Navigating the rapidly evolving universe of cell fate conversion and neural cell programming
The advent of cell reprogramming and iPS cell technology has triggered numerous efforts to exploit controlled expression of transcription factors for programming diverse neural subtypes from either pluripotent or somatic stem cells. This field is evolving with enormous pace, making it challenging to follow all the individual developments.
IRN scientists are now providing two comprehensive reviews with in-a-nutshell coverage of key somatic cell fate conversion and forward programming studies relating to the nervous system.
Flitsch, L.J. and Brüstle, O. (2019)
Evolving principles underlying neural lineage conversion and their relevance for biomedical translation
F1000Research 2019. doi: 10.12688/f1000research.18926.1
Flitsch, L.J., Laupman, K.E., Brüstle, O. (2020)
Transcription factor-based fate specification and forward programming for neural regeneration
Front Cell Neurosci.doi.org/10.3389/fncel.2020.00121