Department of Epileptology

University of Bonn

Publications of the Neurophysics Group



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in press

Andrzejak RG, Mormann F, Widman G, Kreuz T, Elger CE, Lehnertz K
“Improved spatial characterization of the epileptic brain by focusing on nonlinearity.”
Epilepsy Res


(57) Chernihovskyi A., Mormann F., Müller M., Elger, C.E., Baier, G., Lehnertz, K. (2005):
"EEG analysis with nonlinear excitable media"
J. Clin. Neurophysiol. 22, 314-329 (abstract)

(56) Müller, A., Osterhage, H., Sowa, R., Andrzejak, R.G.,  Mormann, F., Lehnertz K.
"A distributed computing system for multivariate time series analyses of multichannel neurophysiological data.”
J Neurosci Methods. 2005 Oct 24; [Epub ahead of print]  (abstract)

(55) Mormann, F., Andrzejak, R. G., Elger, C.E., Lehnertz, K (2005).
Comment on: Seizure Anticipation: Do Mathematical Measures Correlate with Video-EEG Evaluation? by Navarro et al. Epilepsia 2005;46:385-96.
Epilepsia, 46(8):1335-6; author reply 1336-7.

(54) Sowa, R., Chernihovskyi, A. Mormann, F., Lehnertz, K. (2005):
"Estimating phase synchronization in dynamical systems with cellular nonlinear networks"
Phys Rev E 71, 061926  (abstract) (PRE-Homepage)
This work was selected by the Virtual Journal of Biological Physics Research  Vol 10 (Issue 1) July 2005

(53) Mormann, F., Kreuz, K., Rieke, C., Andrzejak, R.G. , Kraskov, A., David, P., Elger, C.E., Lehnertz, K. (2005):
"On the predictability of epileptic seizures“
Clin. Neurophysiol.  116, 569-587  (abstract)

(52) Lehnertz, K., Litt, B. and the International Seizure Prediction Group (2005):
"The First International Collaborative Workshop on Seizure Prediction:  Summary and Data Descriptions.“
Clin. Neurophysiol.  116, 493-505  (abstract)

(51) A. Chernihovskyi, R. Sowa, S. Florin, C. E. Elger, K. Lehnertz (2004):
"Pattern Recognition in Noisy and Non-stationary Time Series with Cellular Neural Networks“.
In T. Roska, M. Gili, B, Shi, A. Zarandy (Eds.): Proc. 8th IEEE International Workshop on
Cellular Neural Networks and Applications (CNNA2004). Amulett’98 Kft, Budapest, Ungarn<>

(50) R. Sowa, F. Mormann, A. Chernihovskyi, S. Florin, C.E. Elger, K. Lehnertz (2004):
"Estimating Synchronization in Brain Electrical Activity from Epilepsy Patients with Cellular Neuronal Networks“.
In T. Roska, M. Gili, B, Shi, A. Zarandy (Eds.): Proc. 8th IEEE International Workshop on
Cellular Neural Networks and Applications (CNNA2004). Amulett’98 Kft, Budapest, Ungarn

(49) Elger, C.E., Lehnertz, K. (2004):
"Prediction of seizure occurrence by chaos analysis: Technique and therapeutic implications”
In F. Rosenow und H.O. Lüders (Eds.): Presurgical assessment of the epilepsies with clinical neurophysiology and functional imaging.
Handbook of Clinical Neurophysiology, Vol.3. pp 491-500. Elsevier, Amsterdam,  pp. 491-500.

(48) Kreuz, T., Andrzejak, R.G., Mormann, F., Kraskov, A., Stögbauer, H., Elger, C.E., Lehnertz, K., Grassberger, P. (2004):
“Time profile surrogates: a method to validate the performance of epileptic seizure prediction algorithms”
Phys Rev E 69, 061915  (abstract) (PRE-Homepage)

(47) Rieke, C., Andrzejak, R.G., Mormann, F., Lehnertz, K. (2004):
“Improved statistical test for nonstationarity using recurrence time statistics.”
Phys Rev E. 69, 046111  (abstract) (PRE-Homepage)

(46) Rieke, C., Andrzejak, R.G., Mormann, F., Kreuz, T., David, P., Elger, C.E., Lehnertz, K (2003=.
“Discerning nonstationarity from nonlinearity in pre-seizure EEG recordings from epilepsy patients.”
IEEE Trans. Biomed. Eng. 50, 634-639 (Special Issue Epileptic Seizure Prediction) (abstract)

