Publications » Institute of Reconstructive Neurobiology



Wen, J., Zellner, A., Braun, N.C., Bajaj, T., Gassen, N.C., Peitz, M., Brüstle, O. (2023)
Loss of function of FIP200 in human pluripotent stem cell-derived neurons leads to axonal pathology and hyperactivity
Transl Psychiatry. 13:143. doi: 10.1038/s41398-023-02432-3.

Röderer, P.#, Belu, A.#, Heidrich, L., Siobal, M., Isensee, J., Prolingheuer, J., Janocha, E.,
Valdor, M., Hagendorf, S., Bahrenberg, G., Opitz, T., Segschneider, M., Haupt, S., Nitzsche, A.,
Brüstle, O.*, Hucho, T.*
Emergence of nociceptive functionality and opioid signaling in human iPSC-derived sensory neurons
Pain. doi: 10.1097/j.pain.0000000000002860. Online ahead of print.

Mathews, M., Wißfeld, J., Flitsch, L.J., Shahraz, A., Semkova, V., Breitkreuz, Y., Neumann, H., Brüstle, O. (2023)
Reenacting neuroectodermal exposure of hematopoietic progenitors enables scalable production of cryopreservable iPSC-derived human microglia
Stem Cell Rev Rep. 19:455-474. doi: 10.1007/s12015-022-10433-w.

Berg, L.J., Brüstle, O. (2023)
Stem cell programming – prospects for perinatal medicine
J Perinat Med. Online ahead of print.

Alich, T.C.#, Röderer, P.#, Szalontai, B., Golcuk, K., Tariq, S., Peitz, M., Brüstle, O., Mody, I. (2023)
Bringing to light the physiological and pathological firing patterns of human induced pluripotent stem cell-derived neurons using optical recordings
Front Cell Neurosci. Online ahead of print.

Müller-Miny, L., Thiel, K., Meinert, S., Hahn, T., Kircher, T., Nenadić, I., Krug, A., Hufschmidt, F., Liao, H., Neumann, H., Dannlowski, U., Lünemann, J.D. (2023)
Association of polysialic acid serum levels with schizophrenia spectrum and bipolar disorder-related structural brain changes and hospitalization
Sci Rep. 13:2085. doi: 10.1038/s41598-023-29242-3.

Kebir, S., Ullrich, V., Berger, P., Dobersalske, C., Langer, S., Rauschenbach, L., Trageser, D.,
Till, A., Lorbeer, F.K., Wieland, A., Wilhelm-Buchstab, T., Ahmad, A., Fröhlich, H., Cima, I., Prasad, S., Matschke, J., Jendrossek, V., Remke, M., Grüner, B.M., Roesch, A., Siveke, J.T., Herold-Mende, C., Blau, T., Keyvani, K., van Landeghem, F.K.H., Pietsch, T., Felsberg, J., Reifenberger, G., Weller, M., Sure, U., Brüstle, O., Simon, M., Glas, M., Scheffler, B. (2023)
A sequential targeting strategy interrupts AKT-driven subclone-mediated progression in glioblastoma
Clin Cancer Res. 29:488-500. doi: 10.1158/1078-0432.CCR-22-0611.

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Flitsch, L.J., Börner K., Stüllein, C., Ziegler, S., Sonntag‑Buck, V., Wiedtke, E., Semkova, V., AuYeung, S.W.C., Schlee, J., Hajo, M., Mathews, M., Ludwig, B.S., Kossatz, S., Kessler, H., Grimm, D., Brüstle, O. (2022)
Identification of adeno‑associated virus variants for gene transfer into human neural cell types by parallel capsid screening
Scientific Reports. 12:8356.

Semkova, V., Haupt, S., Segschneider, M., Bell, C., Ingelman-Sundberg, M., Hajo, M.,
Weykopf, B., Muthukottiappan, P., Till, A.*✉︎, Brüstle, O.*✉︎ (2022)
Dynamics of metabolic pathways and stress response patterns during human neural stem cell proliferation and differentiation
Cells. 11:1388.

Vuidel, A., Cousin, L., Weykopf, B., Haupt, S., Hanifehlou, Z., Wiest-Daesslé, N.,
Segschneider, M., Lee, J., Kwon, Y.-J., Peitz, M., Ogier, A., Brino, L., Brüstle, O., Sommer, P., Wilbertz, J.H.
High-content phenotyping of Parkinson’s disease patient stem cell-derived midbrain dopaminergic neurons using machine learning classification
Stem Cell Reports. 17:1-16.

Wischhof, L., Lee, H.M., Tutas, J., Overkott, C., Tedt, E., Stork, M., Peitz, M., Brüstle, O., Ulas, T., Händler, K., Schultze, J.L., Ehninger, D., Nicotera, P., Salomoni, P., Bano, D. (2022)
BCL7A-containing SWI/SNF/BAF complexes modulate mitochondrial bioenergetics during neural progenitor differentiation
EMBO J. 41:e110595. doi: 10.15252/embj.2022110595.

Wen, J., Peitz, M., Brüstle, O. (2022)
A defined human-specific platform for modeling neuronal network stimulation in vitro and in silico
J Neurosci Methods. 373:109562.

Roll, L., Lessmann, K., Brüstle, O., Faissner, A. (2022)
Cerebral organoids maintain the expression of neural stem cell-associated glycoepitopes and extracellular matrix
Cells. 11:760.

Yang, N.J., Isensee, J., Neel, D.V., Quadros, A.U., Zhang, H.B., Lauzadis, J., Liu, S.M., Shiers, S., Belu, A., Palan, S., Marlin, S., Maignel, J., Kennedy-Curran, A., Tong, V.S., Moayeri, M.,
Röderer, P., Nitzsche, A., Lu, M., Pentelute, B.L., Brüstle, O., Tripathi, V., Foster, K.A., Price, T.J., Collier, R.J., Leppla, S.H., Puopolo, M., Bean, B.P., Cunha, T.M., Hucho, T., Chiu, I.M. (2022)
Anthrax toxins regulate pain signaling and can deliver molecular cargoes into ANTXR2+ DRG sensory neurons
Nat Neurosci. 25:168-179. doi: 10.1038/s41593-021-00973-8.

Wolf, C., Pouya, A., Bitar, S., Pfeiffer, A., Bueno, D., Rojas-Charry, L., Arndt, S., Gomez-Zepeda, D., Tenzer, S., Dal Bello, F., Vianello, C., Ritz, S., Schwirz, J., Dobrindt, K., Peitz, M., Hanschmann, E.-M., Mencke, P., Boussaad, I., Silies, M., Brüstle, O., Giacomello, M., Krüger, R., Methner, A. (2022)
GDAP1 loss of function inhibits the mitochondrial pyruvate dehydrogenase complex by altering the actin cytoskeleton
Commun Biol. 5:541.

Gather, F., Ihrig-Biedert, I., Kohlhas, P., Krutenko, T., Peitz, M., Brüstle, O., Pautz, A., Kleinert, H. (2022)
A specific, non-immune system-related isoform of the human inducible nitric oxide synthase is expressed during differentiation of human stem cells into various cell types
Cell Commun Signal. 20:47. doi: 10.1186/s12964-022-00855-x.

Rodriguez-Gatica, J.E.#, Iefremova, V.#, Sokhranyaeva, L., Yeung, S.W.C.A., Breitkreuz, Y., Brüstle, O.✉︎, Schwarz, M.K.✉︎, Kubitscheck, U.✉︎ (2022)
Imaging three-dimensional brain organoid architecture from meso- to nanoscale across development
Development. 149:dev200439. doi: 10.1242/dev.200439

Radtke, F., Palladino, V.S., McNeill, R.V., Chiocchetti, A.G., Haslinger, D., Leyh, M., Gersic, D., Frank, M., Grünewald, L., Klebe, S., Brüstle, O., Günther, K., Edenhofer, F., Kranz, T.M., Reif, A., Kittel-Schneider, S. (2022)
ADHD-associated PARK2 copy number variants: A pilot study on gene expression and effects of supplementary deprivation in patient-derived cell lines
Am J Med Genet B Neuropsychiatr Genet. 189:257-270. doi: 10.1002/ajmg.b.32918.

Jabali, A., Hoffrichter, A., Uzquiano, A., Marsoner, F., Wilkens, R., Siekmann, M., Bohl, B., Rossetti, A.C., Horschitz, S., Koch, P., Francis, F., Ladewig, J. (2022)
Human cerebral organoids reveal progenitor pathology in EML1-linked cortical malformation
EMBO Rep. 23:e54027. doi: 10.15252/embr.202154027.

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Wißfeld, J., Nozaki, I., Mathews, M., Raschka, T., Ebeling, C., Hornung, V., Brüstle, O., Neumann, H. (2021)
Deletion of Alzheimer's disease-associated CD33 results in an inflammatory human microglia phenotype
Glia. 69:1393-1412. doi: 10.1002/glia.23968.

Schmid, B., Holst, B., Clausen, C., Bahnassawy, L., Reinhardt, P., Bakker, M.H.M., Díaz-Guerra, E., Vicario, C., Martino-Adami, P.V., Thoenes, M., Ramirez, A., Flissbach, K., Grezella, C., Brüstle, O., Peitz, M., Ebneth, A., Cabrera-Socorro, A. (2021)
Generation of a set of isogenic iPSC lines carrying all APOE genetic variants (Ɛ2/Ɛ3/Ɛ4) and knock-out for the study of APOE biology in health and disease
Stem Cell Res. 52:102180. doi: 10.1016/j.scr.2021.102180.

Manstein, F., Ullmann, K., Kropp, C., Halloin, C., Triebert, W., Franke, A., Farr, C.M., Sahabian, A., Haase, A., Breitkreuz, Y., Peitz, M., Brüstle, O., Kalies, S., Martin, U., Olmer, R., Zweigerdt, R. (2021)
High density bioprocessing of human pluripotent stem cells by metabolic control and in silico modeling
Stem Cells Transl Med. 10:1063–1080. doi: 10.1002/sctm.20-0453.

Wißfeld, J., Mathews, M., Mossad, O., Picardi, P., Cinti, A., Redaelli, L., Pradier, L., Brüstle, O., Neumann, H. (2021)
Reporter cell assay for human CD33 validated by specific antibodies and human iPSC-derived microglia
Sci Rep. 11:13462.

Cenini, G., Hebisch, M., Iefremova, V., Flitsch, L.J., Breitkreuz, Y., Tanzi, R.E., Kim, D.Y., Peitz, M., Brüstle, O. (2021)
Dissecting Alzheimer's disease pathogenesis in human 2D and 3D models
Mol Cell Neurosci. 110:103568. doi: 10.1016/j.mcn.2020.103568. Review.

