Medline: 8068936

Blood 84(5): 1361-1392, 1994.

A revised European-American classification of lymphoid neoplasms: a proposal from the International Lymphoma Study Group.

Harris NL, Jaffe ES, Stein H, et al.


A meeting of the International Lymphoma Study Group in Berlin in April, 1993, decided that the most practical approach at present is to define those diseases clinicians think they can recognize with currently available morphologic, immunologic, and genetic techniques. B-cell neoplasms consist of: precursor B-lymphoblastic leukemia/lymphoma; peripheral B-cell neoplasms (11 types); B-cell chronic lymphocytic leukemia/prolymphocytic leukemia/small lymphocytic lymphoma; lymphoplasmacytoid lymphoma/immunocytoma; mantle cell lymphoma; follicle center lymphoma, small cell, mixed small and large, and predominantly small cell type; marginal zone B-cell lymphoma, extranodal MALT type, and nodal; splenic marginal zone lymphoma; hairy cell leukemia; plasmacytoma/plasma cell myeloma; diffuse large B-cell lymphoma, with a thymic B-cell subtype; Burkitt's lymphoma; and high-grade b-cell lymphoma, and Burkitt-like. T-cell and putative NK-cell neoplasms include precursor T-lymphoblastic lymphoma/leukemia and peripheral T-cell and NK-cell neoplasms including ten subtypes; T-cell chronic lymphocytic leukemia/prolymphocytic leukemia; large granular lymphocyte leukemia (T-cell or NK-cell types); mycosis fungoides/Sezary syndrome; peripheral T-cell lymphomas, unspecified, with three provisional categories; angioimmunoblastic T-cell lymphomas; angiocentric lymphoma; intestinal T-cell lymphoma; adult T-cell lymphoma/leukemia; anaplastic large cell lymphoma, CD30+, T- and null-cell types; and (provisionally) anaplastic large-cell lymphoma, Hodgkin's-like. Hodgkin's disease includes the five types of lymphocyte predominance, nodular sclerosis, mixed cellularity, lymphocyte depletion, and (provisionally) lymphocyte-rich classical Hodgkin's disease. The proposed scheme is compared with the Kiel classification and the Working formulation. Categories are detailed under the headings synonyms, morphology, immunophenotype, genetic features, clinical features, and postulated normal counterpart. Tables feature differential diagnosis of low-grade lymphomas, with morphologic, immunohistologic and genetic features; a test of the reproducibility of the classification of 23 large B-cell lymphoma cases in the hands of 12 participants; and the contrast between immunologic and cytologic features of lymphocyte predominance and classic type Hodgkin's disease; 16 figures show cytological appearance. (296 Refs.)

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