Department of Developmental Pathology


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The Department of Developmental Pathology is devoted to translational research, connecting basic molecular biology with medical sciences. Using modern molecular biology approaches, we address questions relating to genetic and epigenetic regulation in the field of stem cell biology. Here, we address the question, how pluripotency is regulated during early embryogenesis and during germ cell tumor development. We focus on early lineage specification, hematopoesis and the biology of germ cells and germ cell tumors. Generating 'gain of function' and 'loss of function' animal models for genes involved in regulating proliferation and differentiation processes, we study effects in a physiologically relevant environment. Using germ cell tumor cell lines, we analyze the genetic and epigenetic regulation of the context-dependent cross-talk between tumor and stroma cells.

Research in our Lab is funded by grants from Deutsche Forschungsgemeinschaft (DFG), the Wilhelm Sander Stiftung, BONFOR and Bonner Forum Biomedizin (BFB).

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                              Prof. Dr. Hubert Schorle

                              Department of Developmental Pathology

                              University of Bonn Medical School

                              Sigmund Freud Strasse 25

                              53127 Bonn, Germany

Phone                    +49 228 287 16342

Fax                        +49 228 287 19757

E-Mail                    General Information:



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                                           Last Modified: 01/06/17