Neural Regeneration Group - Publications

 

2017-2016

Intramembranous processing by γ-secretase regulates reverse signaling of ephrin-B2 in migration of microglia.
Kemmerling N, Wunderlich P, Theil S, Linnartz-Gerlach B, Hersch N, Hoffmann B, Heneka MT, de Strooper B, Neumann H, Walter J. Glia. 2017 Jul;65(7):1103-1118.

Polysialic acid production using Escherichia coli K1 in a disposable bag reactor.
de Vries I, Busse Ch, Kopatz J, Neumann H, Beutel S, Scheper T.
Eng. Life Sci., 17: 723–731.

Polysialic acid blocks mononuclear phagocyte reactivity, inhibits complement activation and protects from vascular damage in the retina.
Karlstetter M, Kopatz J, Aslanidis A, Shahraz A, Caramoy A, Linnartz-Gerlach B, Lin Y, Lückoff A, Fauser S, Düker K, Claude J, Wang Y, Ackermann J, Schmidt T, Hornung V, Skerka C, Langmann T and Neumann H
EMBO Mol Med. 2017 Feb;9(2):154-166.

Age-related macular degeneration associated polymorphism rs10490924 in ARMS2 results in deficiency of a complement activator.
Micklisch S, Lin Y, Jacob S, Karlstetter M, Dannhausen K, Dasari P,  von der Heide M, Dahse H-M, Schmoelz L, Grassmann F, Alene M, Fauser S, Neumann H, Lorkowski S, Pauly D, Weber B, Joussen A, Langmann T, Zipfel P, Skerka C.
Journal of Neuroinflammation, 2017 Jan 5;14(1):4. doi: 10.1186/s12974-016-0776-3.

Polysialylation and lipopolysaccharide-induced shedding of E-selectin ligand-1 and neuropilin-2 by microglia and THP-1macrophages
Werneburg S, Buettner FFR, Erben L, Mathews M, Neumann H, Mühlenhoff M, Hildebrandt H.
Glia, 2016, Aug;64(8):1314-30. doi: 10.1002/glia.23004. Epub 2016 May 9.

Characterization of inflammatory markers and transcriptome profiles of differentially activated embryonic stem cell-derived microglia.
Beins E, Ulas T, Ternes S, Neumann H, Schultze JL, Zimmer A.
Glia. 2016 Jun;64(6):1007-20. doi: 10.1002/glia.22979. Epub 2016 Mar 9.

Loss of the smallest subunit of cytochrome c oxidase, COX8A, causes Leigh-like syndrome and epilepsy.
Hallmann K, Kudin AP, Zsurka G, Kornblum C, Reimann J, Stüve B, Waltz S, Hattingen E, Thiele H, Nürnberg P, Rüb C, Voos W, Kopatz J, Neumann H and Kunz WS.
Brain. 2016 Feb;139(Pt 2):338-45. doi: 10.1093/brain/awv357. Epub 2015 Dec 17.

 

2015-2013

Anti-inflammatory activity of low molecular weight polysialic acid on human macrophages.
Shahraz A, Kopatz J, Mathy R, Kappler J, Winter D, Kapoor S, Schütza V, Scheper T, Gieselmann V and Neumann H.
Sci Rep. 2015 Nov 19;5:16800. doi: 10.1038/srep16800.

Sialylation of neurites inhibits complement-mediated macrophage removal in a human macrophage-neuron coculture system.
Linnartz-Gerlach B, Schuy C, Shahraz A, Tenner AJ, and Neumann H.
Glia. 2015 Aug 10. doi: 10.1002/glia.22901. [Epub ahead of print]

Activated Microglia/Macrophage Whey Acidic Protein (AMWAP) inhibits NFκB signaling and induces a neuroprotective phenotype in microglia.
Aslanidis A, Karlstetter M, Scholz R, Fauser S, Neumann H, Fried C, Pietsch M, and Langmann T
J Neuroinflammation. 2015 Apr 19;12:77.

