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2. Ablasser, A., Hertrich, C., Waflermann, R., and Hornung, V. (2013b). Nucleic acid driven sterile inflammation. Clin Immunol. 147, 207-215.

3. Ablasser, A., and Hornung, V. (2013). DNA sensing unchained. Cell Res. 23, 585-587.

4. Ablasser, A., Schmid-Burgk, J.L., Hemmerling, I., Horvath, G.L., Schmidt, T., Latz, E., and Hornung, V. (2013c). Cell intrinsic immunity spreads to bystander cells via the intercellular transfer of cGAMP. Nature. 503, 530-534.

5. Bartok, E., Bauernfeind, F., Khaminets, M.G., Jakobs, C., Monks, B., Fitzgerald, K.A., Latz, E., and Hornung, V. (2013). iGLuc: a luciferase-based inflammasome and protease activity reporter. Nat Methods. 10, 147-154.

6. Baudisch, F., Draaken, M., Bartels, E., Schmiedeke, E., Bagci, S., Bartmann, P., Nöthen, M.M., Ludwig, M., and Reutter, H. (2013). CNV analysis in monozygotic twin pairs discordant for urorectal malformations. Twin Res Hum Genet. 16, 802-807.

7. Bauernfeind, F., and Hornung, V. (2013). Of inflammasomes and pathogens--sensing of microbes by the inflammasome. EMBO Mol Med. 5, 814-826.

8. Baumgartner, S., Kelly, E.R., van der Made, S., Berendschot, T.T., Husche, C., Lütjohann, D., and Plat, J. (2013a). The influence of consuming an egg or an egg-yolk buttermilk drink for 12 wk on serum lipids, inflammation, and liver function markers in human volunteers. Nutrition. 29, 1237-1244.

9. Baumgartner, S., Mensink, R.P., Hartog, G.D., Bast, A., Bekers, O., Husche, C., Lütjohann, D., and Plat, J. (2013b). Oxyphytosterol formation in humans: Identification of high vs. low oxidizers. Biochem Pharmacol. 86, 19-25.

10. Baumgartner, S., Mensink, R.P., Husche, C., Lütjohann, D., and Plat, J. (2013c). Effects of plant sterol- or stanol-enriched margarine on fasting plasma oxyphytosterol concentrations in healthy subjects. Atherosclerosis. 227, 414-419.

11. Bieghs, V., Hendrikx, T., van Gorp, P.J., Verheyen, F., Guichot, Y.D., Walenbergh, S.M., Jeurissen, M.L., Gijbels, M., Rensen, S.S., Bast, A., et al. (2013). The cholesterol derivative 27-hydroxycholesterol reduces steatohepatitis in mice. Gastroenterology. 144, 167-178.e161.

12. Blass, S.C., Goost, H., Burger, C., Tolba, R.H., Stoffel-Wagner, B., Stehle, P., and Ellinger, S. (2013). Extracellular micronutrient levels and pro-/antioxidant status in trauma patients with wound healing disorders: results of a cross-sectional study. Nutr J. 12, 157.

13. Boeck, S., Wittwer, C., Heinemann, V., Haas, M., Kern, C., Stieber, P., Nagel, D., and Holdenrieder, S. (2013). Cytokeratin 19-fragments (CYFRA 21-1) as a novel serum biomarker for response and survival in patients with advanced pancreatic cancer. Br J Cancer. 108, 1684-1694.

14. Burg, V.K., Grimm, H.S., Rothhaar, T.L., Grösgen, S., Hundsdörfer, B., Haupenthal, V.J., Zimmer, V.C., Mett, J., Weingärtner, O., Laufs, U., et al. (2013). Plant sterols the better cholesterol in Alzheimer's disease? A mechanistical study. J Neurosci. 33, 16072-16087.

15. Cavlar, T., Deimling, T., Ablasser, A., Hopfner, K.P., and Hornung, V. (2013). Species-specific detection of the antiviral small-molecule compound CMA by STING. EMBO J. 32, 1440-1450.

16. Civril, F., Deimling, T., de Oliveira Mann, C.C., Ablasser, A., Moldt, M., Witte, G., Hornung, V., and Hopfner, K.P. (2013). Structural mechanism of cytosolic DNA sensing by cGAS. Nature. 498, 332-337.

17. Coch, C., Lück, C., Schwickart, A., Putschli, B., Renn, M., Höller, T., Barchet, W., Hartmann, G., and Schlee, M. (2013). A human in vitro whole blood assay to predict the systemic cytokine response to therapeutic oligonucleotides including siRNA. PLoS ONE. 8, e71057.

