H. (2010)
Immune-mediated CNS damage
Results Probl Cell Differ 51:173-196

Larionov, S., Wielgat, P., Wang, Y., Thal, R.D., Neumann, H. (2010)
Spatially pathogenic forms of tau detected in Alzheimer's disease brain tissue by fluorescence lifetime-based Förster resonance energy transfer
J Neurosci Methods 192(1):127-137

Linker, R.A., Lee, D.-H., Cetin, S., Wiese, S., Kruse, N., Siglienti, I., Gerhardt, E., Neumann, H., Sendtner, M., Lühder, F., Gold, R. (2010)
Functional role of brain derived neurotrophic factor in neuroprotective autoimmunity: therapeutic implications in a model of multiple sclerosis
Brain 133(Pt 8):2248-2263

Napoli, I., Neumann, H. (2010)
Protective effects of microglia in multiple sclerosis
Exp Neurol 225(1):24-28

Linnartz, B., Wang, Y., Neumann, H. (2010)
Microglial immunoreceptor tyrosine-based activation and inhibition motif (ITAM/ITIM) signaling in neuroinflammation
International Journal of Alzheimer’s disease, Volume 2010, Article ID 587463, doi:10.4061/2010/587463

Melchior, B., Garcia, A.E., Hsiung, B.-K., Lo, K.M., Doose, J.M., Thrash, J.C., Stalder, A.K., Staufenbiel, M., Neumann, H., Carson, M.J. (2010)
Dual induction of TREM2 and tolerance-related transcript, Tmem176b, in amyloid transgenic mice: implications for vaccine-based therapies for Alzheimer’s disease
ASN NEURO 2(3):157-170

Schwarting, S., Neumann, H. (2010)
Immunoregulatory neuroprotection of cerebral ischaemia by haematopoietic stem and precursor cells
EU Neurological Review 4(2):42-45

Wang, Y., Neumann, H. (2010)
Alleviation of neurotoxicity by microglial human Siglec-11
J Neurosci 30(9):3482–3488

Gaikwad, S., Larionov, S., Wang, Y., Dannenberg, H., Matozaki, T., Monsonego, A., Thal, D.R., Neumann, H. (2009)
Signal regulatory protein-β1: a microglial modulator of phagocytosis in Alzheimer’s disease
Am J Pathol 175(6):2528-2539

Gorlovoy, P., Larionov, S., Pham, T.T., Neumann, H. (2009)
Accumulation of tau induced in neurites by microglial proinflammatory mediators
FASEB J 23(8):2502-2513

Napoli, I., Kierdorf, K., Neumann, H. (2009)
Microglial precursors derived from mouse embryonic stem cells
Glia 57(15):1660-1671

Napoli, I., Neumann, H. (2009)
Microglial clearance function in health and disease
Neuroscience 158(3):1030-1038

Neumann, H., Kotter, M.R., Franklin, R.J. (2009)
Debris clearance by microglia: an essential link between degeneration and regeneration
Brain 132(Pt 2):288-295

Walter, L., Neumann, H. (2009)
Role of microglia in neuronal degeneration and regeneration
Semin Immunopath 31(4):513-525

Witan, H., Gorlovoy, P., Kaya, A.M., Koziollek-Drechsler, I., Neumann, H., Behl, C., Clement, A.M. (2009)
Wild-type Cu/Zn superoxide dismutase (SOD1) does not facilitate, but impedes the formation of protein aggregates of amyotrophic lateral sclerosis causing mutant SOD1
Neurobiol of Disease 36(2):331-342

Schwarting, S., Litwak, S., Hao, W., Bähr, M., Weise, J., Neumann H. (2008)
Hematopoietic stem cells reduce postischemic inflammation and ameliorateischemic brain injury
Stroke 39(10):2867-2875

Biber, K., Neumann, H., Inoue, K., Boddeke, H. (2007)
Neuronal on and off signals control microglial
Trends Neurosci 30:596-602

