Publications 2009-2002


Anastassiadis K., Fu J., Patsch C., Hu S., Weidlich S., Duerschke K., Buchholz F., Edenhofer F., Stewart A.F. (2009)
Dre recombinase, like Cre, is a highly efficient site-specific recombinase in E. coli, mammalian cells and mice
Dis Model Mech 2(9-10):508-515

Andrews, P.W., Arias-Diaz, J., Auerbach, J., lvarez, M., Ahrlund-Richter, L., Baker, D., Benvenisty, N., Ben-Josef, D., Blin, G., Borghese, L., Borstlap, J., Bruce, K., Brüstle, O., Buckle, R., Carter, P., Camby, C., Choo, A., Chen, W., Collins, D., Colman, A., Crombie, C., Crook, J., Cypess, R., De Sousa, P., Dhawan, J., Douay, L., Dvorak, P., Dyke, T., Eriksson, L., Firpo, M., Fitzgerald, C., Glover, C., Gokhale, P., Greene, M., Ha, H.-Y., Hampl, A., Healy, L., Hei, D., Holm, F., Hovatta, O., Hunt, C., Hwang, S.-M., Inamdar, M., Isasi, R., Iskovitz-Eldor, J., Jessie, N., Kim, D.-W., Kirzner, R., Kitpongsang, S., Knowles, B., Kuo, H.-C., Laughlin, M., Lavon, N., Ludwig, T., Lakov, M., Lee, D.-R., Macauley, J., McKay, R., Menasche, P., Menendez, P., Michalska, A., Mileikovskaia, M., Minger, S., Mishra, G., Moody, J., Montgomery, K., Morris, C., Mummery, C., Nagy, A., Nakamura, Y., Nakatsuji, N., Nishikawa, S.-I., Nierras, C., Oh, S., Oh, S.K., Olson, P., Otonkoski, T., Patole, M., Park, H.S., Pei, X., Pera, M., Puceat, M. Rajala, K., Reubinoff, B., Robbins, A., Rooke, H., Rumayor, V., Scotmann, H., Sherlock, J., Simon, C., Stacey, G., Sipp, D., Skinner, R., Smith, D., Stefanovic, S., Strehl, R., Taft, R., Takahashi, T., Talib, S., Terstegge, S., Turner, R., Tuuri, T., Yu, J., Zandstra, P., Zapata, A., Zeng, F., Zhou, Q. (2009)
Consensus guidance for banking and supply of human embryonic stem cell lines for research purposes. International Cell Banking Initiative
Stem Cell Rev Rep 5:301-314

Bosnali, M., Münst, B., Thier M., Edenhofer, F. (2009)
Deciphering the stem cell machinery as a basis for understanding reprogramming
Cell Mol Life Sci 66(21):3403-3420

Capasso, P., Aliprandi, M., Ossolengo, G., Edenhofer, F., de Marco, A. (2009)
Monodispersity of recombinant Cre recombinase correlates with its effectiveness in vivo
BMC Biotechnol 9:80

Corsini, N.S., Sancho-Martinez, I., Laudenklos, S., Glagow, D., Kumar, S., Letellier, E., Koch, P., Teodorczyk, M., Kleber, S., Klussmann, S., Wiestler. B., Brüstle, O., Müller, W., Gieffers, C., Hill, O., Thiemann, M., Seedorf, M., Gretz, N., Sprengel, R., Celikel, T., Martin-Villalba, A. (2009)
The death receptor CD95 activates adult neural stem cells for working memory formation and brain repair
Cell Stem Cell 5(2):178-190

Gaikwad, S., Larionov, S., Wang, Y., Dannenberg, H., Matozaki, T., Monsonego, A., Thal, D.R., Neumann, H. (2009)
Signal regulatory protein-β1: a microglial modulator of phagocytosis in Alzheimer’s disease
Am J Pathol 175(6):2528-2539

Gorlovoy, P., Larionov, S., Pham, T.T., Neumann, H. (2009)
Accumulation of tau induced in neurites by microglial proinflammatory mediators
FASEB J 23(8):2502-2513

Hammond, R., Blaess, S., Abeliovich, A. (2009)
Sonic hedgehog is a chemoattractant for midbrain dopaminergic axons
PLoS ONE. 2009 4(9): e7007

