Publications

Islam, K.U.S.,  Blaess, S. (2024)
The impact of the mesoprefrontal dopaminergic system on the maturation of interneurons in the murine prefrontal cortex
Front. Neurosci. 18:1403402. doi: 10.3389/fnins.2024.1403402

Tan, R.L., Sciandra, F., Hübner, W., Bozzi, M., Reimann, J., Schoch, S., Brancaccio, A., Blaess, S. (2024)
The missense mutation (C667F) in murine β-dystroglycan causes embryonic lethality, myopathy and blood-brain barrier destabilization
Dis Model Mech. 2024 Apr 15:dmm.050594. doi: 10.1242/dmm.050594.

Kim, H., Melliti, N., Breithausen, E., Michel, K., Colomer, S.F., Poguzhelskaya, E., Nemcova, P., Ewell, L., Blaess, S., Becker, A., Pitsch, J., Dietrich, D., Schoch, S. (2024)
Paroxysmal dystonia results from the loss of RIM4 in Purkinje cells
Brain. 147:3171-3188. doi: 10.1093/brain/awae081.

Tang, S., Fuß, A., Fattahi, Z., Culmsee, C. (2024)
Drp1 depletion protects against ferroptotic cell death by preserving mitochondrial integrity and redox homeostasis
Cell Death Dis. 15:626. doi: 10.1038/s41419-024-07015-8.

Masala, N., Pofahl, M., Haubrichm A.N., Sameen Islam, K.U., Nikbakht, N., Pasdarnavab, M., Bohmbach, K., Araki, K., Kamali, F., Henneberger, C., Golcuk, K., Ewell, L.A., Blaess, S., Kelly, T., Beck, H. (2023)
Targeting aberrant dendritic integration to treat cognitive comorbidities of epilepsy
Brain. 146:2399-2417. doi: 10.1093/brain/awac455.

Blaess, S., Krabbe, S. (2023)
Cell type specificity for circuit output in the midbrain dopaminergic system
Curr Opin Neurobiol. 83:102811. doi.org/10.1016/j.conb.2023.102811

Blaess, S., Herrera, A.J. (2023)
Editorial: Factors contributing to dopaminergic cell death
Front Mol Neurosci. 16:1136930. doi: 10.3389/fnmol.2023.1136930. eCollection 2023.

Petese, A., Fries, F.L., Broske, B., Stumm, R., Blaess, S. (2022)
Lineage analysis of Cxcr4-expressing cells in the developing midbrain suggests that progressive competence restriction in dopaminergic progenitor cells contributes to the establishment of dopaminergic neuronal diversity
eNeuro. 9:ENEURO.0052-22.2022. doi: 10.1523/ENEURO.0052-22.2022.

Masala, N., Pofahl, M., Haubrich, A.N., Islam, K.U.S., Nikbakht, N., Pasdarnavab, M., Bohmbach, K., Araki, K., Kamali, F., Henneberger, C., Golcuk, K., Ewell, L.A., Blaess, S., Kelly, T., Beck, H. (2022)
Targeting aberrant dendritic integration to treat cognitive comorbidities of epilepsy
Brain. awac455. doi: 10.1093/brain/awac455.

Tolve, M., Ulusoy, A., Patikas, N., Islam, K.U.S., Bodea, G.O., Öztürk, E., Broske, B., Mentani, A., Wagener, A., van Loo, K.M.J., Britsch, S., Liu, P., Khaled, W.T., Metzakopian, E., Baader, S.L.,Di Monte, D.A., Blaess, S. (2021)
The transcription factor BCL11A defines distinct subsets of midbrain dopaminergic neurons
Cell Reports. 36:109697. DOI:https://doi.org/10.1016/j.celrep.2021.109697

Islam, K.U.S., Meli, N., Blaess, S. (2021)
The development of the mesoprefrontal dopaminergic system in health and disease
Front Neural Circuits. 15:746582. doi: 10.3389/fncir.2021.746582.

Blaess, S., Wachten, D. (2021)
The BBSome: a nexus controlling energy metabolism in the brain
J Clin Invest. 131:e148903. doi: 10.1172/JCI148903.

Paß, T., Aßfalg, M., Tolve, M., Blaess, S., Rothermel, M., Wiesner, R.J., Ricke, K.M. (2020)
The impact of mitochondrial dysfunction on dopaminergic neurons in the olfactory bulb and odor detection
Mol Neurobiol. 57:3646-3657. doi: 10.1007/s12035-020-01947-w.

van Loo, K.M.J., Rummel, C.K., Pitsch, J., Müller, A. J., Bikbaev, A.F., Martinez Chavez, E., Blaess, S., Dietrich, D., Heine, M., Becker, A.J., Schoch, S. (2019)
Calcium channel subunit α2δ4 is regulated by early growth response 1 and facilitates epileptogenesis
J Neurosci. pii: 1731-18. doi: 10.1523/JNEUROSCI.1731-18.2019

