Publications » Institute of Reconstructive Neurobiology


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Mathews, M., Wißfeld, J., Flitsch, L.J., Shahraz, A., Semkova, V., Breitkreuz, Y., Neumann, H., Brüstle, O. (2022)
Reenacting neuroectodermal exposure of hematopoietic progenitors enables scalable production of cryopreservable iPSC-derived human microglia
Stem Cell Rev Rep. doi: 10.1007/s12015-022-10433-w. Online ahead of print.

Flitsch, L.J., Börner K., Stüllein, C., Ziegler, S., Sonntag‑Buck, V., Wiedtke, E., Semkova, V., AuYeung, S.W.C., Schlee, J., Hajo, M., Mathews, M., Ludwig, B.S., Kossatz, S., Kessler, H., Grimm, D., Brüstle, O. (2022)
Identification of adeno‑associated virus variants for gene transfer into human neural cell types by parallel capsid screening
Scientific Reports. 12:8356.

Semkova, V., Haupt, S., Segschneider, M., Bell, C., Ingelman-Sundberg, M., Hajo, M., Weykopf, B., Muthukottiappan, P., Till, A.*, Brüstle, O.* (2022)
Dynamics of metabolic pathways and stress response patterns during human neural stem cell proliferation and differentiation
Cells. 11:1388.

Vuidel, A., Cousin, L., Weykopf, B., Haupt, S., Hanifehlou, Z., Wiest-Daesslé, N., Segschneider, M., Lee, J., Kwon, Y.-J., Peitz, M., Ogier, A., Brino, L., Brüstle, O., Sommer, P., Wilbertz, J.H.
High-content phenotyping of Parkinson’s disease patient stem cell-derived midbrain dopaminergic neurons using machine learning classification
Stem Cell Reports. 17:1-16.

Wischhof, L., Lee, H.M., Tutas, J., Overkott, C., Tedt, E., Stork, M., Peitz, M., Brüstle, O., Ulas, T., Händler, K., Schultze, J.L., Ehninger, D., Nicotera, P., Salomoni, P., Bano, D. (2022)
BCL7A-containing SWI/SNF/BAF complexes modulate mitochondrial bioenergetics during neural progenitor differentiation
EMBO J. 2022 Oct 28:e110595. doi: 10.15252/embj.2022110595. Online ahead of print.

Yang, N.J., Isensee, J., Neel, D.V., Quadros, A.U., Zhang, H.B., Lauzadis, J., Liu, S.M., Shiers, S., Belu, A., Palan, S., Marlin, S., Maignel, J., Kennedy-Curran, A., Tong, V.S., Moayeri, M., Röderer, P., Nitzsche, A., Lu, M., Pentelute, B.L., Brüstle, O., Tripathi, V., Foster, K.A., Price, T.J., Collier, R.J., Leppla, S.H., Puopolo, M., Bean, B.P., Cunha, T.M., Hucho, T., Chiu, I.M. (2022)
Anthrax toxins regulate pain signaling and can deliver molecular cargoes into ANTXR2+ DRG sensory neurons
Nat Neurosci. 25:168-179. doi: 10.1038/s41593-021-00973-8.

Wen, J., Peitz, M., Brüstle, O. (2022)
A defined human-specific platform for modeling neuronal network stimulation in vitro and in silico
J Neurosci Methods. 373:109562.

Roll, L., Lessmann, K., Brüstle, O., Faissner, A. (2022)
Cerebral organoids maintain the expression of neural stem cell-associated glycoepitopes and extracellular matrix
Cells. 11:760.

Wolf, C., Pouya, A., Bitar, S., Pfeiffer, A., Bueno, D., Rojas-Charry, L., Arndt, S., Gomez-Zepeda, D., Tenzer, S., Dal Bello, F., Vianello, C., Ritz, S., Schwirz, J., Dobrindt, K., Peitz, M., Hanschmann, E.-M., Mencke, P., Boussaad, I., Silies, M., Brüstle, O., Giacomello, M., Krüger, R., Methner, A. (2022)
GDAP1 loss of function inhibits the mitochondrial pyruvate dehydrogenase complex by altering the actin cytoskeleton
Commun Biol. 5:541.

Petese, A., Fries, F.L., Broske, B., Stumm, R., Blaess, S. (2022)
Lineage analysis of Cxcr4-expressing cells in the developing midbrain suggests that progressive competence restriction in dopaminergic progenitor cells contributes to the establishment of dopaminergic neuronal diversity
eNeuro. doi: 10.1523/ENEURO.0052-22.2022. Online ahead of print.

Gather, F., Ihrig-Biedert, I., Kohlhas, P., Krutenko, T., Peitz, M., Brüstle, O., Pautz, A., Kleinert, H. (2022)
A specific, non-immune system-related isoform of the human inducible nitric oxide synthase is expressed during differentiation of human stem cells into various cell types
Cell Commun Signal. 20:47. doi: 10.1186/s12964-022-00855-x.

Rodriguez-Gatica, J.E.#, Iefremova, V.#, Sokhranyaeva, L., Yeung, S.W.C.A., Breitkreuz, Y., Brüstle, O.*, Schwarz, M.K.*, Kubitscheck, U.* (2022)
Imaging three-dimensional brain organoid architecture from meso- to nanoscale across development
Development. 149:dev200439. doi: 10.1242/dev.200439

Radtke, F., Palladino, V.S., McNeill, R.V., Chiocchetti, A.G., Haslinger, D., Leyh, M., Gersic, D., Frank, M., Grünewald, L., Klebe, S., Brüstle, O., Günther, K., Edenhofer, F., Kranz, T.M., Reif, A., Kittel-Schneider, S. (2022)
ADHD-associated PARK2 copy number variants: A pilot study on gene expression and effects of supplementary deprivation in patient-derived cell lines
Am J Med Genet B Neuropsychiatr Genet. doi: 10.1002/ajmg.b.32918. Online ahead of print.

Kebir, S., Ullrich, V., Berger, P., Dobersalske, C., Langer, S., Rauschenbach, L., Trageser, D., Till, A., Lorbeer, F.K., Wieland, A., Wilhelm-Buchstab, T., Ahmad, A., Fröhlich, H., Cima, I., Prasad, S., Matschke, J., Jendrossek, V., Remke, M., Grüner, B.M., Roesch, A., Siveke, J.T., Herold-Mende, C., Blau, T., Keyvani, K., van Landeghem, F.K.H., Pietsch, T., Felsberg, J., Reifenberger, G., Weller, M., Sure, U., Brüstle, O., Simon, M., Glas, M., Scheffler, B. (2022)
A sequential targeting strategy interrupts AKT-driven subclone-mediated progression in glioblastoma
Clin Cancer Res. doi: 10.1158/1078-0432.CCR-22-0611. Online ahead of print.

Paolicelli, R.C., Sierra, A.,…, Neumann, H., …Wyss-Coray, T. (2022)
Microglia states and nomenclature: A field at its crossroads
Neuron. 110: 3458-3483.

Shahraz, A., Lin, Y., Mbroh, J., Winkler, J., Liao, H., Lackmann, M., Bungartz, A., Zipfel, P.F., Skerka, C., Neumann, H. (2022)
Low molecular weight polysialic acid binds to properdin and reduces the activity of the alternative complement pathway
Scientific Reports 12:5818.

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Schmid, B., Holst, B., Clausen, C., Bahnassawy, L., Reinhardt, P., Bakker, M.H.M., Díaz-Guerra, E., Vicario, C., Martino-Adami, P.V., Thoenes, M., Ramirez, A., Flissbach, K., Grezella, C., Brüstle, O., Peitz, M., Ebneth, A., Cabrera-Socorro, A. (2021)
Generation of a set of isogenic iPSC lines carrying all APOE genetic variants (Ɛ2/Ɛ3/Ɛ4) and knock-out for the study of APOE biology in health and disease
Stem Cell Res. 52:102180. doi: 10.1016/j.scr.2021.102180.

Wißfeld, J., Nozaki, I., Mathews, M., Raschka, T., Ebeling, C., Hornung, V., Brüstle, O., Neumann, H. (2021)
Deletion of Alzheimer's disease-associated CD33 results in an inflammatory human microglia phenotype
Glia. 69:1393-1412. doi: 10.1002/glia.23968.

Manstein, F., Ullmann, K., Kropp, C., Halloin, C., Triebert, W., Franke, A., Farr, C.M., Sahabian, A., Haase, A., Breitkreuz, Y., Peitz, M., Brüstle, O., Kalies, S., Martin, U., Olmer, R., Zweigerdt, R. (2021)
High density bioprocessing of human pluripotent stem cells by metabolic control and in silico modeling
Stem Cells Transl Med. 10:1063–1080. doi: 10.1002/sctm.20-0453.

Liao, H., Winkler, J., Wißfeld, J., Shahraz, A., Klaus, C., Neumann, H. (2021)
Low molecular weight polysialic acid prevents lipopolysaccharide-induced inflammatory dopaminergic neurodegeneration in humanized SIGLEC11 transgenic mice
Glia. 69:2845–2862.

Tolve, M., Ulusoy, A., Patikas, N., Islam, K.U.S., Bodea, G.O., Öztürk, E., Broske, B., Mentani, A., Wagener, A., van Loo, K.M.J., Britsch, S., Liu, P., Khaled, W.T., Metzakopian, E., Baader, S.L.,Di Monte, D.A., Blaess, S. (2021)
The transcription factor BCL11A defines distinct subsets of midbrain dopaminergic neurons
Cell Reports. 36:109697. DOI:

Lünemann J.D., von Gunten, S., Neumann, H. (2021)
Targeting sialylation to treat central nervous system diseases
Trends Pharmacol Sci. 42:998-1008. doi: 10.1016/

Cenini, G., Hebisch, M., Iefremova, V., Flitsch, L.J., Breitkreuz, Y., Tanzi, R.E., Kim, D.Y., Peitz, M., Brüstle, O. (2021)
Dissecting Alzheimer's disease pathogenesis in human 2D and 3D models
Mol Cell Neurosci. 110:103568. doi: 10.1016/j.mcn.2020.103568. Review.

Wißfeld, J., Mathews, M., Mossad, O., Picardi, P., Cinti, A., Redaelli, L., Pradier, L., Brüstle, O., Neumann, H. (2021)
Reporter cell assay for human CD33 validated by specific antibodies and human iPSC-derived microglia
Sci Rep. 11:13462.

Shahraz, A., Wißfeld, J., Ginolhac, A., Mathews, M., Sinkkonen, L., Neumann, H. (2021)
Phagocytosis-related NADPH oxidase 2 subunit gp91phox contributes to neurodegeneration after repeated systemic challenge with lipopolysaccharides
Glia. 69:137-150. doi: 10.1002/glia.23890.

Ibach, M., Mathews, M., Linnartz-Gerlach, B., Theil, S., Kumar, S., Feederle, R., Brüstle, O., Neumann, H., Walter, J. (2021)
A reporter cell system for the triggering receptor expressed on myeloid cells 2 reveals differential effects of disease-associated variants on receptor signaling and activation by antibodies against the stalk region
Glia. 69:1126-1139. doi: 10.1002/glia.23953

Wedekind, H., Kats, E., Weiss, A-C., Thiesler, H., Klaus, C., Kispert, A., Horstkorte, R., Neumann, H., Weinhold, B., Münster-Kühnel, A., Abeln, M. (2021)
Gne deletion in mice leads to lethal intracerebral hemorrhage during embryonic development
Glycobiology. 31:1478–1489.

Islam, K.U.S., Meli, N., Blaess, S. (2021)
The development of the mesoprefrontal dopaminergic system in health and disease
Front Neural Circuits. 15:746582. doi: 10.3389/fncir.2021.746582.

Piotrowskia, T., Rippel, O., Elanzew, A., Nießing, B., Stucken, S., Jung, S., König, N., Haupt, S., Stappert, L., Brüstle, O., Schmitt, R., Jonas, S. (2021)
Deep-learning-based multi-class segmentation for automated, non-invasive routine assessment of human pluripotent stem cell culture status
Comput Biol Med. 129:104172.

Fumagalli, F., Young, F.L., Boeynaems, S., De Decker, M., Mehta, A.R., Swijsen, A., Fazal, R., Guo, W., Moisse, M., Beckers, J., Dedeene, L., Selvaraj, B.T., Vandoorne, T., Madan, V., van Blitterswijk, M., Raitcheva, D., McCampbell, A., Poesen, K., Gitler, A.D., Koch, P., Berghe, P.V., Rudolf, D., Verfaillie, C., Chandran, S., Van Den Bosch, L., Bullock, S.L., Van Damme, P. (2021)
C9orf72-derived arginine-containing dipeptide repeats associate with axonal transport machinery and impede microtubule-based motility
Sci Adv. 7:eabg3013. doi: 10.1126/sciadv.abg3013.

Klaus, C., Liao, H., Allendorf, D.H., Brown, G.C., Neumann, H. (2021)
Sialylation acts as a checkpoint for innate immune responses in the central nervous system
Glia. 69:1619-1636. doi: 10.1002/glia.23945.

Blaess, S., Wachten, D. (2021)
The BBSome: a nexus controlling energy metabolism in the brain
J Clin Invest. 131:e148903. doi: 10.1172/JCI148903.

