2014

1. Akkerman, S., Prickaerts, J., Bruder, A.K., Wolfs, K.H., De Vry, J., Vanmierlo, T., and Blokland, A. (2014). PDE5 Inhibition Improves Object Memory in Standard Housed Rats but Not in Rats Housed in an Enriched Environment: Implications for Memory Models? PLoS ONE. 9, e111692.

2. Bald, T., Landsberg, J., Lopez-Ramos, D., Renn, M., Glodde, N., Jansen, P., Gaffal, E., Steitz, J., Tolba, R., Kalinke, U., et al. (2014a). Immune cell-poor melanomas benefit from PD-1 blockade after targeted type I IFN activation. Cancer Discov. 4, 674-687.

3. Bald, T., Quast, T., Landsberg, J., Rogava, M., Glodde, N., Lopez-Ramos, D., Kohlmeyer, J., Riesenberg, S., van den Boorn-Konijnenberg, D., Hömig-Hölzel, C., et al. (2014b). Ultraviolet-radiation-induced inflammation promotes angiotropism and metastasis in melanoma. Nature. 507, 109-113.

4. Bonde, Y., Breuer, O., Lütjohann, D., Sjöberg, S., Angelin, B., and Rudling, M. (2014). Thyroid hormone reduces PCSK9 and stimulates bile acid synthesis in humans. J Lipid Res. 55, 2408-2415.

5. Bökenkamp, A., Levtchenko, E., Recker, F., and Ludwig, M. (2014). Clinical utility gene card for: Lowe syndrome. Eur J Hum Genet.

6. Claudepierre, M.C., Hortelano, J., Schaedler, E., Kleinpeter, P., Geist, M., Remy-Ziller, C., Brandely, R., Tosch, C., Laruelle, L., Jawhari, A., et al. (2014). Yeast virus-derived stimulator of the innate immune system augments the efficacy of virus vector-based immunotherapy. J Virol. 88, 5242-5255.

7. Conrad, R., Geiser, F., Kleiman, A., Zur, B., and Karpawitz-Godt, A. (2014). Temperament and character personality profile and illness-related stress in central serous chorioretinopathy. ScientificWorldJournal. 2014, 631687.

8. De Nardo, D., Labzin, L.I., Kono, H., Seki, R., Schmidt, S.V., Beyer, M., Xu, D., Zimmer, S., Lahrmann, C., Schildberg, F.A., et al. (2014). High-density lipoprotein mediates anti-inflammatory reprogramming of macrophages via the transcriptional regulator ATF3. Nat Immunol. 15, 152-160.

9. Denk, G., Omary, A.J., Reiter, F.P., Hohenester, S., Wimmer, R., Holdenrieder, S., and Rust, C. (2014). Soluble intracellular adhesion molecule, M30 and M65 as serum markers of disease activity and prognosis in cholestatic liver diseases. Hepatol Res. 44, 1286-1298.

10. Derme, A.M., Wilsmann-Theis, D., Hoelzel, M., Bieber, T., and Wenzel, J. (2014). IL-36 gamma (IL-1F9) is a specific Marker of Psoriasis. J Dtsch Dermatol Ges. 12, E13-E13.

11. Dierkes, G., Weiss, T., Modick, H., Käfferlein, H.U., Brüning, T., and Koch, H.M. (2014). N-Acetyl-4-aminophenol (paracetamol), N-acetyl-2-aminophenol and acetanilide in urine samples from the general population, individuals exposed to aniline and paracetamol users. Int J Hyg Environ Health. 217, 592-599.

12. Draaken, M., Baudisch, F., Timmermann, B., Kuhl, H., Kerick, M., Proske, J., Wittler, L., Pennimpede, T., Ebert, A.K., Rösch, W., et al. (2014). Classic bladder exstrophy: Frequent 22q11.21 duplications and definition of a 414 kb phenocritical region. Birth Defects Res A Clin Mol Teratol. 100, 512-517.

13. Dworschak, G.C., Draaken, M., Hilger, A.C., Schramm, C., Bartels, E., Schmiedeke, E., Grasshoff-Derr, S., Märzheuser, S., Holland-Cunz, S., Lacher, M., et al. (2014). Genome-wide mapping of copy number variations in patients with both anorectal malformations and central nervous system abnormalities. Birth Defects Res A Clin Mol Teratol.