Ibach, M., Mathews, M., Linnartz-Gerlach, B., Theil, S., Kumar, S., Feederle, R., Brüstle, O., Neumann, H., Walter, J. (2021)
A reporter cell system for the triggering receptor expressed on myeloid cells 2 reveals differential effects of disease-associated variants on receptor signaling and activation by antibodies against the stalk region
Glia. 69:1126-1139. doi: 10.1002/glia.23953

Piotrowskia, T., Rippel, O., Elanzew, A., Nießing, B., Stucken, S., Jung, S., König, N., Haupt, S., Stappert, L., Brüstle, O., Schmitt, R., Jonas, S. (2021)
Deep-learning-based multi-class segmentation for automated, non-invasive routine assessment of human pluripotent stem cell culture status
Comput Biol Med. 129:104172.

Fumagalli, F., Young, F.L., Boeynaems, S., De Decker, M., Mehta, A.R., Swijsen, A., Fazal, R., Guo, W., Moisse, M., Beckers, J., Dedeene, L., Selvaraj, B.T., Vandoorne, T., Madan, V., van Blitterswijk, M., Raitcheva, D., McCampbell, A., Poesen, K., Gitler, A.D., Koch, P., Berghe, P.V., Rudolf, D., Verfaillie, C., Chandran, S., Van Den Bosch, L., Bullock, S.L., Van Damme, P. (2021)
C9orf72-derived arginine-containing dipeptide repeats associate with axonal transport machinery and impede microtubule-based motility
Sci Adv. 7:eabg3013. doi: 10.1126/sciadv.abg3013.

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Peitz, M., Krutenko, T., Brüstle, O. (2020)
Protocol for the standardized generation of forward programmed cryopreservable excitatory and inhibitory forebrain neurons
STAR Protocols (Cell Press) 1, 100038.

Flitsch, L.J., Laupman, K.E., Brüstle, O. (2020)
Transcription factor-based fate specification and forward programming for neural regeneration
Front Cell Neurosci. 14:121.

Cheffer, A., Flitsch, L.J., Krutenko, T., Röderer, P., Sokhranyaeva, L., Iefremova, V., Hajo, M., Peitz, M., Schwarz, M.K., Brüstle, O. (2020)
Human stem cell-based models for studying autism spectrum disorder-related neuronal dysfunction
Molecular Autism 11:99.

Elanzew, A., Nießing, B., Langendoerfer, D., Rippel, O., Piotrowski, T., Schenk, F., Kulik, M., Peitz, M., Breitkreuz, Y., Jung, S., Wanek, P., Stappert, L., Schmitt, R.H., Haupt, S., Zenke, M., König, N., Brüstle, O. (2020)
The StemCellFactory: A modular system integration for automated generation and expansion of human induced pluripotent stem cells
Front Bioeng Biotechnol. 8:580352. doi: 10.3389/fbioe.2020.580352.

Tabari, D., Scholl, C., Steffens, M., Weickhardt, S., Elgner, F., Bender, D., Herrlein, M.L., Sabino, C., Semkova, V., Peitz, M., Till, A., Brüstle, O., Hildt, E., Stingl, J. (2020)
Impact of Zika virus infection on human neural stem cell microRNA signatures
Viruses. 12:E1219. doi: 10.3390/v12111219.

Palladino, V.S., Chiocchetti, A.G., Frank, L., Haslinger, D., McNeill, R., Radtke, F., Till, A., Haupt, S., Brüstle, O., Günther, K., Edenhofer, F., Hoffmann, P., Reif, A., Kittel-Schneider, S. (2020)
Energy metabolism disturbances in cell models of PARK2 CNV carriers with ADHD
J Clin Med. 9:4092. doi: 10.3390/jcm9124092.

Rauschenbach, L., Wieland, A., Reinartz, R., Kebir, S., Till, A., Darkwah Oppong, M., Dobersalske, C., Ullrich, V., Ahmad, A., Jabbarli, R., Pierscianek, D., Fröhlich, H., Simon, M., Brüstle, O., Sure, U., Glas, M., Scheffler, B. (2020)
Drug repositioning of antiretroviral ritonavir for combinatorial therapy in glioblastoma
Eur J Cancer. 140:130-139. doi: 10.1016/j.ejca.2020.09.017.

Memmert, S., Nogueira, A.V.B., Damanaki, A., Nokhbehsaim, M., Rath-Deschner, B., Götz, W., Gölz, L., Cirelli, J.A., Till, A., Jäger, A., Deschner, J. (2020)
Regulation of the autophagy-marker Sequestosome 1 in periodontal cells and tissues by biomechanical loading
J Orofac Orthop. 81:10-21. doi: 10.1007/s00056-019-00197-3.

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Flitsch, L.J. and Brüstle, O. (2019)
Evolving principles underlying neural lineage conversion and their relevance for biomedical translation
F1000Research 2019. doi: 10.12688/f1000research.18926.1

Ostermann, L.#Ladewig, J.#, Müller, F.J., Kesevan, J., Tailor, J., Smith, A., Brüstle, O.✉︎Koch, P.✉︎ (2019)
In vitro recapitulation of developmental transitions in human neural stem cells
Stem Cells. 37:1429-1440. doi: 10.1002/stem.3065

Giesselmann, P., Brändl, B., Raimondeau, E., Bowen, R., Rohrandt, C., Tandon, R., Kretzmer, H., Assum, G., Galonska, C., Siebert, R., Ammerpohl, O., Heron, A., Schneider, S.A., Ladewig, J., Koch, P., Schuldt, B.M., Graham, J.E., Meissner, A., Müller, F.J. (2019)
Analysis of short tandem repeat expansions and their methylation state with nanopore sequencing
Nat Biotechnol. 37:1478-1481. doi: 10.1038/s41587-019-0293-x

Rehbach, K.Kesavan, J., Hauser, S., Ritzenhofen, S.Jungverdorben, J., Schüle, R., Schöls, L., Peitz, M.Brüstle, O. (2019)
Multiparametric rapid screening of neuronal process pathology for drug target identification in HSP patient-specific neurons
Scientific Reports. 9:9615. doi: 10.1038/s41598-019-45246-4

Ojeda, D.S., Till, A., Quarleri, J. (2019)
Are the mechanisms involved in astrocyte and lymphocyte death during HIV infection similar?
Neural Regen Res. 14:1707-1708. doi: 10.4103/1673-5374.257519

Meijer, M.#, Rehbach, K.#, Brunner, J.W., Classen, J.A., Lammertse, H.C.A., van Linge, L.A., Schut, D., Krutenko, T., Hebisch, M., Cornelisse, L.N., Sullivan, P.F., Peitz, M.✉︎, Toonen, R.F., Brüstle, O.✉︎, Verhage, M.✉︎ (2019)
A single-cell model for synaptic transmission and plasticity in human iPSC-derived neurons
Cell Reports. 27:2199-2211.doi: 10.1016/j.celrep.2019.04.058

Wiatr, K., Piasecki, P., Marczak, Ł., Wojciechowski, P., Kurkowiak, M., Płoski, R., Rydzanicz, M., Handschuh, L., Jungverdorben, J., Brüstle, O., Figlerowicz, M., Figiel, M. (2019)
Altered levels of proteins and phosphoproteins, in the absence of early causative transcriptional changes, shape the molecular pathogenesis in the brain of young presymptomatic Ki91 SCA3/MJD mouse
Mol Neurobiol. 56:8168-8202. doi: 10.1007/s12035-019-01643-4

Rhee, H.J.#, Shaib, A.H.#, Rehbach, K.#, Lee, C.K., Seif, P., Thomas, C., Gideons, E., Guenther, A., Krutenko, T., Hebisch, M., Peitz, M., Brose, N., Brüstle, O.*, Rhee, J.S.* (2019)
An autaptic culture system for standardized analyses of iPSC-derived human neurons
Cell Reports. 27:2212-2228. doi: 10.1016/j.celrep.2019.04.059

Vaswani, A.R.Weykopf, B., Hagemann, C., Fried, H.-U., Brüstle, O., Blaess, S. (2019)
Correct setup of the substantia nigra requires Reelin-mediated fast, laterally-directed migration of dopaminergic neurons
eLife. 8:e41623. doi: 10.7554/eLife.41623

Weykopf, B. , Haupt, S. , Jungverdorben, J. , Flitsch, L. J., Hebisch, M. , Liu, G. , Suzuki, K. , Belmonte, J. C., Peitz, M. , Blaess, S. , Till, A., Brüstle, O. (2019)
Induced pluripotent stem cell‐based modeling of mutant LRRK2‐associated Parkinson's Disease
Eur J Neurosci. 49:561-589. doi:10.1111/ejn.14345

Thier, M.C., Hommerding, O., Panten, J., Pinna, R., García-González, D., Berger, T., Wörsdörfer, P., Assenov, Y., Scognamiglio, R., Przybylla, A., Kaschutnig, P., Becker, L., Milsom, M.D., Jauch, A., Utikal, J., Herrmann, C., Monyer, H., Edenhofer, F., Trumpp, A. (2019)
Identification of embryonic neural plate border stem cells and their generation by direct reprogramming from adult human blood cells
Cell Stem Cell. 24:166-182. doi: 10.1016/j.stem.2018.11.015

Memmert, S., Damanaki, A., Weykopf, B., Rath-Deschner, B., Nokhbehsaim, M., Götz, W., Gölz, L., Till, A., Deschner, J., Jäger, A. (2019)
Autophagy in periodontal ligament fibroblasts under biomechanical loading
Cell Tissue Res. 378:499-511. doi: 10.1007/s00441-019-03063-1.