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Peitz, M., Krutenko, T., Brüstle, O. (2020)
Protocol for the standardized generation of forward programmed cryopreservable excitatory and inhibitory forebrain neurons
STAR Protocols (Cell Press) 1, 100038.

Flitsch, L.J., Laupman, K.E., Brüstle, O. (2020)
Transcription factor-based fate specification and forward programming for neural regeneration
Front Cell Neurosci. 14:121.

Cheffer, A., Flitsch, L.J., Krutenko, T., Röderer, P., Sokhranyaeva, L., Iefremova, V., Hajo, M., Peitz, M., Schwarz, M.K., Brüstle, O. (2020)
Human stem cell-based models for studying autism spectrum disorder-related neuronal dysfunction
Molecular Autism 11:99.

Paß, T., Aßfalg, M., Tolve, M., Blaess, S., Rothermel, M., Wiesner, R.J., Ricke, K.M. (2020)
The impact of mitochondrial dysfunction on dopaminergic neurons in the olfactory bulb and odor detection
Mol Neurobiol. 57:3646-3657. doi: 10.1007/s12035-020-01947-w.

Elanzew, A., Nießing, B., Langendoerfer, D., Rippel, O., Piotrowski, T., Schenk, F., Kulik, M., Peitz, M., Breitkreuz, Y., Jung, S., Wanek, P., Stappert, L., Schmitt, R.H., Haupt, S., Zenke, M., König, N., Brüstle, O. (2020)
The StemCellFactory: A modular system integration for automated generation and expansion of human induced pluripotent stem cells
Front Bioeng Biotechnol. 8:580352. doi: 10.3389/fbioe.2020.580352.

Jäger, A., Heim, N., Kramer, F.J., Setiawan, M., Peitz, M., Konermann, A. (2020)
A novel serum-free medium for the isolation, expansion and maintenance of stemness and tissue-specific markers of primary human periodontal ligament cells
Ann Anat. 2020 Mar 27;231:151517. doi: 10.1016/j.aanat.2020.151517.

Liao, H., Klaus, C., Neumann, H. (2020)
Control of innate immunity by sialic acids in the nervous tissue
Int J Mol Sci. 21:E5494. doi: 10.3390/ijms21155494.

Klaus, C., Hansen, N.J., Ginolhac, A., Gérard, D., Gnanapragassam, V., Horstkorte, R., Rossdam, Ch., Buettner, F., Sauter, T., Sinkkonen, L., Neumann, H., Linnartz-Gerlach, B. (2020)
Reduced sialylation triggers homeostatic synapse and neuronal loss in middle-aged mice
Neurobiology of Aging. 88:91-107.

Palladino, V.S., Chiocchetti, A.G., Frank, L., Haslinger, D., McNeill, R., Radtke, F., Till, A., Haupt, S., Brüstle, O., Günther, K., Edenhofer, F., Hoffmann, P., Reif, A., Kittel-Schneider, S. (2020)
Energy metabolism disturbances in cell models of PARK2 CNV carriers with ADHD
J Clin Med. 9:4092. doi: 10.3390/jcm9124092.

Tabari, D., Scholl, C., Steffens, M., Weickhardt, S., Elgner, F., Bender, D., Herrlein, M.L., Sabino, C., Semkova, V., Peitz, M., Till, A., Brüstle, O., Hildt, E., Stingl, J. (2020)
Impact of Zika virus infection on human neural stem cell microRNA signatures
Viruses. 12:E1219. doi: 10.3390/v12111219.

Rauschenbach, L., Wieland, A., Reinartz, R., Kebir, S., Till, A., Darkwah Oppong, M., Dobersalske, C., Ullrich, V., Ahmad, A., Jabbarli, R., Pierscianek, D., Fröhlich, H., Simon, M., Brüstle, O., Sure, U., Glas, M., Scheffler, B. (2020)
Drug repositioning of antiretroviral ritonavir for combinatorial therapy in glioblastoma
Eur J Cancer. 140:130-139. doi: 10.1016/j.ejca.2020.09.017.

Memmert, S., Nogueira, A.V.B., Damanaki, A., Nokhbehsaim, M., Rath-Deschner, B., Götz, W., Gölz, L., Cirelli, J.A., Till, A., Jäger, A., Deschner, J. (2020)
Regulation of the autophagy-marker Sequestosome 1 in periodontal cells and tissues by biomechanical loading
J Orofac Orthop. 81:10-21. doi: 10.1007/s00056-019-00197-3.

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Flitsch, L.J. and Brüstle, O. (2019)
Evolving principles underlying neural lineage conversion and their relevance for biomedical translation
F1000Research 2019. doi: 10.12688/f1000research.18926.1

Ostermann, L.#Ladewig, J.#, Müller, F.J., Kesevan, J., Tailor, J., Smith, A., Brüstle, O.*Koch, P.* (2019)
In vitro recapitulation of developmental transitions in human neural stem cells
Stem Cells. 37:1429-1440. doi: 10.1002/stem.3065

Giesselmann, P., Brändl, B., Raimondeau, E., Bowen, R., Rohrandt, C., Tandon, R., Kretzmer, H., Assum, G., Galonska, C., Siebert, R., Ammerpohl, O., Heron, A., Schneider, S.A., Ladewig, J., Koch, P., Schuldt, B.M., Graham, J.E., Meissner, A., Müller, F.J. (2019)
Analysis of short tandem repeat expansions and their methylation state with nanopore sequencing
Nat Biotechnol. 37:1478-1481. doi: 10.1038/s41587-019-0293-x

Rehbach, K.Kesavan, J., Hauser, S., Ritzenhofen, S.Jungverdorben, J., Schüle, R., Schöls, L., Peitz, M.Brüstle, O. (2019)
Multiparametric rapid screening of neuronal process pathology for drug target identification in HSP patient-specific neurons
Scientific Reports. 9:9615. doi: 10.1038/s41598-019-45246-4

Ojeda, D.S., Till, A., Quarleri, J. (2019)
Are the mechanisms involved in astrocyte and lymphocyte death during HIV infection similar?
Neural Regen Res. 14:1707-1708. doi: 10.4103/1673-5374.257519

Meijer, M.#, Rehbach, K.#, Brunner, J.W., Classen, J.A., Lammertse, H.C.A., van Linge, L.A., Schut, D., Krutenko, T., Hebisch, M., Cornelisse, L.N., Sullivan, P.F., Peitz, M.*, Toonen, R.F., Brüstle, O.*, Verhage, M.* (2019)
A single-cell model for synaptic transmission and plasticity in human iPSC-derived neurons
Cell Reports. 27:2199-2211.doi: 10.1016/j.celrep.2019.04.058

Wiatr, K., Piasecki, P., Marczak, Ł., Wojciechowski, P., Kurkowiak, M., Płoski, R., Rydzanicz, M., Handschuh, L., Jungverdorben, J., Brüstle, O., Figlerowicz, M., Figiel, M. (2019)
Altered levels of proteins and phosphoproteins, in the absence of early causative transcriptional changes, shape the molecular pathogenesis in the brain of young presymptomatic Ki91 SCA3/MJD mouse
Mol Neurobiol. 56:8168-8202. doi: 10.1007/s12035-019-01643-4

Rhee, H.J.#, Shaib, A.H.#, Rehbach, K.#, Lee, C.K., Seif, P., Thomas, C., Gideons, E., Guenther, A., Krutenko, T., Hebisch, M., Peitz, M., Brose, N., Brüstle, O.*, Rhee, J.S.* (2019)
An autaptic culture system for standardized analyses of iPSC-derived human neurons
Cell Reports. 27:2212-2228. doi: 10.1016/j.celrep.2019.04.059

Boßmann, D., Bartling, B., de Vries, I., Winkler, J., Neumann, H., Lammers, F., Beutel, S., Scheper, T. (2019)
Charged aerosol detector HPLC as a characterization and quantification application of biopharmaceutically relevant polysialic acid from E. coli K1
J Chromatogr A. 1599:85-94. doi: 10.1016/j.chroma.2019.03.069

Schäfer, N., Gielen, G.H., Rauschenbach, L., Kebir, S., Till, A., Reinartz, R., Simon, M., Niehusmann, P., Kleinschnitz, C., Herrlinger, U., Pietsch, T., Scheffler, B., Glas, M. (2019)
Longitudinal heterogeneity in glioblastoma: moving targets in recurrent versus primary tumors
J Transl Med. 17:96. doi: 10.1186/s12967-019-1846-y

van Loo, K.M.J., Rummel, C.K., Pitsch, J., Müller, A. J., Bikbaev, A.F., Martinez Chavez, E., Blaess, S., Dietrich, D., Heine, M., Becker, A.J., Schoch, S. (2019)
Calcium channel subunit α2δ4 is regulated by early growth response 1 and facilitates epileptogenesis
J Neurosci. pii: 1731-18. doi: 10.1523/JNEUROSCI.1731-18.2019

Vaswani, A.R.Weykopf, B., Hagemann, C., Fried, H.-U., Brüstle, O., Blaess, S. (2019)
Correct setup of the substantia nigra requires Reelin-mediated fast, laterally-directed migration of dopaminergic neurons
eLife. 8:e41623. doi: 10.7554/eLife.41623

Mukherjee, S., Klaus, C., Pricop-Jeckstadt, M., Miller, J.A., Struebing, F.L. (2019)
A microglial signature directing human aging and neurodegeneration-related gene networks
Front Neurosci. 13:2. doi: 10.3389/fnins.2019.00002

Weykopf, B. , Haupt, S. , Jungverdorben, J. , Flitsch, L. J., Hebisch, M. , Liu, G. , Suzuki, K. , Belmonte, J. C., Peitz, M. , Blaess, S. , Till, A., Brüstle, O. (2019)
Induced pluripotent stem cell‐based modeling of mutant LRRK2‐associated Parkinson's Disease
Eur J Neurosci. 49:561-589. doi:10.1111/ejn.14345

Brodski, C., Blaess, S., Partanen, J., Prakash, N. (2019)
Crosstalk of intercellular signaling pathways in the generation of midbrain dopaminergic neurons in vivo and from stem cells
J Dev Biol. 7:3. doi: 10.3390/jdb7010003. Review

Linnartz-Gerlach, B., Bodea, L.G., Klaus, C., Ginolhac, A., Halder, R., Sinkkonen, L., Walter, J., Colonna, M., Neumann, H. (2019)
TREM2 triggers microglial density and age-related neuronal loss
Glia. 67:539-550. doi: 10.1002/glia.23563

Thier, M.C., Hommerding, O., Panten, J., Pinna, R., García-González, D., Berger, T., Wörsdörfer, P., Assenov, Y., Scognamiglio, R., Przybylla, A., Kaschutnig, P., Becker, L., Milsom, M.D., Jauch, A., Utikal, J., Herrmann, C., Monyer, H., Edenhofer, F., Trumpp, A. (2019)
Identification of embryonic neural plate border stem cells and their generation by direct reprogramming from adult human blood cells
Cell Stem Cell. 24:166-182. doi: 10.1016/j.stem.2018.11.015

Memmert, S., Damanaki, A., Weykopf, B., Rath-Deschner, B., Nokhbehsaim, M., Götz, W., Gölz, L., Till, A., Deschner, J., Jäger, A. (2019)
Autophagy in periodontal ligament fibroblasts under biomechanical loading
Cell Tissue Res. 378:499-511. doi: 10.1007/s00441-019-03063-1.

