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for Publications of the Schorle Lab using Pubmed follow this link: SCHORLE LAB Publications

  1.     Establishment of a versatile seminoma model indicates cellular plasticity of germ cell tumor cells.
    Nettersheim D, Westernströer B, Haas N, Leinhaas A, Brüstle O, Schlatt S, Schorle H.
    Genes Chromosomes Cancer. 2012 Apr 5. doi: 10.1002/gcc.21958. [Epub ahead of print] PMID: 22489004 .  

  2.     MYCN and ALKF1174L are sufficient to drive neuroblastoma development from neural crest progenitor cells.
    Schulte JH, Lindner S, Bohrer A, Maurer J, De Preter K, Lefever S, Heukamp L, Schulte S, Molenaar J, Versteeg R, Thor T, Künkele A, Vandesompele J, Speleman F, Schorle H, Eggert A, Schramm A.
    Oncogene. 2012 Apr 9. doi: 10.1038/onc.2012.106. [Epub ahead of print] PMID: 22484425  

  3.     The role of transcription factor Tcfap2c/TFAP2c in trophectoderm development
    Peter Kuckenberg , Caroline Kubaczka, Hubert Schorle.
    Reprod. Biomed. Online Available online 3 March 2012.

  4.     PDGF signalling controls age-dependent proliferation in pancreatic β-cells
    Hainan Chen, Xueying Gu, Yinghua Liu, Jing Wang, Stacey E. Wirt, Rita Bottino, Hubert Schorle, Julien Sage & Seung K. Kim.
    Nature 12 October 2011, doi:10.1038/nature10502

  5.     The Seminoma Cell Line TCam-2 is sensitive to HDAC-inhibitor Depsipeptide but tolerates various other chemotherapeutic drugs and loss of NANOG-expression
    Nettersheim D, Gillis A, Biermann K, Looijenga L, Schorle H.
    Genes Chromosomes Cancer 2011, 11 Dec;50(12):1033-42. doi: 10.1002/gcc.20918. Epub 2011 Aug 24

  6.     Transgenic overexpression of Tcfap2c/AP-2gamma results in liver failure and intestinal dysplasia
    Holl D, Kuckenberg P, Woynecki T, Egert A, Becker A, Huss S, Stabenow D, Zimmer A, Knolle P, Tolba R, Fischer H-P, Schorle H.
    PlosOne, 2011, July 13, vol 6 (7), pp. e22034. doi 101371/journal.pone.0022034

  7.       TGF-β1, EGF and FGF4 synergistically induce differentiation of the seminoma cell line TCam-2 into a cell type resembling mixed non-seminoma 
    Nettersheim D, Gillis A, Looijenga L, Schorle H.
    Int. J. Androl. (2011 Jun 8. doi: 10.1111/j.1365-2605.2011.01172.x. [Epub ahead of print] PMID:21649665

  8.     The role of BLIMP1 and its putative downstream target TFAP2C in germ cell development and germ cell tumors
    Schäfer S, Anschlag J, Nettersheim D, Haas N, Pawig L, Schorle H.
    Int. J. Androl. 2011 May 12. doi: 10.1111/j.1365-2605.2011.01167.x. [Epub ahead of print] PMID:21564135

  9.     Lineage Conversion of Murine Extraembryonic Trophoblast Stem Cells to Pluripotent Stem Cells  
    Kuckenberg P, Peitz M, Kubaczka C, Becker A, Egert A, Wardelmann E, Zimmer A, Brüstle O, Schorle H.
    Mol. Cell. Biol. doi:10.1128/MCB.01047-10

  10.     Production of chick embryo extract for the cultivation of murine neural crest stem cells.
    Pajtler K, Bohrer A, Maurer J, Schorle H, Schramm A, Eggert A, Schulte JH. 
    J Vis Exp. 2010 Nov 27;(45). pii: 2380. doi: 10.3791/2380 PMID: 21178955

  11.     NANOG Promoter methylation and expression correlation during normal and malignant human germ cell development
    Nettersheim D, Biermann K, Gillis A, Steger K, Looijenga L, Schorle H.    
    Epigenetics (Vol 6 (1), 114-122, Jan 2011), PMID: 20930529

  12.     Interference with  Activator Protein-2 transcription factors leads to indcution of apoptosis and an increase in chemo- and radiation- sensitivity in breast cancer cells 
    Thewes V, Orso F, Jäger R, Eckert D , Schäfer S , Kirfel G, Garbe S, Taverna D, Schorle H.   
    BMC Cancer. 2010 May 11;10(1):192. PMID: 20459791 [PubMed - as supplied by publisher]