14. Eckstein, M., Scheele, D., Weber, K., Stoffel-Wagner, B., Maier, W., and Hurlemann, R. (2014). Oxytocin facilitates the sensation of social stress. Hum Brain Mapp. 35, 4741-4750.

15. Fernandez-Cuesta, L., Plenker, D., Osada, H., Sun, R., Menon, R., Leenders, F., Ortiz-Cuaran, S., Peifer, M., Bos, M., Dafller, J., et al. (2014). CD74-NRG1 Fusions in Lung Adenocarcinoma. Cancer Discov. 4, 415-422.

16. Friedrich, M.J., Randau, T.M., Wimmer, M.D., Reichert, B., Kuberra, D., Stoffel-Wagner, B., Wirtz, D.C., and Gravius, S. (2014). Lipopolysaccharide-binding protein: a valuable biomarker in the differentiation between periprosthetic joint infection and aseptic loosening? Int Orthop. 38, 2201-2207.

17. Gao, P., Zillinger, T., Wang, W., Ascano, M., Dai, P., Hartmann, G., Tuschl, T., Deng, L., Barchet, W., and Patel, D.J. (2014). Binding-pocket and lid-region substitutions render human STING sensitive to the species-specific drug DMXAA. Cell Rep. 8, 1668-1676.

18. Gezer, U., and Holdenrieder, S. (2014). Post-translational histone modifications in circulating nucleosomes as new biomarkers in colorectal cancer. In Vivo. 28, 287-292.

19. Glodde, N., Boorn-Konijnenberg, D.V.D., Bald, T., Uting, T.T., and Hoelzel, M. (2014). A modular murine melanoma model to study determinants of multimodal immunotherapeutic regimens. Exp Dermatol. 23, E44-E44.

20. Goldeck, M., Schlee, M., Hartmann, G., and Hornung, V. (2014). Enzymatic synthesis and purification of a defined RIG-I ligand. Methods Mol Biol. 1169, 15-25.

21. Goubau, D., Schlee, M., Deddouche, S., Pruijssers, A.J., Zillinger, T., Goldeck, M., Schuberth, C., Van der Veen, A.G., Fujimura, T., Rehwinkel, J., et al. (2014). Antiviral immunity via RIG-I-mediated recognition of RNA bearing 5'-diphosphates. Nature. 514, 372-375.

22. Gylling, H., Plat, J., Turley, S., Ginsberg, H.N., Ellegard, L., Jessup, W., Jones, P.J., Lütjohann, D., Maerz, W., Masana, L., et al. (2014). Plant sterols and plant stanols in the management of dyslipidaemia and prevention of cardiovascular disease. Atherosclerosis. 232, 346-360.

23. Haas, M., Kern, C., Kruger, S., Michl, M., Modest, D.P., Giessen, C., Schulz, C., von Einem, J.C., Ormanns, S., Laubender, R.P., et al. (2014). Assessing novel prognostic serum biomarkers in advanced pancreatic cancer: the role of CYFRA 21-1, serum amyloid A, haptoglobin, and 25-OH vitamin D3. Tumour Biol.

24. Hermann, N., Dreflen, K., Schildberg, F.A., Jakobs, C., and Holdenrieder, S. (2014). Methodical and pre-analytical characteristics of a multiplex cancer biomarker immunoassay. World J Methodol. 4, 219-231.

25. Hofmann, K., Thiele, C., Schött, H.F., Gaebler, A., Schoene, M., Kiver, Y., Friedrichs, S., Lütjohann, D., and Kuerschner, L. (2014). A novel alkyne cholesterol to trace cellular cholesterol metabolism and localization. J Lipid Res. 55, 583-591.

26. Holdenrieder, S., Dharuman, Y., Standop, J., Trimpop, N., Herzog, M., Hettwer, K., Simon, K., Uhlig, S., and Micallef, J. (2014). Novel serum nucleosomics biomarkers for the detection of colorectal cancer. Anticancer Res. 34, 2357-2362.