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Martinez-Chavez, E., Scheerer, C., Wizenmann, A., Blaess, S. (2018)
The zinc finger transcription factor Gli3 is a regulator of precerebellar neuronal migration
Development. 145:dev166033. doi: 10.1242/dev.166033

Stappert, L., Klaus, F., Brüstle, O. (2018)
MicroRNAs engage in complex circuits regulating adult neurogenesis
Front Neurosci. 12:707. doi: 10.3389/fnins.2018.00707. Review

Sheng, C., Jungverdorben, J., Wiethoff, H., Lin, Q., Flitsch, L.J., Eckert, D., Hebisch, H., Fischer, J., Kesavan, J., Weykopf, B., Schneider, L., Holtkamp, D., Beck, H., Till, A., Wüllner, U., Ziller, M.J., Wagner, W., Peitz, M., Brüstle, O. (2018)
A stably self-renewing adult blood-derived induced neural stem cell exhibiting patternability and epigenetic rejuvenation
Nat Commun. 29:4047. doi: 10.1038/s41467-018-06398-5
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Fülle, L., Offermann, N., Hansen, J.N., Breithausen, B., Erazo, A.B., Schanz, O., Radau, L., Gondorf, F., Knöpper, K., Alferink, J., Abdullah, Z., Neumann, H., Weighardt, H., Henneberger, C., Halle, A., Förster, I. (2018)
CCL17 exerts a neuroimmune modulatory function and is expressed in hippocampal neurons
Glia. 66:2246-2261. doi: 10.1002/glia.23507

Allison, T.F., Andrews, P.W., Avior, Y., Barbaric, I., Benvenisty, N., Bock, C., Brehm, J., Brüstle, O., Damjanov, I., Elefanty, A., Felkner, D., Gokhale, P.J., Halbritter, F., Healy, L.E., Hu, T.X., Knowles, B.B., Loring, J.F., Ludwig, T.E., Mayberry, R., Micallef, S., Mohamed, J.S., Müller, F.-J., Mummery, C.L., Nakatsuji, N., Ng, E.S., Oh, S.K.W., O’Shea, O., Pera, M.F., Reubinoff, B., Robson, P., Rossant, J., Schuldt, B.M., Solter, D., Sourris, K., Stacy, G., Stanley, E.G., Suemori, H., Takahashi, K., Yamanaka, S. (2018)
Assessment of established techniques to determine developmental and malignant potential of human pluripotent stem cells
Nat Commun. 9:1925. doi: 10.1038/s41467-018-04011-3

Kumar, P., Efstathopoulos, P., Millischer, V., Olsson, E., Bin Wei, Y., Brüstle, O., Schalling, M., Villaescusa, J.C., Ösby, U., Lavebratt, C. (2018)
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Münst, S., Koch, P., Kesavan, J., Alexander-Mays, M., Münst, B., Blaess, S., Brüstle, O. (2018)
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de Boni, L., Gasparoni, G., Haubenreich, C., Tierling, S., Schmitt, I., Peitz, M., Koch, P., Walter, J., Wüllner, U., Brüstle, O. (2018)
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Siegel, G., Gerber, H., Koch, P., Brüstle, O., Fraering, P.C., Rajendran, L. (2017)
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Luxen, D., Gielen, G.H., Waha, A., Isselstein, L., Müller, T., Koch, P., Hammes, J., Becker, A., Simon, M., Wurst, P., Endl, E., Pietsch, T., Gessi, M., Waha, A. (2017)
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Badenes, S.M., Fernandes, T.G., Miranda, C.C, Pusch-Klein, A., Haupt, S., Rodrigues, C.A.V., Diogoa, M.M., Brüstle, O., Cabrala, J.M.S (2017)
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Wörsdörfer, P., Bosen, F., Gebhardt, M., Russ, N., Zimmermann, K., Komla Kessie, D., Sekaran, T., Egert, A., Ergün, S., Schorle, H., Pfeifer, A., Edenhofer, F., Willecke, K. (2017)
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Kebir, S., Khurshid, Z., Gaertner, F.C., Essler, M., Hattingen, E., Fimmers, R., Scheffler, B., Herrlinger, U., Bundschuh, R.A., Glas, M. (2017)
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Memmert, S., Damanaki, A., Nogueira, A.V.B., Eick, S., Nokhbehsaim, M., Papadopoulou, A.K., Till, A., Rath, B., Jepsen, S., Götz, W., Piperi, C., Basdra, E.K., Cirelli, J.A., Jäger, A., Deschner, J. (2017)
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Hattingen, E., Müller, A., Jurcoane, A., Mädler, B., Ditter, P., Schild, H., Herrlinger, U., Glas, M., Kebir, S. (2017)
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de Vries, I., Busse, C., Kopatz, J., Neumann, H., Beutel, S., Scheper, T. (2017)
Polysialic acid production using Escherichia coli K1 in a disposable bag reactor
Engineering in Life Sciences 17:723-731

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Roese-Koerner, B., Stappert, L., Berger, T., Braun, N.C., Veltel, M., Jungverdorben, J., Evert, B.O., Peitz, M., Borghese, L., Brüstle, O. (2016)
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Schwenk, B.M., Hartmann, H., Serdaroglu, A., Schludi, M.H., Hornburg, D., Meissner, F., Orozco, D., Colombo, A., Tahirovic, S., Michaelsen, M., Schreiber, F., Haupt, S., Peitz, M., Brüstle, O., Küpper, C., Klopstock, T., Otto, M., Ludolph, A.C., Arzberger, T., Kuhn, P.H., Edbauer, D. (2016)
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Mack, F., Baumert, B.G., Schäfer, N., Hattingen, E., Scheffler, B., Herrlinger, U., Glas, M. (2016)
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Vadodaria, K.C., Mertens, J., Paquola, A., Bardy, C., Li, X., Jappelli, R., Fung, L., Marchetto, M.C., Hamm, M., Gorris, M., Koch, P., Gage, F.H. (2016)
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Gazea, M., Tasouri, E., Tolve, M., Bosch, V., Kabanova, A., Gojak, C., Kurtulmus, B., Novikov, O., Spatz, J., Pereira, G., Hübner, W., Brodski, C., Tucker, K.L., Blaess, S. (2016)
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Gazea, M.*, Tasouri, E.*, Heigl, T., Bosch, V., Tucker, K.L., Blaess, S. (2016)
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*Authors contributed equally

Münst, B., Their, M.C., Winnemöller, D., Helfen, M.,Thummer, R.P., Edenhofer, F. (2016)
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Human induced pluripotent stem cell-derived cortical neurons integrate in stroke-injured cortex and improve functional recovery
Brain 136(12):3561-3577

Ladewig, J.*, Koch, P.*, Brüstle, O. (2013)
Leveling Waddington: the emergence of direct programming and the loss of cell fate hierarchies
Nature Rev Mol Cell Biol 14(4):225-236

Glas, M., Coch, C., Trageser, D., Simon, M., Koch, P., Mertens, J., Quandel, T., Lüdenbach, B., Daßler, J., Lünskens, R., Reinartz, R., Wieland, A., Eisenreich, R., Höfer, H.,, Keller, M., von Lehe, M., Pusch, A., Schlee, M., Neumann, H., Fimmers, R., Herrlinger, U., Brüstle, O., Besch, R., Hartmann, G., Scheffler, B. (2013)
Targeting the cytosolic innate immune receptors RIG-I and MDA5 effectively counteracts cancer cell heterogeneity in glioblastoma
Stem Cells 31(6):1064-1074

Neumann, H., Daly, M.J. (2013)
Variant TREM2 as risk factor for Alzheimer's disease
N Engl J Med 368(2):182-184

Zhang, B.*, Gaiteri, C.*, Bodea, L.G.*, Wangm Z,*, McElwee, J., Podtelezhnikov, A.A., Zhang, C., Xie, T., Tran, L., Dobrin, R., Fluder, E., Clurman, B., Melquist, S., Narayanan, M., Suver, C., Shah, H., Mahajan, M., Gillis, T., Mysore, J., MacDonald, M.E., Lamb, J.R., Bennett, D.A., Molony, C., Stone, D.J., Gudnason, V., Myers, A.J., Schadt, E.E., Neumann, H., Zhu, J., Emilsson, V. (2013)
Integrated systems approach identifies genetic nodes and networks in late-onset Alzheimer’s disease
Cell 153(3):707-720

Mertens, J., Stüber, K., Poppe, D., Doerr, J., Ladewig, J., Brüstle, O.*, Koch, P.* (2013)
Embryonic stem cell-based modeling of tau pathology in human neurons
Am J Pathol 182(5):1769-1779

Bianco, P., Barker, R., Brüstle, O., Cattaneo, E., Clevers, H., Daley, G.Q., De Luca, M., Goldstein, L., Lindvall, O., Mummery, C., Robey, P.G., Sattler de Sousa e Brito, C., Smith, A. (2013)
Regulation of stem cell therapies under attack in Europe: for whom the bell tolls
The EMBO Journal 32(11):1489-1495

Wieland, A., Trageser, D., Gogolok, S., Reinartz, R., Höfer, H., Keller, M., Leinhaas, A., Schelle, R., Normann, S., Klaas, L., Waha, A., Koch, P., Fimmers, R., Pietsch, T., Yachnis, A.T., Pincus, D.W., Steindler, D.A., Brüstle, O., Simon, M., Glas, M., Scheffler, B. (2013)
Anticancer effects of niclosamide in human glioblastoma
Clin Cancer Res 19(15):4124-4136

Stappert, L.*, Borghese, L*., Roese-Koerner, B., Weinhold, S., Koch, P., Terstegge, S., Uhrberg, M., Wernet, P., Brüstle, O. (2013).
MicroRNA-based promotion of human neuronal differentiation and subtype specification
PLoS One 8(3):e59011

Mertens, J., Koch, P., Brüstle, O. (2013)
Human pluripotent and multipotent stem cells as tools for modeling neurodegeneration
In: Programmed Cells from Basic Neuroscience to Therapy (Eds.: Gage, F.H., Christen, Y.), Research and Perspectives in Neurosciences, Foundation IPSEN, Springer, pp.57-66.

Schäfer, N., Scheffler, B., Stuplich, M., Schaub, C., Kebir, S., Rehkämper, C., Mack, F., Niehusmann, P., Simon, M., Greschus, S., Kuchelmeister, K., Herrlinger, U., Glas, M. (2013)
Vemurafenib for leptomeningeal melanomatosis
J Clin Oncol 31(11):e173-174

Neumann, H., Wekerle, H. (2013)
Brain microglia: Watchdogs with pedigree
Nat Neurosci 16(3):253-255

Garbes, L., Heesen, L., Hölker, I., Bauer, T., Schreml, J., Zimmermann, K., Thoenes, M., Walter, M., Dimos, J., Peitz, M., Brüstle, O., Heller, R., Wirth, B. (2013)
VPA response in SMA is suppressed by the fatty acid translocase CD36
Hum Mol Genet 22(2):398-407

Claude, J., Linnartz-Gerlach, B., Kudinm A.P., Kunz, W.S.,Neumann, H. (2013)
Microglial CD33-related Siglec-E inhibits neurotoxicity by preventing the phagocytosis associated oxidative burst
J Neurosci 33(46):18270-18276

Silver, D.J., Siebzehnrubl, F.A., Schildts, M.J., Yachnis, A.T., Smith, G.M., Smith, A.A., Scheffler, B., Reynolds, B.A., Silver, J., Steindler, D.A. (2013)
Chondroitin sulfate proteoglycans potently inhibit invasion and serve as a central organizer of the brain tumor microenvironment
J Neurosci 33(39):15603-15617

Linnartz, B., Neumann, H. (2013)
Microglial activatory (immunoreceptor tyrosine-based activation motif)- and inhibitory (immunoreceptor tyrosine-based inhibition motif)-signaling receptors for recognition of the neuronal glycocalyx
Glia 61(1):37-46

Kopatz, J.*, Beutner, C.*, Welle, K., Bodea, L.G., Reinhardt, J., Claude, J., Linnartz-Gerlach, B., Neumann, H. (2013)
Siglec-h on activated microglia for recognition and engulfment of glioma cells
Glia 61(7):1122-1133

Beutner, C.*, Linnartz-Gerlach, B.*, Schmidt, S.V., Beyer, M., Mallmann, M.R., Staratschek-Jox, A., Schultze, J.L., Neumann, H. (2013)
Unique transcriptome signature of mouse microglia
Glia 61(9):1429-1442

Hennen, E., Safina, D., Haussmann, U., Wörsdörfer, P., Edenhofer, F., Poetsch, A., Faissner, A. (2013)
A LewisX-glycoprotein screen identifies the low density lipoprotein receptor-related protein 1 (LRP1) as a modulator of oligodendrogenesis in mice
J Biol Chem 288(23):16538-16545

Sekaran, T., Thummer, R.P., Edenhofer, F. (2013)
Exploring the neural reprogrammome using bioinformatics approaches
J Stem Cell Res Ther 3:146

Wunderlich, P., Glebov, K., Kemmerling, N., Tien, N.T., Neumann, H., Walter, J. (2013)
Sequential proteolytic processing of the triggering receptor expressed on myeloid cells-2 (TREM2) by ectodomain shedding and γ-secretase dependent intramembranous cleavage
J Biol Chem 288(46):33027-33036

Roese-Koerner, B., Stappert, L., Koch, P., Brüstle, O.‡, Borghese, L.‡ (2013)
Pluripotent stem cell-derived somatic stem cells as tool to study the role of microRNAs in early human neural development
Curr Mol Med 13(5):707-722

Peitz, M., Jungverdorben, J., Brüstle, O. (2013)
Disease-specific iPS cell models in neuroscience
Curr Mol Med 13(5):832-841

Peitz, M., Jungverdorben, J., Brüstle, O. (2013)
Disease-specific iPS cell models in neuroscience
Curr Mol Med 13(5):832-841

Wörsdörfer, P., Thier, M., Iqbal, K.A., Edenhofer, F. (2013)
Roadmap to cellular reprogramming – Manipulating transcriptional networks with DNA, RNA, proteins and small molecules
Curr Mol Med 13(5):868-878

Sieber, M.W., Jaenisch, N., Brehm, M., Guenther, M., Linnartz-Gerlach, B., Neumann, H., Witte, O.W., Frahm, C. (2013)
Attenuated inflammatory response in Triggering receptor expressed on myeloid cells 2 (TREM2) knock-out mice following stroke
PLoS ONE 8(1): e52982

Sierra, A., Abiega, O., Shahraz, A., Neumann, H. (2013)
Janus-faced microglia: beneficial and detrimental consequences of microglial phagocytosis
Front Cell Neurosci 2013;7:6. doi: 10.3389/fncel.2013.00006.

Haseleu, J., Anlauf, E., Blaess, S., Endl, E., Derouiche, A. (2013)
Studying subcellular detail in fixed astrocytes: dissociation of morphologically intact glial cells (DIMIGs)
Front Cell Neurosci 7:54 doi: 10.3389/fncel.2013.00054.