Haupt, S., Grützner, J., Rath, B.H., Möhlig, H., Brüstle, O. (2009)
Automated selection and collection of pluripotent stem cell colonies using the CellCelector™
Nature Methods 6, doi:10.1038/nmeth.f.252 [Non peer-reviewed application note]

Kierdorf, K., Wang, Y., Neumann, H. (2009)
Immune-Mediated CNS Damage
Results Probl Cell Differ 51:173-196

Klotz, L., Hucke, S., Thimm, D., Classen, S., Gaarz, A., Schultze, J., Edenhofer, F., Kurts, C., Klockgether, T., Limmer, A., Knolle, P., Burgdorf, S.
 (2009)
Increased antigen cross-presentation but impaired cross-priming after activation of peroxisome proliferator-activated receptor is mediated by up-regulation of B7H1
J Immunol 183(1):129-136

Ko, K., Tapia, N., Wu, G., Kim, J.B., Arauzo Bravo, M.J., Sasse, P., Glaser, T., Ruau, D., Han, D.W., Greber, B., Hausdörfer, K., Sebastiano, V., Stehling, M., Fleischmann, B.K., Brüstle, O., Zenke, M., Schöler, H.R. (2009)
Induction of pluripotency in adult unipotent germline stem cells
Cell Stem Cell 5(1):87-96

Koch, P., Kokaia, Z., Lindvall, O., Brüstle, O. (2009)
Emerging concepts in neural stem cell research: autologous repair and cell-based disease modeling
Lancet Neurol 8(9):819-829

Koch, P., Opitz, T., Steinbeck, J., Ladewig, J., Brüstle, O. (2009)
A rosette-type, self-renewing human ES cell-derived neural stem cell with potential for in vitro instruction and synaptic integration
Proc Natl Acad Sci USA 106(9):3225-3230

Lienenklaus, S., Cornitescu M. , Zietara N., Lyszkiewicz M., Gekara N., Jablonska J., Edenhofer F. , Rajewsky K. , Bruder D. , Hafner M., Staeheli P., Weiss S. (2009)
Novel reporter mouse reveals constitutive and inflammatory expression of IFN-b in vivo
J Immunol 183(5):3229-3236

Münst, B., Patsch, C., Edenhofer, F. (2009)
Engineering cell-permeable protein
J Vis Exp. 28;(34). pii: 1627. doi: 10.3791/1627

Napoli, I., Kierdorf, K., Neumann, H. (2009)
Microglial precursors derived from mouse embryonic stem cells
Glia 57(15):1660-1671

Napoli, I., Neumann, H. (2009)
Microglial clearance function in health and disease
Neuroscience 158(3):1030-1038

Napoli, I., Neumann, H. (2009)
Protective effects of microglia in multiple sclerosis
Exp Neurol 225(1):24-28

Neumann, H., Kotter, M.R., Franklin, R.J. (2009)
Debris clearance by microglia: an essential link between degeneration and regeneration
Brain 132(Pt 2):288-295

Papadimou, E., Moiana, A., Goffredo, D., Koch, P., Bertuzzi, S., Brüstle, O., Cattaneo, E., Conti, L. (2009)
p66ShcA adaptor molecule accelerates ES cell neural induction
Mol Cell Neurosci 41(1):74-84

Roßbach, M. (2009)
Creative Innovation – Insights from neurobiology and economics and their implications for social decision-making
In: Rationalität der Kreativität? Multidisziplinäre Beiträge zur Analyse der Produktion, Organisation und Bildung von Kreativität (Jansen, S. A., Schröter, E., Stehr, N.)
Wiesbaden,
VS Verlag für Sozialwissenschaften, pp. 13-29

Terstegge, S., Rath, B.H., Laufenberg, I., Limbach, N., Buchstaller, A., Schütze, K., Brüstle, O. (2009)
Laser-assisted selection and passaging of human pluripotent stem cell colonies
J Biotechnol 143(3):224-230

Terstegge, S., Brüstle, O. (2009)
Automated method for embryonic stem cell culture
In: Emerging technology platforms for stem cells. (Lakshmipathy, U., Chesnut, J.D., Thyagarajan, B., eds.),
Wiley, New Jersey, pp. 275-281

Walter, L., Neumann, H. (2009)
Role of microglia in neuronal degeneration and regeneration
Semin Immunopath 31(4):513-525