  13.     The transcription factor TFAP2C/AP-2gamma cooperates with CDX2 to maintain trophectoderm formation
    Kuckenberg P, Buhl S, Woynecki T, van Fürden B, Tolkunova E, Seiffe F, Moser M, Tomilin A, Winterhager E, Schorle H.   
    Mol Cell Biol. 2010 Apr 19. PMID: 20404091 

  14.     Loss of transcription factor AP-2gamma/TFAP2C impairs branching morphogenesis of the murine mammary gland
    Jäger R, Schäfer, S, Hau-Liersch M, Schorle H.   
    Dev Dyn. 2010 Feb 3;239(3):1027-1033. PMID: 20131354

  15.     Critical function of AP-2gamma/TCFAP2C in mouse embryonic germ cell maintenance
    Weber S, Eckert D, Nettersheim D, Gillis A, Schäfer S, Kuckenberg P, Ehlermann J, Werling U, Biermann K, Looijenga L, Schorle H.   
    Biol Reprod. 2010 Jan;82(1):214-23. Epub 2009 Sep 23.PMID: 19776388  

  16.     AP2gamma regulates basal progenitor fate in a region- and layer-specific manner in the developing cortex.
    Pinto L, Drechsel D, Schmid MT, Ninkovic J, Irmler M, Brill MS, Restani L, Gianfranceschi L, Cerri C, Weber SN, Tarabykin V, Baer K, Guillemot F, Beckers J, Zecevic N, Dehay C, Caleo M, Schorle H, Götz M.   
    Nat Neurosci. 2009 Oct;12(10):1229-37. Epub 2009 Sep 13. Erratum in: Nat Neurosci. 2009 Oct;12(10):1237. PMID: 19749747  

  17.     Loss of connexin43 mediated gap junctional coupling in the mesenchyme of limb buds leads to altered expression of morphogens in mice.  
    Dobrowolski R, Hertig G, Lechner H, Wörsdörfer P, Wulf V, Dicke N, Eckert D, Bauer R, Schorle H, Willecke K.  
    Hum Mol Genet. 2009 Aug 1;18(15):2899-911. Epub 2009 May 12.PMID: 19439426

  18.     AP-2α Regulates Migration of GN-11 Neurons via a Specific Genetic Program involving the AXL receptor tyrosine kinase  
    Orso F, Jäger R, Calogero R A, Schorle H, Sismondi P, De Bortoli M, Taverna D.  
    Hum Mol Genet. 2009 Aug 1;18(15):2899-911. Epub 2009 May 12.PMID: 19439426 

  19.    An activating mutation in the PDGF receptor alpha results in embryonic lethality caused by malformation of the vascular system.  
    Kurth P, Moenning A, Jäger R, Beine G, Schorle H.  
    Dev Dyn. 2009 May;238(5):1064-72.PMID: 19334281 

  20.    Autochthonous liver tumors induce systemic T cell tolerance associated with T cell receptor downmodulation.
    Ney JT, Schmidt T, Kurts C, Zhou Q, Eckert D, Felsher DW, Schorle H, Knolle P, Tüting T, Barchet W, Büttner R, Limmer A, Gütgemann I.  
    Hepatology. 2009 Feb;49(2):471-81. Erratum in: Hepatology. 2009 Mar;49(3):1058. PMID: 19105207 [PubMed - indexed for MEDLINE]      

  21.     Sustained PDGFRa signalling in osteoblasts results in craniosynostosis by overactivating the PLCg pathway. 
    Moenning A, Jäger R, Egert A, Kress W, Wardelmann E, Schorle H.  
    Mol Cell Biol    . 2009 Feb;29(3):881-91. Epub 2008 Dec 1.

  22.     Expression of BLIMP1/PRMT5 and concurrent histone H2A/H4 arginine 3 dimethylation in fetal gern cells, CIS/IGCNU and germ cell tumors. 
    Eckert D, Biermann K, Nettersheim D, Gillis AJ, Steger K, Jäck HM, Müller AM, Looijenga LH, Schorle H. 
    BMC Dev. Biol. 2008, Nov 7;8(1):106. 

  23.     Lactogenic differentiation of HC11 cells is not accompanied by downregulation of AP-2 transcription factor genes. 
    Jäger R, Pappas L, Schorle H. 
    BMC Research Notes 2008 Jun 23;1:29

  24.     [On the role of transcription factor family AP-2 for development and disease--lessons from mouse models]
     Schorle H.
    Verh Dtsch Ges Pathol. 2007;91:91-7. German.  