CXCL10 Triggers Early Microglial Activation in the Cuprizone Model.
Clarner T, Janssen K, Nellessen L, Stangel M, Skripuletz T, Krauspe B, Hess FM, Denecke B, Beutner C, Linnartz-Gerlach B, Neumann H, Vallières L, Amor S, Ohl K, Tenbrock K, Beyer C, Kipp M.
J Immunol. 2015 Apr 1;194(7):3400-13. doi: 10.4049/jimmunol.1401459. Epub 2015 Feb 27.

Siglec functions of microglia.
Linnartz-Gerlach B, Kopatz J and Neumann H. (2014).
Glycobiology. 2014 Sep;24(9):794-9. doi: 10.1093/glycob/cwu044. Epub 2014 May 15.

Neurodegeneration by activation of the microglial complement-phagosome pathway.
Bodea LG, Wang Y, Linnartz-Gerlach B, Kopatz J, Sinkkonen L, Musgrove R, Kaoma T, Muller A, Vallar L, Di Monte DA, Balling R and Neumann H. (2014).
J Neurosci. 2014 Jun 18;34(25):8546-56. doi: 10.1523/JNEUROSCI.5002-13.2014.

Sensing the neuronal glycocalyx by glial sialic acid binding immunoglobulin-like lectins.
Linnartz-Gerlach B, Mathews M and Neumann H. (2014).
Neuroscience. 2014 Sep 5;275:113-24. doi: 10.1016/j.neuroscience.2014.05.061. Epub 2014 Jun 9.

Translocator protein (18 kDa) (TSPO) is expressed on reactive retinal microglia and modulates microglial inflammation and phagocytosis.
Karlstetter M, Nothdurfter C, Aslanidis A, Moeller K, Horn F, Scholz R, Neumann H, Weber B HF, Rupprecht R and Langmann T. (2014).
J Neuroinflammation. 2014 Jan 8;11:3. doi: 10.1186/1742-2094-11-3.

Microglial CD33-related Siglec-E inhibits neurotoxicity by preventing the phagocytosis associated oxidative burst.
Claude J, Linnartz-Gerlach B, Kudin AP, Kunz WS and Neumann H. (2013).
J Neurosci. 2013 Nov 13;33(46):18270-6. doi: 10.1523/JNEUROSCI.2211-13.2013.

Sequential proteolytic processing of the triggering receptor expressed on myeloid cells-2 (TREM2) by ectodomain shedding and γ-secretase dependent intramembranous cleavage.
Wunderlich P, Glebov K, Kemmerling N, Tien NT, Neumann H and Walter J. (2013).
J Biol Chem. 2013 Nov 15;288(46):33027-36. doi: 10.1074/jbc.M113.517540

Unique transcriptome signature of mouse microglia.
Beutner C*, Linnartz-Gerlach B*, Schmidt SV, Beyer M, Mallmann MR, Staratschek-Jox A, Schultze JL and Neumann H. (2013). *co-first.
Glia. 2013 Sep;61(9):1429-42. doi: 10.1002/glia.22524

Integrated systems approach identifies genetic nodes and networks in late-onset Alzheimer's disease.
Zhang B*, Gaiteri C*, Bodea LG*, Wang Z, McElwee J, Podtelezhnikov AA, Zhang C, Xie T, Tran L, Dobrin R, Fluder E, Clurman B, Melquist S, Narayanan M, Suver C, Shah H, Mahajan M, Gillis T, Mysore J, MacDonald ME, Lamb JR, Bennett DA, Molony C, Stone DJ, Gudnason V, Myers AJ, Schadt EE, Neumann H, Zhu J and Emilsson V. (2013).
Cell. 2013 Apr 25;153(3):707-20. doi: 10.1016/j.cell.2013.03.030.

Siglec-h on Activated Microglia for Recognition and Engulfment of Glioma Cells.
Kopatz J*, Beutner C*, Welle K, Bodea LG, Reinhardt J, Claude J, Linnartz-Gerlach B and Neumann H. (2013). *co-first.
Glia. 2013 Jul;61(7):1122-33. doi: 10.1002/glia.22501. Epub 2013 Apr 30.

Brain microglia: watchdogs with pedigree.
Neumann H and Wekerle H. (2013).
Nat Neurosci. 2013 Mar;16(3):253-5. doi: 10.1038/nn.3338.

