2009

1. Ablasser, A., Bauernfeind, F., Hartmann, G., Latz, E., Fitzgerald, K.A., and Hornung, V. (2009a). RIG-I-dependent sensing of poly(dA:dT) through the induction of an RNA polymerase III-transcribed RNA intermediate. Nat Immunol. 10, 1065-1072.

2. Ablasser, A., Poeck, H., Anz, D., Berger, M., Schlee, M., Kim, S., Bourquin, C., Goutagny, N., Jiang, Z., Fitzgerald, K.A., et al. (2009b). Selection of molecular structure and delivery of RNA oligonucleotides to activate TLR7 versus TLR8 and to induce high amounts of IL-12p70 in primary human monocytes. J Immunol. 182, 6824-6833.

3. Acimovic, J., Lövgren-Sandblom, A., Monostory, K., Rozman, D., Golicnik, M., Lutjohann, D., and Björkhem, I. (2009). Combined gas chromatographic/mass spectrometric analysis of cholesterol precursors and plant sterols in cultured cells. J Chromatogr B Analyt Technol Biomed Life Sci. 877, 2081-2086.

4. Anz, D., Thaler, R., Stephan, N., Waibler, Z., Trauscheid, M.J., Scholz, C., Kalinke, U., Barchet, W., Endres, S., and Bourquin, C. (2009). Activation of melanoma differentiation-associated gene 5 causes rapid involution of the thymus. J Immunol. 182, 6044-6050.

5. Bauernfeind, F., and Hornung, V. (2009). TLR2 joins the interferon gang. Nat Immunol. 10, 1139-1141.

6. Bauernfeind, F.G., Horvath, G., Stutz, A., Alnemri, E.S., MacDonald, K., Speert, D., Fernandes-Alnemri, T., Wu, J., Monks, B.G., Fitzgerald, K.A., et al. (2009). Cutting edge: NF-kappaB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression. J Immunol. 183, 787-791.

7. Bekeredjian-Ding, I., Schäfer, M., Hartmann, E., Pries, R., Parcina, M., Schneider, P., Giese, T., Endres, S., Wollenberg, B., and Hartmann, G. (2009). Tumour-derived prostaglandin E and transforming growth factor-beta synergize to inhibit plasmacytoid dendritic cell-derived interferon-alpha. Immunology. 128, 439-450.

8. Berger, M., Ablasser, A., Kim, S., Bekeredjian-Ding, I., Giese, T., Endres, S., Hornung, V., and Hartmann, G. (2009). TLR8-driven IL-12-dependent reciprocal and synergistic activation of NK cells and monocytes by immunostimulatory RNA. J Immunother. 32, 262-271.

9. Berthold, H.K., Giannakidou, E., Krone, W., Mantzoros, C.S., and Gouni-Berthold, I. (2009a). The Leu72Met polymorphism of the ghrelin gene is associated with a decreased risk for type 2 diabetes. Clin Chim Acta. 399, 112-116.

10. Berthold, H.K., Giesen, T.A., and Gouni-Berthold, I. (2009b). The stable isotope ketoisocaproic acid breath test as a measure of hepatic decarboxylation capacity: a quantitative analysis in normal subjects after oral and intravenous administration. Liver Int. 29, 1356-1364.

11. Berthold, H.K., Schober, P., Scheurlen, C., Marklein, G., HorrÈ, R., Gouni-Berthold, I., and Sauerbruch, T. (2009c). Use of the lactose-[13C]ureide breath test for diagnosis of small bowel bacterial overgrowth: comparison to the glucose hydrogen breath test. J Gastroenterol. 44, 944-951.

12. Besbas, N., Draaken, M., Ludwig, M., Deren, O., Orhan, D., Bilginer, Y., and Ozaltin, F. (2009). A novel CLCN7 mutation resulting in a most severe form of autosomal recessive osteopetrosis. Eur J Pediatr. 168, 1449-1454.