Walton, N.M., Snyder G.E., Park, D., Kobeissy, F., Scheffler, B., Steindler, D.A. (2009)
Gliotypic neural stem cells transiently adopt tumorigenic properties during normal differentiation
Stem Cells 27(2):280-289

Witan, H., Gorlovoy, P., Kaya, A.M., Koziollek-Drechsler, I., Neumann, H., Behl, C., Clement, A.M. (2009)
Wild-type Cu/Zn superoxide dismutase (SOD1) does not facilitate, but impedes the formation of protein aggregates of amyotrophic lateral sclerosis causing mutant SOD1
Neurobiol of Disease 36(2):331-342

Blaess S, Stephen D, Joyner AL (2008)
Gli3 coordinates three-dimensional patterning and growth of the tectum and cerebellum by integrating Shh and Fgf8 signaling.
Development 135(12): 2093-103

Bosnali, M., Edenhofer, F. (2008)
Generation of transducible versions of transcription factors Oct4 and Sox2
Biol Chem 389(7): 851-861

Calvanese, V., Horrillo, A., Hmadcha, A., Suarez-Alvarez, B., Fernandez, A.F., Lara, E., Casado, S., Menendez, P., Bueno, C., Garcia-Castro, J., Rubio, R., Lapunzina, P., Alaminos, M., Borghese, L., Terstegge, S., Harrison, N.J., Moore, H.D., Brüstle, O., Lopez-Larrea, C., Andrews, P.W., Soria, B., Esteller, M., Fraga, M.F. (2008)
Cancer genes hypermethylated in human embryonic stem cells
PLoS ONE 3(9):e3294

Edenhofer, F. (2008)
Protein transduction revisited: novel insights into the mechanism underlying intracellular delivery of proteins
Curr Pharm Des 14(34):3628-3636

Firkowska, I., Giannona, S., Rojas-Chapana, J.A., Luecke, K., Brüstle, O., Giersig, M. (2008)
Biocompatible nanomaterials and nanodevices promising for biomedical applications
In: Nanomaterials for Application in Medicine and Biology (Giersig, M. & Khomutov, G.B., ed.),
NATO Science and Security Series – B: Physics and Biophysics,
Spinger, Dordrecht, The Netherlands, pp.1-15

Geisthövel, F., Brüstle, O., Beier, H.M., Frommel, M., Schockenhoff, E., Taupitz, J. (2008)
The interaction between the German Embryo Protection Act and the Stem Cell Act – an interdisciplinary panel discussion held on November 30, 2007, on the occasion of the 2nd DVR Congress in Bonn/Bad Godesberg
J Reproduktionsmed Endokrinol 5:114-120

Glaser, T., Opitz, T., Kischlat, T., Konang, R., Sasse, P., Fleischmann, B.F., Engel, W., Nayernia, K., Brüstle, O. (2008)
Adult germline stem cells as a source of functional neurons and glia
Stem Cells 26(9):2434-2443

Glaser, T., Schmandt, T., Brüstle, O. (2008)
Generation and potential biomedical applications of embryonic stem cell-derived glial precursors
J Neurol Sci 265(1-2):47-58

Husseini, L., Schmandt, T., Scheffler, B., Schröder, W., Seifert, G., Brüstle, O., Steinhäuser, C. (2008)
Functional analysis of ES cell-derived glial cells after integration into hippocampal slice cultures
Stem Cells Dev 17(6):1141-1152

Kuhn, G., Brüstle, O., Martens, U., Wobus, A., Unsicker, K. (2008)
Stem cells: established facts, open issues, and future directions
Cell Tiss Res 331(1):1-3

Ladewig, J., Koch, P., Endl, E., Meiners, B., Opitz, T., Couillard-Despres, S., Aigner, L., Brüstle, O. (2008)
Lineage selection of functional and cryopreservable human embryonic stem cell-derived neurons
Stem Cells 26(7):1705-1712

Landry, J.R., Kinston, S., Knezevi, K., de Bruijn, M.F., Wilson, N., Nottingham, W.T., Peitz, M., Edenhofer, F., Pimanda, J.E., Ottersbach, K., Göttgens, B. (2008)
Runx genes are direct targets of Scl/Tal1 in the yolk sac and fetal liver
Blood 111(6): 3005-3014

Nolden, L., Brüstle, O. (2008)
Human embryonic stem cells: Perspectives for the study and therapy of neurological disorders
Bundesgesundheitsblatt 51(9):1026-1032