Engineered stem cell-derived microglia as therapeutic vehicle for experimental autoimmune encephalomyelitis.
Beutner C, Lepperhof V, Dann A, Linnartz-Gerlach B, Litwak S, Napoli I, Prinz M and Neumann H. (2013)
.
Gene Ther. 2013 Aug;20(8):797-806. doi: 10.1038/gt.2012.100.

Targeting the cytosolic innate immune receptors RIG-I and MDA5 effectively counteracts cancer cell heterogeneity in glioblastoma.
Glas M, Coch C, Trageser D, Simon M, Koch P, Mertens J, Quandel T, Lüdenbach B, Daßler J, Lünskens R, Reinartz R, Wieland A, Eisenreich R, Höfer H,, Keller M, von Lehe M, Pusch A, Schlee M, Neumann H, Fimmers R, Herrlinger U, Brüstle O, Besch R, Hartmann G and Scheffler B. (2013).
Stem Cells, 2013 Jun;31(6):1064-74. doi: 10.1002/stem.1350.

Attenuated inflammatory response in Triggering receptor expressed on myeloid cells 2 (TREM2) knock-out mice following stroke.

Sieber MW, Jaenisch N, Brehm M, Guenther M, Linnartz-Gerlach B, Neumann H, Witte OW and Frahm C. (2013).
PLoS One 2013; 8(1): e52982. doi:10.1371/journal.pone.0052982

Janus-faced microglia: beneficial and detrimental consequences of microglial phagocytosis.
Sierra A, Abiega O, Shahraz A and Neumann H. (2013).
Front Cell Neurosci. 2013 Jan 30;7:6. doi: 10.3389/fncel.2013.00006. Epub 2013 Jan 30.

Microglial activatory (immunoreceptor tyrosine-based activation motif)- and inhibitory (immunoreceptor tyrosine-based inhibition motif)-signaling receptors for recognition of the neuronal glycocalyx.
Linnartz B and Neumann H. (2013).
Glia. 2013 Jan;61(1):37-46. doi: 10.1002/glia.22359. Epub 2012 May 21. Review.

Variant TREM2 as risk factor for Alzheimer's disease.
Neumann H and Daly MJ. (2013).
N Engl J Med. 2013 Jan 10;368(2):182-4. doi: 10.1056/NEJMe1213157. Epub 2012 Nov 14.

 

2012-2010

Microglial carbohydrate binding receptors for neural repair.
Linnartz B, Bodea, LG and Neumann H. (2012).
Cell Tissue Res. 2012 Jul;349(1):215-27.

Licensing of myeloid cells promotes central nervous system autoimmunity and is controlled by PPARγ.
Hucke S, Floßdorf J, Grützke B, Dunay IR, Frenzel K, Jungverdorben J, Linnartz B, Mack M, M. Peitz, Brüstle O, Kurts C, Klockgether T, Neumann H, Prinz M, Knolle P and Klotz L. (2012).
Brain 2012 May;135(Pt 5):1586-605.

Sialic acid on the neuronal glycocalyx prevents complement C1 binding and complement receptor-3 mediated removal by microglia.
Linnartz B, Kopatz J, Tenner AJ and Neumann H. (2012).
J. Neurosci. 32(3):946-952.

Perspectives of Stem Cell-Derived Microglia for Medicine.
Roy K, Beutner C and Neumann H. (2011).
Book chapter in: Embryonic Stem Cells - Recent Advances in Pluripotent Stem Cell-Based Regenerative Medicine, ISBN 978-953-307-198-5, Edited by: Craig Atwood, Publisher: InTech, April 2011.

Immune-mediated CNS damage.
Kierdorf K, Wang Y and Neumann H. (2010).
Results Probl Cell Differ. 2010;51:173-196.

Spatially pathogenic forms of tau detected in Alzheimer's disease brain tissue by fluorescence lifetime-based Förster resonance energy transfer.
Larionov S, Wielgat P, Wang Y, Thal RD and Neumann H. (2010).
J Neurosci Methods. Sep 30;192(1):127-37.