27. Hoyer, F.F., Khoury, M., Slomka, H., Kebschull, M., Lerner, R., Lutz, B., Schott, H., Lütjohann, D., Wojtalla, A., Becker, A., et al. (2014). Inhibition of endocannabinoid-degrading enzyme fatty acid amide hydrolase increases atherosclerotic plaque vulnerability in mice. J Mol Cell Cardiol. 66, 126-132.

28. Kaut, O., Jacobi, H., Coch, C., Prochnicki, A., Minnerop, M., Klockgether, T., and Wüllner, U. (2014). A randomized pilot study of stochastic vibration therapy in spinocerebellar ataxia. Cerebellum. 13, 237-242.

29. Kepp, O., Senovilla, L., Vitale, I., Vacchelli, E., Adjemian, S., Agostinis, P., Apetoh, L., Aranda, F., Barnaba, V., Bloy, N., et al. (2014). Consensus guidelines for the detection of immunogenic cell death. Oncoimmunology. 3, e955691.

30. Kim, S., Becker, J., Bechheim, M., Kaiser, V., Noursadeghi, M., Fricker, N., Beier, E., Klaschik, S., Boor, P., Hess, T., et al. (2014a). Characterizing the genetic basis of innate immune response in TLR4-activated human monocytes. Nat Commun. 5, 5236.

31. Kim, S., Kaiser, V., Beier, E., Bechheim, M., Guenthner-Biller, M., Ablasser, A., Berger, M., Endres, S., Hartmann, G., and Hornung, V. (2014b). Self-priming determines high type I IFN production by plasmacytoid dendritic cells. Eur J Immunol. 44, 807-818.

32. Koivisto, H., Grimm, M.O., Rothhaar, T.L., Berkecz, R., Lütjohann D, D., Giniatullina, R., Takalo, M., Miettinen, P.O., Lahtinen, H.M., Giniatullin, R., et al. (2014). Special lipid-based diets alleviate cognitive deficits in the APPswe/PS1dE9 transgenic mouse model of Alzheimer's disease independent of brain amyloid deposition. J Nutr Biochem. 25, 157-169.

33. Leszinski, G., Lehner, J., Gezer, U., and Holdenrieder, S. (2014). Increased DNA integrity in colorectal cancer. In Vivo. 28, 299-303.

34. Liehl, P., Zuzarte-Luís, V., Chan, J., Zillinger, T., Baptista, F., Carapau, D., Konert, M., Hanson, K.K., Carret, C., Lassnig, C., et al. (2014). Host-cell sensors for Plasmodium activate innate immunity against liver-stage infection. Nat Med. 20, 47-53.

35. Ludwig, M., Levtchenko, E., and Bökenkamp, A. (2014). Clinical utility gene card for: Dent disease (Dent-1 and Dent-2). Eur J Hum Genet. 22.

36. Mankan, A.K., Schmidt, T., Chauhan, D., Goldeck, M., Höning, K., Gaidt, M., Kubarenko, A.V., Andreeva, L., Hopfner, K.P., and Hornung, V. (2014). Cytosolic RNA:DNA hybrids activate the cGAS-STING axis. EMBO J. 33, 2937-2946.

37. Merz, W.M., Leufgen, C., Fimmers, R., Stoffel-Wagner, B., and Gembruch, U. (2014). Reference Intervals for N-Terminal Pro-B-Type Natriuretic Peptide in Amniotic Fluid between 10 and 34 Weeks of Gestation. PLoS ONE. 9, e114416.

38. Middleton, C.H., Irving, W., Robertson, J.F., Murray, A., Parsy-Kowalska, C.B., Macdonald, I.K., McElveen, J., Allen, J., Healey, G.F., Thomson, B.J., et al. (2014). Serum autoantibody measurement for the detection of hepatocellular carcinoma. PLoS ONE. 9, e103867.

39. Modick, H., Weiss, T., Dierkes, G., Brüning, T., and Koch, H.M. (2014). Ubiquitous presence of paracetamol in human urine: sources and implications. Reproduction. 147, R105-117.

40. Oseledchyk, A., Abramian, A., Kaiser, C., Debald, M., Domroese, C., Kiefer, N., Putensen, C., Pantelis, D., Kuhn, W., Schaefer, N., and Keyver-Paik, M.-D. (2014a). Total or Subtotal Colectomy in Patients Undergoing Surgery for Primary or Recurrent Epithelial Ovarian Cancer. Oncol Res. 37, 448-454.

