Prof. Dr. Hubert Schorle
Biosketch
2004 - present
Professor for Developmental Pathology at University of Bonn Medical School
2004 - 2005
Professor for Developmental Biology at the Zentrum
für Medizinische Biotechnologie (ZMB) at the University of Duisburg-Essen
2001 - 2004
Head of the Transgenic Facility at the Institute of
Pathology, University
of Bonn Medical School
1996 - 2001
Junior Research Group Leader at the Institute for
Toxicology
and Genetics, Forschungszentrum Karlsruhe
1996
Postdoctorate Associate with Prof. Dr. R. Jaenisch Whitehead Institute for
Biomedical Research/M.I.T., Cambridge, USA
1993 - 1996
Postdoctorate Fellow (DFG Stipendiat) with Prof. Dr. R. Jaenisch; Whitehead
Institute for Biomedical Research/M.I.T., Cambridge, USA
1992
Postdoc with Prof. Dr. I. Horak (Emeritus
of FMP, Berlin), Institute for
Virology, Universität Würzburg
Selected Publications
Kuckenberg
P, Peitz M, Kubaczka C, Becker A, Egert A, Wardelmann
E, Zimmer
A, Brüstle O,
Schorle H.
Lineage
Conversion of Murine Extraembryonic Trophoblast Stem Cells to Pluripotent Stem
Cells
.
Mol. Cell. Biol. doi:10.1128/MCB.01047-10
Kuckenberg
P, Buhl S, Woynecki T, van Fürden B, Tolkunova E, Seiffe F, Moser M, Tomilin A,
Winterhager E, Schorle
H.
The
transcription factor TFAP2C/AP-2gamma
cooperates with CDX2 to maintain trophectoderm formation.
Mol Cell Biol. 2010 Apr 19.
Weber
S,
Eckert
D, Nettersheim D, Gillis A, Schäfer S, Kuckenberg P,
Ehlermann J,
Werling
U, Biermann K, Looijenga L, Schorle H.
Critical
function of AP-2gamma/TCFAP2C
in mouse embryonic germ cell maintenance
. Biol
Reprod. 2010 Jan;82(1):214-23. Epub 2009 Sep 23.PMID:
19776388
Moenning
A, Jäger R, Egert A, Kress W, Wardelmann E, Schorle H. Sustained
PDGFRa
signalling
in osteoblasts results in craniosynostosis by overactivating the PLCg
pathway
. Mol
Cell Biol. 2009 Feb;29(3):881-91.
Eckert
D, Biermann K, Nettersheim D, Gillis AJ, Steger K, Jäck HM, Müller AM,
Looijenga LH, Schorle H. Expression
of BLIMP1/PRMT5 and concurrent histone H2A/H4 arginine 3 dimethylation in fetal
gern cells, CIS/IGCNU and germ cell tumors.
BMC Dev. Biol. 2008, Nov 7;8(1):106.
Maurer, J., S. Fuchs, R. Jager, B. Kurz, L. Sommer, and H.
Schorle. 2007. Establishment and controlled differentiation of neural crest stem
cell lines using conditional transgenesis. Differentiation. PMID 17381545
Eckert, D., S. Buhl, S. Weber, R. Jager, and H. Schorle. 2005.
The AP-2 family of transcription factors. Genome Biol 6:246.(Review)
Pauls K, Jager R, Weber S, Wardelmann E, Koch A, Buttner R, Schorle H.
Transcription factor AP-2gamma, a novel marker of gonocytes and seminomatous
germ cell tumors.Int J Cancer. 2005 Feb 7;
Jager R, Maurer J, Jacob A, Schorle H.
Cell type-specific conditional regulation of the c-myc proto-oncogene by
combining Cre/loxP recombination and tamoxifen-mediated activation.
Genesis. 2004 Mar;38(3):145-50.
Jager R, Werling U, Rimpf S, Jacob A, Schorle H.
Transcription factor AP-2gamma stimulates proliferation and apoptosis and
impairs differentiation in a transgenic model.
Mol Cancer Res. 2003 Oct;1(12):921-9.
Werling U, Schorle H.
Transcription factor gene AP-2 gamma essential for early murine development.
Mol Cell Biol. 2002 May;22(9):3149-56.
Pfisterer P, Ehlermann J, Hegen M, Schorle H.
A subtractive gene expression screen suggests a role of transcription factor
AP-2 alpha in control of proliferation and differentiation.
J Biol Chem. 2002 Feb 22;277(8):6637-44. Epub 2001 Dec 10.