Beutner, C., Lepperhof, V., Dann, A., Linnartz-Gerlach, B., Litwak, S., Napoli, I., Prinz, M., Neumann, H. (2013)
Engineered stem cell-derived microglia as therapeutic vehicle for experimental autoimmune encephalomyelitis
Gene Therapy 20(8):797-806

Brösicke, N., van Landeghem, F.K., Scheffler, B., Faissner, A. (2013)
Tenascin-C is expressed by human glioma in vivo and shows a strong association with tumor blood vessels
Cell Tissue Res 354(2):409-430

Schaub, C., Greschus, S., Seifert, M., Waha, A., Blasius, E., Rasch, K., Landwehr, C., Mack, F., Schäfer, N., Stuplich, M., Kebir, S., Vilz, B., Scheffler, B., Boström, J., Simon, M., Urbach, H., Glas, M., Herrlinger, U. (2013)
FLAIR-only progression in bevacizumab-treated relapsing glioblastoma does not predict short survival
Oncology 85(3):191-195

McLaren, D., Gorba, T., Marguerie de Rotrou, A., Pillai, G., Chappell, C., Stacey, A., Lingard, S., Falk, A., Smith, A., Koch, P., Brüstle, O., Vickers, R., Tinsley, J., Flanders, D.,  Bello, P., Craig, S. (2013)
Automated large-scale culture and medium-throughput chemical screen for modulators of proliferation and viability of human induced pluripotent stem cell-derived neuroepithelial-like stem cells
J Biomol Screen 18(3):258-68

Zhang, R., Mjoseng, H.K., Hoeve, M.A., Bauer, N.G., Pells, S., Besseling, R., Velugotla, S., Tourniaire, G., Kishen, R.E., Tsenkina, Y., Armit, C., Duffy, C.R., Helfen, M., Edenhofer, F., de Sousa, P.A., Bradley, M. (2013)
A thermoresponsive and chemically defined hydrogel for long-term culture of human embryonic stem cells
Nat Commun. 4:1335. doi: 10.1038/ncomms2341

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Ladewig, J., Mertens, J.*, Kesavan, J.*, Doerr, J., Poppe, D., Glaua, F., Herms, S., Wernet, P., Kögler, G., Müller, F.-J., Koch, P. #, Brüstle, O. # (2012)
Small molecules enable highly efficient neuronal conversion of human fibroblasts
Nature Methods 9(6):575-578

Thier, M., Wörsdörfer, P., Lakes, Y. B., Gorris, R., Herms, S., Opitz, T., Seiferling, D., Quandel, T., Hoffmann, P., Nöthen, M.M., Brüstle, O., Edenhofer, F. (2012)
Direct conversion of fibroblasts into stably expandable neural stem cells
Cell Stem Cell 10(4):473-479

Koch, P.*, Tamboli, I.Y.*, Mertens, J.*, Wunderlich, P., Ladewig, J., Stüber, K., Esselmann, H., Wiltfang, J., Brüstle, O.‡, Walter, J.‡ (2012)
Presenilin-1 L166P mutant human pluripotent stem cell-derived neurons exhibit partial loss of γ-secretase activity in endogenous amyloid-β generation
Am J Pathol 180(6):2404-2416

Ahmad, A., Wolber, W., Eckardt, S., Koch, P., Schmitt, J., Semechkin, R., Geis, C., Heckmann, M., Brüstle, O., McLaughlin, J.K., Sirén, A.-L., Müller, A. (2012)
Functional neuronal cells generated by human parthenogenetic stem cells.
PLoS ONE 7(8):e42800

Haupt, S., Grützner, J. Thier, M.C., Kallweit, T., Rath, B.H., Laufenberg, I., Forgber, M., Eberhardt, J., Edenhofer, F., Brüstle, O. (2012)
Automated selection and harvesting of pluripotent stem cell colonies
Biotechnol Appl Biochem 59(2):77-87

Nettersheim, D., Westernströer, B., Haas, N., Leinhaas, A., Brüstle, O., Schlatt, S., Schorle, H. (2012)
Establishment of a versatile seminoma model indicates cellular plasticity of germ cell tumor cells
Genes Chrom Cancer 51(7):717-726

Lindvall, O., Barker, R.A., Brüstle, O., Isacson, O., Svendsen, C. (2012)
Clinical translation of stem cells in neurodegenerative disorders
Cell Stem Cell 10:151-155

Falk, A.*, Koch, P.*, Kesavan, J., Takashima, Y., Ladewig, J., Alexander, M., Wiskow, O., Tailor, J., Pollard, S., Smith, A., Brüstle, O. (2012)
Capture of neuroepithelial-like stem cells from pluripotent stem cells provides a versatile system for in vitro production of human neurons
PLoS ONE 7(1):e29597

Kim, B.-M., Thier, M., Oh, S., Sherwood, R., Kanellopoulou, C., Edenhofer, F., Choi, M.Y. (2012)
MicroRNAs are indispensable for reprogramming mouse embryonic fibroblasts into induced stem cell-like cells
PLoS One 7(6):e39239

Hucke, S., Floßdorf, J., Grützke, B., Dunay, I.R., Frenzel, K., Jungverdorben, J., Linnartz, B., Mack, M., Peitz, M., Brüstle, O., Kurts, C., Klockgether, T., Neumann, H., Prinz, M., Knolle, P., Klotz, L. (2012)
Licensing of myeloid cells promotes central nervous system autoimmunity and is controlled by PPARγ
Brain 135(Pt 5):1586-1605

Oki, K.*, Tatarishvili, J.*, Woods, J.*, Koch, P.*, Wattananit, S., Mine, Y., Monni, E., Prietro, D.T., Ahlenius, H., Ladewig, J., Brüstle, O., Lindvall, O., Kokaia, Z. (2012)
Human induced pluripotent stem cells form functional neurons and improve recovery after grafting in stroke-damaged brain
Stem Cells 30(6):1120-1133

Linnartz, B., Kopatz, J., Tenner, A.J., Neumann, H. (2012)
Sialic acid on the neuronal glycocalyx prevents complement C1 binding and complement receptor-3 mediated removal by microglia
J Neurosci 32(3):946-952

Haupt, S., Borghese, L., Brüstle, O., Edenhofer, F. (2012)
Non-genetic modulation of notch activity by artificial delivery of Notch intracellular domain into neural stem cells
Stem Cells Rev Rep 8(3):672-684

Koch, P., Müller, F.-J., Brüstle, O. (2012)
Differentiation of human pluripotent stem cells into neural precursors
In: Human stem cell manual - A laboratory guide (eds.: Loring, J.F & Peterson, S.E.), 2nd edition, Elsevier Press, pp. 375-384

Steinbeck, J.A., Koch, P., Derouiche, A., Brüstle, O. (2012)
Human embryonic stem cell-derived neurons establish region-specific, long-range projections in the adult brain
Cell Mol Life Sci 69(3):461-470

Kebir, S., Kuchelmeister, K., Niehusmann, P., Nelles, M., Kim, Y., Thanendrarajan, S., Schäfer, N., Stuplich, M., Mack, F., Scheffler, B., Urbach, H., Glas, M., Herrlinger, U. (2012)
Intravascular CNS lymphoma: Successful therapy using high-dose methotrexate-based polychemotherapy
Exp Hematol Oncol 1(1):37

von dem Knesebeck, A., Felsberg, J., Waha, A., Hartmann, W., Scheffler, B., Glas, M., Hammes, J., Mikeska, T., Yan, P.S., Endl, E., Simon, M., Reifenberger, G., Pietsch, T., Waha, A. (2012)
RANK (TNFRSF11A) is epigenetically inactivated and induces apoptosis in gliomas
Neoplasia 14(6):526-34

Vo, D.T., Abdelmohsen, K., Martindale, J.L., Qiao, M., Tominaga, K., Burton, T.L., Gelfond, J.A., Brenner, A.J., Patel, V., Trageser, D., Scheffler, B., Gorospe, M., Penalva, L.O. (2012)
The oncogenic RNA-binding protein Musashi1 is regulated by HuR via mRNA translation and stability in glioblastoma cells
Mol Cancer Res 10(1):143-155

Steindler, D.A., Okun, M.S., Scheffler, B. (2012)
Stem cell pathologies and neurological disease
Modern Pathol 25(2):157-162

Linnartz, B., Bodea, L., Neumann, H. (2012)
Microglial carbohydrate binding receptors for neural repair
Cell Tissue Res 349(1):215-227

Haddad-Tóvolli, R., Heide, M., Zhou, X., Blaess, S., Alvarez-Bolado, G. (2012)
Mouse thalamic differentiation: Gli-dependent pattern and Gli-independent prepattern.
Front Neurosci 6:27

Bodea, G.O., Blaess, S. (2012)
Organotypic slice cultures of embryonic ventral midbrain: a system to study dopaminergic neuronal development in vitro
J Vis Exp 31;(59) doi: 10.3791/3350

Alvarez-Bolado, G., Paul, F.A., Blaess, S. (2012)
Sonic hedgehog lineage in the mouse hypothalamus: From progenitor domains to hypothalamic regions
Neural Dev 20;7(1):4

Derouiche, A., Pannicke, T., Haseleu, J., Blaess, S., Grosche, J., Reichenbach, A. (2012)
Beyond polarity: functional membrane domains in astrocytes and Müller cells.
Neurochem Res. 37(11):2513-23

Thier, M., Münst, B., Mielke, S., Edenhofer, F. (2012)
Cellular reprogramming employing recombinant Sox2 protein
Stem Cells Intern 2012:549846 doi:10.1155/2012/549846

Oki, K., Tatarishvili, J., Woods, J., Koch, P., Wattananit, S., Mine, Y., Monni, E., Prietro, D.T., Ahlenius, H., Ladewig, J., Brüstle, O., Lindvall, O., Kokaia, Z. (2012)
Human induced pluripotent stem cells form functional neurons and improve recovery after grafting in stroke-damaged brain
Stem Cells 30:1120-1133

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Koch, P.*, Breuer, P*., Peitz, M.*, Jungverdorben, J.*, Kesavan, J., Poppe, D., Doerr, J., Ladewig, J., Mertens, J., Tüting, T., Hoffmann, P., Klockgether, T., Evert, B.O., Wüllner, U., Brüstle, O. (2011)
Excitation-induced ataxin-3 aggregation in neurons from patients with Machado-Joseph disease
Nature 480:543-546

Iliou, M.S., Lujambio, A., Portela, A., Brüstle, O., Koch, P., Andersson-Vincent, P.H., Sundström, E., Hovatta, O., Esteller, M. (2011)
Bivalent histone modifications in stem cells poise miRNA loci for CpG island hypermethylation in human cancer
Epigenetics 6(11):1344-1353

Siemen, H., Colas, D., Heller, H.C., Brüstle, O., Reijo-Pera, R.A. (2011)
Pumilio-2 function in the mouse nervous system
PLoS One 6(10):e25932

Higashi, H., Brüstle, O., Daley, G.Q., Yamanaka, S. (2011)
The nomenclature system should be sustainable, but also practical
Cell Stem Cell 8:606-607 [Letter]

Hussein, S.M.I., Batada, N., Vuoristo, S., Ching, R.W., Autio, R., Närvä, E., Ng, S., Sourour, M., Hämäläinen, R., Olsson, C., Lundin, K., Mikkola, M., Trokovic, R., Peitz, M., Brüstle, O., Bazett-Jones, D.P., Alitalo, K., Lahesmaa, R., Nagy, A., Otonkoski, T. (2011)
Copy number variation and selection during reprogramming to pluripotency
Nature 471:58-62

Azari, H., Osborne, G.W., Yasuda, T., Golmohammadi, M.G., Rahman, M., Deleyrolle, L.P., Esfandiari, E., Adams, D.J., Scheffler, B., Steindler, D.A., Reynolds, B. (2011)
Purification of immature neuronal cells from neural stem cell progeny
PLOS ONE 6(6):e20941

Lee, S.B., Doberstein, K., Baumgarten, P., Wieland, A., Ungerer, C., Bürger, C., Hardt, K., Boehncke, W.H., Pfeilschifter, J., Mihic-Probst, D., Mittelbronn, M., Gutwein, P. (2011)
PAX2 regulates ADAM10 expression and mediates anchorage-independent cell growth of melanoma cells.
PLoS ONE 6(8): e22312

Blaess, S., Bodea, G.O., Kabanova, A., Chanet, S., Mugniery, E., Derouiche, A., Stephen, D., Joyner, A.L. (2011)
Temporal-spatial changes in Sonic Hedgehog expression and signaling reveal different potentials of ventral mesencephalic progenitors to populate distinct ventral midbrain nuclei
Neural Dev 20:6(1):29

Glassman, A., Reichmann, K., Scheffler, B., Glas, M., Veit, N., Probstmeier, R. (2011)
Pharmacological targeting of constitutive activated MEK/MAPK-dependent signal pathway in glioma cells inhibits cell proliferation and migration
Int J Oncol 39(6):1567-1574

Kuckenberg, P., Peitz, M., Kubaczka, C., Becker, A., Egert, A., Wardelmann, E., Zimmer, A., Brüstle, O., Schorle, H. (2011)
Lineage conversion of murine extraembryonic trophoblast stem cells to pluripotent stem cells
Mol Cell Biol 31:1748-56

Li, Y., Li, A., Glas, M., Lal, B., Ying, M., Sang, Y., Xia, S., Trageser, D., Guerrero-Cázares, H., Eberhart, C., Quiñones-Hinojosa, A., Scheffler, B., Laterra, J. (2011)
c-Met signaling induces a reprogramming network and supports the glioblastoma stem-like phenotype
Proc Natl Acad Sci USA 108(24):9951-9956