13. Besch, R., Poeck, H., Hohenauer, T., Senft, D., Häcker, G., Berking, C., Hornung, V., Endres, S., Ruzicka, T., Rothenfusser, S., and Hartmann, G. (2009). Proapoptotic signaling induced by RIG-I and MDA-5 results in type I interferon-independent apoptosis in human melanoma cells. J Clin Invest. 119, 2399-2411.

14. Bourquin, C., Schmidt, L., Lanz, A.L., Storch, B., Wurzenberger, C., Anz, D., Sandholzer, N., Mocikat, R., Berger, M., Poeck, H., et al. (2009). Immunostimulatory RNA oligonucleotides induce an effective antitumoral NK cell response through the TLR7. J Immunol. 183, 6078-6086.

15. Braun, M., Polcher, M., Debald, M., Flucke, U., Walgenbach-Bruenagel, G., Holler, T., Wolfgarten, M., Sauerwald, A., Rudlowski, C., Buttner, R., and Kuhn, W. (2009). Improved detection of Lymphangiinvasion with D2-40 (Podoplanin) in case of gynecologic tumor and breast cancer - is it a time for revaluation of L-Status? Geburtshilfe Frauenheilkd. 69, 767-767.

16. Bökenkamp, A., Böckenhauer, D., Cheong, H.I., Hoppe, B., Tasic, V., Unwin, R., and Ludwig, M. (2009). Dent-2 disease: a mild variant of Lowe syndrome. J Pediatr. 155, 94-99.

17. Clement, A.B., Gamerdinger, M., Tamboli, I.Y., Lütjohann, D., Walter, J., Greeve, I., Gimpl, G., and Behl, C. (2009). Adaptation of neuronal cells to chronic oxidative stress is associated with altered cholesterol and sphingolipid homeostasis and lysosomal function. J Neurochem. 111, 669-682.

18. Coch, C., Busch, N., Wimmenauer, V., Hartmann, E., Janke, M., Abdel-Mottaleb, M.M., Lamprecht, A., Ludwig, J., Barchet, W., Schlee, M., and Hartmann, G. (2009). Higher activation of TLR9 in plasmacytoid dendritic cells by microbial DNA compared with self-DNA based on CpG-specific recognition of phosphodiester DNA. J Leukoc Biol. 86, 663-670.

19. Ebert, A.K., Reutter, H., Ludwig, M., and Rosch, W.H. (2009). The Exstrophy-epispadias complex. Orphanet J Rare Dis. 4, 23-23.

20. Faumont, N., Durand-Panteix, S., Schlee, M., Grömminger, S., Schuhmacher, M., Hölzel, M., Laux, G., Mailhammer, R., Rosenwald, A., Staudt, L.M., et al. (2009). c-Myc and Rel/NF-kappaB are the two master transcriptional systems activated in the latency III program of Epstein-Barr virus-immortalized B cells. J Virol. 83, 5014-5027.

21. García, M., Dogusan, Z., Moore, F., Sato, S., Hartmann, G., Eizirik, D.L., and Rasschaert, J. (2009). Regulation and function of the cytosolic viral RNA sensor RIG-I in pancreatic beta cells. BBA - MOL CELL RES. 1793, 1768-1775.

22. Gross, O., Poeck, H., Bscheider, M., Dostert, C., Hannesschläger, N., Endres, S., Hartmann, G., Tardivel, A., Schweighoffer, E., Tybulewicz, V., et al. (2009). Syk kinase signalling couples to the Nlrp3 inflammasome for anti-fungal host defence. Nature. 459, 433-436.

23. Hartmann, G. (2009). Gene silencing below the immune radar. J Clin Invest. 119, 438-442.

24. Herrera, J., Amigo, L., Husche, C., Benitez, C., Zanlungo, S., Lutjohann, D., Miquel, J.F., and Nervi, F. (2009). Fecal bile acid excretion and messenger RNA expression levels of ileal transporters in high risk gallstone patients. Lipids Health Dis. 8, 53.