Prozorovski, T., Schulze-Topphoff, U., Glumm, R., Baumgart, J., Schröter, F., Ninnemann, O., Siegert, E., Bendix, I., Brüstle, O., Nitsch, R., Zipp, F., Aktas, O. (2008)
Sirt1 contributes critically to the redox-dependent fate of neuralprogenitors
Nature Cell Biol 10(4):385-394

Schormann, W., Hammersen, F.J., Brulport, M., Hermes, M., Bauer, A., Rudolph, C., Schug, M., Lehmann, T., Nussler, A., Ungefroren, H., Hutchinson, J., Fändrich, F., Petersen, J., Wursthorn, K., Burda, M.R., Brüstle, O., Krishnamurthi, K., von Mach, M., Hengstler, J.G. (2008)
Tracking of human cells in mice
Histochem Cell Biol 130(2):329-338

Schwarting, S., Litwak, S., Hao, W., Bähr, M., Weise, J., Neumann H. (2008)
Hematopoietic stem cells reduce postischemic inflammation and ameliorateischemic brain injury
Stroke 39(10):2867-2875

Siemen, H., Nolden, L., Terstegge, S., Koch, P., Brüstle, O. (2008)
Nucleofection of human embryonic stem cells
In: Methods in Molecular Medicine – Electroporation Protocols: Experimental and Clinical Medicine (Ed.: Li, S.),
Humana Press, Totowa, New Jersey, pp131-138

Biber, K., Neumann, H., Inoue, K., Boddeke, H. (2007)
Neuronal on and off signals control microglial
Trends Neurosci 30:596-602

Fischer, Y.H., Miletic, H., Giroglou, T., Litwak, S., Stenzel, W., Neumann, H., von Laer, D. (2007)
A retroviral packaging cell line for pseudotype vectors based on glioma-infiltrating progenitor cells
Journal of Gene Medicine 9:335-344

Glaser, T., Brose, C., Franceschini, I., Hamann, K., Smorodchenko, A., Zipp,F., Dubois-Dalcq, M., Brüstle, O. (2007)
NCAM polysialylation enhances the sensitivity of ES cell-derived neural precursors to migration guidance cues
Stem Cells 25(12):3016-3025

Glaser, T., Pollard, S.M., Smith, A., Brüstle, O. (2007)
NCAM polysialylation enhances the sensitivity of ES cell-derived neural precursors to migration guidance cues
Stem Cells 25(12):3016-3025

Glaser, T., Pollard, S.M., Smith, A., Brüstle, O. (2007)
Tripotential differentiation of adherently expandable neural stem (NS) cells
PLoS ONE 2:e298

Gossrau, G., Thiele, J., Konang, R., Schmandt, T., Brüstle, O. (2007)
BMP-mediated modulation of lineage diversification during neural differentiation of embryonic stem cells
Stem Cells 25:939-949

Haupt, S., Edenhofer, F., Peitz, M., Leinhaas, A., Brüstle, O. (2007)
Stage specific conditional mutagenesis in embryonic stem cell-derived neural cells and post-mitotic neurons by direct delivery of biologically active Cre recombinase
Stem Cells 25:181-188

Klotz, L., Dani, I., Edenhofer, F., Nolden, L., Evert, B., Paul, B., Kolanus, W., Klockgether, T., Knolle, P., Diehl, L. (2007)
Peroxisome proliferator-activated receptor gamma control of dendritic cell function contributes to development of CD4+ T cell anergy.
J Immunol 178(4):2122-2131

Klotz, L., Diehl, L., Dani, I., Neumann, H., von Oppen, N., Dolf, A., Endl, E., Klockgether, T., Engelhardt, B., Knolle, P. (2007)
Brain endothelial PPARγ controls inflammationinduced CD4+ T cell adhesion and transmigration in vitro
J Neuroimmunol 190:34-43

Li, T., Steinbeck, J.A., Lusardi, T., Fedele, D.E., Koch, P., Lan, J.Q., Wilz, A., Segschneider, M., Simpson, E.M., Simon, R.P., Brüstle, O., Boison, D. (2007)
Suppression of kindling epileptogenesis by adenosine releasing stem cell-derived brain implants
Brain 130:1276-88