Milde, T., Kleber, s., Korshunov, A., Witt, H., Hielscher, T., Koch, P., Kopp, H.-G., Jugold, M., Deubzer, H.E., Oehme, I., Lodrini, M., Gröne, H.-J., Benner, A., Brüstle, O., Gilbertson, R.J., von Deimling, A., Kulozik, A.E., Pfister, S.M., Martin-Villalba, A., Witt, T. (2011)
A novel human high-risk ependymoma stem cell model reveals the differentiation-inducing potential of the histone deacetylase inhibitor Vorinostat
Acta Neuropathol 122(5):637-650

Ming, G.L., Brüstle, O., Muotri, A., Studer, L., Wernig, M., Christian, K.M. (2011)
Cellular reprogramming: Recent advances in modeling neurological diseases
J. Neurosci. 31(45):16070-16075

Doberstein, K., Wieland, A., Lee, S.B., Blaheta, R.A., Wedel, S., Moch, H., Schraml, P., Pfeilschifter, J., Kristiansen, G., Gutwein, P. (2011)
L1-CAM expression in ccRCC correlates with shorter patients survival times and confers chemoresistance in renal cell carcinoma cells.
Carcinogenesis 32(3): 262-270

Patsch, C., Kesseler, D., Edenhofer, F. (2011)
Genetic engineering of mammalian cells by direct delivery of FLP recombinase protein
Methods 53:386-393

Roßbach, M., Hadenfeld, M., Brüstle, O. (2011)
Industrial applications of stem cells
In: Translational stem cell research, stem cell biology and regenerative medicine (eds.: Hug, K., Hermerén, G.; series editor: Turksen, K.), Springer pp. 91-101

Roy, K., Beutner, C., Neumann, H. (2011)
Perspectives of stem cell-derived microglia for medicine.
In: Embryonic stem cells - Recent advances in pluripotent stem cell-based regenerative medicine, ISBN 978-953-307-198-5, Edited by: Craig Atwood, Publisher: InTech, April 2011

Schäfer, N., Tichy, J., Thanendrarajan, S., Kim, Y., Stuplich, M., Mack, F., Rieger, J., Simon, M., Scheffler, B., Boström, J., Steinbach, J.P., Herrlinger, U., Glas, M. (2011)
Ifosfamide, carboplatin, and etoposide in recurrent malignant glioma
Oncology 80(5-6):330-332

Schäfer, N., Rasch, K., Möhlenbruch, M., Urbach, H., Stuplich, M., Blasius, E., Scheffler, B., Herrlinger, U., Glas, M. (2011)
Leptomeningeal melanomatosis: Stabilization of disease due to radiation, temozolomide and intrathecal liposomal cytarabine
Acta Oncol 50(8):1260-1262

Steinbeck, J.A., Henke, N., Opatz, J., Gruszczyńska-Biegała, J., Schneider, L., Theis, S., Hamacher, N., Steinfarz, B., Golz, S., Brüstle, O., Kużnicki, J., Methner, A. (2011) Store-operated calcium entry modulates neuronal network activity in a model of chronic epilepsy
Exp Neurology 232(2):185-194

Steinbeck, J.A., Stuplich, M., Blasius, E., Pels, H., Glas, M., Schlegel, U., Herrlinger, U. (2011)
Relapse of primary central nervous system lymphoma 13 years after high-dose methotrexate-based polychemotherapy
J Clin Neurosci. 18(11): 1554-1555

Terstegge, S., Edenhofer, F., Brüstle, O. (2011)
Stammzellen – Bedeutung für die Klinische Medizin
In: Humangenetik (eds.: Murken, J., Grimm, T., Holinski-Feder, E., Zerres, K.), 8. Auflage, Georg Thieme Verlag Stuttgart, New York, pp. 567-573

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Beutner, C., Roy, K., Linnartz, B., Napoli, I., Neumann, H. (2010)
Generation of microglial cells from mouse embryonic stem cells
Nat Protoc 5(9):1481-1494

Borghese, L., Dolezalova, D., Opitz, T., Haupt, S., Leinhaas, A., Steinfarz, B., Koch, P., Edenhofer, F., Hampl, A., Brüstle, O. (2010)
Inhibition of Notch signaling in human embryonic stem cell–derived neural stem cells delays G1/s phase transition and accelerates neuronal differentiation in vitro and in vivo
Stem Cells 28(5):955-964

Glas, M., Rath, BH, Simon, M., Reinartz, R., Schramme, A., Trageser, D., Eisenreich, R., Leinhaas, A., Keller, M., Schildhaus, HU, Garbe, S., Steinfarz, B., Pietsch, T., Steindler, DA, Schramm, J., Herrlinger, U., Brüstle, O., Scheffler, B. (2010)
Residual tumor cells are unique cellular targets in glioblastoma
Ann Neurol 68(2):264-269

Kierdorf, K., Wang, Y., Neumann, H. (2010)
Immune-mediated CNS damage
Results Probl Cell Differ 51:173-196

Keramari, M., Razavi, J., Ingman, K.A., Patsch, C., Edenhofer, F., Ward, C.M., Kimber, S.J. (2010)
Sox2 is essential for formation of trophectoderm in the preimplantation embryo
PLoS ONE 5(11):e13952

Kiss, E., Popovic, Z.V., Bedke, J., Adams, J., Bonrouhi, M., Babelova, A., Schmidt, C., Edenhofer, F., Zschiedrich, I., Domhan, S., Abdollahi, A., Schäfer, L., Gretz, N., Porubsky, S., Gröne, H.J. (2010)
Peroxisome proliferator-activated receptor (PPAR)gamma can inhibit chronic renal allograft damage
Am J Pathol 176(5):2150-2162

Larionov, S., Wielgat, P., Wang, Y., Thal, R.D., Neumann, H. (2010)
Spatially pathogenic forms of tau detected in Alzheimer's disease brain tissue by fluorescence lifetime-based Förster resonance energy transfer
J Neurosci Methods 192(1):127-137

Linker, R.A., Lee, D.-H., Cetin, S., Wiese, S., Kruse, N., Siglienti, I., Gerhardt, E., Neumann, H., Sendtner, M., Lühder, F., Gold, R. (2010)
Functional role of brain derived neurotrophic factor in neuroprotective autoimmunity: therapeutic implications in a model of multiple sclerosis
Brain 133(Pt 8):2248-2263

Napoli, I., Neumann, H. (2010)
Protective effects of microglia in multiple sclerosis
Exp Neurol 225(1):24-28

Linnartz, B., Wang, Y., Neumann, H. (2010)
Microglial immunoreceptor tyrosine-based activation and inhibition motif (ITAM/ITIM) signaling in neuroinflammation
International Journal of Alzheimer’s disease, Volume 2010, Article ID 587463, doi:10.4061/2010/587463

Melchior, B., Garcia, A.E., Hsiung, B.-K., Lo, K.M., Doose, J.M., Thrash, J.C., Stalder, A.K., Staufenbiel, M., Neumann, H., Carson, M.J. (2010)
Dual induction of TREM2 and tolerance-related transcript, Tmem176b, in amyloid transgenic mice: implications for vaccine-based therapies for Alzheimer’s disease
ASN NEURO 2(3):157-170

Närvä, E., Autio, R., Rahkonen, N., Kong, L., Harrison, N., Kitsberg, D., Borghese, L., Itskovitz-Eldor, J., Rasool, O., Dvorak, P., Hovatta, O., Otonkoski, T., Tuuri, T., Cui, W., Brüstle, O., Baker, D., Maltby, E., Moore, H.D., Benvenisty, N., Andrews, P.W., Yli-Harja, O., Lahesmaa, R. (2010)
High-resolution DNA analysis of human embryonic stem cell lines reveals culture-induced copy number changes and loss of heterozygosity
Nat Biotechnol 28(4):371-377

Patsch, C., Peitz, M., Otte, D.M., Kesseler, D., Jungverdorben, J., Wunderlich, T., Brüstle, O., Zimmer, A., Edenhofer, F. (2010)
Engineering cell-permeant FLP recombinase for tightly controlled inducible and reversible overexpression in embryonic stem cells
Stem Cells 28(5):894-902

Pusch, A., Boeckenhoff, A., Glaser, T., Kaminski, T., Kirfel, G., Hans, M., Steinfarz, B., Swandulla, D., Kubitscheck, U., Gieselmann, V., Brüstle, O., Kappler, J. (2010)
CD44 and hyaluronan promote invasive growth of B35 neuroblastoma cells into the brain.
Biochim Biophys Acta 1803(2):261-274

Rossbach, M. (2010)
Small Non-Coding RNAs as Novel Therapeutics (CMM 10-4 / Pp. 361-368)

Schwarting, S., Neumann, H. (2010)
Immunoregulatory neuroprotection of cerebral ischaemia by haematopoietic stem and precursor cells
EU Neurological Review 4(2):42-45

Stock, K., Nolden, L., Edenhofer, F., Quandel, T., Brüstle, O. (2010)
Transcription factor-based modulation of neural stem cell differentiation using direct protein transduction
Cell Mol Life Sci 67(14):2439-2449

Thier, M., Münst, B. Edenhofer, F. (2010)
Exploring refined conditions for reprogramming cells by recombinant Oct4 protein
Int J Dev Biol  54:1713-1721

Terstegge, S., Winter, F., Rath, B.H., Laufenberg, I., Schwarz, C., Leinhaas, A., Levod, F., Dolf, A., Haupt, S., Endl, E., Brüstle, O. (2010)
Laser-assisted photoablation of human pluripotent stem cells from differentiating cultures
Stem Cell Rev Rep 6 (2):260-269

Wang, Y., Neumann, H. (2010)
Alleviation of neurotoxicity by microglial human Siglec-11
J Neurosci 30(9):3482–3488

Reimann, J., Schnell, S., Schwartz, S., Kappes-Horn, K., Dodel, R., Bacher, M. (2010)
Macrophage migration inhibitory factor in normal human skeletal muscle and inflammatory myopathies.
J Neuropathol Exp Neurol 69(6): 654-662

Stock, K., Nolden, L., Edenhofer, F., Quandel, T., Brüstle, O. (2010)
Modulation of neural stem cell differentiation with a recombinant cell-permeant transcription factor
Cell Mol Life Sci (2010) 67:2439-2449

Närvä, E., Autio, R., Rahkonen, N., Kong, L., Harrison, N., Kitsberg, D., Borghese, B., Itskovitz-Eldor, J., Rasool, O., Dvorak, P., Hovatta, O., Otonkoski, T., Tuuri, T., Cui, W., , Brüstle, O., Baker, D., Maltby, E., Moore, H.D., Benvenisty. N., Andrews, P.W., Yli-Harja, O., Lahesmaa, R. (2010)
High resolution DNA analysis reveals loss of heterozygosity and copynumber variation changes associated with culture and affecting gene expression in human embryonic stem cell lines
Nat Biotechnol 28(4):371-377

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Anastassiadis K., Fu J., Patsch C., Hu S., Weidlich S., Duerschke K., Buchholz F., Edenhofer F., Stewart A.F. (2009)
Dre recombinase, like Cre, is a highly efficient site-specific recombinase in E. coli, mammalian cells and mice
Dis Model Mech 2(9-10):508-515

Andrews, P.W., Arias-Diaz, J., Auerbach, J., lvarez, M., Ahrlund-Richter, L., Baker, D., Benvenisty, N., Ben-Josef, D., Blin, G., Borghese, L., Borstlap, J., Bruce, K., Brüstle, O., Buckle, R., Carter, P., Camby, C., Choo, A., Chen, W., Collins, D., Colman, A., Crombie, C., Crook, J., Cypess, R., De Sousa, P., Dhawan, J., Douay, L., Dvorak, P., Dyke, T., Eriksson, L., Firpo, M., Fitzgerald, C., Glover, C., Gokhale, P., Greene, M., Ha, H.-Y., Hampl, A., Healy, L., Hei, D., Holm, F., Hovatta, O., Hunt, C., Hwang, S.-M., Inamdar, M., Isasi, R., Iskovitz-Eldor, J., Jessie, N., Kim, D.-W., Kirzner, R., Kitpongsang, S., Knowles, B., Kuo, H.-C., Laughlin, M., Lavon, N., Ludwig, T., Lakov, M., Lee, D.-R., Macauley, J., McKay, R., Menasche, P., Menendez, P., Michalska, A., Mileikovskaia, M., Minger, S., Mishra, G., Moody, J., Montgomery, K., Morris, C., Mummery, C., Nagy, A., Nakamura, Y., Nakatsuji, N., Nishikawa, S.-I., Nierras, C., Oh, S., Oh, S.K., Olson, P., Otonkoski, T., Patole, M., Park, H.S., Pei, X., Pera, M., Puceat, M. Rajala, K., Reubinoff, B., Robbins, A., Rooke, H., Rumayor, V., Scotmann, H., Sherlock, J., Simon, C., Stacey, G., Sipp, D., Skinner, R., Smith, D., Stefanovic, S., Strehl, R., Taft, R., Takahashi, T., Talib, S., Terstegge, S., Turner, R., Tuuri, T., Yu, J., Zandstra, P., Zapata, A., Zeng, F., Zhou, Q. (2009)
Consensus guidance for banking and supply of human embryonic stem cell lines for research purposes. International Cell Banking Initiative.
Stem Cell Rev and Rep 5:301-314

