Medline: 2927862

Obstetrics and Gynecology 73(4): 657-660, 1989.

Treatment of vaginal intraepithelial neoplasia with laser and topical 5-fluorouracil.

Krebs HB


The records of 59 women with grades 2 and 3 vaginal intraepithelial neoplasia were reviewed to define the role of CO2 laser ablation and topical 5-fluorouracil (5-FU) in the treatment of vaginal intraepithelial neoplasia. The patients in each treatment group were comparable in their personal characteristics and in distribution and severity of the lesions. Thirty-one patients used prophylactic 5-FU. Seventy-eight percent of all patients were free of vaginal intraepithelial neoplasia at the first follow-up examination. The results of treatment were not influenced by the grade of the lesion or previous radiation exposure of the patient. Topical 5-FU appeared to be as effective as laser. Periodic applications of 5-FU (once weekly for 10 weeks) were as effective as 5-FU applied in a continuous fashion (three 7-day courses 1 week apart), and caused fewer side effects.

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Rheinische Friedrich- Wilhelms- Universität Bonn
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Dr. G. Quade