(45) Lehnertz, K., Mormann, F., Kreuz, T., Andrzejak, R.G., Rieke, C., David, P., Elger, C.E. (2003)
“Seizure prediction by nonlinear EEG analysis.”
IEEE EMB Magazine 22(1), 57-63 (abstract)

(44) Mormann, F., Kreuz, T., Andrzejak, R.G., David, P., Lehnertz, K., Elger, C.E. (2003)
“Epileptic seizures are preceded by a decrease in synchronization.”
Epilepsy Res., 53(3), 173-185 (abstract)

(43) Mormann, F., Andrzejak, R.G., Kreuz, T., Rieke, C., David, P., Elger, C.E., Lehnertz, K. (2003)
"Automated detection of a pre-seizure state based on a decrease in synchronization in inctracranial EEG recordings from epilepsy patients.”
Phys Rev E. 67, 021912 (abstract) (PRE-Homepage)

(42) Andrzejak, R.G., Kreuz, T., Mormann, F., Rieke, C., Kraskov, A., Elger, C.E., Lehnertz, K. (2003)
“Testing the null hypothesis of the non-existence of a pre-seizure state.”
Phys. Rev. E, 67, 010901 (abstract) (PRE-Homepage)
This work was selected by the Virtual Journal of Biological Physics Research  Vol 5 (Issue 2) January 2003

(41) Lehnertz, K. (2003):
“Nonlinear approaches to learning and memory.”
Proc. of the 1st International IEEE EMBS Conference on Neural Engineering. pp. 38, IEEE-Press

(40) Quian Quiroga, R., Arnhold, J., Lehnertz, K., Grassberger, P. (2002)
“Reply to “Comments on Kullback-Leibler and renormalized entropy: Applications to EEGs of epilepsy patients."
Phys. Rev. E, 66, 043903 (abstract) (cond-mat/0208148) (PRE-Homepage)

(39) Rieke C, Sternickel K, Andrzejak RG, Elger CE, David P, Lehnertz K (2002)
“Measuring non-staionarity by analyzing the loss of recurrence in dynamical systems.”
Phys. Rev. Lett.,89, DOI 10.1103. (abstract)(PRL-Homepage)

(38) Lehnertz K, Andrzejak RG, Kreuz T, Mormann F, Rieke C, David P, Elger CE (2002)
"Analysis of EEG data in epilepsy.“
in: Nardulli G, Stramaglia S (Eds.): Modelling biomedical signals. World Scientific, Singapore

(37) Lehnertz K (2002)
“Nichtlineare EEG-Analysen.”
in Zschocke S: Klinische Elektroenzephalographie. 2. Auflage, Springer Verlag, pp.601-624.

(36) Elger CE, Mormann F, Kreuz T, Andrzejak RG, Rieke C, Sowa R, Florin S, David P, Lehnertz K (2002)
“Characterizing the spatio-temporal dynamics of the epileptogenic process with nonlinear EEG analysis.”
In: Tetzlaff R (Ed.) Proceedings of the 7th IEEE International Workshop on Cellular Neural Networks and Their Applications.
World Scientific, Singapore, pp 228-242.

(35) Lehnertz, K. (2001):
“Nonlinear EEG analysis in epilepsy.”
Proc. of the 23rd Annual International IEEE Conference on Engineering in Medicine & Biology (EMBS)

(34) Lehnertz, K. (2001):
„Seizure anticipation techniques: state of the art and future requirements.“
Proc. of the 23rd Annual International IEEE Conference on Engineering in Medicine & Biology (EMBS)

(33) Andrezjak RG, Lehnertz K, Mormann F, Rieke C, David P, Elger CE (2001)
“Indications of nonlinear deterministic and finite dimensional structures in time series of brain electrical activity – dependence on recording region and brain state.”
Phys Rev E. 64 DOI 061907 (abstract)(PRE-Homepage) (EEG Time Series Download Page)
This work was selected by the Virtual Journal of Biological Physics Research  Vol 2 (Issue 12) December 2001

(32) Lehnertz K, Andrzejak RG, Arnhold J, Kreuz T, Mormann F, Rieke C, Widman G, Elger CE (2001)
“Nonlinear EEG analysis in epilepsy: Its possible use for interical focus localization, seizure anticipation, and prevention”.
J. Clin. Neurophysiol. 18, 209-222 (abstract)