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Stappert, L., Klaus, F., Brüstle, O. (2018)
MicroRNAs engage in complex circuits regulating adult neurogenesis
Front Neurosci. 12:707. doi: 10.3389/fnins.2018.00707. Review

Sheng, C., Jungverdorben, J., Wiethoff, H., Lin, Q., Flitsch, L.J., Eckert, D., Hebisch, H., Fischer, J., Kesavan, J., Weykopf, B., Schneider, L., Holtkamp, D., Beck, H., Till, A., Wüllner, U., Ziller, M.J., Wagner, W., Peitz, M., Brüstle, O. (2018)
A stably self-renewing adult blood-derived induced neural stem cell exhibiting patternability and epigenetic rejuvenation
Nat Commun. 29:4047. doi: 10.1038/s41467-018-06398-5
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Allison, T.F., Andrews, P.W., Avior, Y., Barbaric, I., Benvenisty, N., Bock, C., Brehm, J., Brüstle, O., Damjanov, I., Elefanty, A., Felkner, D., Gokhale, P.J., Halbritter, F., Healy, L.E., Hu, T.X., Knowles, B.B., Loring, J.F., Ludwig, T.E., Mayberry, R., Micallef, S., Mohamed, J.S., Müller, F.-J., Mummery, C.L., Nakatsuji, N., Ng, E.S., Oh, S.K.W., O’Shea, O., Pera, M.F., Reubinoff, B., Robson, P., Rossant, J., Schuldt, B.M., Solter, D., Sourris, K., Stacy, G., Stanley, E.G., Suemori, H., Takahashi, K., Yamanaka, S. (2018)
Assessment of established techniques to determine developmental and malignant potential of human pluripotent stem cells
Nat Commun. 9:1925. doi: 10.1038/s41467-018-04011-3

Kumar, P., Efstathopoulos, P., Millischer, V., Olsson, E., Bin Wei, Y., Brüstle, O., Schalling, M., Villaescusa, J.C., Ösby, U., Lavebratt, C. (2018)
Mitochondrial DNA copy number is associated with psychosis severity and anti-psychotic treatment.
Sci Rep. 8:12743. doi: 10.1038/s41598-018-31122-0

Evert, B.O., Nalavade, R., Jungverdorben, J., Matthes, F., Weber, S., Rajput, A., Bonn, S., Brüstle, O., Peitz, M., Krauß, S. (2018)
Upregulation of miR-370 and miR-543 is associated with reduced expression of heat shock protein 40 in spinocerebellar ataxia type 3.
PLoS One. 13:e0201794. doi: 10.1371/journal.pone.0201794

Merten, N., Fischer, J., Simon, K., Zhang, L., Schröder, R., Peters, L., Letombe, A.-G., Hennen, S., Schrage, R., Bödefeld, T., Vermeiren, C., Gillard, M., Mohr, K., Lu, Q.R., Brüstle, O., Gomeza, J., Kostenis, E. (2018)
Repurposing HAMI3379 to block GPR17 and promote rodent and human oligodendrocyte differentiation
Cell Chem Biol. 25:775-786.e5. doi: 10.1016/j.chembiol.2018.03.012

Peitz, M., Bechler, T., Thiele, C.C., Veltel, M., Bloschies, M., Fliessbach, K., Ramirez, A., Brüstle, O. (2018)
Blood-derived integration-free iPS cell line UKBi011-A from a diagnosed male Alzheimer's disease patient with APOE ɛ4/ɛ4 genotype
Stem Cell Res. 29:250-253. doi: 10.1016/j.scr.2018.04.011

Memmert, S., Nogueira, A.V.B., Damanaki, A., Nokhbehsaim, M., Eick, S., Divnic-Resnik, T., Spahr, A., Rath-Deschner, B., Till, A., Götz, W., Cirelli, J.A., Jäger, A., Deschner, J. (2018)
Damage-regulated autophagy modulator 1 in oral inflammation and infection
Clin Oral Investig. 22:2933-2941. doi: 10.1007/s00784-018-2381-6

Poppe, D., Doerr, J., Schneider, M., Wilkens, R., Steinbeck, J.A., Ladewig, J., Tam, A., Paschon, D.E., Gregory, P.D., Reik, A., Müller, C.E., Koch, P., Brüstle, O. (2018)
Genome editing in neuroepithelial stem cells to generate human neurons with high adenosine-releasing capacity
Stem Cells Transl Med. 7:477-486. doi: 10.1002/sctm.16-0272

Ojeda, D.S., Grasso, D., Urquiza, J., Till, A., Vaccaro, M.I., Quarleri, J. (2018)
Cell death is counteracted by mitophagy in HIV-productively infected astrocytes but is promoted by inflammasome activation among non-productively infected cells
Front Immunol. 9:2633. doi: 10.3389/fimmu.2018.02633

Jungverdorben, J., Till, A., Brüstle, O. (2018)
Modellierung neurodegenerativer Erkrankungen mittels induziert pluripotenter Stammzellen (iPS-Zellen): ein Fokus auf Autophagie
In: Stammzellforschung - Aktuelle wissenschaftliche und gesellschaftliche Entwicklungen (Eds.: Senke, M., Marx-Stölting, L., Schickl, H.), Forschungsberichte der Interdisziplinären Arbeitsgruppen der Berlin-Brandenburgischen Akademie der Wissenschaften, Nomos, Kapitel 3.2

Cam, M., Durieu, E., Bodin, M., Manousopoulou, A., Koslowski, S., Vasylieva, N., Barnych, B., Hammock, B.D., Bohl, B., Koch, P., Omori, C., Yamamoto, K., Hata, S., Suzuki, T., Karg, F., Gizzi, P., Erakovic-Haber, V., Bencetic Mihaljevic, V., Tavcar, B., Portelius, E., Pannee, J., Blennow, K., Zetterberg, H., Garbis, S.D., Auvray, P., Gerber, H., Fraering, J., Fraering, P.C., Meijer, L. (2018)
Induction of amyloid-β42 production by fipronil and other pyrazole insecticides
J Alzheimers Dis. 62:1663-1681. doi: 10.3233/JAD-170875

de Boni, L., Gasparoni, G., Haubenreich, C., Tierling, S., Schmitt, I., Peitz, M., Koch, P., Walter, J., Wüllner, U., Brüstle, O. (2018)
DNA methylation alterations in iPSC- and hESC-derived neurons: potential implications for neurological disease modeling
Clin Epigenetics. 10:13. doi: 10.1186/s13148-018-0440-0

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Doerr, J., Schwarz, M.K., Wiedermann, D., Leinhaas, A., Jakobs, A., Schloen, F., Schwarz, I., Diedenhofen, M., Braun, N.C., Koch, P., Peterson, D.A., Kubitscheck, U., Hoehn, M., Brüstle, O. (2017)
Whole-brain 3D mapping of human neural transplant innervation
Nat Commun. 8:14162. doi: 10.1038/ncomms14162

Roese-Koerner, B., Stappert, L., Brüstle, O. (2017)
Notch/Hes signaling and miR-9 engage in complex feedback interactions controlling neural progenitor cell proliferation and differentiation
Neurogenesis. 4:1. e1313647. doi:10.1080/23262133.2017.1313647

Koch, P., Ladewig, J. (2017)
A little bit of guidance: Mini brains on their route to adolescence
Cell Stem Cell. 21:157-158. doi: 10.1016/j.stem.2017.07.001

Siegel, G., Gerber, H., Koch, P., Brüstle, O., Fraering, P.C., Rajendran, L. (2017)
The Alzheimer's disease γ-secretase generates higher 42:40 ratios for β-amyloid than for p3 peptides
Cell Rep. 19:1967-1976. doi: 10.1016/j.celrep.2017.05.034

Jungverdorben, J., Till, A., Brüstle, O. (2017)
Induced pluripotent stem cell-based modeling of neurodegenerative diseases: a focus on autophagy
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Reinartz, R., Wang, S., Kebir, S., Silver, D.J., Wieland, A., Zheng, T., Küpper, M., Rauschenbach, L., Fimmers, R., Shepherd, T., Trageser, D., Till, A., Schäfer, N., Glas, M., Hillmer, A.M., Cichon, S., Smith, A., Pietsch, T., Liu, Y., Reynolds, B.A., Yachnis, A.T., Pincus, D.W., Simon, M., Brüstle, O., Steindler, D.A., Scheffler, B. (2017)
Functional subclone profiling for prediction of treatment-induced intra-tumor population shifts and discovery of rational drug combinations in human glioblastoma
Clin Cancer Res. 23:562-574. doi: 10.1158/1078-0432.CCR-15-2089

Terstegge, S., Edenhofer, F., Brüstle, O. (2017)
Stammzellen – Bedeutung für die Klinische Medizin
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Tornero, D., Tsupykov, O., Granmo, M., Rodriguez, C., Grønning-Hansen, M., Thelin, J., Smozhanik, E., Laterza, C., Wattananit, S., Ge, R., Tatarishvili, J., Grealish, S., Brüstle, O., Skibo, G., Parmar, M., Schouenborg, J., Lindvall, O., Kokaia, Z. (2017)
Synaptic inputs from stroke-injured brain to grafted human stem cell-derived neurons activated by sensory stimuli
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Minnerop, M., Kurzwelly, D., Wagner, H., Soehn, A.S., Reichbauer, J., Tao, F., Rattay, T.W., Peitz, M., Rehbach, K., Giorgetti, A., Pyle, A., Thiele, H., Altmüller, J., Timmann, D., Karaca, I., Lennarz, M., Baets, J., Hengel, H., Synofzik, M., Atasu, B., Feely, S., Kennerson, M., Stendel, C., Lindig, T., Gonzalez, M.A., Stirnberg, R., Sturm, M., Roeske, S., Jung, J., Bauer, P., Lohmann, E., Herms, S., Heilmann-Heimbach, S., Nicholson, G., Mahanjah, M., Sharkia, R., Carloni, P., Brüstle, O., Klopstock, T., Mathews, K.D., Shy, M.E., de Jonghe, P., Chinnery, P,F,, Horvath, R., Kohlhase, J., Schmitt, I., Wolf, M., Greschus, S., Amunts, K., Maier, W., Schöls, L., Nürnberg, P., Zuchner, S., Klockgether, T., Ramirez, A., Schüle, R. (2017)
Hypomorphic mutations in POLR3A are a frequent cause of sporadic and recessive spastic ataxia
Brain. 140:1561-1578. doi: 10.1093/brain/awx095

Choi, S.H., D’Avanzo, C., Kim, Y.H., Bylykbashi, E., Hebisch, M., Brüstle, O., Tanzi, R.E., Kim, D.Y. (2017)
Three-dimensional cultures of human neural stem cells: An application for modeling Alzheimer’s disease pathogenesis
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Rapid establishment of the European Bank for induced Pluripotent Stem Cells (EBiSC) - the Hot Start experience
Stem Cell Research. 20:105-114

Kandasamy, M., Roll, L., Langenstroth, D., Brüstle, O., Faissner, A. (2017)
Glycoconjugates reveal diversity of human neural stem cells (hNSCs) derived from human induced pluripotent stem cells (hiPSCs)
Cell Tissue Res. 368:531-549. doi: 10.1007/s00441-017-2594-z

Badenes, S.M., Fernandes, T.G., Miranda, C.C, Pusch-Klein, A., Haupt, S., Rodrigues, C.A.V., Diogoa, M.M., Brüstle, O., Cabrala, J.M.S (2017)
Long-term expansion of human induced pluripotent stem cells in a microcarrier-based dynamic system
J Chem Technol Biotechnol. 92:492-503 DOI: 10.1002/jctb.5074

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Roese-Koerner, B., Stappert, L., Berger, T., Braun, N.C., Veltel, M., Jungverdorben, J., Evert, B.O., Peitz, M., Borghese, L., Brüstle, O. (2016)
Reciprocal regulation between bifunctional miR-9/9* and its transcriptional modulator Notch in human neural stem cell self-renewal and differentiation
Stem Cell Reports. 2016 Aug 9;7(2):207-19. doi: 10.1016/j.stemcr.2016.06.008. Epub 2016 Jul 14.