18. De Nardo, D., Labzin, L., Kono, H., Seki, R., Schmidt, S., Vogelhuber, J., Kraut, M., Kerksiek, A., Krebs, W., Bode, N., et al. (2013a). Investigating the anti-inflammatory effects of HDL in macrophages. Cytokine. 63, 258-258.

19. De Nardo, D., Labzin, L.I., Kono, H., Seki, R., Schmidt, S.V., Beyer, M., Xu, D., Zimmer, S., Lahrmann, C., Schildberg, F.A., et al. (2013b). High-density lipoprotein mediates anti-inflammatory reprogramming of macrophages via the transcriptional regulator ATF3. Nat Immunol.

20. Debald, M., Schildberg, F.A., Linke, A., Walgenbach, K., Kuhn, W., Hartmann, G., and Walgenbach-Brünagel, G. (2013). Specific expression of k63-linked ubiquitination of calmodulin-like protein 5 in breast cancer of premenopausal patients. J Cancer Res Clin Oncol. 139, 2125-2132.

21. Draaken, M., Mughal, S.S., Pennimpede, T., Wolter, S., Wittler, L., Ebert, A.K., Rösch, W., Stein, R., Bartels, E., Schmidt, D., et al. (2013). Isolated bladder exstrophy associated with a de novo 0.9 Mb microduplication on chromosome 19p13.12. Birth Defects Res A Clin Mol Teratol. 97, 133-139.

22. Dworschak, G., Draaken, M., Marcelis, C., de Blaauw, I., Pfundt, R., van Rooij, I., Bartels, E., Hilger, A., Jenetzky, E., Schmiedeke, E., et al. (2013a). De Novo 13q Deletions in Two Patients With Mild Anorectal Malformations as Part of VATER/VACTERL and VATER/VACTERL-Like Association and Analysis of epsilon FNB2 in Patients With Anorectal Malformations. Am 23. J Med Genet A. 161, 3035-3041.

24. Dworschak, G.C., Draaken, M., Hilger, A., Born, M., Reutter, H., and Ludwig, M. (2013b). An incompletely penetrant novel MAFB (p.Ser56Phe) variant in autosomal dominant multicentric carpotarsal osteolysis syndrome. Int J Mol Med. 32, 174-178.

25. Dworschak, G.C., Draaken, M., Marcelis, C., de Blaauw, I., Pfundt, R., van Rooij, I.A., Bartels, E., Hilger, A., Jenetzky, E., Schmiedeke, E., et al. (2013c). De novo 13q deletions in two patients with mild anorectal malformations as part of VATER/VACTERL and VATER/VACTERL-like association and analysis of EFNB2 in patients with anorectal malformations. Am J 26. Med Genet A. 161, 3035-3041.

27. Ellermeier, J., Wei, J., Duewell, P., Hoves, S., Stieg, M.R., Adunka, T., Noerenberg, D., Anders, H.J., Mayr, D., Poeck, H., et al. (2013). Therapeutic efficacy of bifunctional siRNA combining TGF-?1 silencing with RIG-I activation in pancreatic cancer. Cancer Res. 73, 1709-1720.

28. Fahmueller, Y.N., Nagel, D., Hoffmann, R.T., Tatsch, K., Jakobs, T., Stieber, P., and Holdenrieder, S. (2013a). CA 15-3 is a predictive and prognostic biomarker in patients with metastasized breast cancer undergoing Selective Internal Radiation Therapy. Int J Clin Pharmacol Ther. 51, 63-66.

29. Fahmueller, Y.N., Nagel, D., Hoffmann, R.T., Tatsch, K., Jakobs, T., Stieber, P., and Holdenrieder, S. (2013b). Immunogenic cell death biomarkers HMGB1, RAGE, and DNAse indicate response to radioembolization therapy and prognosis in colorectal cancer patients. Int J Cancer. 132, 2349-2358.

30. Gao, P., Ascano, M., Wu, Y., Barchet, W., Gaffney, B.L., Zillinger, T., Serganov, A.A., Liu, Y., Jones, R.A., Hartmann, G., et al. (2013a). Cyclic [G(2',5')pA(3',5')p] is the metazoan second messenger produced by DNA-activated cyclic GMP-AMP synthase. Cell. 153, 1094-1107.

31. Gao, P., Ascano, M., Zillinger, T., Wang, W., Dai, P., Serganov, A.A., Gaffney, B.L., Shuman, S., Jones, R.A., Deng, L., et al. (2013b). Structure-function analysis of STING activation by c[G(2',5')pA(3',5')p] and targeting by antiviral DMXAA. Cell. 154, 748-762.