41. Oseledchyk, A., Kaiser, C., Nemes, L., Döbler, M., Abramian, A., Keyver-Paik, M.D., Leutner, C., Schild, H.H., Kuhn, W., and Debald, M. (2014b). Preoperative MRI in patients with locoregional recurrent breast cancer: influence on treatment modalities. Acad Radiol. 21, 1276-1285.

42. Plat, J., Hendrikx, T., Bieghs, V., Jeurissen, M.L., Walenbergh, S.M., van Gorp, P.J., De Smet, E., Konings, M., Vreugdenhil, A.C., Guichot, Y.D., et al. (2014a). Protective role of plant sterol and stanol esters in liver inflammation: insights from mice and humans. PLoS ONE. 9, e110758.

43. Plat, J., Theuwissen, E., Husche, C., Lütjohann, D., Gijbels, M.J., Jeurissen, M., Shiri-Sverdlov, R., van der Made, I., and Mensink, R.P. (2014b). Oxidised plant sterols as well as oxycholesterol increase the proportion of severe atherosclerotic lesions in female LDL receptor+/†- mice. Br J Nutr. 111, 64-70.

44. Randau, T.M., Friedrich, M.J., Wimmer, M.D., Reichert, B., Kuberra, D., Stoffel-Wagner, B., Limmer, A., Wirtz, D.C., and Gravius, S. (2014). Interleukin-6 in serum and in synovial fluid enhances the differentiation between periprosthetic joint infection and aseptic loosening. PLoS ONE. 9, e89045.

45. Recker, F., Zaniew, M., Böckenhauer, D., Miglietti, N., Bökenkamp, A., Moczulska, A., Rogowska-Kalisz, A., Laube, G., Said-Conti, V., Kasap-Demir, B., et al. (2014). Characterization of 28 novel patients expands the mutational and phenotypic spectrum of Lowe syndrome. Pediatr Nephrol.

46. Reutter, H., Draaken, M., Pennimpede, T., Wittler, L., Brockschmidt, F.F., Ebert, A.K., Bartels, E., Rösch, W., Boemers, T.M., Hirsch, K., et al. (2014). Genome-wide association study and mouse expression data identify a highly conserved 32 kb intergenic region between WNT3 and WNT9b as possible susceptibility locus for isolated classic exstrophy of the bladder. Hum Mol Genet. 23, 5536-5544.

47. Saeed, A.A., Genove, G., Li, T., Luetjohann, D., Olin, M., Mast, N., Pikuleva, I.A., Crick, P., Wang, Y., Griffiths, W., et al. (2014). Effects of a Disrupted Blood-Brain Barrier on Cholesterol Homeostasis in the Brain. Journal of Biological Chemistry 289, 23712-23722.

48. Saisawat, P., Kohl, S., Hilger, A.C., Hwang, D.-Y., Gee, H.Y., Dworschak, G.C., Tasic, V., Pennimpede, T., Natarajan, S., Sperry, E., et al. (2014). Whole-exome resequencing reveals recessive mutations in TRAP1 in individuals with CAKUT and VACTERL association. Kidney International 85, 1310-1317.

49. Scheele, D., Kendrick, K.M., Khouri, C., Kretzer, E., Schlaefer, T.E., Stoffel-Wagner, B., Guentuerkuen, O., Maier, W., and Hurlemann, R. (2014). An Oxytocin-Induced Facilitation of Neural and Emotional Responses to Social Touch Correlates Inversely with Autism Traits. Neuropsychopharmacology 39, 2078-2085.

50. Scheffer, A.-R., Holdenrieder, S., Kristiansen, G., von Ruecker, A., Mueller, S.C., and Ellinger, J. (2014). Circulating microRNAs in serum: novel biomarkers for patients with bladder cancer? World Journal of Urology 32, 353-358.

51. Schoett, H.-F., Luister, A., Husche, C., Schaefers, H.-J., Boehm, M., Plat, J., Luetjohann, D., Laufs, U., and Weingaertner, O. (2014). The relationships of phytosterols and oxyphytosterols in plasma and aortic valve cusps in patients with severe aortic stenosis. Biochemical and Biophysical Research Communications 446, 805-810.