Vaswani, A.R., Weykopf, B., Hagemann, C., Fried, H.-U., Brüstle, O., Blaess, S. (2019)
Correct setup of the substantia nigra requires Reelin-mediated fast, laterally-directed migration of dopaminergic neurons
eLife. 8:e41623. doi: 10.7554/eLife.41623

Weykopf, B. , Haupt, S. , Jungverdorben, J. , Flitsch, L. J., Hebisch, M. , Liu, G. , Suzuki, K. , Belmonte, J. C., Peitz, M. , Blaess, S. , Till, A., Brüstle, O. (2019)
Induced pluripotent stem cell‐based modeling of mutant LRRK2‐associated Parkinson's Disease
Eur J Neurosci. 49:561-589. doi:10.1111/ejn.14345

Brodski, C., Blaess, S., Partanen, J., Prakash, N. (2019)
Crosstalk of intercellular signaling pathways in the generation of midbrain dopaminergic neurons in vivo and from stem cells
J Dev Biol. 7:3. doi: 10.3390/jdb7010003. Review

Martinez-Chavez, E., Scheerer, C., Wizenmann, A., Blaess, S. (2018)
The zinc finger transcription factor Gli3 is a regulator of precerebellar neuronal migration
Development. 145:dev166033. doi: 10.1242/dev.166033

Jovanovic, V.M., Salti, A., Tilleman, H., Zega, K., Jukic, M.M., Zou, H., Friedel, R.H., Prakash, N., Blaess, S., Edenhofer, F., Brodski, C. (2018)
BMP/SMAD pathway promotes neurogenesis of midbrain dopaminergic neurons in vivo and in human induced pluripotent and neural stem cells
J Neurosci. 38:1662-1676. doi: 10.1523/JNEUROSCI.1540-17.2018

Münst, S., Koch, P., Kesavan, J., Alexander-Mays, M., Münst, B., Blaess, S., Brüstle, O. (2018)
In vitro segregation and isolation of human pluripotent stem cell-derived neural crest cells
Methods. 133:65-80. doi: 10.1016/j.ymeth.2017.09.012

Sciandra, F., Scicchitano, B.M., Signorino, G., Bigotti, M.G., Tavazzi, B., Lombardi, F., Bozzi, M., Sica, G., Giardina, B., Blaess, S., Brancaccio, A. (2017)
Evaluation of the effect of a floxed Neo cassette within the dystroglycan (Dag1) gene
BMC Res Notes. 10:601. doi: 10.1186/s13104-017-2926-9

Gazea, M., Tasouri, E., Tolve, M., Bosch, V., Kabanova, A., Gojak, C., Kurtulmus, B., Novikov, O., Spatz, J., Pereira, G., Hübner, W., Brodski, C., Tucker, K.L., Blaess, S. (2016)
Primary cilia are critical for Sonic hedgehog-mediated dopaminergic neurogenesis in the embryonic midbrain
Dev Biol. 2016 Jan 1;409(1):55-71. doi: 10.1016/j.ydbio.2015.10.033.

Gazea, M.*, Tasouri, E.*, Heigl, T., Bosch, V., Tucker, K.L., Blaess, S. (2016)
Definition of a critical spatiotemporal window within which primary cilia control midbrain dopaminergic neurogenesis
Neurogenesis (Austin). 2016 Oct 20;3(1):e1248206. doi: 10.1080/23262133.2016.1248206.
*Authors contributed equally

Vaswani, A.R., Blaess S. (2016)
Reelin signaling in the migration of ventral brain stem and spinal cord neurons
Front Cell Neurosci. 2016 Mar 11;10:62. doi: 10.3389/fncel.2016.00062. eCollection 2016. Review.

Kabanova, A*., Pabst, M., Lorkowski*, M., Braganza, O., Boehlen, A., Nikbakht, N., Pothmann, L., Vaswani, A.R., Musgrove, R., Di Monte, D.A., Sauvage, M., Beck, H., Blaess, S. (2015)
Function and developmental origin of a mesocortical inhibitory circuit
Nat Neurosci. 2015 Jun;18(6):872-82. doi: 10.1038/nn.4020.
*Authors contributed equally

Blaess, S., Szabó, N., Haddad-Tóvolli, N., Zhou, X., Álvarez-Bolado, G. (2015)
Sonic hedgehog signalling in the development of the mouse hypothalamus
Front Neuroanat 2015 Jan 6;8:156. doi: 10.3389/fnana.2014.00156. eCollection 2014. Review.

Blaess, S., Ang, S.-L. (2015)
Genetic control of midbrain dopaminergic neuron development
Wiley Interdiscip Rev Dev Biol. 2015 Mar-Apr;4(2):113-34. doi: 10.1002/wdev.169.

Haddad-Tóvolli, R., Paul, F.A., Zhang, Y., Zhou, X., Theil, T., Puelles, L., Blaess, S., Alvarez-Bolado, G. (2015)
Differential requirements for Gli2 and Gli3 in the regional specification of the mouse hypothalamus
Front Neuroanat 2015 Mar 25;9:34. doi: 10.3389/fnana.2015.00034. eCollection 2015.