(31) Andrzejak RG, Widman G, Lehnertz K, Rieke C, David P, Elger CE (2001)
”The epileptic process as nonlinear deterministic dynamics in a stochastic environment – an evaluation of mesial temporal lobe epilepsy.”
Epilepsy Res, 44, 129-140 (abstract)

(30) Sternickel K, Effern A, Lehnertz K, Schreiber T, David P (2001)
“Nonlinear denoising using reference data.”
Phys. Rev. E 63, 036209 (abstract)(PRE-Homepage)
This work was selected by the Virtual Journal of Biological Physics Research  Vol 2 (Issue 3) March 2001

(29) Quian Quiroga R, Arnhold J, Lehnertz K, Grassberger P (2000)
"Kullback-Leibler and renormalized entropy: Applications to EEGs of epilepsy patients."
Phys. Rev. E, 62, 8380-8386 (abstract)(PRE-Homepage)
This work was selected by the Virtual Journal of Biological Physics Research  Vol 1 (Issue 12) December 2000

(28) Effern A, Lehnertz K, Grunwald T, Fernandez G, David P, Elger CE (2000)
"Time adaptive denoising of single trial event related potentials in wavelet domain"
Psychophysiology, 37, 859-865 (abstract)

(27) Effern A, Lehnertz K, Fernandez G, Grunwald T, David P, Elger CE (2000)
“Single trial analysis of event related potentials: nonlinear denoising with wavelets.”
Clin. Neurophysiol, 111, 2255-2263 (abstract)

(26) Elger CE, Widman G, Andrzejak R, Arnhold J, David P, Lehnertz K (2000)
"Nonlinear EEG analysis and its potential role in epileptology."
Epilepsia, 41, Suppl.3, S34-S38 (abstract)

(25) Widman G, Lehnertz K, Urbach H, Elger CE (2000)
"Spatial distribution of neuronal complexity loss in neocortical epilepsies"
Epilepsia, 41, 811-817 (abstract)

(24) Mormann F, Lehnertz K, David P, Elger CE (2000)
”Mean phase coherence as a measure for phase synchronization and its application to the EEG of epilepsy patients.”
Physica D, 144, 358-369 (abstract)

(23) Arnhold J, Grassberger P, Lehnertz K (2000)
"Chaos im Kopf? Nichtlineare Dynamik und Epilepsie"
Physikalische Blätter, 56, April, 2000, 27-32 (abstract)(PhysBl-Homepage)

(22) Effern A, Lehnertz K, Schreiber T, David P, Elger CE (2000)
"Nonlinear denoising of transient signals with application to event related potentials"
Physica D, 140, 257-266 (abstract)(physics/0001069)

(21) Lehnertz K, Arnhold J, Grassberger P, Elger CE (Eds.) (2000)
Chaos in Brain ?
World Scientific, Singapore.

(20) Lehnertz K, Andrzejak RG, Arnhold J, Widman G, Burr W, David P, Elger CE (2000)
"Possible clinical and research applications of nonlinear EEG analysis in humans."
In: Lehnertz K, Arnhold J, Grassberger P, Elger CE (Eds.) Chaos in Brain ?,
World Scientific, Singapore, 134-155

(19) Widman G, Rehberg B, Hoeft A, Lehnertz K, Elger CE (2000)
"Correlation sums from EEG time series: a measure to quantify depth of anesthesia."
In: Lehnertz K, Arnhold J, Grassberger P, Elger CE (Eds.) Chaos in Brain ?,
World Scientific, Singapore, 275-278.

(18) Effern A, Lehnertz K, Grunwald T, David P, Elger CE (2000)
"Nonlinear filtering in wavelet domain: application to single trial analysis of limbic P300 potentials."
In: Lehnertz K, Arnhold J, Grassberger P, Elger CE (Eds.) Chaos in Brain ?,
World Scientific, Singapore, 305-308.

(17) Arnhold J, Grassberger P, Lehnertz K, Elger CE (2000)
"Detecting interdependences in intracranial EEG recordings of epilepsy patients."
In: Lehnertz K, Arnhold J, Grassberger P, Elger CE (Eds.) Chaos in Brain ?,
World Scientific, Singapore, 325-328.