Bosnali, M., Münst, B., Thier M., Edenhofer, F. (2009)
Deciphering the stem cell machinery as a basis for understanding reprogramming
Cell Mol Life Sci 66(21):3403-3420

Capasso, P., Aliprandi, M., Ossolengo, G., Edenhofer, F., de Marco, A. (2009)
Monodispersity of recombinant Cre recombinase correlates with its effectiveness in vivo
BMC Biotechnol 9:80

Corsini, N.S., Sancho-Martinez, I., Laudenklos, S., Glagow, D., Kumar, S., Letellier, E., Koch, P., Teodorczyk, M., Kleber, S., Klussmann, S., Wiestler. B., Brüstle, O., Müller, W., Gieffers, C., Hill, O., Thiemann, M., Seedorf, M., Gretz, N., Sprengel, R., Celikel, T., Martin-Villalba, A. (2009)
The death receptor CD95 activates adult neural stem cells for working memory formation and brain repair
Cell Stem Cell 5(2):178-90

Gaikwad, S., Larionov, S., Wang, Y., Dannenberg, H., Matozaki, T., Monsonego, A., Thal, D.R., Neumann, H. (2009)
Signal regulatory protein-β1: a microglial modulator of phagocytosis in Alzheimer’s disease
Am J Pathol 175(6):2528-2539

Gorlovoy, P., Larionov, S., Pham, T.T., Neumann, H. (2009)
Accumulation of tau induced in neurites by microglial proinflammatory mediators
FASEB J 23(8):2502-2513

Hammond, R.*, Blaess, S.*, Abeliovich, A. (2009)
Sonic hedgehog is a chemoattractant for midbrain dopaminergic axons
PLoS ONE. 2009 4(9): e7007
*Authors contributed equally

Haupt, S., Grützner, J., Rath, B.H., Möhlig, H., Brüstle, O. (2009)
Automated selection and collection of pluripotent stem cell colonies using the CellCelector™
Nature Methods 6, doi:10.1038/nmeth.f.252 [Non peer-reviewed application note]

Kierdorf, K., Wang, Y., Neumann, H. (2009)
Immune-Mediated CNS Damage
Results Probl Cell Differ 51:173-196

Klotz, L., Hucke, S., Thimm, D., Classen, S., Gaarz, A., Schultze, J., Edenhofer, F., Kurts, C., Klockgether, T., Limmer, A., Knolle, P., Burgdorf, S.
Increased antigen cross-presentation but impaired cross-priming after activation of peroxisome proliferator-activated receptor is mediated by up-regulation of B7H1
J Immunol 183(1):129-136

Ko, K., Tapia, N., Wu, G., Kim, J.B., Arauzo Bravo, M.J., Sasse, P., Glaser, T., Ruau, D., Wook Han, D., Greber, B., Hausdörfer, K., Sebastiano, V., Stehling, M., Fleischmann, B.K., Brüstle, O., Zenke, M., Schöler, H.R. (2009)
Induction of pluripotency in adult unipotent germline stem cells
Cell Stem Cell 5(1):87-96.

Koch, P., Kokaia, Z., Lindvall, O., Brüstle, O. (2009)
Emerging concepts in neural stem cell research: autologous repair and cell-based disease modelling
Lancet Neurol 8(9):819-829

Koch, P., Opitz, T., Steinbeck, J., Ladewig, J., Brüstle, O. (2009)
A rosette-type, self-renewing human ES cell-derived neural stem cell with potential for in vitro instruction and synaptic integration
Proc Natl Acad Sci USA 106(9):3225-30

Lienenklaus, S., Cornitescu M. , Zietara N., Lyszkiewicz M., Gekara N., Jablonska J., Edenhofer F. , Rajewsky K. , Bruder D. , Hafner M., Staeheli P., Weiss S. (2009)
Novel reporter mouse reveals constitutive and inflammatory expression of IFN-b in vivo
J Immunol 183(5):3229-3236

Münst, B., Patsch, C., Edenhofer, F. (2009)
Engineering cell-permeable protein
J Vis Exp. 28;(34). pii: 1627. doi: 10.3791/1627

Napoli, I., Kierdorf, K., Neumann, H. (2009)
Microglial precursors derived from mouse embryonic stem cells
Glia 57(15):1660-1671

Napoli, I., Neumann, H. (2009)
Microglial clearance function in health and disease
Neuroscience 158(3):1030-1038

Napoli, I., Neumann, H. (2009)
Protective effects of microglia in multiple sclerosis
Exp Neurol 225(1):24-28

Neumann, H., Kotter, M.R., Franklin, R.J. (2009)
Debris clearance by microglia: an essential link between degeneration and regeneration
Brain 132(Pt 2):288-295

Roßbach, M. (2009)
Creative Innovation – Insights from neurobiology and economics and their implications for social decision-making
In: Rationalität der Kreativität? Multidisziplinäre Beiträge zur Analyse der Produktion, Organisation und Bildung von Kreativität (eds.: Jansen, S. A., Schröter, E., Stehr, N.), Wiesbaden, VS Verlag für Sozialwissenschaften, pp. 13-29

Papadimou, E., Moiana, A., Goffredo, D., Koch, P., Bertuzzi, S., Brüstle, O., Cattaneo, E., Conti, L. (2009)
p66ShcA adaptor molecule accelerates ES cell neural induction
Mol Cell Neurosci 41(1):74-84

Terstegge, S., Rath, B.H., Laufenberg, I., Limbach, N., Buchstaller, A., Schütze, K., Brüstle, O. (2009)
Laser-assisted selection and passaging of human pluripotent stem cell colonies
J Biotechnol 143(3):224-230

Terstegge, S., Brüstle, O. (2009)
Automated method for embryonic stem cell culture
In: Emerging technology platforms for stem cells (eds.: Lakshmipathy, U., Chesnut, J.D., Thyagarajan, B.), Wiley, New Jersey, pp. 275-281

Walter, L., Neumann, H. (2009)
Role of microglia in neuronal degeneration and regeneration
Semin Immunopath 31(4):513-525

Walton, N.M., Snyder G.E., Park, D., Kobeissy, F., Scheffler, B., Steindler, D.A. (2009)
Gliotypic neural stem cells transiently adopt tumorigenic properties during normal differentiation
Stem Cells 27(2):280-289

Witan, H., Gorlovoy, P., Kaya, A.M., Koziollek-Drechsler, I., Neumann, H., Behl, C., Clement, A.M. (2009)
Wild-type Cu/Zn superoxide dismutase (SOD1) does not facilitate, but impedes the formation of protein aggregates of amyotrophic lateral sclerosis causing mutant SOD1
Neurobiol of Disease 36(2):331-342

Edenhofer, F., Terstegge, S., Brüstle, O. (2009)
Stem cell technology in technology guide (ed.: Bullinger, H.-J.), 1st edition, Springer 166-169

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Blaess, S., Stephen, D., Joyner, A.L. (2008)
Gli3 coordinates three-dimensional patterning and growth of the tectum and cerebellum by integrating Shh and Fgf8 signaling
Development 135(12):2093-2103

Bosnali, M., Edenhofer, F. (2008)
Generation of transducible versions of transcription factors Oct4 and Sox2
Biol Chem 389(7): 851-861

Calvanese, V., Horrillo, A., Hmadcha, A., Suarez-Alvarez, B., Fernandez, A.F., Lara, E., Casado, S., Menendez, P., Bueno, C., Garcia-Castro, J., Rubio, R., Lapunzina, P., Alaminos, M., Borghese, L., Terstegge, S., Harrison, N.J., Moore, H.D., Brüstle, O., Lopez-Larrea, C., Andrews, P.W., Soria, B., Esteller, M., Fraga, M.F. (2008)
Cancer genes hypermethylated in human embryonic stem cells
PLoS ONE 3(9):e3294

Edenhofer, F. (2008)
Protein transduction revisited: novel insights into the mechanism underlying intracellular delivery of proteins
Curr Pharm Des 14(34):3628-3636

Firkowska, I., Giannona, S., Rojas-Chapana, J.A., Luecke, K., Brüstle, O., Giersig, M. (2008)
Biocompatible nanomaterials and nanodevices promising for biomedical applications
In: Nanomaterials for Application in Medicine and Biology (eds.: Giersig, M. & Khomutov, G.B.),
NATO Science and Security Series – B: Physics and Biophysics, Spinger, Dordrecht, The Netherlands, pp.1-15

Geisthövel, F., Brüstle, O., Beier, H.M., Frommel, M., Schockenhoff, E., Taupitz, J. (2008)
The interaction between the German Embryo Protection Act and the Stem Cell Act – an interdisciplinary panel discussion held on November 30, 2007, on the occasion of the 2nd DVR Congress in Bonn/Bad Godesberg
J Reproduktionsmed Endokrinol 5:114-120

Glaser, T., Opitz, T., Kischlat, T., Konang, R., Sasse, P., Fleischmann, B.F., Engel, W., Nayernia, K., Brüstle, O. (2008)
Adult germline stem cells as a source of functional neurons and glia
Stem Cells 26:2434-2443

Glaser, T., Schmandt, T., Brüstle, O. (2008)
Generation and potential biomedical applications of embryonic stem cell-derived glial precursors
J Neurol Sci 265(1-2):47-58

Husseini, L., Schmandt, T., Scheffler, B., Schröder, W., Seifert, G., Brüstle, O., Steinhäuser, C. (2008)
Functional analysis of ES cell-derived glial cells after integration into hippocampal slice cultures
Stem Cells Dev. 17(6):1141-1152

Kuhn, G., Brüstle, O., Martens, U., Wobus, A., Unsicker, K. (2008)
Stem cells: established facts, open issues, and future directions
Cell Tiss Res 331(1):1-3

Schwarting, S., Litwak, S., Hao, W., Bähr, M., Weise, J., Neumann H. (2008)
Hematopoietic stem cells reduce postischemic inflammation and ameliorateischemic brain injury
Stroke 39(10):2867-2875

Ladewig, J.*, Koch, P.*, Endl, E., Meiners, B., Opitz, T., Couillard-Despres, S., Aigner, L., Brüstle, O. (2008)
Lineage selection of functional and cryopreservable human embryonic stem cell-derived neurons
Stem Cells 26(7):1705-1712

Siemen, H., Nolden, L., Terstegge, S., Koch, P., Brüstle, O. (2008)
Nucleofection of human embryonic stem cells
In: Methods in molecular medicine – Electroporation protocols: Experimental and clinical medicine (Ed.: Li, S.), Humana Press,Totowa, New Jersey, pp131-138

Landry, J.R., Kinston, S., Knezevi, K., de Bruijn, M.F., Wilson, N., Nottingham, W.T., Peitz, M., Edenhofer, F., Pimanda, J.E., Ottersbach, K., Göttgens, B. (2008)
Runx genes are direct targets of Scl/Tal1 in the yolk sac and fetal liver
Blood 111(6): 3005-3014

Nolden, L., Brüstle, O. (2008)
Human embryonic stem cells: Perspectives for the study and therapy of neurological disorders
Bundesgesundheitsblatt 51(9):1026-1032

Prozorovski, T., Schulze-Topphoff, U., Glumm, R., Baumgart, J., Schröter, F., Ninnemann, O., Siegert, E., Bendix, I., Brüstle, O., Nitsch, R., Zipp, F., Aktas, O. (2008)
Sirt1 contributes critically to the redox-dependent fate of neuralprogenitors
Nature Cell Biol 10(4):385-394

Schormann, W., Hammersen, F.J., Brulport, M., Hermes, M., Bauer, A., Rudolph, C., Schug, M., Lehmann, T., Nussler, A., Ungefroren, H., Hutchinson, J., Fändrich, F., Petersen, J., Wursthorn, K., Burda, M.R., Brüstle, O., Krishnamurthi, K., von Mach, M., Hengstler, J.G. (2008)
Tracking of human cells in mice
Histochem Cell Biol 130(2):329-338

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Biber, K., Neumann, H., Inoue, K., Boddeke, H. (2007)
Neuronal on and off signals control microglial
Trends Neurosci 30:596-602

Fischer, Y.H., Miletic, H., Giroglou, T., Litwak, S., Stenzel, W., Neumann, H., von Laer, D. (2007)
A retroviral packaging cell line for pseudotype vectors based on glioma-infiltrating progenitor cells
Journal of Gene Medicine 9:335-344

Glaser, T., Brose, C., Franceschini, I., Hamann, K., Smorodchenko, A., Zipp,F., Dubois-Dalcq, M., Brüstle, O. (2007)
NCAM polysialylation enhances the sensitivity of ES cell-derived neural precursors to migration guidance cues
Stem Cells 25(12):3016-3025

Glaser, T., Pollard, S.M., Smith, A., Brüstle, O. (2007)
Tripotential differentiation of adherently expandable neural stem (NS) cells
PLoS ONE 2:e298

Gossrau, G., Thiele, J., Konang, R., Schmandt, T., Brüstle, O. (2007)
BMP-mediated modulation of lineage diversification during neural differentiation of embryonic stem cells
Stem Cells 25:939-949