Miletic, H., Fischer, Y., Litwak, S., Giroglou, T., Waerzeggers, Y., Winkeler, S., Li, H., Himmelreich, U., Stenzel, W., Deckert, M., Lange, C., Neumann, H., Jacobs, AH., von Laer D. (2007)
Bystander killing of malignant glioma by bone marrow-derived tumorinfiltrating progenitor cells expressing a suicide gene
Molecular Therapy 15:1373-1381

Neumann H., Takahashi, K. (2007)
Essential role of the triggering receptor expressed on myeloid cells-2 (TREM2) for central nervous tissue immune homeostasis
J Neuroimmunol 184:92-99

Nolden, L., Edenhofer, F., Peitz, M., Brüstle, O. (2007)
Stem cell engineering using transducible Cre recombinase
Methods in Molecular Medicine 140:17-32

Nolden, L., Edenhofer, F., Peitz, M., Brüstle, O. (2007)
Stem cell engineering using transducible Cre recombinase
In: Methods in Molecular Medicine – Tissue Engineering 2nd Edition, (Eds.: Hauser, H., Fussenegger, M.),
Humana Press, Totowa, New Jersey, pp17-32

Opitz, T., Scheffler, B., Steinfarz, B., Schmandt, T., Brüstle, O. (2007)
Electrophysiological evaluation of engrafted stem cell-derived neurons
Nat Protoc 2:1603-1613

Patsch, C., Edenhofer, F. (2007)
Conditional mutagenesis by cell-permeable proteins: potential, limitations and prospects
Handb Exp Pharmacol 178:203-232

Peitz, M., Jäger, R., Patsch, C., Jäger, A., Egert, A., Schorle, H., Edenhofer, F. (2007)
Enhanced purification of cell-permeant Cre and germline transmission after transduction into mouse embryonic stem cells
Genesis 45(8):508-517

Takahashi, K., Prinz, M., Stagi, M., Chechneva, O., Neumann H. (2007)
TREM2-transduced myeloid precursors mediate nervous tissue debris clearance and facilitate repair in an animal model of multiple sclerosis
PLoS Med. 4(4):e124

Terstegge, S., Laufenberg, I., Pochert, J., Schenk, S., Itskovitz-Eldor, J., Endl, E., Brüstle, O. (2007)
Automated maintenance of embryonic stem cell cultures
Biotech Bioengineer 96:195-201

Testa, G., Borghese, L., Steinbeck, J.A., Brüstle, O. (2007)
Breakdown of the potentiality principle and its impact on global stem cell research
Cell Stem Cell 1:153-156

Benzing, C., Segschneider, M., Leinhaas, A., Itskovitz-Eldor, J., Brüstle, O. (2006)
Neural conversion of human embryonic stem cell colonies in the presence of fibroblast growth factor-2
Neuroreport 17:1675-1681

Edenhofer, F. (2006)
On the materiality of life
In: Entry Paradise - New Worlds of Design, G. Seltmann, W. Lippert (eds.)
Birkhäuser/Springer.

Götz, A.K., Scheffler, B., Chen, H.-X., Wang, S., Suslov, O., Xiang, H., Brüstle, O., Roper, S.N., Steindler, D.A. (2006)
Temporally restricted substrate interactions direct fate and specification of neural precursors derived from embryonic stem cells
Proc Natl Acad Sci USA 103:11063-11068

Klein, D., Schmandt, T., Muth-Köhne, E., Perez-Bouza, A., Segschneider, M., Gieselmann, V., Brüstle, O. (2006)
Embryonic stem cell-based reduction of CNS sulfatide storage in an animal model of metachromatic leukodystrophy
Gene Therapy 13:1686-1696

Koch, P., Siemen, H., Biegler, A., Itskovitz-Eldor, J., Brüstle, O. (2006)
Transduction of human embryonic stem cells by ecotropic retroviral vectors
Nucl Acids Res 34(18):e120

Liu, Y., Hao, W., Letiembre, M., Walter, S., Kulanga, M., Neumann, H. and Fassbender, K. (2006)
Suppression of microglial inflammatory activity by myelin phagocytosis: role of p47-PHOX-mediated generation of reactive oxygen species
J Neurosci 26:12904-12913

Neumann, H. (2006)
Microglia: a cellular vehicle for CNS gene therapy
J Clin Invest 116:2857-2860 (invited commentary)

Nolden, L., Edenhofer, F., Haupt, S., Wunderlich, T.F., Siemen, H., Brüstle, O. (2006)
Site-specific recombination in human embryonic stem cells induced by cell-permeant Cre recombinase
Nature Methods 3:461-467