25. Hirsch-Reinshagen, V., Donkin, J., Stukas, S., Chan, J., Wilkinson, A., Fan, J., Parks, J.S., Kuivenhoven, J.A., Lütjohann, D., Pritchard, H., and Wellington, C.L. (2009). LCAT synthesized by primary astrocytes esterifies cholesterol on glia-derived lipoproteins. J Lipid Res. 50, 885-893.

26. Hooijmans, C.R., Van der Zee, C.E., Dederen, P.J., Brouwer, K.M., Reijmer, Y.D., van Groen, T., Broersen, L.M., Lütjohann, D., Heerschap, A., and Kiliaan, A.J. (2009). DHA and cholesterol containing diets influence Alzheimer-like pathology, cognition and cerebral vasculature in APPswe/PS1dE9 mice. Neurobiol Dis. 33, 482-498.

27. Hornung, V., Ablasser, A., Charrel-Dennis, M., Bauernfeind, F., Horvath, G., Caffrey, D.R., Latz, E., and Fitzgerald, K.A. (2009). AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC. Nature. 458, 514-518.

28. Janke, M., Poth, J., Wimmenauer, V., Giese, T., Coch, C., Barchet, W., Schlee, M., and Hartmann, G. (2009). Selective and direct activation of human neutrophils but not eosinophils by Toll-like receptor 8. J Allergy Clin Immunol. 123, 1026-1033.

29. Jansen, P.J., Lütjohann, D., Thelen, K.M., von Bergmann, K., van Leuven, F., Ramaekers, F.C., and Monique, M. (2009). Absence of ApoE upregulates murine brain ApoD and ABCA1 levels, but does not affect brain sterol levels, while human ApoE3 and human ApoE4 upregulate brain cholesterol precursor levels. J Alzheimers Dis. 18, 319-329.

30. Karasinska, J.M., Rinninger, F., Lütjohann, D., Ruddle, P., Franciosi, S., Kruit, J.K., Singaraja, R.R., Hirsch-Reinshagen, V., Fan, J., Brunham, L.R., et al. (2009). Specific loss of brain ABCA1 increases brain cholesterol uptake and influences neuronal structure and function. J Neurosci. 29, 3579-3589.

31. Kenny, E.E., Gusev, A., Riegel, K., Lütjohann, D., Lowe, J.K., Salit, J., Maller, J.B., Stoffel, M., Daly, M.J., Altshuler, D.M., et al. (2009). Systematic haplotype analysis resolves a complex plasma plant sterol locus on the Micronesian Island of Kosrae. Proc Natl Acad Sci U S A. 106, 13886-13891.

32. Kohlmeyer, J., Cron, M., Landsberg, J., Bald, T., Renn, M., Mikus, S., Bondong, S., Wikasari, D., Gaffal, E., Hartmann, G., and Tüting, T. (2009). Complete regression of advanced primary and metastatic mouse melanomas following combination chemoimmunotherapy. Cancer Res. 69, 6265-6274.

33. Koschack, J., Lütjohann, D., Schmidt-Samoa, C., and Irle, E. (2009). Serum 24S-hydroxycholesterol and hippocampal size in middle-aged normal individuals. Neurobiol Aging. 30, 898-902.

34. Kristof, R.A., Rother, M., Neuloh, G., and Klingmüller, D. (2009). Incidence, clinical manifestations, and course of water and electrolyte metabolism disturbances following transsphenoidal pituitary adenoma surgery: a prospective observational study. J Neurosurg. 111, 555-562.

35. Kuehnle, K., Ledesma, M.D., Kalvodova, L., Smith, A.E., Crameri, A., Skaanes-Brunner, F., Thelen, K.M., Kulic, L., Lütjohann, D., Heppner, F.L., et al. (2009). Age-dependent increase in desmosterol restores DRM formation and membrane-related functions in cholesterol-free DHCR24-/- mice. Neurochem Res. 34, 1167-1182.