  25.     [Embryonal germ cells and germ cell tumors]
    Biermann K, Heukamp LC, Nettersheim D, Steger K, Zhou H, Franke FE, Guetgemann I, Sonnack V, Brehm R, Berg J,   Bastian PJ, Müller SC, Wang-Eckert L, Schorle H, Büttner R.
    Verh Dtsch Ges Pathol. 2007;91:39-48. German.

  26.     TCam-2 but not JKT-1 cells resemble seminoma in cell culture. 
    Eckert D, Nettersheim D, Heukamp LC, Kitazawa S, Biermann K, Schorle H.  
    Cell Tissue Res. 2008 Feb;331(2):529-38

  27.     Gene expression profiling identifies new biological markers of neoplastic germ cells. 
    Biermann K, Heukamp LC, Steger K, Zhou H, Franke FE, Guetgemann I, Sonnack V, Brehm R, Berg J, Bastian PJ, Müller SC, Wang-Eckert L, Schorle H, Büttner R.
    Anticancer Res. 2007 Sep-Oct;27(5A):3091-100.

  28.     c-KIT is frequently mutated in bilateral germ cell tumours and down-regulated during progression from intratubular germ cell neoplasia to seminoma. 
    Biermann K, Göke F, Nettersheim D, Eckert D, Zhou H, Kahl P, Gashaw I, Schorle H, Büttner R.
    J Pathol. 2007 Nov;213(3):311-8.

  29.     Enhanced purification of cell-permeant Cre and germline transmission after transduction into mouse embryonic stem cells. 
    Peitz M, Jäger R, Patsch C, Jäger A, Egert A, Schorle H, Edenhofer F.  
    Genesis    . 2007 Aug;45(8):508-17. 

  30.     Essential role of Ubiquitin specific protease 8 (UBPy) for receptor tyrosine kinase stability and endocytic trafficking in vivo. 
    Niendorf S, Oksche A, Kisser A, Löhler J, Prinz M, Schorle H, Feller S, Lewitzky M, Horak I, Knobeloch KP. 
    Mol Cell Biol. 2007 Jul;27(13):5029-39. 

  31.     Deficiency in the LIM-only protein Fhl2 impairs skin wound healing. 
    Wixler V, Hirner S, Müller JM, Gullotti L, Will C, Kirfel J, Günther T, Schneider H, Bosserhoff A, Schorle H, Park J, Schüle R, Buettner R. 
    J Cell Biol. 2007 Apr9;177(1):163-72.

  32.     Establishment and controlled differentiation of neural crest stem cell lines using conditional transgenesis. 
    Maurer J, Fuchs S, Jäger R, Kurz B, Sommer L, Schorle H. 
    Differentiation. 2007 Sep;75(7):580-91.     

  33.     Diagnostic value of markers M2A, OCT3/4, AP-2gamma, PLAP and c-KIT in the detection of extragonadal seminomas. 
    Biermann K, Klingmüller D, Koch A, Pietsch T, Schorle H, Büttner R, Zhou H.
    Histopathology    . 2006 Sep;49(3):290-7.

  34.     Normal embryonic development and cardiac morphogenesis in mice with Wnt1-Cre-mediated deletion of connexin43. 
    Kretz M, Eckardt D, Krüger O, Kim JS, Maurer J, Theis M, van Rijen HV, Schorle H, Willecke K.
    Genesis. 2006 Jun;44(6):269-76.

  35.     The AP-2 family of transcription factors. 
    Eckert D, Buhl S, Weber S, Jäger R, Schorle H.  
    Genome Biol. 2005;6(13):246.

  36.     Spatial expression of germ cell markers during maturation of human fetal male gonads: an immunohistochemical study. 
    Pauls K, Schorle H, Jeske W, Brehm R, Steger K, Wernert N, Büttner R, Zhou H.
    Hum Reprod. 2006 Feb;21(2):397-404.       

  37.      Cell-specific deletion of glucosylceramide synthase in brain leads to severe neural defects after birth. 
    Jennemann R, Sandhoff R, Wang S, Kiss E, Gretz N, Zuliani C, Martin-Villalba A, Jäger R, Schorle H, Kenzelmann M, Bonrouhi M, Wiegandt H, Gröne HJ.
    Proc Natl Acad Sci U S A. 2005 Aug 30;102(35):12459-64.  

  38.     Mice transgenic for NPM-ALK develop non-Hodgkin lymphomas. 
    Jäger R, Hahne J, Jacob A, Egert A, Schenkel J, Wernert N, Schorle H, Wellmann A.     
    Anticancer Res. 2005 Sep-Oct;25(5):3191-6.  