Fischer, Y.H., Miletic, H., Giroglou, T., Litwak, S., Stenzel, W., Neumann, H., von Laer, D. (2007)
A retroviral packaging cell line for pseudotype vectors based on glioma-infiltrating progenitor cells
Journal of Gene Medicine 9:335-344

Klotz, L., Diehl, L., Dani, I., Neumann, H., von Oppen, N., Dolf, A., Endl, E., Klockgether, T., Engelhardt, B., Knolle, P. (2007)
Brain endothelial PPARγ controls inflammationinduced CD4+ T cell adhesion and transmigration in vitro
J Neuroimmunol 190:34-43

Miletic, H., Fischer, Y., Litwak, S., Giroglou, T., Waerzeggers, Y., Winkeler, S., Li, H., Himmelreich, U., Stenzel, W., Deckert, M., Lange, C., Neumann, H., Jacobs, AH., von Laer D. (2007)
Bystander killing of malignant glioma by bone marrow-derived tumorinfiltrating progenitor cells expressing a suicide gene
Molecular Therapy 15:1373-1381

Neumann H., Takahashi, K. (2007)
Essential role of the triggering receptor expressed on myeloid cells-2 (TREM2) for central nervous tissue immune homeostasis
J Neuroimmunol 184:92-99

Takahashi, K., Prinz, M., Stagi, M., Chechneva, O., Neumann H. (2007)
TREM2-transduced myeloid precursors mediate nervous tissue debris clearance and facilitate repair in an animal model of multiple sclerosis
PLoS Med. 4(4):e124

Liu, Y., Hao, W., Letiembre, M., Walter, S., Kulanga, M., Neumann, H. and Fassbender, K. (2006)
Suppression of microglial inflammatory activity by myelin phagocytosis: role of p47-PHOX-mediated generation of reactive oxygen species
J Neurosci 26:12904-12913

Neumann, H. (2006)
Microglia: a cellular vehicle for CNS gene therapy
J Clin Invest 116:2857-2860 (invited commentary)

Stagi, M., Gorlovoy, P., Larinov, S., Takahashi, K., Neumann H. (2006)
Unloading kinesin transported cargoes from the tubulin track via the inflammatory c-Jun N-terminal kinase pathway
FASEB J 20:2573-2575

Stagi, M., Dittrich, P., Frank, N., Iliev, A., Schwille, P., Neumann, H. (2005)
Breakdown of axonal synaptic vesicle precursor transport by microglial nitric oxide
J.Neurosci., 25(2): 352-62.

Takahashi, K., Rochford, C.D., Neumann, H. (2005)
Clearance of apoptotic neurons without inflammation by microglial triggering receptor expressed on myeloid cells-2
J. Exp. Med., 201(4): 647-57.

Liu, Y., Walter, S., Stagi, M., Cherny, D., Letiembre, M., Schulz-Schaeffer, W., Heine, H., Penke, B., Neumann, H.,,Fassbender, K. (2005)
LPS receptor (CD14): a receptor for phagocytosis of Alzheimer’s amyloid peptide
Brain, 128(Pt 8):1778-89.

Miletic, H., Fischer, Y., Neumann, H., Hans, V., Stenzel, W., Giroglou, T., Deckert, M., von Laer, D. (2004)
Selective transduction of malignant glioma by lentiviral vectors pseudotyped with LCMV glycoproteins
Hum. Gene Therapy 15 (11):1091-100.

Iliev, A., Stringaris, A.K., Nau, R., Neumann, H. (2004)
Neuronal injury mediated via stimulation of microglial toll-like receptor-9 (TLR9)
FASEB J. 18, 412-414.

Kempermann, G., Neumann, H. (2003)
Microglia: The enemy within?
Science 302, 1689-1690 (Perspective).

Neumann, H. (2003)
Molecular mechanisms of axonal damage in inflammatory central nervous system diseases
Curr. Opin. Neurology, 16: 267-273 (Review).

Neumann, H., Medana, I., Bauer, J., Lassmann, H. (2002)
Cytotoxic T lymphocytes in autoimmune and degenerative CNS diseases
Trends in Neurosci. 25 (6), 313-319 (Review).