52. Silbernagel, G., Chapman, M.J., Genser, B., Kleber, M.E., Fauler, G., Scharnagl, H., Grammer, T.B., Maekelae, K.-M., Kaehoenen, M., Carmena, R., et al. (2014). Intestinal Cholesterol Absorption and Cardiovascular Risk Reply. Journal of the American College of Cardiology 63, 696-697.

53. Smiljanic, K., Vanmierlo, T., Mladenovic Djordjevic, A., Perovic, M., Ivkovic, S., Lutjohann, D., and Kanazir, S. (2014). Cholesterol metabolism changes under long-term dietary restrictions while the cholesterol homeostasis remains unaffected in the cortex and hippocampus of aging rats. Age (Dordrecht, Netherlands) 36, 9654-9654.

54. Spaan, L., Zhao, F., Sucker, A., Coch, C., Hartmann, G., Schadendorf, D., Trilling, M., and Paschen, A. (2014). Targeted activation of RIG-I enhances melanoma immunogenicity and increases its T cell sensitivity independent of autocrine type I interferon signaling. Journal Der Deutschen Dermatologischen Gesellschaft 12, 6-6.

55. Stoetzer, O.J., Lehner, J., Fersching-Gierlich, D., Nagel, D., and Holdenrieder, S. (2014). Diagnostic relevance of plasma DNA and DNA integrity for breast cancer. Tumor Biology 35, 1183-1191.

56. Stoffels, B., Hupa, K.J., Snoek, S.A., van Bree, S., Stein, K., Schwandt, T., Vilz, T.O., Lysson, M., Veer, C.V., Kummer, M.P., et al. (2014). Postoperative ileus involves interleukin-1 receptor signaling in enteric glia. Gastroenterology. 146, 176-187.e171.

57. Stötzer, O.J., Lehner, J., Fersching-Gierlich, D., Nagel, D., and Holdenrieder, S. (2014). Diagnostic relevance of plasma DNA and DNA integrity for breast cancer. Tumour Biol. 35, 1183-1191.

58. Szczepanska, M., Zaniew, M., Recker, F., Mizerska-wasiak, M., Zaluska-lesniewska, I., Kilis-pstrusinska, K., Adamczyk, P., Zawadzki, J., Pawlaczyk, K., Ludwig, M., and Sikora, P. (2014). Dent Disease In Children - Data From Polish Registry Of Inherited Tubulopathies. Pediatric Nephrology 29, 1833-1833.

59. Timmermans, S., Bogie, J.F.J., Vanmierlo, T., Luetjohann, D., Stinissen, P., Hellings, N., and Hendriks, J.J.A. (2014b). High Fat Diet Exacerbates Neuroinflammation in an Animal Model of Multiple Sclerosis by Activation of the Renin Angiotensin System. Journal of Neuroimmune Pharmacology 9, 209-217.

60. van de Kraats, C., Killestein, J., Popescu, V., Rijkers, E., Vrenken, H., Luetjohann, D., Barkhof, F., Polman, C.H., and Teunissen, C.E. (2014). Oxysterols and cholesterol precursors correlate to magnetic resonance imaging measures of neurodegeneration in multiple sclerosis. Multiple Sclerosis Journal 20, 412-417.

61. van den Boorn, J.G., and Hartmann, G. (2014). Therapeutic Tissue Regeneration by a Macrophage Colony-Stimulating Factor Fc Conjugate. Molecular Therapy 22, 1577-1579.

62. van der Made, S.M., Kelly, E.R., Berendschot, T.T.J.M., Kijlstra, A., Luetjohann, D., and Plat, J. (2014). Consuming a Buttermilk Drink Containing Lutein-Enriched Egg Yolk Daily for 1 Year Increased Plasma Lutein but Did Not Affect Serum Lipid or Lipoprotein Concentrations in Adults with Early Signs of Age-Related Macular Degeneration. Journal of Nutrition 144, 1370-1377.

63. Waiskopf, N., Ofek, K., Gilboa-Geffen, A., Bekenstein, U., Bahat, A., Bennett, E.R., Podoly, E., Livnah, O., Hartmann, G., and Soreq, H. (2014). AChE and RACK1 Promote the Anti-Inflammatory Properties of Fluoxetine. Journal of Molecular Neuroscience 53, 306-315.