32. Gautier, E.L., Westerterp, M., Bhagwat, N., Cremers, S., Shih, A., Abdel-Wahab, O., Lütjohann, D., Randolph, G.J., Levine, R.L., Tall, A.R., and Yvan-Charvet, L. (2013). HDL and Glut1 inhibition reverse a hypermetabolic state in mouse models of myeloproliferative disorders. J Exp Med. 210, 339-353.

33. Gehrke, N., Mertens, C., Zillinger, T., Wenzel, J., Bald, T., Zahn, S., Tüting, T., Hartmann, G., and Barchet, W. (2013). Oxidative damage of DNA confers resistance to cytosolic nuclease TREX1 degradation and potentiates STING-dependent immune sensing. Immunity. 39, 482-495.

34. Gezer, U., Ustek, D., Yörüker, E.E., Cakiris, A., Abaci, N., Leszinski, G., Dalay, N., and Holdenrieder, S. (2013). Characterization of H3K9me3- and H4K20me3-associated circulating nucleosomal DNA by high-throughput sequencing in colorectal cancer. Tumour Biol. 34, 329-336.

35. Glas, M., Coch, C., Trageser, D., Dafller, J., Simon, M., Koch, P., Mertens, J., Quandel, T., Gorris, R., Reinartz, R., et al. (2013). Targeting the Cytosolic Innate Immune Receptors RIG-I and MDA5 Effectively Counteracts Cancer Cell Heterogeneity in Glioblastoma. Stem Cells. 31, 1064-1074.

36. Haas, M., Heinemann, V., Kullmann, F., Laubender, R.P., Klose, C., Bruns, C.J., Holdenrieder, S., Modest, D.P., Schulz, C., and Boeck, S. (2013). Prognostic value of CA 19-9, CEA, CRP, LDH and bilirubin levels in locally advanced and metastatic pancreatic cancer: results from a multicenter, pooled analysis of patients receiving palliative chemotherapy. J Cancer Res Clin Oncol. 139, 681-689.

37. Hagmann, C.A., Herzner, A.M., Abdullah, Z., Zillinger, T., Jakobs, C., Schuberth, C., Coch, C., Higgins, P.G., Wisplinghoff, H., Barchet, W., et al. (2013). RIG-I Detects Triphosphorylated RNA of Listeria monocytogenes during Infection in Non-Immune Cells. PLoS ONE. 8, e62872.

38. Hilger, A., Schramm, C., Pennimpede, T., Wittler, L., Dworschak, G.C., Bartels, E., Engels, H., Zink, A.M., Degenhardt, F., Müller, A.M., et al. (2013). De novo microduplications at 1q41, 2q37.3, and 8q24.3 in patients with VATER/VACTERL association. Eur J Hum Genet. 21, 1377-1382.

39. Hofmann, K., Thiele, C., Schött, H.F., Gaebler, A., Schoene, M., Kiver, Y., Friedrichs, S., Lütjohann, D., and Kuerschner, L. (2013). A novel alkyne cholesterol to trace cellular cholesterol metabolism and localization. J Lipid Res.

40. Holdenrieder, S., Spelsberg, F., Hatz, R., Waidelich, R., Untch, M., Hofmann, K., Wehnl, B., Heinemann, V., and Stieber, P. (2013). Pattern of S100-release in benign and malignant diseases beside malignant melanoma. LaboratoriumsMedizin. 37, 21-28.

41. Horenstein, R.B., Mitchell, B.D., Post, W.S., Lütjohann, D., von Bergmann, K., Ryan, K.A., Terrin, M., Shuldiner, A.R., and Steinle, N.I. (2013). The ABCG8 G574R Variant, Serum Plant Sterol Levels, and Cardiovascular Disease Risk in the Old Order Amish. Arterioscler Thromb Vasc Biol. 33, 413-419.

42. Hoyer, F.F., Khoury, M., Slomka, H., Kebschull, M., Lerner, R., Lutz, B., Schott, H., Lütjohann, D., Wojtalla, A., Becker, A., et al. (2013). Inhibition of endocannabinoid-degrading enzyme fatty acid amide hydrolase increases atherosclerotic plaque vulnerability in mice. J Mol Cell Cardiol. 66C, 126-132.

43. Hölzel, M., Bovier, A., and Tüting, T. (2013). Plasticity of tumour and immune cells: a source of heterogeneity and a cause for therapy resistance? Nat Rev Cancer. 13, 365-376.