Dual induction of TREM2 and tolerance-related transcript, Tmem176b, in amyloid transgenic mice: implications for vaccine-based therapies for Alzheimer’s disease.
Melchior B, Garcia AE, Hsiung B-K, Lo KM, Doose JM, Thrash JC, Stalder AK, Staufenbiel M., Neumann H and Carson MJ. (2010).
ASN NEURO 2(3):art:e00037.doi:10.1042/AN20100010

Functional role of brain derived neurotrophic factor in neuroprotective autoimmunity: therapeutic implications in a model of multiple sclerosis.
Linker RA, Lee D-H, Cetin S, Wiese S, Kruse N, Siglienti I, Gerhardt E, Neumann H, Sendtner M, Lühder F and Gold R. (2010).
Brain. 2010 Aug;133(Pt 8):2248-63.

Microglial immunoreceptor tyrosine-based activation and inhibition motif (ITAM/ITIM) signaling in neuroinflammation.
Linnartz B, Wang Y and Neumann H. (2010). Review.
International Journal of Alzheimer’s disease, Volume 2010, Article ID 587463, doi:10.4061/2010/587463.

Generation of microglial cells from mouse embryonic stem cells.
Beutner C, Roy K, Linnartz B, Napoli I and Neumann H. (2010).
Nat Protoc. 2010 Sep;5(9):1481-94.


Immunoregulatory neuroprotection of cerebral ischaemia by haematopoietic stem and precursor cells.
Schwarting S and Neumann H. (2010). Review.
EU Neurological Review 4 (2): 42-45.

Alleviation of neurotoxicity by microglial human Siglec-11.
Wang Y and Neumann H. (2010).
J. Neurosci., 30(9):3482–3488.

Protective effects of microglia in multiple sclerosis.
Napoli I and Neumann H. (2010).
Exp Neurol 225(1):24-28.


2009-2007

Role of microglia in neuronal degeneration and regeneration.
Walter L, Neumann H. (2009).
Semin. Immunopath., Sep 9. [Epub ahead of print] doi: 10.1007/s00281-009-0180-5.

Signal regulatory protein-β1: a microglial modulator of phagocytosis in Alzheimer’s disease.
Gaikwad S, Larionov S, Wang Y, Dannenberg H, Matozaki T, Monsonego A, Thal DR and Neumann H. (2009).
Am. J. of Pathology, Dec;175(6):2528-39. Epub 2009 Nov 5.

Wild-type Cu/Zn superoxide dismutase (SOD1) does not facilitate, but impedes the formation of protein aggregates of amyotrophic lateral sclerosis causing mutant SOD1.
Witan H, Gorlovoy P, Kaya AM, Koziollek-Drechsler I, Neumann H, Behl C, Clement AM (2009).
Neurobiol. of Disease, Nov;36(2):331-42. Epub 2009 Aug 4.

Microglial precursors derived from mouse embryonic stem cells.
Napoli I, Kierdorf K, Neumann H. (2009)
GLIA, Nov 15;57(15):1660-71. Epub 2009 May 19.

Accumulation of tau induced in neurites by microglial proinflammatory mediators.
Gorlovoy P, Larionov S, Pham TT, Neumann H. (2009)
FASEB J. Aug;23(8):2502-13. Epub 2009 Mar 16.

Microglial clearance function in health and disease.
Napoli, I., Neumann, H. (2009)
Neuroscience. Feb 6;158(3):1030-8. Epub 2008 Jul 1.

Debris clearance by microglia: an essential link between degeneration and regeneration.
Neumann H, Kotter MR, Franklin RJ (2009)
Brain. Feb;132(Pt 2):288-95. Epub 2008 Jun 20.

Hematopoietic stem cells reduce postischemic inflammation and ameliorate ischemic brain injury.
Schwarting S., Litwak S., Hao W., Bähr M., Weise J. and Neumann H. (2008)
Stroke. Oct;39(10):2867-75. Epub 2008 Jul 24.

Neuronal 'On' and 'Off' signals control microglia.
Biber K., Neumann H., Inoue K., Boddeke H.(2007)
Trends Neurosci., Nov;30(11):596-602. Epub 2007 Oct 24.