  39.     A mouse model for cystic biliary dysgenesis in autosomal recessive polycystic kidney disease (ARPKD).
    Moser M, Matthiesen S, Kirfel J, Schorle H, Bergmann C, Senderek J, Rudnik-Schöneborn S, Zerres K, Buettner R.
    Hepatology. 2005 May;41(5):1113-21.

  40.     Dual role of AP-2gamma in ErbB-2-induced mammary tumorigenesis. 
    Jäger R, Friedrichs N, Heim I, Büttner R, Schorle H.     
    Breast Cancer Res Treat. 2005 Apr; 90(3):273-80. 

  41.     Transcription factor AP-2gamma, a novel marker of gonocytes and seminomatous germ cell tumors.
    Pauls K, Jäger R, Weber S, Wardelmann E, Koch A, Büttner R, Schorle H. 
    Int J Cancer. 2005 Jun 20; 115(3):470-7.

  42.     Towards dissecting the complexity of the AP-1 (activator protein 1) family. 
    Unal R, Weih F, Schorle H, Herrlich P.     
    Adv Exp Med Biol. 2004 553:331-6.  

  43.     Distinct spatial expression patterns of AP-2alpha and AP-2gamma in non-neoplastic human breast and breast cancer. 
    Friedrichs N, Jäger R, Paggen E, Rudlowski C, Merkelbach-Bruse S, Schorle H, Buettner R.      
    Mod Pathol. 2005 Mar;18(3):431-8. 

  44.     Cell type-specific conditional regulation of the c-myc proto-oncogene by combining Cre/loxP recombination and tamoxifen-mediated activation. 
    Jäger R, Maurer J, Jacob A, Schorle H. 
    Genesis. 2004 Mar;38(3):145-50.

  45.     Starvation response in mouse liver shows strong correlation with life-span-prolonging processes.
    Bauer M, Hamm AC, Bonaus M, Jacob A, Jaekel J, Schorle H, Pankratz MJ, Katzenberger JD.
    Physiol Genomics. 2004 Apr 13;17(2):230-44.  

  46.     Transcription factor AP-2gamma stimulates proliferation and apoptosis and impairs differentiation in a transgenic model. 
    Jäger R, Werling U, Rimpf S, Jacob A, Schorle H. 
    Mol Cancer Res. 2003 Oct;1(12):921-9.

  47.       Differential role of p300 and CBP acetyltransferase during myogenesis: p300 acts upstream of MyoD and Myf5. 
     Roth JF, Shikama N, Henzen C, Desbaillets I, Lutz W, Marino S, Wittwer J, Schorle H, Gassmann M, Eckner R. 
    Embo J. 2003 Oct 1; 22(19):5186-96.

  48.     Cloning, expression and characterization of the murine Efemp1, a gene mutated in Doyne-Honeycomb retinal dystrophy. 
     Ehlermann J, Weber S, Pfisterer P, Schorle H. 
    Gene Expr Patterns. 2003 Aug;3(4):441-7.  

  49.     Dynamic expression of Kruppel-like factor 4 (Klf4), a target of transcription factor AP-2alpha during murine mid-embryogenesis. 
    Ehlermann, J, Pfisterer     Ehlermann, J, Pfisterer P, Schorle H.
    Anat Rec A Discov Mol Cell Evol Biol. 2003 Aug;273:677-80.

  50.     Terminal renal failure in mice lacking transcription factor AP-2 beta. 
     Moser M, Dahmen S, Kluge R, Gröne H, Dahmen J, Kunz D, Schorle H, Buettner R.
    Lab Invest. 2003 Apr;83:571-8.

  51.     Mutation of the SBF2 gene, encoding a novel member of the myotubularin family, in Charcot-Marie-Tooth neuropathy type 4B2/11p15. 
    Senderek J, Bergmann C, Weber S, Ketelsen UP, Schorle H, Rudnik-Schöneborn S, Büttner R, Buchheim E, Zerres K.      
    Hum Mol Genet. 2003 Feb1;12:349-56.

  52.     [Anthrax. The growing danger]. 
    Schorle, H.
    Pathologe. 2002 May;23:167-9.  

  53.     Exencephaly in a subset of animals heterozygous for AP-2alpha mutation.
    Kohlbecker A, Lee AE, Schorle H.
    Teratology. 2002 May;65:213-8.