Falk, A., Heine, V.M., Harwood, A.J., Sullivan, P.F., Peitz, M., Brüstle, O., Shen, S., Sun, Y.-M., Glover, J.C., Posthuma, D., Djurovic, S. (2016)
Modeling psychiatric disorders: from genomic findings to cellular phenotypes
Mol Psychiatry. 2016 Sep;21(9):1167-79. doi: 10.1038/mp.2016.89. Epub 2016 May 31.

Schwenk, B.M., Hartmann, H., Serdaroglu, A., Schludi, M.H., Hornburg, D., Meissner, F., Orozco, D., Colombo, A., Tahirovic, S., Michaelsen, M., Schreiber, F., Haupt, S., Peitz, M., Brüstle, O., Küpper, C., Klopstock, T., Otto, M., Ludolph, A.C., Arzberger, T., Kuhn, P.H., Edbauer, D. (2016)
TDP-43 loss of function inhibits endosomal trafficking and alters trophic signaling in neurons
EMBO J. 2016 Nov 2;35(21):2350-2370.

Seidel, D., Obendorf, J., Englich, B., Jahnke, H.-G., Semkova, V., Haupt, S., Girard, M., Peschanski, M., Brüstle, O., Robitzki, A.A. (2016)
Impedimetric real-time monitoring of neural pluripotent stem cell differentiation process on microelectrode arrays
Biosens Bioelectron. 2016 Dec 15;86:277-86. doi: 10.1016/j.bios.2016.06.056. Epub 2016 Jun 20.

Ben Halima, S., Mishra, S., Raja, K.M., Willem, M., Baici, A., Simons, K., Brüstle, O., Koch, P., Haass, C., Caflisch, A., Rajendran, L. (2016)
Specific inhibition of β-secretase processing of the Alzheimer Disease amyloid precursor protein
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Heesen, L.*, Peitz, M.*, Torres-Benito, L., Hölker, I., Hupperich, K., Dobrindt, K., Jungverdorben, J., Ritzenhofen, S., Weykopf, B., Eckert, D., Hosseini-Barkooie, S.M., Storbeck, M., Fusaki, N., Lonigro, R., Heller, R., Kye, M.J., Brüstle, O.‡, Wirth, B.‡ (2015)
Plastin 3 is upregulated in iPSC-derived motoneurons from asymptomatic SMN1-deleted individuals
Cell Mol Life Sci. 2016 May;73(10):2089-104. doi: 10.1007/s00018-015-2084-y. Epub 2015 Nov 16.

Klionsky, D.J., … Till, A., … Tong, C.K. (2016)
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
Autophagy. 12:1-222. doi: 10.1080/15548627.2015.1100356.

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Kim, Y.H., Choi, S.H., D’Avanzo, C., Hebisch, M., Sliwinski, C., Bylykbashi, E., Washicosky, K.J. Klee, J.B., Brüstle, O., Tanzi, R.E.,Kim, D.Y. (2015)
A 3D human neural cell culture system for modeling Alzheimer’s disease
Nature Protocols. 2015 Jul;10(7):985-1006. doi: 10.1038/nprot.2015.065. Epub 2015 Jun 11.

Brennand, K.J, Marchetto, M.C., Benvenisty, N., Brüstle, O., Ebert, A., Izpisua Belmonte, J.C., Kaykas, A., Lancaster, M.A., Livesey, F.J., McConnell, M.J., McKay, R.D., Morrow, E.M., Muotri, A.R., Panchision, D.M., Rubin, L.L., Sawa, A., Soldner, F., Song, H., Studer, L., Temple, S., Vaccarino, H.F.M, Wu, J., Vanderhaeghen, P., Gage, F.H., Jaenisch, R. (2015)
Creating patient-specific neural cells for the in vitro study of brain disorders
Stem Cell Reports. 2015 Dec 8;5(6):933-45. doi: 10.1016/j.stemcr.2015.10.011. Epub 2015 Nov 21.

Gorris, R.*, Fischer, J.*, Erwes, K.L., Kesavan, J., Peterson, D.A., Alexander, M., Nöthen, M.M., Peitz, M., Quandel, T., Karus, M., Brüstle O. (2015)
Pluripotent stem cell-derived radial glia-like cells as stable intermediate for efficient generation of human oligodendrocytes
Glia. 2015 Dec;63(12):2152-67. doi: 10.1002/glia.22882. Epub 2015 Jun 30.

Doerr, J., Böckenhoff, A., Ewald, B., Ladewig, J., Eckhardt, M., Gieselmann, V., Matzner, U., Brüstle, O.*, Koch, P.* (2015)
Arylsulfatase A overexpressing human iPSC-derived neural cells reduce CNS sulfatide storage in a mouse model of metachromatic leukodystrophy
Mol Ther. 2015 Sep;23(9):1519-1531. doi: 10.1038/mt.2015.106. Epub 2015 Jun 10.

Stappert, L., Roese-Koerner, B., Brüstle, O. (2015)
The role of microRNAs in human neural stem cells, neuronal differentiation and subtype specification
Cell Tissue Res. 359(1):47-64. doi: 10.1007/s00441-014-1981-y. Epub 2014 Aug 30. Review

Ladewig, J., Koch, P., Brüstle, O. (2015)
In vitro migration assays for neural stem cells, intermediate neurogenic progenitors and immature neurons
Bio-Protocol. 5(1):e1371

Elanzew, A.*, Sommer, A.*, Pusch-Klein, A., Brüstle, O., Haupt, S. (2015)
A reproducible and versatile system for the dynamic expansion of human pluripotent stem cells in suspension
Biotechnol J. 2015 Oct;10(10):1589-99. doi: 10.1002/biot.201400757. Epub 2015 Aug 11.

Fernandes, T.G.*, Duarte, S.T.*, Ghazvini, M., Gaspar, C., Santos, D.C., Porteira, A.R., Rodrigues, G.M., Haupt, S., Rombo, D.M., Armstrong, J., Sebastião, A.M., Gribnau, J., Garcia-Cazorla, À., Brüstle, O., Henrique, D., Cabral, J.M., Diogo, M.M. (2015)
Neural commitment of human pluripotent stem cells under defined conditions recapitulates neural development and generates patient-specific neural cells
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Mitschka, S., Ulas, T., Goller, T., Schneider, K., Egert, A., Mertens, J., Brüstle, O., Schorle, H., Beyer, M., Klee, K., Xue, J., Günther, P., Bassler, K., Schultze, J.L., Kolanus, W. (2015)
Co-existence of intact stemness and priming of neural differentiation programs in mES cells lacking Trim71
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Miranda, C.C.*, Fernandes, T.G.*, Pascoal, J.F., Haupt, S., Brüstle, O., Cabral, J.M., Diogo, M.M. (2015)
Spatial and temporal control of cell aggregation efficiently directs human pluripotent stem cells towards neural commitment
Biotechnol J. 2015 Oct;10(10):1612-24. doi: 10.1002/biot.201400846. Epub 2015 Apr 28.

Ruschel, J., Hellal, F., Flynn, K.C., Dupraz, S., Elliott, D.A., Tedeschi, A., Bates, M., Sliwinski, C., Brook, G., Dobrindt, K., Peitz, M., Brüstle, O., Norenberg, M.D., Blesch, A., Weidner, N., Bunge, M.B., Bixby, J.L., Bradke, F. (2015)
Systemic administration of epothilone B promotes axon regeneration after spinal cord injury
Science. 348(6232):347-352. doi: 10.1126/science.aaa2958. Epub 2015 Mar 12.

Andrews, P.W., Baker, D., Benvinisty, N., Miranda, B., Bruce, K., Brüstle, O., Choi, M., Choi, Y.-M., Crook, J.M., de Sousa, P.A., Dvorak, P., Freund, C., Firpo, M., Furue, M.K., Gokhale, P., Ha, H.-Y., Han, E., Haupt, S., Healy, L., Hei, D.J., Hovatta, O., Hunt, C., Hwang, S.-M., Inamdar, M.S., Isasi, R.M., Jaconi, M., Jekerle, V., Kamthorn, P., Kibbey, M.C., Knezevic, I., Knowles, B.B., Koo, S.-K., Laabi, Y., Leopoldo, L., Liu, P., Lomax, G.P., Loring, J.F., Ludwig, T.E., Montgomery, K., Mummery, C., Nagy, A., Nakamura, Y., Nakatsuji, N., Oh, S., Oh, S.-K., Otonkoski, T., Pera, M., Peschanski, M., Pranke, P., Rajala, K.M., Rao, M., Ruttachuk, R., Reubinoff, B., Ricco, L., Rooke, H., Sipp, D., Stacey, G.N., Suemori, H., Takahashi, T.A., Takada, K., Talib, S., Tannenbaum, S., Yuan, B.-Z., Zeng, F., Zhou, Q. (2015)
Points to consider in the development of seed stocks of pluripotent stem cells for clinical applications: International Stem Cell Banking Initiative (ISCBI)
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Kadari, A., Mekala, S, Wagner, N., Malan, D., Köth, J., Doll, K., Stappert, L., Brüstle, O., Matthes, J., Sasse, P., Herzig, S., Ergün, S., Edenhofer, F. (2015)
Robust generation of cardiomyocytes from human iPS cells requires precise modulation of Bmp and Wnt signaling
Stem Cell Rev. 2015 Aug;11(4):560-9. doi: 10.1007/s12015-014-9564-6.

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Ladewig, J.*, Koch, P.*, Brüstle, O. (2014)
Auto-attraction of neural precursors and their neuronal progeny impairs neuronal migration
Nature Neuroscience 17(1):24-26. doi: 10.1038/nn.3583.

Karus, M., Blaess, S., Brüstle, O. (2014)
Self-organisation of neural tissue architectures from pluripotent stem cells
J Comp Neurol 522(12):2831-2844. doi: 10.1002/cne.23608.

Choi, S.H., Kim, Y.H., Hebisch, M., Sliwinski, C., Lee, S., D'Avanzo, C., Chen, H., Hooli, B., Asselin, C., Muffat, J., Klee, J.B., Zhang, C., Wainger, B.J., Peitz, M., Kovacs, D.M., Woolf, C.J., Wagner, S.L., Tanzi, R.E., Kim, D.Y. (2014)
A three-dimensional human neural cell culture model of Alzheimer's disease
Nature 2014 Oct 12. doi: 10.1038/nature13800. [Epub ahead of print]

Qin, J., Sontag, S., Lin, Q., Mitzka, S., Leisten, I., Schneider, R.K., Wang, X., Jauch, A., Peitz, M., Brüstle, O., Wagner, W., Zhao, R.C., Zenke, M. (2014)
Cell fusion enhances mesendodermal differentiation of human induced pluripotent stem cells
Stem Cells Dev 23(23):2875-2882. doi: 10.1089/scd.2014.0120.