44. Jakobs, C., Bartok, E., Kubarenko, A., Bauernfeind, F., and Hornung, V. (2013). Immunoblotting for active caspase-1. Methods Mol Biol. 1040, 103-115.

45. Jansen, D., Zerbi, V., Arnoldussen, I.A., Wiesmann, M., Rijpma, A., Fang, X.T., Dederen, P.J., Mutsaers, M.P., Broersen, L.M., Lütjohann, D., et al. (2013a). Effects of Specific Multi-Nutrient Enriched Diets on Cerebral Metabolism, Cognition and Neuropathology in A?PPswe-PS1dE9 Mice. PLoS ONE. 8, e75393.

46. Jansen, D., Zerbi, V., Janssen, C.I., van Rooij, D., Zinnhardt, B., Dederen, P.J., Wright, A.J., Broersen, L.M., Lütjohann, D., Heerschap, A., and Kiliaan, A.J. (2013b). Impact of a multi-nutrient diet on cognition, brain metabolism, hemodynamics, and plasticity in apoE4 carrier and apoE knockout mice. Brain Struct Funct.

47. Kane, L., Moore, K., Lütjohann, D., Bikle, D., and Schwartz, J.B. (2013). Vitamin D3 effects on lipids differ in statin and non-statin-treated humans: superiority of free 25-OH D levels in detecting relationships. J Clin Endocrinol Metab. 98, 4400-4409.

48. Karasinska, J.M., de Haan, W., Franciosi, S., Ruddle, P., Fan, J., Kruit, J.K., Stukas, S., Lütjohann, D., Gutmann, D.H., Wellington, C.L., and Hayden, M.R. (2013). ABCA1 influences neuroinflammation and neuronal death. Neurobiol Dis. 54, 445-455.

49. Kaut, O., Jacobi, H., Coch, C., Prochnicki, A., Minnerop, M., Klockgether, T., and Wüllner, U. (2013). A Randomized Pilot Study of Stochastic Vibration Therapy in Spinocerebellar Ataxia. Cerebellum.

50. Kessler, A., Siekmann, L., Weykamp, C., Geilenkeuser, W.J., Dreazen, O., Middle, J., Schumann, G., and Medicine, I.C.o.T.i.L. (2013). External Quality Assessment Scheme for reference laboratories - review of 8 years' experience. Clin Chem Lab Med. 51, 997-1005.

51. Kim, S., Kaiser, V., Beier, E., Bechheim, M., Guenthner-Biller, M., Ablasser, A., Berger, M., Endres, S., Hartmann, G., and Hornung, V. (2013). Self-priming determines high type I IFN production by plasmacytoid dendritic cells. Eur J Immunol.

52. Kohles, N., Nagel, D., Jüngst, D., Stieber, P., and Holdenrieder, S. (2013). DNase is a prognostic marker in liver cancer patients receiving transarterial chemoembolization therapy. Int J Clin Pharmacol Ther. 51, 80-83.

53. Kuebler, U., Linnebank, M., Semmler, A., Stoffel-Wagner, B., La Marca, R., Ehlert, U., and Wirtz, P.H. (2013). Plasma homocysteine levels increase following stress in older but not younger men. Psychoneuroendocrinology. 38, 1381-1387.

54. Lehner, J., Stötzer, O.J., Fersching, D., Nagel, D., and Holdenrieder, S. (2013a). Circulating plasma DNA and DNA integrity in breast cancer patients undergoing neoadjuvant chemotherapy. Clin Chim Acta. 425, 206-211.

55. Lehner, J., Stötzer, O.J., Fersching, D.M., Nagel, D., and Holdenrieder, S. (2013b). Plasma DNA integrity indicates response to neoadjuvant chemotherapy in patients with locally confined breast cancer. Int J Clin Pharmacol Ther. 51, 59-62.

56. Liehl, P., Zuzarte-Luís, V., Chan, J., Zillinger, T., Baptista, F., Carapau, D., Konert, M., Hanson, K.K., Carret, C., Lassnig, C., et al. (2013). Host-cell sensors for Plasmodium activate innate immunity against liver-stage infection. Nat Med.

57. Marinova, M., Lütjohann, D., Breuer, O., Kölsch, H., Westhofen, P., Watzka, M., Mengel, M., Stoffel-Wagner, B., Hartmann, G., Coch, C., and Oldenburg, J. (2013). VKORC1-dependent pharmacokinetics of intravenous and oral phylloquinone (vitamin K1) mixed micelles formulation. Eur J Clin Pharmacol. 69, 467-475.

