Teaching » Institute of Reconstructive Neurobiology



Internships for students in the fields of medicine, biology, biochemistry and related disciplines are offered upon request. Please contact our office for further information.

Modules organized by the Reconstructive Neurobiology Group:

Practical Course ‘From Bench to Bedside’ for the Study Program ‘Molecular Biomedicine’

General information
• 1 week (16.-20.11.2020), 10:00 to 17:00 h
• Course rooms at the Institute of Reconstructive Neurobiology, Life & Brain Building, 4th floor

This four week practical course (elective module A) for the Study Program Molecular Biomedicine is conducted in cooperation with the LIMES Institute, the Laboratory of Molecular Developmental Biology, the Institute of Pathology and the Institute of Human Genetics.
The fourth week, carried out at IRN, is focused on ‘Programming Stem Cells for Neurological Disease Modeling and Therapy Development’. It provides information on the development of the central nervous system, insight into targeted differentiation of stem cells into neural subtypes and know-how on the generation of 3D cortical-like organoids. Particular focus is put on methods of reprogramming into iPS cells, direct conversion into neural cells and the use of these in vitro generated cells for disease modeling.

Practical Course ‘Developmental Neurobiology, Stem Cells and Disease’ for the Study Program ‘Master of Neuroscience’

General information
• 2 weeks (06.-17.9.2021), 10:00 to 17:00 h
• Course rooms at the Institute of Reconstructive Neurobiology, Life & Brain Building, 4th floor

Together with the lecture series Developmental Neurobiology, Stem Cells and Disease, this course is part of the elective module WPM 7 of the study program Master of Neuroscience.
During this practical course students gain insights into the development of the central nervous system, learn about reprogramming strategies and obtain knowledge in the biomedical applications of iPS cells in disease modeling. Besides the use of differentiation protocols and cell culture techniques for PSCs and PSC-derived neural cells, students acquire experience in surface marker-based flow cytometry for quality control of pluripotent cells. They design gRNAs for CRISPR/Cas9 and use assays to evaluate genome editing efficiency. Furthermore, students prepare embryonic tissue for 3D imaging analysis, perform immunohistochemistry on adult mouse brain sections and analyze the specimens using advanced microscope techniques. In addition, students work on 3D cortical-like organoids and get to know the principles of image-based analyses of cellular (patho-)phenotypes. With a focus on industrial applications of iPS cells, students perform automated detection, harvesting and deposition of hiPSC clones using the CellCelectorTM. (This description is only an extract from the contents of the practical course).

Practical Course ‘Neural Stem Cells’ for the Study Program ‘Master of Neuroscience’ (WPP 3)

General information
• 8 weeks (11.1.-5.3.2021), 09:00 to 17:00
• Project-based lab work at the Institute of Reconstructive Neurobiology, Life & Brain Building,
4th floor

In this 8-week internship, students work on a small research project. Supervised by an experienced postdoc, students gain knowledge on neural stem cell biology, acquire hands-on experience in controlled differentiation and characterization of stem cells and learn about reprogramming strategies as well as the therapeutic use of pluripotent stem cell-derived neural cells for central nervous system diseases.
Depending on the available project, the main focus lies on:
• Neurodevelopmental genetics
• Cell programming
• Neural fate determination
• Direct conversion into neurons and glia
• Stem cell-based disease modeling
• Genetic modification of stem cells
• Generation of 3D organoids
• Image-based phenotype analysis
• Industrial applications of stem cells

Workshop-Module M 20: ‘Stem Cell Biology: Cultivation, Manipulation and Differentiation of Stem Cells’ for the ‘Bonn International Graduate School of Neuroscience’.

Lecture series organized by the Reconstructive Neurobiology Group:

Lectue Series Stem Cell Biology

(accepted for Molecular Biomedicine, Wahlfach I Medizin)

Coordination: Prof. O. Brüstle
SS 21, Mon 17.30-18.00; Room EG.612 LIFE & BRAIN, weekly

  • 12.04.21 – Kick-off & Pluripotent Stem Cells and Reprogramming (Michael Peitz)
    19.04.21 – The Role of Transcription Factors in Stem Cell Specification (Sandra Blaess and Lea Flitsch)
    26.04.21 – Direct Cell Fate Conversion (Lea Flitsch)
    03.05.21 – Neural Stem Cells (Oliver Brüstle)
    10.05.21 – Genome Editing and Disease Modeling (Michael Peitz)
    17.05.21 – Self-Organisation und Organoids (Vira Iefremova)
    24.05.21 – Pfingstferien – vorlesungsfrei
    31.05.21 – Using Stem Cell Paradigms to Unravel Early Lineage Decisions Enabling Synthetic Embryogenesis (Hubert Schorle)
    07.06.21 – Germ Cells (Lena Arévalo)
    14.06.21 – Stem Cells and Cardiovascular Repair (Wilhelm Röll)
    21.06.21 – Stem Cells in Ophthalmology (Volker Busskamp)
    28.06.21 – Hematopoietic Stem Cells (Tobias Holderried)
    05.07.21 – to be announced (Andreas Till)
    12.07.21 – Chances and Risks of Stem Cell Research: Ethical Aspects (Michael Fuchs)

Preliminary schedule of lectures | Learning objective

Lecture Series Developmental Neurobiology, Stem Cells and Disease

(accepted for Master of Neuroscience, Master of Medical Immunosciences and Infection, Master of Molecular Biotechnology, Wahlfach I Medizin)

Coordination: Prof. O. Brüstle
SS 21 Wed 17.15 – 17.45; Room EG. 612 LIFE & BRAIN, weekly

  • 14.04.21 – Kick-off & From Neurulation to Early Patterning of the Nervous System (Sandra Blaess)
    21.04.21 – Fate Instruction and Regional Determination (Sandra Blaess)
    28.04.21 – Stem Cell Niches and Recruitment into the CNS (to be announced)
    05.05.21 – Molecular and Cellular Aspects of Cortical Development (Oliver Brüstle)
    12.05.21 – Glia Cells and Myelin (to be announced)
    19.05.21 – Dies Academicus – no lecture
    26.05.21 – Pfingstferien – no lecture
    02.06.21 – Principles of Neural Cell Replacement (Oliver Brüstle)
    09.06.21 – Self-Organization and 3D Cultures (Vira Iefremova)
    16.06.21 – Circuit Formation and Repair (Sandra Blaess)
    23.06.21 – In vitro Models of Neural Development and Neurodegeneration (Michael Peitz)
    30.06.21 – Cell Fate Specification for Retinal Repair (Volker Busskamp)
    07.07.21 – Stem Cells and Neural Crest (Pascal Röderer)
    14.07.21 – Neurodevelopment, Stem Cells and Psychiatric Disease (Arquimedes Cheffer)
    21.07.21 – 1. Exam (except MSc Neurosci Students; 17:15 h, Room EG. 612)
    27.09.21 – 1. Exam MSc Neurosci Students; 2. Exam all other Students (10:00 h, Room EG. 612)

Preliminary schedule of lectures | Learning objective

Institute of Reconstructive Neurobiology

University of Bonn
Venusberg-Campus 1
Building 76
D-53105 Bonn/Germany

How to find us

Phone +49 (0)228 - 6885 - 500
Fax +49 (0)228 - 6885 - 501

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