Haupt, S., Edenhofer, F., Peitz, M., Leinhaas, A., Brüstle, O. (2007)
Stage specific conditional mutagenesis in embryonic stem cell-derived neural cells and post-mitotic neurons by direct delivery of biologically active Cre recombinase
Stem Cells 25:181-188

Klotz, L., Dani, I., Edenhofer, F., Nolden, L., Evert, B., Paul, B., Kolanus, W., Klockgether, T., Knolle, P., Diehl, L. (2007)
Peroxisome proliferator-activated receptor gamma control of dendritic cell function contributes to development of CD4+ T cell anergy.
J Immunol 178(4):2122-2131

Klotz, L., Diehl, L., Dani, I., Neumann, H., von Oppen, N., Dolf, A., Endl, E., Klockgether, T., Engelhardt, B., Knolle, P. (2007)
Brain endothelial PPARγ controls inflammationinduced CD4+ T cell adhesion and transmigration in vitro
J Neuroimmunol 190:34-43

Li, T., Steinbeck, J.A., Lusardi, T., Fedele, D.E., Koch, P., Lan, J.Q., Wilz, A., Segschneider, M., Simpson, E.M., Simon, R.P., Brüstle, O., Boison, D. (2007)
Suppression of kindling epileptogenesis by adenosine releasing stem cell-derived brain implants
Brain 130:1276-88

Miletic, H., Fischer, Y., Litwak, S., Giroglou, T., Waerzeggers, Y., Winkeler, S., Li, H., Himmelreich, U., Stenzel, W., Deckert, M., Lange, C., Neumann, H., Jacobs, AH., von Laer D. (2007)
Bystander killing of malignant glioma by bone marrow-derived tumorinfiltrating progenitor cells expressing a suicide gene
Molecular Therapy 15:1373-1381

Nolden, L., Edenhofer, F., Peitz, M., Brüstle, O. (2007)
Stem cell engineering using transducible Cre recombinase
Methods in Molecular Medicine 140:17-32

Neumann H., Takahashi, K. (2007)
Essential role of the triggering receptor expressed on myeloid cells-2 (TREM2) for central nervous tissue immune homeostasis
J Neuroimmunol 184:92-99

Nolden, L., Edenhofer, F., Peitz, M., Brüstle, O. (2007)
Stem cell engineering using transducible Cre recombinase
In: Methods in Molecular Medicine – Tissue Engineering 2nd Edition, (Eds.: Hauser, H., Fussenegger, M.),
Humana Press, Totowa, New Jersey, pp17-32

Opitz, T., Scheffler, B., Steinfarz, B., Schmandt, T., Brüstle, O. (2007)
Electrophysiological evaluation of engrafted stem cell-derived neurons
Nat. Protoc. 2:1603-1613

Patsch, C., Edenhofer, F. (2007)
Conditional mutagenesis by cell-permeable proteins: potential, limitations and prospects
Handb Exp Pharmacol 178:203-232

Peitz, M., Jäger, R., Patsch, C., Jäger, A., Egert, A., Schorle, H., Edenhofer, F. (2007)
Enhanced purification of cell-permeant Cre and germline transmission after transduction into mouse embryonic stem cells
Genesis 45(8):508-517

Takahashi, K., Prinz, M., Stagi, M., Chechneva, O., Neumann H. (2007)
TREM2-transduced myeloid precursors mediate nervous tissue debris clearance and facilitate repair in an animal model of multiple sclerosis
PLoS Med. 4(4):e124

Terstegge, S., Laufenberg, I., Pochert, J., Schenk, S., Itskovitz-Eldor, J., Endl, E., Brüstle, O. (2007)
Automated maintenance of embryonic stem cell cultures
Biotech. Bioengineer 96:195-201

Testa, G., Borghese, L., Steinbeck, J.A., Brüstle, O. (2007)
Breakdown of the potentiality principle and its impact on global stem cell research
Cell Stem Cell 1:153-156

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Benzing, C., Segschneider, M., Leinhaas, A., Itskovitz-Eldor, J., Brüstle, O. (2006)
Neural conversion of human embryonic stem cell colonies in the presence of fibroblast growth factor-2
Neuroreport 17:1675-1681

Edenhofer, F. (2006)
On the materiality of life
In: Entry Paradise - New Worlds of Design, G. Seltmann, W. Lippert (eds.)

Götz, A.K., Scheffler, B., Chen, H.-X., Wang, S., Suslov, O., Xiang, H., Brüstle, O., Roper, S.N., Steindler, D.A.(2006)
Temporally restricted substrate interactions direct fate and specification of neural precursors derived from embryonic stem cells
Proc. Natl. Acad. Sci. USA 103:11063-11068

Klein, D., Schmandt, T., Muth-Köhne, E., Perez-Bouza, A., Segschneider, M., Gieselmann, V., Brüstle, O. (2006)
Embryonic stem cell-based reduction of CNS sulfatide storage in an animal model of metachromatic leukodystrophy
Gene Therapy 13:1686-1696

Koch, P., Siemen, H., Biegler, A., Itskovitz-Eldor, J., Brüstle, O. (2006)
Transduction of human embryonic stem cells by ecotropic retroviral vectors
Nucleic Acids Research 34(18):e120

Liu, Y., Hao, W., Letiembre, M., Walter, S., Kulanga, M., Neumann, H. and Fassbender, K. (2006)
Suppression of microglial inflammatory activity by myelin phagocytosis: role of p47-PHOX-mediated generation of reactive oxygen species
J Neurosci 26:12904-12913

Neumann, H. (2006)
Microglia: a cellular vehicle for CNS gene therapy
J Clin Invest 116:2857-2860 (invited commentary)

Nolden, L., Edenhofer, F., Haupt, S., Wunderlich, T.F., Siemen, H., Brüstle, O. (2006)
Site-specific recombination in human embryonic stem cells induced by cell-permeant Cre recombinase
Nature Methods 3:461-467

Piepoli, T., Jakupoglu, C., Gu, W., Lualdi, E., Suarez-Merino, B., Poliani, P.L., Cattaneo, M.G., Ortino, B., Goplen, D., Wang, J., Mola, R., Inverardi, F., Frassoni, C., Bjerkvig, R., Steinlein, O., Vicentini, L.M., Brüstle, O., Finocchiaro, G. (2006)
Expression studies in gliomas and glial cells do not support a tumor suppressor role for LGI1
Neuro-Oncology 8:96-108

Scheffler, B., Edenhofer, F., Brüstle, O. (2006)
Merging fields: Stem cells in neurogenesis, transplantation and disease modeling
Brain Pathol. 16:155-168

Scheffler, B., Brüstle, O. (2006)
Symposium: Stem Cells in the Central Nervous System
Brain Pathol. 16:131

Schmandt, T., Gossrau, G., Kischlat, T., Opitz, T., Brüstle, O. (2006)
Animal models of cell and gene therapy in myelin disease
Drug Discovery Today 3:349-358

Schmandt, T., Glaser, T., Brüstle, O. (2006)
Lineage selection and transplantation of ES cell-derived neural precursors
In: Embryonic stem cells – a practical approach (Eds.: Notarianni, E. and Evans, M.)
Oxford University Press, Oxford, pp 189-217

Stagi, M., Gorlovoy, P., Larinov, S., Takahashi, K., Neumann H. (2006)
Unloading kinesin transported cargoes from the tubulin track via the inflammatory c-Jun N-terminal kinase pathway
FASEB J 20:2573-2575

Terstegge, S., Brüstle, O. (2006)
Stammzellen – Bedeutung für die Klinische Medizin
In: Humangenetik (Eds.: Murken, J., Grimm, T., Holinski-Feder, E.)
7. Auflage; Georg Thieme Verlag Stuttgart, New York, pp 558-564

Terstegge, S., Fuhr, G.R., Brüstle, O. (2006)
In: Technologieführer. Grundlagen, Anwendungen, Trends (Ed.: Bullinger, H.J.)
Springer Verlag Berlin, pp 186-191

Tünnemann, G., Martin, R.M., Haupt, S., Patsch, C., Edenhofer, F., Cardoso, M.C. (2006)
Cargo-dependent mode of uptake and bioavailability of TAT-containing proteins and peptides in living cells
FASEB J 20(11):1775-1784

Wiese, C., Rolletschek, A., Kania, G., Navarrete-Santos, A., Anisimov, S.V., Steinfarz, B., Tarasov, K.V., Brugh, S.A., Zahanich, I., Rüschenschmidt, C., Beck, H., Blyszczuk, P., Czyz, J., Heubach, J.F., Ravens, U., Horstmann, O., St-Onge, L., Braun, T., Brüstle, O., Boheler, K.R., Wobus, A.M. (2006)
Signals from embryonic fibroblasts induce adult intestinal epithelial cells to form nestin-positive cells with proliferation and multilineage differentiation capacity in vitro
Stem Cells 24:2085-2097

Corrales, J.D., Blaess, S., Mahoney, E.M., Joyner, A.L. (2006)
The level of Sonic hedgehog signaling regulates the complexity of cerebellar foliation
Development 133(9):1811-1821

Blaess, S., Corrales, J.D., Joyner, A.L. (2006)
Sonic hedgehog regulates Gli activator and repressor functions with spatial and temporal precision in the mid/hindbrain region
Development 133(9):1799-1809

Nolden, L., Edenhofer, F., Haupt, S., Wunderlich, T.F., Siemen, H., Brüstle, O. (2006)
Site-specific recombination in human embryonic stem cells induced by cell-permeant Cre recombinase
Nature Methods 3:461-467

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Coenen, M., Kögler, G., Wernet, P., Brüstle, O. (2005)
Transplantation of human umbilical cord blood-derived adherent progenitors into the developing rodent brain
J. Neuropathol. Exp. Neurol. 64:681-688

Edenhofer, F., Peitz, M. (2005)
CREating designer cells: genetic engineering of stem cells by site-specific recombinase
In: Stem Cell Repair and Regeneration
Imperial College Press, pp 49-65

Glaser, T., Brüstle, O. (2005)
Retinoic acid induction of ES cell-derived neurons: The radial glia connection
Trends Neurosci. 28:397-400. Review

Güttinger, M., Fedele, D., Koch, P., Padrun, V., Pralong, W.F., Brüstle, O., Boison, D. (2005)
Suppression of kindled seizures by paracrine adenosine release from stem cell-derived brain implants
Epilepsia 46:1162-1169

Perez-Bouza, P., Glaser, T., Brüstle, O. (2005)
ES cell-derived glial precursors contribute to remyelination in acutely demyelinated spinal cord lesions
Brain Pathol. 15:208-216

Rüschenschmidt, C., Koch, P.G., Brüstle, O., Beck, H. (2005)
Functional properties of ES cell-derived neurons engrafted into the hippocampus of adult normal and chronically epileptic rats
Epilepsia 46 Suppl 5:174-183

Schmandt, T., Meents, E., Gossrau, G., Gornik, V., Okabe, S., Brüstle, O. (2005)
High-purity lineage selection of embryonic stem cell-derived neurons
Stem Cells Dev. 14:55-64

Siemen, H., Nix, M., Endl, E., Koch, P., Itskovitz-Eldor, J., Brüstle, O. (2005)
Nucleofection of human embryonic stem cells
Stem Cells Dev. 14:378-383

Wernig, G., Janzen, V., Schäfer, R., Zweyer, M., Knauf, U., Hoegemeier, O.,Mundegar, R.R., Garbe, S., Stier, S., Franz, T., Wernig, M., Wernig, A. (2005)
The vast majority of bone-marrow-derived cells integrated into mdx muscle fibers are silent despite long-term engraftment
Proc. Natl. Acad. Sci. U S A. 102:11852-11857

Stagi, M., Dittrich, P., Frank, N., Iliev, A., Schwille, P., Neumann, H. (2005)
Breakdown of axonal synaptic vesicle precursor transport by microglial nitric oxide
J.Neurosci., 25(2): 352-62.

Zervas, M., Blaess, S., Joyner, A.L. (2005)
Classical embryological studies and modern genetic analysis of midbrain and cerebellum development
Current Topics in Developmental Biology 69:101-138

Takahashi, K., Rochford, C.D., Neumann, H. (2005)
Clearance of apoptotic neurons without inflammation by microglial triggering receptor expressed on myeloid cells-2
J. Exp. Med., 201(4): 647-57.

Liu, Y., Walter, S., Stagi, M., Cherny, D., Letiembre, M., Schulz-Schaeffer, W., Heine, H., Penke, B., Neumann, H.,,Fassbender, K. (2005)
LPS receptor (CD14): a receptor for phagocytosis of Alzheimer’s amyloid peptide
Brain, 128(Pt 8):1778-89.