Avaliani, N., S Rensen, A.T., Ledri, M., Bengzon, J., Koch, P., Brüstle, O., Deisseroth, K., Andersson, M., Kokaia, M. (2014)
Optogenetics reveal delayed afferent synaptogenesis on grafted human induced pluripotent stem cell-derived neural progenitors
Stem Cells 32(12):3088-3098. doi: 10.1002/stem.1823.

Tatarishvili, J., Oki K., Monni, E., Koch, P., Memanishvili, T., Buga, A.-M., Verma, V., Popa-Wagner, A., Brüstle, O., Lindvall, O., Kokaia, Z. (2014)
Human induced pluripotent stem cells improve recovery in stroke-injured aged rats
Restor Neurol Neurosci 32(4):547-558. doi: 10.3233/RNN-140404.

Kubaczka, C., Senner, C., Araúzo-Bravo, M.J., Sharma, N., Kuckenberg, P., Becker, A., Zimmer, A., Brüstle, O., Peitz, M., Hemberger, M., Schorle, H (2014)
Derivation and maintenance of murine trophoblast stem cells under defined conditions
Stem Cell Reports 2(2):232-242. doi: 10.1016/j.stemcr.2013.12.013. eCollection 2014 Feb 11.

Peitz, M., Münst, B., Thummer, R.P., Helfen, M., Edenhofer, F. (2014)
Cell-permeant recombinant Nanog protein promotes pluripotency by inhibiting endodermal specification
Stem Cell Res 12(3):680-689 doi: 10.1016/j.scr.2014.02.006

Rodrigues, G. M.C., Matos, A.F.S., Fernandes, T.G., Rodrigues, C.A.V Peitz, M., Haupt, S., Diogo. M.M., Brüstle, O., Cabral, J.M.S. (2014)

Integrated platform for production and purification of human pluripotent stem cell-derived neural precursors

Stem Cells Rev Rep 10(2):151-161. doi: 10.1007/s12015-013-9482-z.

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Mertens, J., Stüber, K., Wunderlich, P., Ladewig, J., Kesevan, J.C., Vandenberghe, R., Vandenbuicke, M., van Damme, P., Walter, J., Brüstle, O.*, Koch, P.* (2013)
APP processing in human pluripotent stem cell-derived neurons is resistant to NSAID-based γ-secretase modulation
Stem Cell Reports 1(6):491-498

Brüstle, O. (2013)
Miniature human brains
Nature 501(7467):319-320 [News & Views]

Tornero, D., Wattananit, S., Grønning Madsen, M., Koch, P., Wood, J., Tatarishvili, J., Mine, Y., Ge, R., Monni, E., Devaraju, K., Hevner, R.F., Brüstle, O., Lindvall, O., Kokaia, Z.
Human induced pluripotent stem cell-derived cortical neurons integrate in stroke-injured cortex and improve functional recovery
Brain 136(12):3561-3577

Ladewig, J.*, Koch, P.*, Brüstle, O. (2013)
Leveling Waddington: the emergence of direct programming and the loss of cell fate hierarchies
Nature Rev Mol Cell Biol 14(4):225-236

Glas, M., Coch, C., Trageser, D., Simon, M., Koch, P., Mertens, J., Quandel, T., Lüdenbach, B., Daßler, J., Lünskens, R., Reinartz, R., Wieland, A., Eisenreich, R., Höfer, H.,, Keller, M., von Lehe, M., Pusch, A., Schlee, M., Neumann, H., Fimmers, R., Herrlinger, U., Brüstle, O., Besch, R., Hartmann, G., Scheffler, B. (2013)
Targeting the cytosolic innate immune receptors RIG-I and MDA5 effectively counteracts cancer cell heterogeneity in glioblastoma
Stem Cells 31(6):1064-1074

Mertens, J., Stüber, K., Poppe, D., Doerr, J., Ladewig, J., Brüstle, O.*, Koch, P.* (2013)
Embryonic stem cell-based modeling of tau pathology in human neurons
Am J Pathol 182(5):1769-1779

Bianco, P., Barker, R., Brüstle, O., Cattaneo, E., Clevers, H., Daley, G.Q., De Luca, M., Goldstein, L., Lindvall, O., Mummery, C., Robey, P.G., Sattler de Sousa e Brito, C., Smith, A. (2013)
Regulation of stem cell therapies under attack in Europe: for whom the bell tolls
The EMBO Journal 32(11):1489-1495

Wieland, A., Trageser, D., Gogolok, S., Reinartz, R., Höfer, H., Keller, M., Leinhaas, A., Schelle, R., Normann, S., Klaas, L., Waha, A., Koch, P., Fimmers, R., Pietsch, T., Yachnis, A.T., Pincus, D.W., Steindler, D.A., Brüstle, O., Simon, M., Glas, M., Scheffler, B. (2013)
Anticancer effects of niclosamide in human glioblastoma
Clin Cancer Res 19(15):4124-4136

Stappert, L.*, Borghese, L*., Roese-Koerner, B., Weinhold, S., Koch, P., Terstegge, S., Uhrberg, M., Wernet, P., Brüstle, O. (2013).
MicroRNA-based promotion of human neuronal differentiation and subtype specification
PLoS One 8(3):e59011

Mertens, J., Koch, P., Brüstle, O. (2013)
Human pluripotent and multipotent stem cells as tools for modeling neurodegeneration
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Garbes, L., Heesen, L., Hölker, I., Bauer, T., Schreml, J., Zimmermann, K., Thoenes, M., Walter, M., Dimos, J., Peitz, M., Brüstle, O., Heller, R., Wirth, B. (2013)
VPA response in SMA is suppressed by the fatty acid translocase CD36
Hum Mol Genet 22(2):398-407

Roese-Koerner, B., Stappert, L., Koch, P., Brüstle, O.‡, Borghese, L.‡ (2013)
Pluripotent stem cell-derived somatic stem cells as tool to study the role of microRNAs in early human neural development
Curr Mol Med 13(5):707-722

Peitz, M., Jungverdorben, J., Brüstle, O. (2013)
Disease-specific iPS cell models in neuroscience
Curr Mol Med 13(5):832-841

McLaren, D., Gorba, T., Marguerie de Rotrou, A., Pillai, G., Chappell, C., Stacey, A., Lingard, S., Falk, A., Smith, A., Koch, P., Brüstle, O., Vickers, R., Tinsley, J., Flanders, D.,  Bello, P., Craig, S. (2013)
Automated large-scale culture and medium-throughput chemical screen for modulators of proliferation and viability of human induced pluripotent stem cell-derived neuroepithelial-like stem cells
J Biomol Screen 18(3):258-68

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Ladewig, J., Mertens, J.*, Kesavan, J.*, Doerr, J., Poppe, D., Glaua, F., Herms, S., Wernet, P., Kögler, G., Müller, F.-J., Koch, P. #, Brüstle, O. # (2012)
Small molecules enable highly efficient neuronal conversion of human fibroblasts
Nature Methods 9(6):575-578

Thier, M., Wörsdörfer, P., Lakes, Y. B., Gorris, R., Herms, S., Opitz, T., Seiferling, D., Quandel, T., Hoffmann, P., Nöthen, M.M., Brüstle, O., Edenhofer, F. (2012)
Direct conversion of fibroblasts into stably expandable neural stem cells
Cell Stem Cell 10(4):473-479

Koch, P.*, Tamboli, I.Y.*, Mertens, J.*, Wunderlich, P., Ladewig, J., Stüber, K., Esselmann, H., Wiltfang, J., Brüstle, O.‡, Walter, J.‡ (2012)
Presenilin-1 L166P mutant human pluripotent stem cell-derived neurons exhibit partial loss of γ-secretase activity in endogenous amyloid-β generation
Am J Pathol 180(6):2404-2416

Ahmad, A., Wolber, W., Eckardt, S., Koch, P., Schmitt, J., Semechkin, R., Geis, C., Heckmann, M., Brüstle, O., McLaughlin, J.K., Sirén, A.-L., Müller, A. (2012)
Functional neuronal cells generated by human parthenogenetic stem cells.
PLoS ONE 7(8):e42800

Haupt, S., Grützner, J. Thier, M.C., Kallweit, T., Rath, B.H., Laufenberg, I., Forgber, M., Eberhardt, J., Edenhofer, F., Brüstle, O. (2012)
Automated selection and harvesting of pluripotent stem cell colonies
Biotechnol Appl Biochem 59(2):77-87

Nettersheim, D., Westernströer, B., Haas, N., Leinhaas, A., Brüstle, O., Schlatt, S., Schorle, H. (2012)
Establishment of a versatile seminoma model indicates cellular plasticity of germ cell tumor cells
Genes Chrom Cancer 51(7):717-726

Lindvall, O., Barker, R.A., Brüstle, O., Isacson, O., Svendsen, C. (2012)
Clinical translation of stem cells in neurodegenerative disorders
Cell Stem Cell 10:151-155

Falk, A.*, Koch, P.*, Kesavan, J., Takashima, Y., Ladewig, J., Alexander, M., Wiskow, O., Tailor, J., Pollard, S., Smith, A., Brüstle, O. (2012)
Capture of neuroepithelial-like stem cells from pluripotent stem cells provides a versatile system for in vitro production of human neurons
PLoS ONE 7(1):e29597

Hucke, S., Floßdorf, J., Grützke, B., Dunay, I.R., Frenzel, K., Jungverdorben, J., Linnartz, B., Mack, M., Peitz, M., Brüstle, O., Kurts, C., Klockgether, T., Neumann, H., Prinz, M., Knolle, P., Klotz, L. (2012)
Licensing of myeloid cells promotes central nervous system autoimmunity and is controlled by PPARγ
Brain 135(Pt 5):1586-1605

Oki, K.*, Tatarishvili, J.*, Woods, J.*, Koch, P.*, Wattananit, S., Mine, Y., Monni, E., Prietro, D.T., Ahlenius, H., Ladewig, J., Brüstle, O., Lindvall, O., Kokaia, Z. (2012)
Human induced pluripotent stem cells form functional neurons and improve recovery after grafting in stroke-damaged brain
Stem Cells 30(6):1120-1133

Haupt, S., Borghese, L., Brüstle, O., Edenhofer, F. (2012)
Non-genetic modulation of notch activity by artificial delivery of Notch intracellular domain into neural stem cells
Stem Cells Rev Rep 8(3):672-684