36.Kölsch, H., Lütjohann, D., Jessen, F., Popp, J., Hentschel, F., Kelemen, P., Friedrichs, S., Maier, T.A., and Heun, R. (2009a). RXRA gene variations influence Alzheimer's disease risk and cholesterol metabolism. J Cell Mol Med. 13, 589-598.

37. Kölsch, H., Lütjohann, D., Jessen, F., Popp, J., Hentschel, F., Kelemen, P., Schmitz, S., Maier, W., and Heun, R. (2009b). CYP46A1 variants influence Alzheimer's disease risk and brain cholesterol metabolism. Eur Psychiatry. 24, 183-190.

38.Kübler, K., Klingmüller, D., Gembruch, U., and Merz, W.M. (2009). High-risk pregnancy management in women with hypopituitarism. J Perinatol. 29, 89-95.

39. Lichtnekert, J., Vielhauer, V., Zecher, D., Kulkarni, O.P., Clauss, S., Segerer, S., Hornung, V., Mayadas, T.N., Beutler, B., Akira, S., and Anders, H.J. (2009). Trif is not required for immune complex glomerulonephritis: dying cells activate mesangial cells via Tlr2/Myd88 rather than Tlr3/Trif. Am J Physiol Renal Physiol. 296, F867-874.

40. Ludwig, M., Ching, B., Reutter, H., and Boyadjiev, S.A. (2009a). Bladder exstrophy-epispadias complex. Birth Defects Res A Clin Mol Teratol. 85, 509-522.

41. Ludwig, M., Rüschendorf, F., Saar, K., Hübner, N., Siekmann, L., Boyadjiev, S.A., and Reutter, H. (2009b). Genome-wide linkage scan for bladder exstrophy-epispadias complex. Birth Defects Res A Clin Mol Teratol. 85, 174-178.

42. Lütjohann, D., Marinova, M., Schneider, B., Oldenburg, J., von Bergmann, K., Bieber, T., Björkhem, I., Diczfalusy, U., and Institute of Clinical Chemistry and Pharmacology, I.o.E.H.a.T.M.D.o.H.a.O. (2009). 4beta-hydroxycholesterol as a marker of CYP3A4 inhibition in vivo - effects of itraconazole in man. Int J Clin Pharmacol Ther. 47, 709-715.

43. Merkens, L.S., Jordan, J.M., Penfield, J.A., Lütjohann, D., Connor, W.E., and Steiner, R.D. (2009). Plasma plant sterol levels do not reflect cholesterol absorption in children with Smith-Lemli-Opitz syndrome. J Pediatr. 154, 557-561.e551.

44. Mosig, S., Rennert, K., Buettner, P., Krause, S., Lutjohann, D., Soufi, M., Heller, R., and Funke, H. (2009). Monocytes of patients with familial hypercholesterolemia show alterations in cholesterol metabolism. BMC Med Genomics. 1, 60.

45. Moskau, S., Semmler, A., Stoffel-Wagner, B., and Linnebank, M. (2009). Plasma homocysteine levels after acute stroke and in the convalescent phase. Can J Neurol Sci. 36, 789-790.

46. Ney, J.T., Schmidt, T., Kurts, C., Zhou, Q., Eckert, D., Felsher, D.W., Schorle, H., Knolle, P., Tüting, T., Barchet, W., et al. (2009). Autochthonous liver tumors induce systemic T cell tolerance associated with T cell receptor down-modulation. Hepatology. 49, 471-481.

47. Reinsberg, J., Wegener-Toper, P., van der Ven, K., van der Ven, H., and Klingmueller, D. (2009). Effect of mono-(2-ethylhexyl) phthalate on steroid production of human granulosa cells. Toxicol Appl Pharmacol. 239, 116-123.

48. Reutter, H., Bökenkamp, A., Ebert, A.K., Rösch, W., Boemers, T.M., Nöthen, M.M., and Ludwig, M. (2009). Possible association of Down syndrome and exstrophy-epispadias complex: report of two new cases and review of the literature. Eur J Pediatr. 168, 881-883.