  54.     Transcription factor gene AP-2 gamma essential for early murine development. 
    Werling U, Schorle H.  
    Mol Cell Biol. 2002 May;22:3149-56.  

  55.     Conditional inactivation of transcription factor AP-2gamma by using the Cre/loxP recombination system. 
    Werling U, Schorle H.
    Genesis. 2002 Feb;32:127-9.  

  56.     A subtractive gene expression screen suggests a role of transcription factor AP-2 alpha in control of proliferation and differentiation.
    Pfisterer P, Ehlermann J, Hegen M, Schorle H.
    J Biol Chem. 2002 Feb 22; 277:6637-44   

  57.     Mice overexpressing genes from the 22q11 region deleted in velo-cardio-facial syndrome/DiGeorge syndrome have middle and inner ear defects. 
    Funke B, Epstein JA, Kochilas LK, Lu MM, Pandita RK, Liao J, Bauerndistel R, Schüler T, Schorle H, Brown MC, Adams J, Morrow BE.     
    Hum Mol Genet. 2001 Oct15;10:2549-56.

  58.     TBX1 is responsible for cardiovascular defects in velo-cardio-facial/DiGeorge syndrome. 
     Merscher S, Funke B, Epstein JA, Heyer J, Puech A, Lu MM, Xavier RJ, Demay MB, Russell RG, Factor S, Tokooya K, Jore BS, Lopez M, Pandita RK, Lia M, Carrion D, Xu H, Schorle H, Kobler JB, Scambler P, Wynshaw-Boris A, Skoultchi AI, Morrow BE, Kucherlapati R.
    Cell. 2001 Feb 22;104:619-29.

  59.    Regulatory roles of AP-2 transcription factors in vertebrate development, apoptosis and cell-cycle control. 
    Hilger-Eversheim K, Moser M, Schorle H, Buettner R.  
    Gene. 2000 Dec 30;260:1-12.

  60.     Expression of Cdcrel-1 (Pnutl1), a gene frequently deleted in velo-cardio-facial syndrome/DiGeorge syndrome. 
    Maldonado-Saldivia J, Funke B, Pandita RK, Schüler T, Morrow BE, Schorle H.
    Mech Dev. 2000 Aug;96:121-4.

  61.     Spatiotemporal expression pattern of keratins in skin of AP-2alpha-deficient mice. 
    Talbot D, Loring J, Schorle H.      
         J Invest Dermatol. 1999 Nov;113:816-20.

  62.     Transcription factor AP-2 essential for cranial closure and craniofacial development. 
    Schorle H, Meier P, Buchert M, Jaenisch R, Mitchell PJ.     
    Nature. 1996 MAy 16;381:235-8.

  63.     [Generalized autoimmune diseases in BALB/c mice with a genetically dependent interleukin-2 deficiency].  
    Löhler J, Sadlack B, Schorle H, Klebb G, Haber H, Horak I. 
    Verh Dtsch Ges Pathol. 1996;80:293-6.

  64.     Generalized autoimmune disease in interleukin-2-deficient mice is triggered by an uncontrolled activation and proliferation of CD4+ T cells. 
    Sadlack B, Löhler J, Schorle H, Klebb G, Haber H, Sickel E, Noelle RJ, Horak I.     
    Eur J Immunol. 1995 Nov;25:3053-9.

  65.    Antiviral immune responses in mice deficient for both interleukin-2 and interleukin-4. 
    Bachmann MF, Schorle H, Kühn R, Müller W, Hengartner H, Zinkernagel RM, Horak I.     
    J Virol.1995 Aug;69:4842-6.

  66.     Development and proliferation of lymphocytes in mice deficient for both interleukins-2 and -4.
    Sadlack B, Kühn R, Schorle H, Rajewsky K, Müller W, Horak I.
    Eur J Immunol. 1994 Jan;24:281-4.

  67.     Immune responses in interleukin-2-deficient mice. 
    Kündig TM, Schorle H, Bachmann MF, Hengartner H, Zinkernagel RM, Horak I.
    Science. 1993 Nov 12; 262:1059-61.  

  68.     Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene. 
    Sadlack B, Merz H, Schorle H, Schimpl A, Feller AC, Horak I. 
    Cell. 1993 Oct 22;75:253-61.

  69.     Development and function of T cells in mice rendered interleukin-2 deficient by gene targeting.
         Schorle H, Holtschke T, Hünig T, Schimpl A, Horak I. 
    Nature. 1991 Aug 15;352:621-4.

 

 

                                           Questions, comments and reprint requests to: hubert.schorle@ukb.uni-bonn.de 
                                           Last Modified: Feb-12