Koch, P., Müller, F.-J., Brüstle, O. (2012)
Differentiation of human pluripotent stem cells into neural precursors
In: Human stem cell manual - A laboratory guide (eds.: Loring, J.F & Peterson, S.E.), 2nd edition, Elsevier Press, pp. 375-384

Steinbeck, J.A., Koch, P., Derouiche, A., Brüstle, O. (2012)
Human embryonic stem cell-derived neurons establish region-specific, long-range projections in the adult brain
Cell Mol Life Sci 69(3):461-470

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Koch, P.*, Breuer, P*., Peitz, M.*, Jungverdorben, J.*, Kesavan, J., Poppe, D., Doerr, J., Ladewig, J., Mertens, J., Tüting, T., Hoffmann, P., Klockgether, T., Evert, B.O., Wüllner, U., Brüstle, O. (2011)
Excitation-induced ataxin-3 aggregation in neurons from patients with Machado-Joseph disease
Nature 480:543-546

Iliou, M.S., Lujambio, A., Portela, A., Brüstle, O., Koch, P., Andersson-Vincent, P.H., Sundström, E., Hovatta, O., Esteller, M. (2011)
Bivalent histone modifications in stem cells poise miRNA loci for CpG island hypermethylation in human cancer
Epigenetics 6(11):1344-1353

Siemen, H., Colas, D., Heller, H.C., Brüstle, O., Reijo-Pera, R.A. (2011)
Pumilio-2 function in the mouse nervous system
PLoS One 6(10):e25932

Higashi, H., Brüstle, O., Daley, G.Q., Yamanaka, S. (2011)
The nomenclature system should be sustainable, but also practical
Cell Stem Cell 8:606-607 [Letter]

Hussein, S.M.I., Batada, N., Vuoristo, S., Ching, R.W., Autio, R., Närvä, E., Ng, S., Sourour, M., Hämäläinen, R., Olsson, C., Lundin, K., Mikkola, M., Trokovic, R., Peitz, M., Brüstle, O., Bazett-Jones, D.P., Alitalo, K., Lahesmaa, R., Nagy, A., Otonkoski, T. (2011)
Copy number variation and selection during reprogramming to pluripotency
Nature 471:58-62

Kuckenberg, P., Peitz, M., Kubaczka, C., Becker, A., Egert, A., Wardelmann, E., Zimmer, A., Brüstle, O., Schorle, H. (2011)
Lineage conversion of murine extraembryonic trophoblast stem cells to pluripotent stem cells
Mol Cell Biol 31:1748-56

Milde, T., Kleber, s., Korshunov, A., Witt, H., Hielscher, T., Koch, P., Kopp, H.-G., Jugold, M., Deubzer, H.E., Oehme, I., Lodrini, M., Gröne, H.-J., Benner, A., Brüstle, O., Gilbertson, R.J., von Deimling, A., Kulozik, A.E., Pfister, S.M., Martin-Villalba, A., Witt, T. (2011)
A novel human high-risk ependymoma stem cell model reveals the differentiation-inducing potential of the histone deacetylase inhibitor Vorinostat
Acta Neuropathol 122(5):637-650

Ming, G.L., Brüstle, O., Muotri, A., Studer, L., Wernig, M., Christian, K.M. (2011)
Cellular reprogramming: Recent advances in modeling neurological diseases
J. Neurosci. 31(45):16070-16075

Roßbach, M., Hadenfeld, M., Brüstle, O. (2011)
Industrial applications of stem cells
In: Translational stem cell research, stem cell biology and regenerative medicine (eds.: Hug, K., Hermerén, G.; series editor: Turksen, K.), Springer pp. 91-101

Steinbeck, J.A., Henke, N., Opatz, J., Gruszczyńska-Biegała, J., Schneider, L., Theis, S., Hamacher, N., Steinfarz, B., Golz, S., Brüstle, O., Kużnicki, J., Methner, A. (2011) Store-operated calcium entry modulates neuronal network activity in a model of chronic epilepsy
Exp Neurology 232(2):185-194

Terstegge, S., Edenhofer, F., Brüstle, O. (2011)
Stammzellen – Bedeutung für die Klinische Medizin
In: Humangenetik (eds.: Murken, J., Grimm, T., Holinski-Feder, E., Zerres, K.), 8. Auflage, Georg Thieme Verlag Stuttgart, New York, pp. 567-573

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Borghese, L., Dolezalova, D., Opitz, T., Haupt, S., Leinhaas, A., Steinfarz, B., Koch, P., Edenhofer, F., Hampl, A., Brüstle, O. (2010)
Inhibition of Notch signaling in human embryonic stem cell–derived neural stem cells delays G1/s phase transition and accelerates neuronal differentiation in vitro and in vivo
Stem Cells 28(5):955-964

Glas, M., Rath, BH, Simon, M., Reinartz, R., Schramme, A., Trageser, D., Eisenreich, R., Leinhaas, A., Keller, M., Schildhaus, HU, Garbe, S., Steinfarz, B., Pietsch, T., Steindler, DA, Schramm, J., Herrlinger, U., Brüstle, O., Scheffler, B. (2010)
Residual tumor cells are unique cellular targets in glioblastoma
Ann Neurol 68(2):264-269

Patsch, C., Peitz, M., Otte, D.M., Kesseler, D., Jungverdorben, J., Wunderlich, T., Brüstle, O., Zimmer, A., Edenhofer, F. (2010)
Engineering cell-permeant FLP recombinase for tightly controlled inducible and reversible overexpression in embryonic stem cells
Stem Cells 28(5):894-902

Pusch, A., Boeckenhoff, A., Glaser, T., Kaminski, T., Kirfel, G., Hans, M., Steinfarz, B., Swandulla, D., Kubitscheck, U., Gieselmann, V., Brüstle, O., Kappler, J. (2010)
CD44 and hyaluronan promote invasive growth of B35 neuroblastoma cells into the brain.
Biochim Biophys Acta 1803(2):261-274

Rossbach, M. (2010)
Small Non-Coding RNAs as Novel Therapeutics (CMM 10-4 / Pp. 361-368)

Terstegge, S., Winter, F., Rath, B.H., Laufenberg, I., Schwarz, C., Leinhaas, A., Levod, F., Dolf, A., Haupt, S., Endl, E., Brüstle, O. (2010)
Laser-assisted photoablation of human pluripotent stem cells from differentiating cultures
Stem Cell Rev Rep 6 (2):260-269

Stock, K., Nolden, L., Edenhofer, F., Quandel, T., Brüstle, O. (2010)
Modulation of neural stem cell differentiation with a recombinant cell-permeant transcription factor
Cell Mol Life Sci (2010) 67:2439-2449

Närvä, E., Autio, R., Rahkonen, N., Kong, L., Harrison, N., Kitsberg, D., Borghese, B., Itskovitz-Eldor, J., Rasool, O., Dvorak, P., Hovatta, O., Otonkoski, T., Tuuri, T., Cui, W., , Brüstle, O., Baker, D., Maltby, E., Moore, H.D., Benvenisty. N., Andrews, P.W., Yli-Harja, O., Lahesmaa, R. (2010)
High resolution DNA analysis reveals loss of heterozygosity and copynumber variation changes associated with culture and affecting gene expression in human embryonic stem cell lines
Nat Biotechnol 28(4):371-377

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Andrews, P.W., Arias-Diaz, J., Auerbach, J., lvarez, M., Ahrlund-Richter, L., Baker, D., Benvenisty, N., Ben-Josef, D., Blin, G., Borghese, L., Borstlap, J., Bruce, K., Brüstle, O., Buckle, R., Carter, P., Camby, C., Choo, A., Chen, W., Collins, D., Colman, A., Crombie, C., Crook, J., Cypess, R., De Sousa, P., Dhawan, J., Douay, L., Dvorak, P., Dyke, T., Eriksson, L., Firpo, M., Fitzgerald, C., Glover, C., Gokhale, P., Greene, M., Ha, H.-Y., Hampl, A., Healy, L., Hei, D., Holm, F., Hovatta, O., Hunt, C., Hwang, S.-M., Inamdar, M., Isasi, R., Iskovitz-Eldor, J., Jessie, N., Kim, D.-W., Kirzner, R., Kitpongsang, S., Knowles, B., Kuo, H.-C., Laughlin, M., Lavon, N., Ludwig, T., Lakov, M., Lee, D.-R., Macauley, J., McKay, R., Menasche, P., Menendez, P., Michalska, A., Mileikovskaia, M., Minger, S., Mishra, G., Moody, J., Montgomery, K., Morris, C., Mummery, C., Nagy, A., Nakamura, Y., Nakatsuji, N., Nishikawa, S.-I., Nierras, C., Oh, S., Oh, S.K., Olson, P., Otonkoski, T., Patole, M., Park, H.S., Pei, X., Pera, M., Puceat, M. Rajala, K., Reubinoff, B., Robbins, A., Rooke, H., Rumayor, V., Scotmann, H., Sherlock, J., Simon, C., Stacey, G., Sipp, D., Skinner, R., Smith, D., Stefanovic, S., Strehl, R., Taft, R., Takahashi, T., Talib, S., Terstegge, S., Turner, R., Tuuri, T., Yu, J., Zandstra, P., Zapata, A., Zeng, F., Zhou, Q. (2009)
Consensus guidance for banking and supply of human embryonic stem cell lines for research purposes. International Cell Banking Initiative.
Stem Cell Rev and Rep 5:301-314

Corsini, N.S., Sancho-Martinez, I., Laudenklos, S., Glagow, D., Kumar, S., Letellier, E., Koch, P., Teodorczyk, M., Kleber, S., Klussmann, S., Wiestler. B., Brüstle, O., Müller, W., Gieffers, C., Hill, O., Thiemann, M., Seedorf, M., Gretz, N., Sprengel, R., Celikel, T., Martin-Villalba, A. (2009)
The death receptor CD95 activates adult neural stem cells for working memory formation and brain repair
Cell Stem Cell 5(2):178-90

Haupt, S., Grützner, J., Rath, B.H., Möhlig, H., Brüstle, O. (2009)
Automated selection and collection of pluripotent stem cell colonies using the CellCelector™
Nature Methods 6, doi:10.1038/nmeth.f.252 [Non peer-reviewed application note]

Ko, K., Tapia, N., Wu, G., Kim, J.B., Arauzo Bravo, M.J., Sasse, P., Glaser, T., Ruau, D., Wook Han, D., Greber, B., Hausdörfer, K., Sebastiano, V., Stehling, M., Fleischmann, B.K., Brüstle, O., Zenke, M., Schöler, H.R. (2009)
Induction of pluripotency in adult unipotent germline stem cells
Cell Stem Cell 5(1):87-96.