49. Roth, C.L., Ludwig, M., Woelfle, J., Fan, Z.C., Brumm, H., Biebermann, H., and Tao, Y.X. (2009). A novel melanocortin-4 receptor gene mutation in a female patient with severe childhood obesity. Endocrine. 36, 52-59.

50. Schiepers, O.J., de Groot, R.H., van Boxtel, M.P., Jolles, J., de Jong, A., Lütjohann, D., Plat, J., and Mensink, R.P. (2009). Consuming functional foods enriched with plant sterol or stanol esters for 85 weeks does not affect neurocognitive functioning or mood in statin-treated hypercholesterolemic individuals. J Nutr. 139, 1368-1373.

51. Schlee, M., Hartmann, E., Coch, C., Wimmenauer, V., Janke, M., Barchet, W., and Hartmann, G. (2009a). Approaching the RNA ligand for RIG-I? Immunol Rev. 227, 66-74.

52. Schlee, M., Roth, A., Hornung, V., Hagmann, C.A., Wimmenauer, V., Barchet, W., Coch, C., Janke, M., Mihailovic, A., Wardle, G., et al. (2009b). Recognition of 5' triphosphate by RIG-I helicase requires short blunt double-stranded RNA as contained in panhandle of negative-strand virus. Immunity. 31, 25-34.

53. Schr¯der, M., Fricke, C., Pilegaard, K., Poulsen, M., Wester, I., Lütjohann, D., and Mortensen, A. (2009). Effect of rapeseed oil-derived plant sterol and stanol esters on atherosclerosis parameters in cholesterol-challenged heterozygous Watanabe heritable hyperlipidaemic rabbits. Br J Nutr. 102, 1740-1751.

54. Semmler, A., Moskau, S., Stoffel-Wagner, B., Weller, M., and Linnebank, M. (2009). The effect of MTHFR c.677C>T on plasma homocysteine levels depends on health, age and smoking. Clin Invest Med. 32, E310.

55. Sethi, S.K., Ludwig, M., Kabra, M., Hari, P., and Bagga, A. (2009). Vitamin A responsive night blindness in Dent's disease. Pediatr Nephrol. 24, 1765-1770.

56. Siekmann, L. (2009). Implementation of the concept of traceability in laboratory medicine in external quality assessment. Clin Biochem. 42, 293-294.

57. Sudhop, T., Reber, M., Tribble, D., Sapre, A., Taggart, W., Gibbons, P., Musliner, T., von Bergmann, K., and Lütjohann, D. (2009). Changes in cholesterol absorption and cholesterol synthesis caused by ezetimibe and/or simvastatin in men. J Lipid Res. 50, 2117-2123.

58. Tomalik-Scharte, D., Lütjohann, D., Doroshyenko, O., Frank, D., Jetter, A., and Fuhr, U. (2009). Plasma 4beta-hydroxycholesterol: an endogenous CYP3A metric? Clin Pharmacol Ther. 86, 147-153.

59. Utsch, B., Brun-Heath, I., Staatz, G., Gravou-Apostolatou, C., Karle, S., Jacobs, U., Ludwig, M., Zenker, M., Dörr, H.G., Rascher, W., et al. (2009). Infantile hypophosphatasia due to a new compound heterozygous TNSALP mutation - functional evidence for a hydrophobic side-chain? Exp Clin Endocrinol Diabetes. 117, 28-33.

60. van den Kommer, T.N., Dik, M.G., Comijs, H.C., Fassbender, K., Lütjohann, D., and Jonker, C. (2009). Total cholesterol and oxysterols: early markers for cognitive decline in elderly? Neurobiol Aging. 30, 534-545.

61. Weingärtner, O., Weingärtner, N., Scheller, B., Lütjohann, D., Gräber, S., Schäfers, H.J., Böhm, M., and Laufs, U. (2009). Alterations in cholesterol homeostasis are associated with coronary heart disease in patients with aortic stenosis. Coron Artery Dis. 20, 376-382.