Brain endothelial PPARγ controls inflammation-induced CD4+ T cell adhesion and transmigration in vitro.
Klotz L., Diehl L., Dani I., Neumann H., von Oppen N., Dolf A., Endl E., Klockgether T., Engelhardt B. and Knolle P. (2007)
J. Neuroimmunol., Oct;190(1-2):34-43.

A retroviral packaging cell line for pseudotype vectors based on glioma-infiltrating progenitor cells.
Fischer Y.H., Miletic H., Giroglou T., Litwak S., Stenzel W., Neumann H. and von Laer D. (2007)
J. of Gene Med. 9(5):335-44.

Bystander Killing of Malignant Glioma by Bone Marrow-Derived Tumor Infiltrating Progenitor Cells Expressing a Suicide Gene.
Miletic H., Fischer Y., Litwak S., Giroglou T., Waerzeggers Y., Winkeler S., Li H., Himmelreich U., Stenzel W., Deckert M., Lange C., Neumann H., Jacobs AH. and von Laer D. (2007)
Mol. Ther. 15(7):1373-81

TREM2-transduced myeloid precursors mediate nervous tissue debris clearance and facilitate recovery in an animal model of multiple sclerosis.
Takahashi K., Prinz M., Stagi M., Chechneva O., and Neumann H. (2007)
PLoS Med. Apr;4(4):e124.

Essential role of the microglial triggering receptor expressed on myeloid cells-2 (TREM2) for central nervous tissue immune homeostasis.
Neumann H. and Takahashi K. (2007)
J of Neuroimmunology, 184:92-9


2006 - 2004

Suppression of microglial inflammatory activity by myelin phagocytosis: role of p47-PHOX-mediated generation of reactive oxygen species.
Liu Y., Hao W., Letiembre M., Walter S., Kulanga M., Neumann H. and Fassbender K.(2006).
J. Neurosci. 26(50):12904-13.

Unloading kinesin transported cargoes from the tubulin track via the inflammatory c-Jun N-terminal kinase pathway.
Stagi M., Gorlovoy P., Larinov S., Takahashi K. and Neumann H. (2006). FASEB J. 20(14):2573-5;[Epub ahead of print:2006 Oct 26].

Microglia: a cellular vehicle for CNS gene therapy.
Neumann H. (2006). J Clin Invest.116(11):2857-60 (invited commentary).

LPS receptor (CD14): a receptor for phagocytosis of Alzheimer’s amyloid peptide.
Liu Y., Walter S., Stagi M., Cherny D., Letiembre M., Schulz-Schaeffer W., Heine H., Penke B., Neumann H. and Fassbender K. (2005). Brain, 128(Pt 8):1778-89.

Clearance of apoptotic neurons without inflammation by microglial triggering receptor expressed on myeloid cells-2.
Takahashi K., Rochford C.D. and Neumann H. (2005). J. Exp. Med., 201(4): 647-57.

Breakdown of axonal synaptic vesicle precursor transport by microglial nitric oxide.
Stagi M., Dittrich P., Frank N., Iliev A., Schwille P. and Neumann H. (2005). J.Neurosci., 25(2): 352-62.

Selective transduction of malignant glioma by lentiviral vectors pseudotyped with LCMV glycoproteins.
Miletic H., Fischer Y., Neumann H., Hans V., Stenzel W., Giroglou T., Deckert M. and von Laer D. (2004). Hum. Gene Therapy 15 (11):1091-100.

Neuronal injury mediated via stimulation of microglial toll-like receptor-9 (TLR9).
Iliev, A., Stringaris, A.K., Nau, R. and Neumann,H. (2004). FASEB J. 18, 412-414.


2003 - 2001

Microglia: The enemy within?.
Kempermann. G., Neumann, H. (2003). Science 302, 1689-1690 (Perspective).

Molecular mechanisms of axonal damage in inflammatory central nervous system diseases.
Neumann H. (2003). Curr. Opin. Neurology, 16: 267-273 (Review).

