Medline: 1637026

Annals of Internal Medicine 117(4): 309-311, 1992.

Increased incidence of Hodgkin disease in homosexual men with HIV infection.

Hessol NA, Katz MH, Liu JY, et al.


To evaluate the incidence of Hodgkin's disease and non-Hodgkin's lymphoma among homosexual men infected with human immunodeficiency virus (HIV). DESIGN: Cohort study with computer-matched identification of participants with the Northern California Cancer Center registry. Population rate comparisons were made with data from the Surveillance, Epidemiology, and End Results (SEER) cancer registry. PARTICIPANTS: The 6704 homosexual men in the San Francisco City Clinic Cohort study. MEASUREMENTS: Incidence of Hodgkin's disease, non-Hodgkin's lymphoma, HIV infection, and the acquired immunodeficiency syndrome (AIDS); calculation of sex and age-adjusted standardized morbidity ratios and attributable risk.

Eight cases of Hodgkin's disease and 90 cases of non-Hodgkin's lymphoma were identified through computer matching among cohort members residing in the San Francisco Bay area from 1978 through 1989. Among the HIV-infected men, the age-adjusted standardized morbidity ratio was 5.0 (95% CI, 2.0 to 10.3) for Hodgkin's disease and 37.7 (CI, 30.3 to 46.7) for non-Hodgkin's lymphoma. The excess risk attributable to HIV infection was 19.3 cases of Hodgkin's disease per 100,000 person-years and 224.9 cases of non-Hodgkin's lymphoma per 100,000 person-years.

An excess incidence of Hodgkin's disease was found in HIV-infected homosexual men. Additional well-designed epidemiologic studies are needed to determine whether Hodgkin's disease should be considered an HIV-related malignancy.

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