Koch, P., Kokaia, Z., Lindvall, O., Brüstle, O. (2009)
Emerging concepts in neural stem cell research: autologous repair and cell-based disease modelling
Lancet Neurol 8(9):819-829

Koch, P., Opitz, T., Steinbeck, J., Ladewig, J., Brüstle, O. (2009)
A rosette-type, self-renewing human ES cell-derived neural stem cell with potential for in vitro instruction and synaptic integration
Proc Natl Acad Sci USA 106(9):3225-30

Roßbach, M. (2009)
Creative Innovation – Insights from neurobiology and economics and their implications for social decision-making
In: Rationalität der Kreativität? Multidisziplinäre Beiträge zur Analyse der Produktion, Organisation und Bildung von Kreativität (eds.: Jansen, S. A., Schröter, E., Stehr, N.), Wiesbaden, VS Verlag für Sozialwissenschaften, pp. 13-29

Papadimou, E., Moiana, A., Goffredo, D., Koch, P., Bertuzzi, S., Brüstle, O., Cattaneo, E., Conti, L. (2009)
p66ShcA adaptor molecule accelerates ES cell neural induction
Mol Cell Neurosci 41(1):74-84

Terstegge, S., Rath, B.H., Laufenberg, I., Limbach, N., Buchstaller, A., Schütze, K., Brüstle, O. (2009)
Laser-assisted selection and passaging of human pluripotent stem cell colonies
J Biotechnol 143(3):224-230

Terstegge, S., Brüstle, O. (2009)
Automated method for embryonic stem cell culture
In: Emerging technology platforms for stem cells (eds.: Lakshmipathy, U., Chesnut, J.D., Thyagarajan, B.), Wiley, New Jersey, pp. 275-281

Edenhofer, F., Terstegge, S., Brüstle, O. (2009)
Stem cell technology in technology guide (ed.: Bullinger, H.-J.), 1st edition, Springer 166-169

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Calvanese, V., Horrillo, A., Hmadcha, A., Suarez-Alvarez, B., Fernandez, A.F., Lara, E., Casado, S., Menendez, P., Bueno, C., Garcia-Castro, J., Rubio, R., Lapunzina, P., Alaminos, M., Borghese, L., Terstegge, S., Harrison, N.J., Moore, H.D., Brüstle, O., Lopez-Larrea, C., Andrews, P.W., Soria, B., Esteller, M., Fraga, M.F. (2008)
Cancer genes hypermethylated in human embryonic stem cells
PLoS ONE 3(9):e3294

Firkowska, I., Giannona, S., Rojas-Chapana, J.A., Luecke, K., Brüstle, O., Giersig, M. (2008)
Biocompatible nanomaterials and nanodevices promising for biomedical applications
In: Nanomaterials for Application in Medicine and Biology (eds.: Giersig, M. & Khomutov, G.B.),
NATO Science and Security Series – B: Physics and Biophysics, Spinger, Dordrecht, The Netherlands, pp.1-15

Geisthövel, F., Brüstle, O., Beier, H.M., Frommel, M., Schockenhoff, E., Taupitz, J. (2008)
The interaction between the German Embryo Protection Act and the Stem Cell Act – an interdisciplinary panel discussion held on November 30, 2007, on the occasion of the 2nd DVR Congress in Bonn/Bad Godesberg
J Reproduktionsmed Endokrinol 5:114-120

Glaser, T., Opitz, T., Kischlat, T., Konang, R., Sasse, P., Fleischmann, B.F., Engel, W., Nayernia, K., Brüstle, O. (2008)
Adult germline stem cells as a source of functional neurons and glia
Stem Cells 26:2434-2443

Glaser, T., Schmandt, T., Brüstle, O. (2008)
Generation and potential biomedical applications of embryonic stem cell-derived glial precursors
J Neurol Sci 265(1-2):47-58

Husseini, L., Schmandt, T., Scheffler, B., Schröder, W., Seifert, G., Brüstle, O., Steinhäuser, C. (2008)
Functional analysis of ES cell-derived glial cells after integration into hippocampal slice cultures
Stem Cells Dev. 17(6):1141-1152

Kuhn, G., Brüstle, O., Martens, U., Wobus, A., Unsicker, K. (2008)
Stem cells: established facts, open issues, and future directions
Cell Tiss Res 331(1):1-3

Ladewig, J.*, Koch, P.*, Endl, E., Meiners, B., Opitz, T., Couillard-Despres, S., Aigner, L., Brüstle, O. (2008)
Lineage selection of functional and cryopreservable human embryonic stem cell-derived neurons
Stem Cells 26(7):1705-1712

Siemen, H., Nolden, L., Terstegge, S., Koch, P., Brüstle, O. (2008)
Nucleofection of human embryonic stem cells
In: Methods in molecular medicine – Electroporation protocols: Experimental and clinical medicine (Ed.: Li, S.), Humana Press,Totowa, New Jersey, pp131-138

Nolden, L., Brüstle, O. (2008)
Human embryonic stem cells: Perspectives for the study and therapy of neurological disorders
Bundesgesundheitsblatt 51(9):1026-1032

Prozorovski, T., Schulze-Topphoff, U., Glumm, R., Baumgart, J., Schröter, F., Ninnemann, O., Siegert, E., Bendix, I., Brüstle, O., Nitsch, R., Zipp, F., Aktas, O. (2008)
Sirt1 contributes critically to the redox-dependent fate of neuralprogenitors
Nature Cell Biol 10(4):385-394

Schormann, W., Hammersen, F.J., Brulport, M., Hermes, M., Bauer, A., Rudolph, C., Schug, M., Lehmann, T., Nussler, A., Ungefroren, H., Hutchinson, J., Fändrich, F., Petersen, J., Wursthorn, K., Burda, M.R., Brüstle, O., Krishnamurthi, K., von Mach, M., Hengstler, J.G. (2008)
Tracking of human cells in mice
Histochem Cell Biol 130(2):329-338

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Glaser, T., Brose, C., Franceschini, I., Hamann, K., Smorodchenko, A., Zipp,F., Dubois-Dalcq, M., Brüstle, O. (2007)
NCAM polysialylation enhances the sensitivity of ES cell-derived neural precursors to migration guidance cues
Stem Cells 25(12):3016-3025

Glaser, T., Pollard, S.M., Smith, A., Brüstle, O. (2007)
Tripotential differentiation of adherently expandable neural stem (NS) cells
PLoS ONE 2:e298

Gossrau, G., Thiele, J., Konang, R., Schmandt, T., Brüstle, O. (2007)
BMP-mediated modulation of lineage diversification during neural differentiation of embryonic stem cells
Stem Cells 25:939-949

Haupt, S., Edenhofer, F., Peitz, M., Leinhaas, A., Brüstle, O. (2007)
Stage specific conditional mutagenesis in embryonic stem cell-derived neural cells and post-mitotic neurons by direct delivery of biologically active Cre recombinase
Stem Cells 25:181-188

Li, T., Steinbeck, J.A., Lusardi, T., Fedele, D.E., Koch, P., Lan, J.Q., Wilz, A., Segschneider, M., Simpson, E.M., Simon, R.P., Brüstle, O., Boison, D. (2007)
Suppression of kindling epileptogenesis by adenosine releasing stem cell-derived brain implants
Brain 130:1276-88

Nolden, L., Edenhofer, F., Peitz, M., Brüstle, O. (2007)
Stem cell engineering using transducible Cre recombinase
Methods in Molecular Medicine 140:17-32

Opitz, T., Scheffler, B., Steinfarz, B., Schmandt, T., Brüstle, O. (2007)
Electrophysiological evaluation of engrafted stem cell-derived neurons
Nat. Protoc. 2:1603-1613

Terstegge, S., Laufenberg, I., Pochert, J., Schenk, S., Itskovitz-Eldor, J., Endl, E., Brüstle, O. (2007)
Automated maintenance of embryonic stem cell cultures
Biotech. Bioengineer 96:195-201

Testa, G., Borghese, L., Steinbeck, J.A., Brüstle, O. (2007)
Breakdown of the potentiality principle and its impact on global stem cell research
Cell Stem Cell 1:153-156

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Benzing, C., Segschneider, M., Leinhaas, A., Itskovitz-Eldor, J., Brüstle, O. (2006)
Neural conversion of human embryonic stem cell colonies in the presence of fibroblast growth factor-2
Neuroreport 17:1675-1681

Götz, A.K., Scheffler, B., Chen, H.-X., Wang, S., Suslov, O., Xiang, H., Brüstle, O., Roper, S.N., Steindler, D.A.(2006)
Temporally restricted substrate interactions direct fate and specification of neural precursors derived from embryonic stem cells
Proc. Natl. Acad. Sci. USA 103:11063-11068

Klein, D., Schmandt, T., Muth-Köhne, E., Perez-Bouza, A., Segschneider, M., Gieselmann, V., Brüstle, O. (2006)
Embryonic stem cell-based reduction of CNS sulfatide storage in an animal model of metachromatic leukodystrophy
Gene Therapy 13:1686-1696

Koch, P., Siemen, H., Biegler, A., Itskovitz-Eldor, J., Brüstle, O. (2006)
Transduction of human embryonic stem cells by ecotropic retroviral vectors
Nucleic Acids Research 34(18):e120

Piepoli, T., Jakupoglu, C., Gu, W., Lualdi, E., Suarez-Merino, B., Poliani, P.L., Cattaneo, M.G., Ortino, B., Goplen, D., Wang, J., Mola, R., Inverardi, F., Frassoni, C., Bjerkvig, R., Steinlein, O., Vicentini, L.M., Brüstle, O., Finocchiaro, G. (2006)
Expression studies in gliomas and glial cells do not support a tumor suppressor role for LGI1
Neuro-Oncology 8:96-108

Scheffler, B., Edenhofer, F., Brüstle, O. (2006)
Merging fields: Stem cells in neurogenesis, transplantation and disease modeling
Brain Pathol. 16:155-168

Scheffler, B., Brüstle, O. (2006)
Symposium: Stem Cells in the Central Nervous System
Brain Pathol. 16:131

Schmandt, T., Gossrau, G., Kischlat, T., Opitz, T., Brüstle, O. (2006)
Animal models of cell and gene therapy in myelin disease
Drug Discovery Today 3:349-358

Schmandt, T., Glaser, T., Brüstle, O. (2006)
Lineage selection and transplantation of ES cell-derived neural precursors
In: Embryonic stem cells – a practical approach (Eds.: Notarianni, E. and Evans, M.)
Oxford University Press, Oxford, pp 189-217

Terstegge, S., Brüstle, O. (2006)
Stammzellen – Bedeutung für die Klinische Medizin
In: Humangenetik (Eds.: Murken, J., Grimm, T., Holinski-Feder, E.)
7. Auflage; Georg Thieme Verlag Stuttgart, New York, pp 558-564

