Neural Development Group - Publications


Koch, P., Ladewig, J. “A little bit of guidance: Mini brains on their route to adolescence” Cell Stem Cell. 2017 Aug 3;21(2):157-158. doi: 10.1016/j.stem.2017.07.001. (2017)

Iefremova, V., Manikakis, G., Krefft, O., Jabali, A., Weynans, K., Wilkens, R., Marsoner, F., Brändl, B., Müller, F.-J., Koch, P., Ladewig, J. “An organoid-based model of cortical development identifies non-cell-autonomous defects in Wnt signaling contributing to Miller-Dieker Syndrome” Cell Reports. 2017 April 4;19(1):50–59. DOI: (2017)

Weick, J.P., Meyer, J.S., Ladewig, J., Guo, W., Liu, Y. “Modeling CNS development and disease” Stem Cells Int. 2016;2016:3241057. doi: 10.1155/2016/3241057. Epub 2016 Aug 24. (2016)

Doerr, J., Böckenhoff, A., Ewald, B., Ladewig, J., Eckhardt, M., Gieselmann, V., Matzner, U., Brüstle, O.*, Koch, P.* “Arylsulfatase A overexpressing human iPSC-derived neural cells reduce CNS sulfatide storage in a mouse model of metachromatic leukodystrophy” Mol Ther. 2015 Sep;23(9):1519-1531. doi: 10.1038/mt.2015.106. Epub 2015 Jun 10. (2015)

Ladewig, J., Koch, P., Brüstle, O. “In vitro migration assays for neural stem cells, intermediate neurogenic progenitors and immature neurons” Bio-Protocol Jan 05 2015;5(1). (2015)

Ladewig, J.*, Koch, P.*, Brüstle, O. “Auto-attraction of neural precursors and their neuronal progeny impairs neuronal migration” Nature Neuroscience 17(1):24-6. doi: 10.1038/nn.3583. Epub 2013 Nov 17. (2014) (IF: 15.251)

Ladewig, J.*, Koch, P.*, Brüstle, O. “Leveling Waddington: The Emergence of Direct Programming and the Loss of Cell Fate Hierarchies” Nature Reviews Molecular Cell Biology 14(4):225-236 (2013) (IF: 39,123)

Mertens, J., Stüber, K., Wunderlich, P., Ladewig, J., Vandenberghe, R., Vandenbulcke, M., van Damme, P., Walter, J., Brüstle, O*., and Koch, P*. “APP Processing in Human Pluripotent Stem Cell-Derived Neurons is Resistant to NSAID-based γ-Secretase Modulation” Stem Cell Reports 1(6):491-8. doi: 10.1016/j.stemcr.2013.10.011. (2013) (IF: no IF yet)

Mertens, J., Stüber, K., Poppe, D., Doerr, J., Ladewig, J., Brüstle, O.*, Koch, P.*
„Embryonic stem cell-based modeling of tau pathology in human neurons“
Am J Pathol 182(5):1769-1779 (2013) (IF: 5.224)

Koch, P., Taboli, I., Mertens, J., Ladewig, J., Stüber, K., Brüstle., O., Walter, J. “Presenilin-1 L166P Mutant Human Pluripotent Stem Cell-Derived Neurons Exhibit Partial Loss of γ-Secretase Activity in Endogenous Amyloid-ß Generation” Am J Pathol. 180(6):2404-2416 (2012) (IF: 5.224)

Ladewig, J., Mertens, J.*, Kesavan, J.*, Doerr, J., Poppe, D., Glaua, F., Herms, S., Wernet, P., Kögler, G., Müller, F.-J., Koch, P.*, Brüstle, O.* (2012) “Small molecules enable highly efficient neuronal conversion of human fibroblast” Nature Methods 9(6):575-578 (2012) (IF: 23.565)

Oki, K.*, Tatarishvili, J*, Wood, J*, Koch,  P*, Mine, Y., Monni, E., Wattanati, S., Ladewig, J., Brüstle, O., Lindvall, O., Zaal, K. “Human induced pluripotent stem cells form functionally integrated neurons and improve recovery after transplantation in stroke-damaged rodent brain” (*equal contribution) Stem Cells. Apr 11. doi: 10.1002/stem.1104. (2012) (IF: 7.871)

Falk, A.*, Koch, P.*, Kesavan, J., Takashima, Y., Ladewig, J., Alexander, M., Smith, A., Brüstle, O. “Capture of neuroepithelial-like stem cells from pluripotent stem cellsprovides a versatile system for in vitro production of human neurons” PLoS One 7(1):e29597. (2012) (IF: 4.411)

Koch, P., Breuer, P., Peitz, M., Jungverdorben, J., Kesavan, J., Poppe, D., Doerr, J., Ladewig, J., Mertens, J., Tüting, T., Hoffmann, P., Klockgether, T., Evert, B.O., Wüllner, U., Brüstle, O. “Excitation-induced ataxin-3 aggregation in neurons from patients with Machado-Joseph disease.” Nature. Nov 23;480(7378):543-6. (2011) (IF: 38.597)

Koch, P., Opitz, T., Steinbeck, J., Ladewig, J., Brüstle, O. “A rosette-type, self-renewing human ES cell-derived neural stem cell with potential for in vitro instruction and synaptic integration” Proc Natl Acad Sci U S A. Mar 3;106(9):3225-30. (2009) (IF: 9.971)

Ladewig, J*., Koch, P.*., Endl, E., Meiners, B., Opitz, T., Couillard-Despres, S., Aigner, L., Brüstle, O. “Lineage selection of functional and cryopreservable human embryonic stem cell-derived neurons” (* equal contribution) Stem Cells. Jul;26(7):1705-12. (2008) (IF: 7.871)