58. Merz, W.M., Kübler, K., Fimmers, R., Willruth, A., Stoffel-Wagner, B., and Gembruch, U. (2013). Cardiorenal syndrome is present in human fetuses with severe, isolated urinary tract malformations. PLoS ONE. 8, e63664.

59. Niemeyer, D., Zillinger, T., Muth, D., Zielecki, F., Horvath, G., Suliman, T., Barchet, W., Weber, F., Drosten, C., and Müller, M.A. (2013). Middle East respiratory syndrome coronavirus accessory protein 4a is a type I interferon antagonist. J Virol. 87, 12489-12495.

60. Pasternack, S.M., Böckenhauer, D., Refke, M., Tasic, V., Draaken, M., Conrad, C., Born, M., Betz, R.C., Reutter, H., and Ludwig, M. (2013). A premature termination mutation in a patient with Lowe syndrome without congenital cataracts: dropping the "O" in OCRL. Klin Padiatr. 225, 29-33.

61. Poeck, H., Bscheider, M., Gross, O., Finger, K., Roth, S., Rebsamen, M., Hannesschläger, N., Schlee, M., Rothenfusser, S., Barchet, W., et al. (2013). Addendum: Recognition of RNA virus by RIG-I results in activation of CARD9 and inflammasome signaling for interleukin 1? production. Nat Immunol. 15, 109.

62. Popp, J., Meichsner, S., Kölsch, H., Lewczuk, P., Maier, W., Kornhuber, J., Jessen, F., and Lütjohann, D. (2013). Cerebral and extracerebral cholesterol metabolism and CSF markers of Alzheimer's disease. Biochem Pharmacol. 86, 37-42.

63. Qi, L., Wang, M., Yagnik, G., Mattheisen, M., Gearhart, J.P., Lakshmanan, Y., Ebert, A.K., Rösch, W., Ludwig, M., Draaken, M., et al. (2013). Candidate gene association study implicates p63 in the etiology of nonsyndromic bladder-exstrophy-epispadias complex. Birth Defects Res A Clin Mol Teratol. 97, 759-763.

64. Reichert, C., Kutschera, E., Nienkemper, M., Scharf, S., Mengel, M., Fimmers, R., Fuhrmann, C., Plötz, C., Gölz, L., Drescher, D., et al. (2013). Influence of time after extraction on the development of gingival invagination: study protocol for a multicenter pilot randomized controlled clinical trial. Trials. 14, 108.

65. Renner, O., Lütjohann, D., Richter, D., Strohmeyer, A., Schimmel, S., Müller, O., Stange, E.F., and Harsch, S. (2013). Role of the ABCG8 19H risk allele in cholesterol absorption and gallstone disease. BMC Gastroenterol. 13, 30.

66. Reutter, H., and Ludwig, M. (2013). VATER/VACTERL Association: Evidence for the Role of Genetic Factors. Mol Syndromol. 4, 16-19.

67. Rácz, I., Markert, A., Mauer, D., Stoffel-Wagner, B., and Zimmer, A. (2013). Long-term ethanol effects on acute stress responses: modulation by dynorphin. Addict Biol. 18, 678-688.

68. Saisawat, P., Kohl, S., Hilger, A.C., Hwang, D.Y., Yung Gee, H., Dworschak, G.C., Tasic, V., Pennimpede, T., Natarajan, S., Sperry, E., et al. (2013). Whole-exome resequencing reveals recessive mutations in TRAP1 in individuals with CAKUT and VACTERL association. Kidney Int.

69. Scheele, D., Wille, A., Kendrick, K.M., Stoffel-Wagner, B., Becker, B., Güntürkün, O., Maier, W., and Hurlemann, R. (2013). Oxytocin enhances brain reward system responses in men viewing the face of their female partner. Proc Natl Acad Sci U S A. 110, 20308-20313.

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73. Semmler, A., Moskau-Hartmann, S., Stoffel-Wagner, B., Elger, C., and Linnebank, M. (2013). Homocysteine plasma levels in patients treated with antiepileptic drugs depend on folate and vitamin B12 serum levels, but not on genetic variants of homocysteine metabolism. Clin Chem Lab Med. 51, 665-669.

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76. Spaan, L., Zhao, F., Heinemann, A., Brinkhaus, R., Coch, C., Hartmann, G., Schadendorf, D., and Paschen, A. (2013). Transfection of melanoma cells by viral RNA mimetics enhances their T-cell sensitivity. J Dtsch Dermatol Ges. 11, 959-959.

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