Medline: 2808792

Journal of the American Academy of Dermatology 21(4 pt 1): 757-762, 1989.

Low-dose methotrexate for the Sezary syndrome.

Zackheim HS, Epstein EH

Abstract:

Seventeen patients with Sezary syndrome were treated with low-dose methotrexate for periods of up to 5 years (median follow-up 22 months). Seven patients (41%) achieved a complete response, and six patients (35%) achieved a partial response (more than 50% improvement). As of their latest evaluation, 10 of 17 (59%) were in a state of either complete or partial response. The estimated 5-year survival rate was 71% (standard error 13%). Toxicity was minor and self-limiting in only one patient. Clinical improvement was accompanied by a decrease in the circulating Sezary cell count.


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