Cytotoxic T lymphocytes in autoimmune and degenerative CNS diseases.
Neumann H., Medana I., Bauer J., Lassmann H. (2002). Trends in Neurosci. 25 (6), 313-319 (Review).

Tumor necrosis factor inhibits neurite outgrowth and branching of hippocampal neurons by a Rho-dependent mechanism.
Neumann,H., Schweigreiter,R., Yamashita,T., Rosenkranz,K., Wekerle,H. and Barde,Y.-A. (2002). J. Neurosci. 22, 854-862.

Transection of major histocompatibiltiy class I-induced neurites by cytotoxic T lymphocytes.
Medana,I., Martinic, M.M.A., Wekerle,H. and Neumann,H. (2001). Am. J. Pathol. 159, 809-815.

Control of glial immune function by neurons.
Neumann,H. (2001). Glia, 36, 191-199 (Review).

Fas Ligand (CD95L) protects neurons against perforin-mediated T lymphocyte cytotoxicity.
Medana,I., Li,Z., Flügel,A., Tschopp,J., Wekerle,H., and Neumann,H. (2001). J. Immunol. 167, 674-681.


2000 - 1998

Anti-inflammatory activity of nerve growth factor in experimental autoimmune encephalomyelitis:Inhibition of monocyte transendothelium migration.
Flügel,A., Matsumuro K., Neumann H., Klinkert, W.E.F., Birnbacher,R., Lassmann,H., Otten,U. and Wekerle H. (2000). Eur. J. Immunol.31,11-22.

Neuronal FasL induces cell death of encephalitogenic T lymphocytes.
Flügel A., Schwaiger F.-W., Neumann H., Medana I., Willem M., Wekerle H., Kreutzberg G.W., Graeber M.B. (2000). Brain Pathol. 10,353-364.

MHC class I-restricted killing of neurons by virus specific CD8+ T lymphocytes is effected through the Fas/FasL, but not the perforin
pathway.
Medana I., Gallimore A., Oxenius A. Martinic M. Wekerle H. and Neumann H. (2000). Eur. J. Immunol. 30, 3623-3633.

Neurotrophins inhibit major histocompatibility class II inducibility of microglia: Involvement of the p75 neurotrophin receptor.
Neumann H., Misgeld T., Matsumuro K. and Wekerle H. (1998). Proc. Natl. Acad. Sci. USA. 95: 5779-5784.

Neuronal control of the immune response in the central nervous system: Linking brain immunity to neurodegeneration.
Neumann H. and Wekerle H. (1998). J. Neuropath. Exp. Neurol. 57(1): 1-9 (Review).

Immune surveillance in the injured nervous system: T-lymphocytes invade the axotomized mouse facial motor nucleus and aggregate around sites of neuronal degeneration.
Raivich G., Jones L.L., Kloss C.U.A., Werner A., Neumann H. and Kreutzberg G.W. (1998). J. Neurosci. 18 (15): 5804-5816.


1997 - 1995

Major histocompatibility complex (MHC) class I gene expression in single neurons of the central nervous system:Differential regulation by interferon (IFN)-gamma and tumor necrosis factor (TNF)-alpha.
Neumann H., Schmidt H., Cavalié A., Jenne D. and Wekerle H. (1997). J. Exp. Med. 185 (2): 305-316.

Interferon- gamma gene expression in sensory neurons: Evidence for autocrine gene regulation.
Neumann H., Schmidt H., Wilharm E., Behrens L. and Wekerle H. (1997). J. Exp. Med. 186 (12): 2023-2031.

Neuronal control of MHC class II inducibility in astrocytes and microglia.
Neumann H., Boucraut J., Hahnel Ch., Misgeld T. and Wekerle H. (1996). Eur. J. Neurosci. 8: 2582-2590.

Induction of MHC class I genes in neurons.
Neumann H., Cavalié A., Jenne D. and Wekerle H. (1995). Science 269:549-552.

Constitutive NF-kB activity in neurons.
Kaltschmidt Ch., Kaltschmidt B., Neumann H., Wekerle H. and Baeuerle P. (1994). Mol. Cell. Biol. 14:3981-3992.