Bodea, G.O., Blaess, S. (2015)
Establishing diversity in the dopaminergic system
FEBS Lett. 589(24):3773–3785. doi: 10.1016/j.febslet.2015.09.016. Review.

Karus, M., Blaess, S., Brüstle, O. (2014)
Self-organisation of neural tissue architectures from pluripotent stem cells
J Comp Neurol 522(12):2831-2844. doi: 10.1002/cne.23608.

Bodea, G.O., Spille, J.H., Abe, P., Andersson, A.S., Acker-Palmer, A., Stumm, R., Kubitscheck, U., Blaess S. (2014)
Reelin and CXCL12 regulate distinct migratory behaviors during the development of the dopaminergic system.
Development 141(3):661-73. doi: 10.1242/dev.099937.

Haseleu, J., Anlauf, E., Blaess, S., Endl, E., Derouiche, A. (2013)
Studying subcellular detail in fixed astrocytes: dissociation of morphologically intact glial cells (DIMIGs)
Front Cell Neurosci 7:54 doi: 10.3389/fncel.2013.00054.

Haddad-Tóvolli, R., Heide, M., Zhou, X., Blaess, S., Alvarez-Bolado, G. (2012)
Mouse thalamic differentiation: Gli-dependent pattern and Gli-independent prepattern.
Front Neurosci 6:27

Bodea, G.O., Blaess, S. (2012)
Organotypic slice cultures of embryonic ventral midbrain: a system to study dopaminergic neuronal development in vitro
J Vis Exp 31;(59) doi: 10.3791/3350

Alvarez-Bolado, G., Paul, F.A., Blaess, S. (2012)
Sonic hedgehog lineage in the mouse hypothalamus: From progenitor domains to hypothalamic regions
Neural Dev 20;7(1):4

Derouiche, A., Pannicke, T., Haseleu, J., Blaess, S., Grosche, J., Reichenbach, A. (2012)
Beyond polarity: functional membrane domains in astrocytes and Müller cells.
Neurochem Res. 37(11):2513-23

Blaess, S., Bodea, G.O., Kabanova, A., Chanet, S., Mugniery, E., Derouiche, A., Stephen, D., Joyner, A.L. (2011)
Temporal-spatial changes in Sonic Hedgehog expression and signaling reveal different potentials of ventral mesencephalic progenitors to populate distinct ventral midbrain nuclei
Neural Dev 20:6(1):29

Hammond, R.*, Blaess, S.*, Abeliovich, A. (2009)
Sonic hedgehog is a chemoattractant for midbrain dopaminergic axons
PLoS ONE. 2009 4(9): e7007
*Authors contributed equally

Blaess, S., Stephen, D., Joyner, A.L. (2008)
Gli3 coordinates three-dimensional patterning and growth of the tectum and cerebellum by integrating Shh and Fgf8 signaling
Development 135(12):2093-2103

Corrales, J.D., Blaess, S., Mahoney, E.M., Joyner, A.L. (2006)
The level of Sonic hedgehog signaling regulates the complexity of cerebellar foliation
Development 133(9):1811-1821

Blaess, S., Corrales, J.D., Joyner, A.L. (2006)
Sonic hedgehog regulates Gli activator and repressor functions with spatial and temporal precision in the mid/hindbrain region
Development 133(9):1799-1809

Zervas, M., Blaess, S., Joyner, A.L. (2005)
Classical embryological studies and modern genetic analysis of midbrain and cerebellum development
Current Topics in Developmental Biology 69:101-138

Corrales, J.D., Rocco, G.L., Blaess, S., Guo, Q., Joyner, A.L. (2004)
Spatial pattern of sonic hedgehog signaling through Gli genes during cerebellum development
Development 131(22):5581-5590

White, D.E., Kurpios, N.A., Zuo, D., Hassell, J.A., Blaess, S., Mueller, U., Muller, W.J. (2004)
Targeted disruption of β1-integrin in a transgenic mouse model of human breast cancer reveals an essential role in mammary tumor induction
Cancer Cell 6(2):159-170

Blaess, S.*, Graus-Porta, D.*, Belvindrah, R., Radakovits, R., Pons, S., Littlewood-Evans, A., Senften, M., Guo, H., Li, Y., Miner, J.H., Reichardt, L.F., Müller, U. (2004)
β1-integrins are critical for cerebellar granule cell precursor proliferation
J Neurosci 24(13):3402-3412
* Authors contributed equally

Graus-Porta, D.*, Blaess, S.*, Senften, M., Littlewood-Evans, A., Damsky, C., Huang, Z., Orban, P., Klein, R., Schittny, J.C., Müller, U. (2001)
β1-class integrins regulate the development of laminae and folia in the cerebral and cerebellar cortex
Neuron 16;31(3):367-379
*Authors contributed equally

Blaess, S., Kammerer, R.A., Hall. H. (1998)
Structural analysis of the sixth immunoglobulin-like domain of mouse neural cell adhesion molecule L1 and its interactions with αvβ3, αIIbβ3, and α5β1 integrins
J Neurochem 71(6):2615-2625