Neumann, H., Schweigreiter, R., Yamashita, T., Rosenkranz, K., Wekerle, H., Barde,Y.-A. (2002)
Tumor necrosis factor inhibits neurite outgrowth and branching of hippocampal neurons by a Rho-dependent mechanism
J. Neurosci. 22, 854-862.

Medana, I., Martinic, M.M.A., Wekerle, H., Neumann, H. (2001)
Transection of major histocompatibiltiy class I-induced neurites by cytotoxic T lymphocytes
Am. J. Pathol. 159, 809-815.

Neumann, H. (2001)
Control of glial immune function by neurons.
Glia, 36, 191-199 (Review).

Medana, I., Li, Z., Flügel, A., Tschopp, J., Wekerle, H., Neumann, H. (2001)
Fas Ligand (CD95L) protects neurons against perforin-mediated T lymphocyte cytotoxicity
J. Immunol. 167, 674-681.

Flügel, A., Matsumuro, K., Neumann, H., Klinkert, W.E.F., Birnbacher, R., Lassmann, H., Otten, U., Wekerle, H. (2000)
Anti-inflammatory activity of nerve growth factor in experimental autoimmune encephalomyelitis:Inhibition of monocyte transendothelium migration
Eur. J. Immunol.31,11-22.

Flügel, A., Schwaiger, F.-W., Neumann, H., Medana, I., Willem, M., Wekerle, H., Kreutzberg, G.W., Graeber, M.B. (2000)
Neuronal FasL induces cell death of encephalitogenic T lymphocytes
Brain Pathol. 10,353-364.

Medana, I., Gallimore, A., Oxenius, A. Martinic, M. Wekerle, H., Neumann, H. (2000)
MHC class I-restricted killing of neurons by virus specific CD8+ T lymphocytes is effected through the Fas/FasL, but not the perforin pathway
Eur. J. Immunol. 30, 3623-3633.

Neumann, H., Misgeld, T., Matsumuro, K., Wekerle H. (1998)
Neurotrophins inhibit major histocompatibility class II inducibility of microglia: Involvement of the p75 neurotrophin receptor
Proc. Natl. Acad. Sci. USA. 95: 5779-5784.

Neumann, H., Wekerle, H. (1998)
Neuronal control of the immune response in the central nervous system: Linking brain immunity to neurodegeneration
J. Neuropath. Exp. Neurol. 57(1): 1-9 (Review).

Raivich, G., Jones, L.L., Kloss, C.U.A., Werner, A., Neumann, H., Kreutzberg, G.W. (1998)
Immune surveillance in the injured nervous system: T-lymphocytes invade the axotomized mouse facial motor nucleus and aggregate around sites of neuronal degeneration
J. Neurosci. 18 (15): 5804-5816.

Neumann, H., Schmidt, H., Cavalié, A., Jenne, D., Wekerle, H. (1997)
Major histocompatibility complex (MHC) class I gene expression in single neurons of the central nervous system:Differential regulation by interferon (IFN)-gamma and tumor necrosis factor (TNF)-alpha
J. Exp. Med. 185 (2): 305-316.

Neumann, H., Schmidt, H., Wilharm, E., Behrens, L., Wekerle, H. (1997)
Interferon- gamma gene expression in sensory neurons: Evidence for autocrine gene regulation
J. Exp. Med. 186 (12): 2023-2031.

Neumann, H., Boucraut, J., Hahnel, Ch., Misgeld, T., Wekerle, H. (1996)
Neuronal control of MHC class II inducibility in astrocytes and microglia
Eur. J. Neurosci. 8: 2582-2590.

Neumann, H., Cavalié, A., Jenne, D., Wekerle, H. (1995)
Induction of MHC class I genes in neurons
Science 269:549-552.

Kaltschmidt, Ch., Kaltschmidt, B., Neumann, H., Wekerle, H., Baeuerle, P. (1994)
Constitutive NF-kB activity in neurons
Mol. Cell. Biol. 14:3981-3992.