64. Weingaertner, O., Bjoerkhem, I., and Luetjohann, D. (2014a). Intestinal Cholesterol Absorption and Cardiovascular Risk. Journal of the American College of Cardiology 63, 695-696.

65. Weingaertner, O., Bogeski, I., Kummerow, C., Schirmer, S., Vanmierlo, T., Hoth, M., Luetjohann, D., and Laufs, U. (2014b). EFFECTS OF A DIET SUPPLEMENTATION WITH PLANT STEROLS ON CIRCULATING MONOCYTES IN HUMANS: A PROSPECTIVE, DOUBLE-BLIND, RANDOMIZED, PLACEBO-CONTROLLED, CROSS-OVER STUDY. Atherosclerosis 235, E292-E292.

66. Weingaertner, O., Luethjohann, D., Schoett, H.F., Speer, T., McCarthy, F., and Laufs, U. (2014c). VASCULAR EFFECTS OF STEROLS, OXYSTEROLS, PHYTOSTEROLS, AND OXYPHYTOSTEROLS IN APOE-/-MICE. Atherosclerosis 235, E262-E263.

67. Weingaertner, O., Luister, A., Schoett, H.F., Husche, C., Schaefers, H.J., Boehm, M., Plat, J., Laufs, U., and Luetjohann, D. (2014d). Phytosterol and oxyphytosterol levels in plasma and aortic valve cusps in patients with severe aortic stenosis. European Heart Journal 35, 219-219.

68. Weingaertner, O., Schoett, H.F., Luister, A., Husche, C., Schaefers, H.J., Boehm, M., Laufs, U., and Luetjohann, D. (2014e). PHYTOSTEROL AND OXYPHYTOSTEROL LEVELS IN PLASMA AND AORTIC VALVE CUSPS IN PATIENTS WITH SEVERE AORTIC STENOSIS. Atherosclerosis 235, E60-E61.

69. Westermann, A.M., Schmidt, D., Holdenrieder, S., Moritz, R., Semjonow, A., Schmidt, M., Kristiansen, G., Mueller, S.C., and Ellinger, J. (2014). Serum microRNAs as Biomarkers in Patients Undergoing Prostate Biopsy: Results from a Prospective Multi-Center Study. Anticancer Research 34, 665-669.

70. Wijers, C.H.W., de Blaauw, I., Zwink, N., Draaken, M., van der Zanden, L.F.M., Brunner, H.G., Brooks, A.S., Hofstra, R.M., Sloots, C.E.J., Broens, P.M.A., et al. (2014). No Major Role for Periconceptional Folic Acid Use and Its Interaction with the MTHFR C677T Polymorphism in the Etiology of Congenital Anorectal Malformations. Birth Defects Research Part a-Clinical and Molecular Teratology 100, 483-492.

71. Zaniew, M., Moczulska, A., Szezepanska, M., Mizerska-wasiak, M., Rogowska-kalisz, A., Gadomskaprokop, K., Wasilewska, A., Zawadziki, J., Pawlaczyk, K., Kiryluk, K., et al. (2014). Genetic Registry Of Inherited Tubulopathies In Poland. Pediatric Nephrology 29, 1672-1672.

72. Zeidler, C., Woelfle, J., Draaken, M., Mughal, S.S., Grosse, G., Hilger, A.C., Dworschak, G.C., Boemers, T.M., Jenetzky, E., Zwink, N., et al. (2014). Heterozygous FGF8 Mutations in Patients Presenting Cryptorchidism and Multiple VATER/VACTERL Features without Limb Anomalies. Birth Defects Research Part a-Clinical and Molecular Teratology 100, 750-759.

73. Zhu, J., Zhang, Y., Ghosh, A., Cuevas, R.A., Forero, A., Dhar, J., Ibsen, M.S., Schmid-Burgk, J.L., Schmidt, T., Ganapathiraju, M.K., et al. (2014). Antiviral Activity of Human OASL Protein Is Mediated by Enhancing Signaling of the RIG-I RNA Sensor. Immunity 40, 936-948.

74. Zur, B., Stoffel-Wagner, B., and Ludwig, M. (2014). Novel Hemoglobin UKB demonstrates the importance of using different methods of detection. Clinica Chimica Acta 431, 58-59.