(16) Andrzejak RG, Widman G, Lehnertz K, David P, Elger CE (2000)
"Nonlinear deterministic dynamics in seizure free EEG epochs as an indicator of the epileptogenic process. A comparison of three surrogate methods."
In: Lehnertz K, Arnhold J, Grassberger P, Elger CE (Eds.) Chaos in Brain ?,
World Scientific, Singapore, 340-343.

(15) Elger CE, Widman G,  Andrzejak R, Dümpelmann M,  Arnhold J, Grassberger P, Lehnertz K (2000)
"Value of nonlinear time series analysis of the EEG in neocortical epilepsies"
In: Williamson PD, Siegel AM, Roberts DW, Thadani VM, Gazzaniga MS (Eds.):
Neocortical epilepsies. Advances in Neurology. Philadelphia: Lippincott, Williams & Wilkins, pp. 317-330

(14) Arnhold J, Grassberger P, Lehnertz K, Elger CE (1999)
"A robust method for detecting interdependences:  application to intracranially recorded EEG."
Physica D, 134, 419-430 (abstract)(chao-dyn/990701)

(13) Lehnertz K (1999)
"Nonlinear time series analysis of intracranial EEG recordings in patients with epilepsy."
Int. J. Psychophysiol., 34, 45-52 (abstract)

(12) Fernandez G, Effern A, Grunwald T, Pezer N, Lehnertz K, Dümpelmann M, van Roost D, Elger CE (1999)
"Real-time tracking of memory formation in the human rhinal cortex and hippocampus."
Science,  285, 1582-1585 (abstract)(Science Homepage)

(11) Widman G, Bingmann D, Lehnertz K, Elger CE (1999)
"Reduced signal complexity of intracellular recordings: a precursor for epileptic activity ?"
Brain Res., 836, 156-163 (abstract)

(10) Lehnertz K, Widman G, Andrzejak R, Arnhold J, Elger CE (1999)
"Is it possible to anticipate seizure onset by non-linear analysis of intracerebral EEG in human partial epilepsies ?"
Rev. Neurol. (Paris), 155(6­7), 454 - ­456  (abstract)

(9) Lehnertz K, Widman G, Andrzejak R, Arnhold J, Elger CE (1999)
"Nichtlineare EEG-Analysen"  (in german)
Schweizer Archiv f. Neurologie und Psychiatrie, 150, 72-78 (abstract)

(8) Widman G, Lehnertz K, Jansen P, Meyer W, Burr W, Elger CE (1998)
"A fast general purpose algorithm for the computation of auto- and cross-correlation integrals from single channel data".
Physica D, 121, 65-74 (abstract)(FORTRAN program)

(7) Weber B, Lehnertz K, Elger CE, Wieser HG (1998)
"Neuronal complexity loss in interictal EEG recorded with foramen ovale electrodes predicts side of primary
epileptogenic area in temporal lobe epilepsy: A replication study".
Epilepsia, 39, 922-927 (abstract)

(6) Elger CE, Lehnertz K, Widman G (1998)
"Interictal focus localization."
In: Schmidt D, Schacter SC (Eds.) Epilepsy: problem solving in clinical practice. Martin Dunitz Publishers, London. 155-166.

(5) Lehnertz K, Elger CE (1998)
"Can epileptic seizures be predicted ? Evidence from nonlinear time series analyses of brain electrical activity"
Phys. Rev. Lett., 80, 5019-5023 (Postcript)(comments in journals and magazines)(PRL Homepage)

(4) Elger CE, Lehnertz K (1998)
"Prediction of epileptic seizures in humans from nonlinear dynamics analysis of brain electrical activity",
Eur. J. Neurosci., 10, 786-789 (abstract)

(3) Lehnertz K, Elger CE (1997)
"Neuronal complexity loss in temporal lobe epilepsy: Effects of carbamazepine on the dynamics of the epileptogenic focus"
Electroenceph. clin Neurophysiol., 103, 376-380 (abstract)

(2) Lehnertz K, Elger CE (1995)
"Spatio-temporal dynamics of the primary epileptogenic area in temporal lobe epilepsy characterized by neuronal complexity loss"
Electroenceph. clin. Neurophysiol., 95, 108 - 117 (abstract)

(1) Elger CE, Lehnertz K (1994)
"Ictogenesis and Chaos"
In: Wolf P (Ed.): Epileptic Seizures and Syndromes. J. Libbey & Co, London, 547 - 552.
 

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last change: July 19, 2005 by Klaus Lehnertz