Medline: 8270972

The abstract Journal of Clinical Oncology 12(1): 155-158, 1994. is available online.

The fulltext Journal of Clinical Oncology 12(1): 155-158, 1994. may be available online for subscribers.

Transdermal clonidine for ameliorating tamoxifen-induced hot flashes.

Goldberg RM, Loprinzi CL, O'Fallon JR, et al.


To determine the efficacy of transdermal clonidine for alleviating tamoxifen-induced hot flashes in women with a history of breast cancer.

Patients and Methods:
A randomized, double-blind, crossover design was used in this prospective study. Women with a history of breast cancer who were receiving tamoxifen and suffering from hot flashes were potentially eligible for this protocol study.

Clonidine did reduce hot-flash frequency to a degree that was statistically impressive (P < .0001), but clinically moderate (20% reduction from baseline). It also decreased hot-flash severity (P = .02, 10% reduction from baseline). Clonidine was related to increased mouth dryness (P < .001), constipation (P < .02), itchiness under the patch (P < .01), and drowsiness (P < .05).

Better means are needed to alleviate hot flashes among patients in whom estrogen therapy is contraindicated.

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Rheinische Friedrich- Wilhelms- Universität Bonn
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Dr. G. Quade