Terstegge, S., Fuhr, G.R., Brüstle, O. (2006)
In: Technologieführer. Grundlagen, Anwendungen, Trends (Ed.: Bullinger, H.J.)
Springer Verlag Berlin, pp 186-191

Wiese, C., Rolletschek, A., Kania, G., Navarrete-Santos, A., Anisimov, S.V., Steinfarz, B., Tarasov, K.V., Brugh, S.A., Zahanich, I., Rüschenschmidt, C., Beck, H., Blyszczuk, P., Czyz, J., Heubach, J.F., Ravens, U., Horstmann, O., St-Onge, L., Braun, T., Brüstle, O., Boheler, K.R., Wobus, A.M. (2006)
Signals from embryonic fibroblasts induce adult intestinal epithelial cells to form nestin-positive cells with proliferation and multilineage differentiation capacity in vitro
Stem Cells 24:2085-2097

Nolden, L., Edenhofer, F., Haupt, S., Wunderlich, T.F., Siemen, H., Brüstle, O. (2006)
Site-specific recombination in human embryonic stem cells induced by cell-permeant Cre recombinase
Nature Methods 3:461-467

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Coenen, M., Kögler, G., Wernet, P., Brüstle, O. (2005)
Transplantation of human umbilical cord blood-derived adherent progenitors into the developing rodent brain
J. Neuropathol. Exp. Neurol. 64:681-688

Glaser, T., Brüstle, O. (2005)
Retinoic acid induction of ES cell-derived neurons: The radial glia connection
Trends Neurosci. 28:397-400. Review

Güttinger, M., Fedele, D., Koch, P., Padrun, V., Pralong, W.F., Brüstle, O., Boison, D. (2005)
Suppression of kindled seizures by paracrine adenosine release from stem cell-derived brain implants
Epilepsia 46:1162-1169

Perez-Bouza, P., Glaser, T., Brüstle, O. (2005)
ES cell-derived glial precursors contribute to remyelination in acutely demyelinated spinal cord lesions
Brain Pathol. 15:208-216

Rüschenschmidt, C., Koch, P.G., Brüstle, O., Beck, H. (2005)
Functional properties of ES cell-derived neurons engrafted into the hippocampus of adult normal and chronically epileptic rats
Epilepsia 46 Suppl 5:174-183

Schmandt, T., Meents, E., Gossrau, G., Gornik, V., Okabe, S., Brüstle, O. (2005)
High-purity lineage selection of embryonic stem cell-derived neurons
Stem Cells Dev. 14:55-64

Siemen, H., Nix, M., Endl, E., Koch, P., Itskovitz-Eldor, J., Brüstle, O. (2005)
Nucleofection of human embryonic stem cells
Stem Cells Dev. 14:378-383

Wernig, G., Janzen, V., Schäfer, R., Zweyer, M., Knauf, U., Hoegemeier, O.,Mundegar, R.R., Garbe, S., Stier, S., Franz, T., Wernig, M., Wernig, A. (2005)
The vast majority of bone-marrow-derived cells integrated into mdx muscle fibers are silent despite long-term engraftment
Proc. Natl. Acad. Sci. U S A. 102:11852-11857

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Brüstle, O., Koch, P., Möhler, H., Boison, D. (2004)
Therapeutic delivery of adenosine into a tissue
U.S. 10/858,929

Fedele, D.E., Koch, P., Scheurer, L., Simpson, E.M., Möhler, H., Brüstle, O.,
Boison, D. (2004)
Engineering embryonic stem cell-derived glia for adenosine delivery
Neurosc. Lett. 370:160-165

Glaser, T., Perez-Bouza, A., Klein, K., Brüstle, O. (2004)
Generation of purified oligodendrocyte progenitors from embryonic stem cells
FASEB J. Express article 10.1096/fj.04-1931fje.
Print version: FASEB J. 19:112-114, 2005

Murakami, M., Ichisaka, T., Maeda, M., Oshiro, N., Hara, K., Edenhofer, F., Kiyama, H., Yonezawa, K., Yamanaka, S. (2004)
mTOR is essential for growth and proliferation in early mouse embryos and embryonic stem cells
Mol. Cell. Biol. 24:6710-6718

Terstegge, S., Pochert, J., Brüstle, O. (2004)
Hamilton’s new CellHost system for full automation of embryonic stem cell cultures
Nature Methods 1:271-272 [Application Note]

Terstegge, S., Brüstle, O. (2004)
Skalierbarer Prozess zur Kultivierung undifferenzierter Stammzellen in Suspension
DE 102 004 043 256.2

Wernig, M., Benninger F., Schmandt, T., Rade, M., Tucker, K.L., Büssow, H., Beck, H., Brüstle O. (2004)
Functional integration of embryonic stem cell-derived neurons in vivo
J. Neurosci. 24:5258-5268

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Benninger, F., Beck, H., Wernig, M., Tucker, K.L., Brüstle, O., Scheffler, B. (2003)
Functional integration of embryonic stem cell-derived neurons in hippocampal slice cultures
J. Neurosci. 23:7075-7083

Peitz, M., Rajewsky, K., Brüstle, O., Edenhofer, F. (2003)
Direct delivery of biologically active proteins into cells: protein transduction as a tool for genomic manipulations in mammalian cells
Eur. J. Cell. Biol. 82 Suppl.53:36

Scheffler, B., Schmandt, T., Schröder, W., Steinfarz, B., Husseini, L., Wellmer, J., Seifert, G., Karram, K., Beck, H., Blümcke, I., Wiestler, O.D., Steinhäuser, C., Brüstle, O. (2003)
Functional network integration of embryonic stem cell-derived astrocytes in hippocampal slice cultures
Development 130:5533-5541

Steffel, J., Wernig, M., Knauf, U., Kumar, S., Wiestler, O.D., Wernig, A., Brüstle, O. (2003)
Migration and differentiation of myogenic precursors following transplantation into the developing rat brain
Stem Cells 21:181-189

Wernig, M., Scheffler, B., Brüstle, O. (2003)
Medizinische Perspektiven der Stammzellforschung
Grundlagen der Molekularen Medizin, Ganten D, Ruckpaul K (eds.)
Springer-Verlag, Berlin, Heidelberg, New York 680-710

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Wernig, M., Tucker, K.L., Gornik, V., Schneiders, A., Buschwald, R., Wiestler, O.D., Barde, Y.A., Brüstle, O. (2002)
Tau EGFP embryonic stem cells: an efficient tool for neuronal lineage selection and transplantation
J. Neurosci. Res. 69:918-924

Wernig, M., Brüstle, O. (2002)
Fifty ways to make a neuron: shifts in stem cell hierarchy and their implications for neuropathology and CNS repair
J. Neuropathol. Exp. Neurol. 61:101-10. Review

Wiestler, O.D., Brüstle O. (2002)
Forschung an embryonalen Stammzellen: Was versprechen sich die klinischen Neurowissenschaften davon?
Stammzellforschung und therapeutisches Klonen, Oduncu F.S, Schroth U, Vossenkuhl W (eds), Vandenhoeck & Ruprecht, Göttingen 68-77

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Brüstle, O. (2001)
Embryonale Stammzellen - neue Perspektiven für die Tranplantationsmedizin.
Humane Stammzellen. Perspektiven und Grenzen in der regenerativen Medizin, Bundesministerium für Bildung und Forschung (eds.),
Schattenhauer Verlagsgesellschaft mbH, Stuttgart 107-118

Brüstle, O., Dubois-Dalq, M. (2001)
CNS stem cells and their gliogenic potential
Glial Cell Development
Basic Principles and Clinical Relevance, Jessen K.R., Richardson W.D. (eds)
Oxford University Press 415-636

Zhang, S.C.‡, Wernig, M., Duncan, I.D., Brüstle, O.‡, Thomson, J.A. (2001)
In vitro differentiation of transplantable neural precursors from human embryonic stem cells
Nat. Biotechnol. 19:1129-1133

Blümcke, I., Schewe, J.C., Normann, S., Brüstle, O., Schramm, J., Elger, C.E., Wiestler, O.D. (2001)
Increase of nestin-immunoreactive neural precursor cells in the dentate gyrus of pediatric patients with early-onset temporal lobe epilepsy
Hippocampus 11:311-321
Erratum in: Hippocampus 11:478

Maskos, U., Brüstle, O., McKay, R.D. (2001)
Long-term survival, migration, and differentiation of neural cells without functional NMDA receptors in vivo
Dev. Biol. 231:103-112

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Brüstle, O. (1999)
Building brains: neural chimeras in the study of nervous system development and repair
Brain Pathol. 9:527-545. Review

Brüstle, O., Jones, K.N., Learish, R.D., Karram, K., Choudhary, K., Wiestler, O.D., Duncan, I.D., McKay, R.D. (1999)
Embryonic stem cell-derived glial precursors: a source of myelinating transplants
Science 285:754-756

Learish, R.D., Brüstle, O., Zhang, S.C., Duncan, I.D. (1999)
Intraventricular transplantation of oligodendrocyte progenitors into a fetal myelin mutant results in widespread formation of myelin
Ann. Neurol. 46:716-722

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Brüstle, O., Choudhary, K., Karram, K., Hüttner, A., Murray, K., Dubois-Dalcq, M., McKay, R.D. (1998)
Chimeric brains generated by intraventricular transplantation of fetal human brain cells into embryonic rats
Nat. Biotechnol. 16:1040-1044

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Brüstle, O., Spiro, A.C., Karram, K., Choudhary, K., Okabe, S., McKay, R.D. (1997)
In vitro-generated neural precursors participate in mammalian brain development
Proc. Natl. Acad. Sci. U S A. 94:14809-14814

Brüstle, O., Cunningham, M., Tabar, V., Studer, L.T.E (1997)
Experimental transplantation in the embryonic, neonatal, and adult mammalian brain
In: Current Protocols in Neuroscience, Crawley, J., Gerfen, C., McKay, R.D.G, Rogowski, M., Sibley, D., Skolnick, P. (eds.)
John Wiley & Sons, Inc., New York 3.10.1-3.10.28

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Brüstle, O. McKay, R.D. (1996)
Neuronal progenitors as tools for cell replacement in the nervous system
Curr. Opin. Neurobiol. 6:688-695. Review

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Brüstle, O., Maskos, U., McKay, R.D. (1995)
Host-guided migration allows targeted introduction of neurons into the embryonic brain
Neuron 15:1275-1285

Brüstle, O. McKay, R.D. (1995)
The neuroepithelial stem cell concept: implications for neuro-oncology
J. Neurooncol. 24:57-59. Review

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Institute of Reconstructive Neurobiology

University of Bonn
Venusberg-Campus 1
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