Institute of Reconstructive Neurobiology

Director: Oliver Brüstle

ES cell-derived type 2 Astrocyte


Due to the limited regenerative potential of the central nervous system, brain and spinal cord repair represent some of the biggest challenges in contemporary biomedicine. The availability of self-renewing stem cells has provided new perspectives for the development of neuroregenerative therapies. A key focus of our research is the derivation of defined neurons and glia from pluripotent embryonic stem cells (ES cells). Using a variety of transplantation and disease models, we explore the potential of these cells to integrate into the nervous system and to contribute to functional repair.