Piepoli, T., Jakupoglu, C., Gu, W., Lualdi, E., Suarez-Merino, B., Poliani, P.L., Cattaneo, M.G., Ortino, B., Goplen, D., Wang, J., Mola, R., Inverardi, F., Frassoni, C., Bjerkvig, R., Steinlein, O., Vicentini, L.M., Brüstle, O., Finocchiaro, G. (2006)
Expression studies in gliomas and glial cells do not support a tumor suppressor role for LGI1
Neuro-Oncology 8:96-108

Scheffler, B., Edenhofer, F., Brüstle, O. (2006)
Merging fields: Stem cells in neurogenesis, transplantation and disease modeling
Brain Pathol 16:155-168

Scheffler, B., Brüstle, O. (2006)
Symposium: Stem Cells in the Central Nervous System
Brain Pathol 16:131

Schmandt, T., Gossrau, G., Kischlat, T., Opitz, T., Brüstle, O. (2006)
Animal models of cell and gene therapy in myelin disease
Drug Discovery Today 3:349-358

Schmandt, T., Glaser, T., Brüstle, O. (2006)
Lineage selection and transplantation of ES cell-derived neural precursors
In: Embryonic stem cells – a practical approach (Eds.: Notarianni, E. and Evans, M.),
Oxford University Press, Oxford, pp 189-217

Stagi, M., Gorlovoy, P., Larinov, S., Takahashi, K., Neumann H. (2006)
Unloading kinesin transported cargoes from the tubulin track via the inflammatory c-Jun N-terminal kinase pathway
FASEB J 20:2573-2575

Terstegge, S., Brüstle, O. (2006)
Stammzellen – Bedeutung für die Klinische Medizin
In: Humangenetik (Eds.: Murken, J., Grimm, T., Holinski-Feder, E.). 7. Auflage,
Georg Thieme Verlag Stuttgart, New York, pp 558-564

Terstegge, S., Fuhr, G.R., Brüstle, O. (2006)
Stammzelltechnologie
In: Technologieführer. Grundlagen, Anwendungen, Trends (Ed.: Bullinger, H.J.),
Springer Verlag Berlin, pp 186-191

Tünnemann, G., Martin, R.M., Haupt, S., Patsch, C., Edenhofer, F., Cardoso, M.C. (2006)
Cargo-dependent mode of uptake and bioavailability of TAT-containing proteins and peptides in living cells
FASEB J 20(11):1775-1784

Wiese, C., Rolletschek, A., Kania, G., Navarrete-Santos, A., Anisimov, S.V., Steinfarz, B., Tarasov, K.V., Brugh, S.A., Zahanich, I., Rüschenschmidt, C., Beck, H., Blyszczuk, P., Czyz, J., Heubach, J.F., Ravens, U., Horstmann, O., St-Onge, L., Braun, T., Brüstle, O., Boheler, K.R., Wobus, A.M. (2006)
Signals from embryonic fibroblasts induce adult intestinal epithelial cells to form nestin-positive cells with proliferation and multilineage differentiation capacity in vitro
Stem Cells 24:2085-2097

Coenen, M., Kögler, G., Wernet, P., Brüstle, O. (2005)
Transplantation of human umbilical cord blood-derived adherent progenitors into the developing rodent brain
J Neuropathol Exp Neurol 64:681-688

Edenhofer, F., Peitz, M. (2005)
CREating designer cells: genetic engineering of stem cells by site-specific recombinase
In: Stem Cell Repair and Regeneration
Imperial College Press, pp 49-65

Glaser, T., Brüstle, O. (2005)
Retinoic acid induction of ES cell-derived neurons: The radial glia connection
Trends Neurosci 28:397-400 [Review]

Güttinger, M., Fedele, D., Koch, P., Padrun, V., Pralong, W.F., Brüstle, O., Boison, D. (2005)
Suppression of kindled seizures by paracrine adenosine release from stem cell-derived brain implants
Epilepsia 46:1162-1169

Perez-Bouza, P., Glaser, T., Brüstle, O. (2005)
ES cell-derived glial precursors contribute to remyelination in acutely demyelinated spinal cord lesions
Brain Pathol 15:208-216