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Brüstle, O., Koch, P., Möhler, H., Boison, D. (2004)
Therapeutic delivery of adenosine into a tissue
U.S. 10/858,929

Fedele, D.E., Koch, P., Scheurer, L., Simpson, E.M., Möhler, H., Brüstle, O.,
Boison, D. (2004)
Engineering embryonic stem cell-derived glia for adenosine delivery
Neurosc. Lett. 370:160-165

Glaser, T., Perez-Bouza, A., Klein, K., Brüstle, O. (2004)
Generation of purified oligodendrocyte progenitors from embryonic stem cells
FASEB J. Express article 10.1096/fj.04-1931fje.
Print version: FASEB J. 19:112-114, 2005

Murakami, M., Ichisaka, T., Maeda, M., Oshiro, N., Hara, K., Edenhofer, F., Kiyama, H., Yonezawa, K., Yamanaka, S. (2004)
mTOR is essential for growth and proliferation in early mouse embryos and embryonic stem cells
Mol. Cell. Biol. 24:6710-6718

Terstegge, S., Pochert, J., Brüstle, O. (2004)
Hamilton’s new CellHost system for full automation of embryonic stem cell cultures
Nature Methods 1:271-272 [Application Note]

Terstegge, S., Brüstle, O. (2004)
Skalierbarer Prozess zur Kultivierung undifferenzierter Stammzellen in Suspension
DE 102 004 043 256.2

Wernig, M., Benninger F., Schmandt, T., Rade, M., Tucker, K.L., Büssow, H., Beck, H., Brüstle O. (2004)
Functional integration of embryonic stem cell-derived neurons in vivo
J. Neurosci. 24:5258-5268

Corrales, J.D., Rocco, G.L., Blaess, S., Guo, Q., Joyner, A.L. (2004)
Spatial pattern of sonic hedgehog signaling through Gli genes during cerebellum development
Development 131(22):5581-5590

White, D.E., Kurpios, N.A., Zuo, D., Hassell, J.A., Blaess, S., Mueller, U., Muller, W.J. (2004)
Targeted disruption of β1-integrin in a transgenic mouse model of human breast cancer reveals an essential role in mammary tumor induction
Cancer Cell 6(2):159-170

Blaess, S.*, Graus-Porta, D.*, Belvindrah, R., Radakovits, R., Pons, S., Littlewood-Evans, A., Senften, M., Guo, H., Li, Y., Miner, J.H., Reichardt, L.F., Müller, U. (2004)
β1-integrins are critical for cerebellar granule cell precursor proliferation
J Neurosci 24(13):3402-3412
* Authors contributed equally

Miletic, H., Fischer, Y., Neumann, H., Hans, V., Stenzel, W., Giroglou, T., Deckert, M., von Laer, D. (2004)
Selective transduction of malignant glioma by lentiviral vectors pseudotyped with LCMV glycoproteins
Hum. Gene Therapy 15 (11):1091-100.

Iliev, A., Stringaris, A.K., Nau, R., Neumann, H. (2004)
Neuronal injury mediated via stimulation of microglial toll-like receptor-9 (TLR9)
FASEB J. 18, 412-414.

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Benninger, F., Beck, H., Wernig, M., Tucker, K.L., Brüstle, O., Scheffler, B. (2003)
Functional integration of embryonic stem cell-derived neurons in hippocampal slice cultures
J. Neurosci. 23:7075-7083

Peitz, M., Rajewsky, K., Brüstle, O., Edenhofer, F. (2003)
Direct delivery of biologically active proteins into cells: protein transduction as a tool for genomic manipulations in mammalian cells
Eur. J. Cell. Biol. 82 Suppl.53:36

Scheffler, B., Schmandt, T., Schröder, W., Steinfarz, B., Husseini, L., Wellmer, J., Seifert, G., Karram, K., Beck, H., Blümcke, I., Wiestler, O.D., Steinhäuser, C., Brüstle, O. (2003)
Functional network integration of embryonic stem cell-derived astrocytes in hippocampal slice cultures
Development 130:5533-5541

Steffel, J., Wernig, M., Knauf, U., Kumar, S., Wiestler, O.D., Wernig, A., Brüstle, O. (2003)
Migration and differentiation of myogenic precursors following transplantation into the developing rat brain
Stem Cells 21:181-189

Kempermann, G., Neumann, H. (2003)
Microglia: The enemy within?
Science 302, 1689-1690 (Perspective).

Neumann, H. (2003)
Molecular mechanisms of axonal damage in inflammatory central nervous system diseases
Curr. Opin. Neurology, 16: 267-273 (Review).

Wernig, M., Scheffler, B., Brüstle, O. (2003)
Medizinische Perspektiven der Stammzellforschung
Grundlagen der Molekularen Medizin, Ganten D, Ruckpaul K (eds.)
Springer-Verlag, Berlin, Heidelberg, New York 680-710

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Wernig, M., Tucker, K.L., Gornik, V., Schneiders, A., Buschwald, R., Wiestler, O.D., Barde, Y.A., Brüstle, O. (2002)
Tau EGFP embryonic stem cells: an efficient tool for neuronal lineage selection and transplantation
J. Neurosci. Res. 69:918-924

Neumann, H., Medana, I., Bauer, J., Lassmann, H. (2002)
Cytotoxic T lymphocytes in autoimmune and degenerative CNS diseases
Trends in Neurosci. 25 (6), 313-319 (Review).

Neumann, H., Schweigreiter, R., Yamashita, T., Rosenkranz, K., Wekerle, H., Barde,Y.-A. (2002)
Tumor necrosis factor inhibits neurite outgrowth and branching of hippocampal neurons by a Rho-dependent mechanism
J. Neurosci. 22, 854-862.

Wernig, M., Brüstle, O. (2002)
Fifty ways to make a neuron: shifts in stem cell hierarchy and their implications for neuropathology and CNS repair
J. Neuropathol. Exp. Neurol. 61:101-10. Review

Wiestler, O.D., Brüstle O. (2002)
Forschung an embryonalen Stammzellen: Was versprechen sich die klinischen Neurowissenschaften davon?
Stammzellforschung und therapeutisches Klonen, Oduncu F.S, Schroth U, Vossenkuhl W (eds), Vandenhoeck & Ruprecht, Göttingen 68-77

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Graus-Porta, D.*, Blaess, S.*, Senften, M., Littlewood-Evans, A., Damsky, C., Huang, Z., Orban, P., Klein, R., Schittny, J.C., Müller, U. (2001)
β1-class integrins regulate the development of laminae and folia in the cerebral and cerebellar cortex
Neuron 16;31(3):367-379
*Authors contributed equally

Medana, I., Martinic, M.M.A., Wekerle, H., Neumann, H. (2001)
Transection of major histocompatibiltiy class I-induced neurites by cytotoxic T lymphocytes
Am. J. Pathol. 159, 809-815.

Neumann, H. (2001)
Control of glial immune function by neurons.
Glia, 36, 191-199 (Review).

Medana, I., Li, Z., Flügel, A., Tschopp, J., Wekerle, H., Neumann, H. (2001)
Fas Ligand (CD95L) protects neurons against perforin-mediated T lymphocyte cytotoxicity
J. Immunol. 167, 674-681.

Brüstle, O. (2001)
Embryonale Stammzellen - neue Perspektiven für die Tranplantationsmedizin.
Humane Stammzellen. Perspektiven und Grenzen in der regenerativen Medizin, Bundesministerium für Bildung und Forschung (eds.),
Schattenhauer Verlagsgesellschaft mbH, Stuttgart 107-118

Brüstle, O., Dubois-Dalq, M. (2001)
CNS stem cells and their gliogenic potential
Glial Cell Development
Basic Principles and Clinical Relevance, Jessen K.R., Richardson W.D. (eds)
Oxford University Press 415-636

Zhang, S.C.‡, Wernig, M., Duncan, I.D., Brüstle, O.‡, Thomson, J.A. (2001)
In vitro differentiation of transplantable neural precursors from human embryonic stem cells
Nat. Biotechnol. 19:1129-1133

Blümcke, I., Schewe, J.C., Normann, S., Brüstle, O., Schramm, J., Elger, C.E., Wiestler, O.D. (2001)
Increase of nestin-immunoreactive neural precursor cells in the dentate gyrus of pediatric patients with early-onset temporal lobe epilepsy
Hippocampus 11:311-321
Erratum in: Hippocampus 11:478

Maskos, U., Brüstle, O., McKay, R.D. (2001)
Long-term survival, migration, and differentiation of neural cells without functional NMDA receptors in vivo
Dev. Biol. 231:103-112

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Flügel, A., Matsumuro, K., Neumann, H., Klinkert, W.E.F., Birnbacher, R., Lassmann, H., Otten, U., Wekerle, H. (2000)
Anti-inflammatory activity of nerve growth factor in experimental autoimmune encephalomyelitis:Inhibition of monocyte transendothelium migration
Eur. J. Immunol.31,11-22.

Flügel, A., Schwaiger, F.-W., Neumann, H., Medana, I., Willem, M., Wekerle, H., Kreutzberg, G.W., Graeber, M.B. (2000)
Neuronal FasL induces cell death of encephalitogenic T lymphocytes
Brain Pathol. 10,353-364.

Medana, I., Gallimore, A., Oxenius, A. Martinic, M. Wekerle, H., Neumann, H. (2000)
MHC class I-restricted killing of neurons by virus specific CD8+ T lymphocytes is effected through the Fas/FasL, but not the perforin pathway
Eur. J. Immunol. 30, 3623-3633.

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Brüstle, O. (1999)
Building brains: neural chimeras in the study of nervous system development and repair
Brain Pathol. 9:527-545. Review

Brüstle, O., Jones, K.N., Learish, R.D., Karram, K., Choudhary, K., Wiestler, O.D., Duncan, I.D., McKay, R.D. (1999)
Embryonic stem cell-derived glial precursors: a source of myelinating transplants
Science 285:754-756

Learish, R.D., Brüstle, O., Zhang, S.C., Duncan, I.D. (1999)
Intraventricular transplantation of oligodendrocyte progenitors into a fetal myelin mutant results in widespread formation of myelin
Ann. Neurol. 46:716-722

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Blaess, S., Kammerer, R.A., Hall. H. (1998)
Structural analysis of the sixth immunoglobulin-like domain of mouse neural cell adhesion molecule L1 and its interactions with αvβ3, αIIbβ3, and α5β1 integrins
J Neurochem 71(6):2615-2625

Neumann, H., Misgeld, T., Matsumuro, K., Wekerle H. (1998)
Neurotrophins inhibit major histocompatibility class II inducibility of microglia: Involvement of the p75 neurotrophin receptor
Proc. Natl. Acad. Sci. USA. 95: 5779-5784.

Neumann, H., Wekerle, H. (1998)
Neuronal control of the immune response in the central nervous system: Linking brain immunity to neurodegeneration
J. Neuropath. Exp. Neurol. 57(1): 1-9 (Review).

Raivich, G., Jones, L.L., Kloss, C.U.A., Werner, A., Neumann, H., Kreutzberg, G.W. (1998)
Immune surveillance in the injured nervous system: T-lymphocytes invade the axotomized mouse facial motor nucleus and aggregate around sites of neuronal degeneration
J. Neurosci. 18 (15): 5804-5816.

Brüstle, O., Choudhary, K., Karram, K., Hüttner, A., Murray, K., Dubois-Dalcq, M., McKay, R.D. (1998)
Chimeric brains generated by intraventricular transplantation of fetal human brain cells into embryonic rats
Nat. Biotechnol. 16:1040-1044

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Neumann, H., Schmidt, H., Cavalié, A., Jenne, D., Wekerle, H. (1997)
Major histocompatibility complex (MHC) class I gene expression in single neurons of the central nervous system:Differential regulation by interferon (IFN)-gamma and tumor necrosis factor (TNF)-alpha
J. Exp. Med. 185 (2): 305-316.

Neumann, H., Schmidt, H., Wilharm, E., Behrens, L., Wekerle, H. (1997)
Interferon- gamma gene expression in sensory neurons: Evidence for autocrine gene regulation
J. Exp. Med. 186 (12): 2023-2031.

Brüstle, O., Spiro, A.C., Karram, K., Choudhary, K., Okabe, S., McKay, R.D. (1997)
In vitro-generated neural precursors participate in mammalian brain development
Proc. Natl. Acad. Sci. U S A. 94:14809-14814

Brüstle, O., Cunningham, M., Tabar, V., Studer, L.T.E (1997)
Experimental transplantation in the embryonic, neonatal, and adult mammalian brain
In: Current Protocols in Neuroscience, Crawley, J., Gerfen, C., McKay, R.D.G, Rogowski, M., Sibley, D., Skolnick, P. (eds.)
John Wiley & Sons, Inc., New York 3.10.1-3.10.28

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Neumann, H., Boucraut, J., Hahnel, Ch., Misgeld, T., Wekerle, H. (1996)
Neuronal control of MHC class II inducibility in astrocytes and microglia
Eur. J. Neurosci. 8: 2582-2590.

Brüstle, O. McKay, R.D. (1996)
Neuronal progenitors as tools for cell replacement in the nervous system
Curr. Opin. Neurobiol. 6:688-695. Review

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Neumann, H., Cavalié, A., Jenne, D., Wekerle, H. (1995)
Induction of MHC class I genes in neurons
Science 269:549-552.

Brüstle, O., Maskos, U., McKay, R.D. (1995)
Host-guided migration allows targeted introduction of neurons into the embryonic brain
Neuron 15:1275-1285

Brüstle, O. McKay, R.D. (1995)
The neuroepithelial stem cell concept: implications for neuro-oncology
J. Neurooncol. 24:57-59. Review

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Kaltschmidt, Ch., Kaltschmidt, B., Neumann, H., Wekerle, H., Baeuerle, P. (1994)
Constitutive NF-kB activity in neurons
Mol. Cell. Biol. 14:3981-3992.

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Institute of Reconstructive Neurobiology

University of Bonn
Venusberg-Campus 1
Building 76
D-53105 Bonn/Germany

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