Rüschenschmidt, C., Koch, P.G., Brüstle, O., Beck, H. (2005)
Functional properties of ES cell-derived neurons engrafted into the hippocampus of adult normal and chronically epileptic rats
Epilepsia 46 Suppl. 5:174-183

Schmandt, T., Meents, E., Gossrau, G., Gornik, V., Okabe, S., Brüstle, O. (2005)
High-purity lineage selection of embryonic stem cell-derived neurons
Stem Cells Dev 14:55-64

Siemen, H., Nix, M., Endl, E., Koch, P., Itskovitz-Eldor, J., Brüstle, O. (2005)
Nucleofection of human embryonic stem cells
Stem Cells Dev 14:378-383

Wernig, G., Janzen, V., Schäfer, R., Zweyer, M., Knauf, U., Hoegemeier, O., Mundegar, R.R., Garbe, S., Stier, S., Franz, T., Wernig, M., Wernig, A. (2005)
The vast majority of bone-marrow-derived cells integrated into mdx muscle fibers are silent despite long-term engraftment
Proc Natl Acad Sci USA 102(33):11852-11857

Brüstle, O., Koch, P., Möhler, H., Boison, D. (2004)
Therapeutic delivery of adenosine into a tissue
U.S. 10/858,929 


Fedele, D.E., Koch, P., Scheurer, L., Simpson, E.M., Möhler, H., Brüstle, O., Boison, D. (2004)
Engineering embryonic stem cell derived glia for adenosine delivery
Neurosci Lett 370(2-3):160-165

Glaser, T., Perez-Bouza, A., Klein, K., Brüstle, O. (2004)
Generation of purified oligodendrocyte progenitors from embryonic stem cells
FASEB J 19(1):112-114

Murakami, M., Ichisaka, T., Maeda, M., Oshiro, N., Hara, K., Edenhofer, F., Kiyama, H., Yonezawa, K., Yamanaka, S. (2004)
mTOR is essential for growth and proliferation in early mouse embryos and embryonic stem cells. Mol Cell Biol 24(15):6710-6718

Terstegge, S., Pochert, J., Brüstle, O. (2004)
Hamilton’s new CellHost system for full automation of embryonic stem cell cultures
Nature Methods 1:271-272 [Application Note]

Terstegge, S., Brüstle, O. (2004)
Skalierbarer Prozess zur Kultivierung undifferenzierter Stammzellen in Suspension
DE 102 004 043 256.2

Wernig, M., Benninger, F., Schmandt, T., Rade, M., Tucker, K.L., Büssow, H., Beck, H., Brüstle, O. (2004)
Functional integration of embryonic stem cell-derived neurons in vivo
J Neurosci 24(22):5258-5268

Benninger F, Beck H, Wernig M, Tucker KL, Brüstle O, Scheffler B. (2003)
Functional integration of embryonic stem cell-derived neurons in hippocampal slice cultures
J Neurosci 23(18):7075-7083 [IF 7.869]

Peitz, M., Rajewsky, K., Brüstle, O., Edenhofer, F. (2003)
Direct delivery of biologically active proteins into cells: protein transduction as a tool for genomic manipulations in mammalian cells
Eur J Cell Biol 82:Suppl.53, 36

Scheffler B, Schmandt T, Schröder W, Steinfarz B, Husseini L, Wellmer J, Seifert G, Karram K, Beck H, Blümcke I, Wiestler OD, Steinhäuser C, Brüstle O. (2003)
Functional network integration of embryonic stem cell-derived astrocytes in hippocampal slice cultures
Development 130(22):5533-5541

Steffel J, Wernig M, Knauf U, Kumar S, Wiestler OD, Wernig A, Brüstle O. (2003)
Migration and differentiation of myogenic precursors following transplantation into the developing rat brain
Stem Cells 21(2):181-189 [IF 8.368]

Wernig, M., Scheffler, B., Brüstle, O. (2003)
Medizinische Perspektiven der Stammzellforschung
Grundlagen der Molekularen Medizin
In: Ganten D, Ruckpaul K (eds.),
Springer-Verlag, Berlin, Heidelberg, New York 680-710

Wernig, M., Tucker, K.L., Gornik, V., Schneiders, A., Buschwald, R., Wiestler, O.D., Barde, Y.A., Brüstle, O. (2002)
Tau EGFP embryonic stem cells: an efficient tool for neuronal lineage selection and transplantation
J Neurosci Res 69:918-924