Medline: 2845275

Nature 335(6191): 606-611, 1988.

The HIV tat gene induces dermal lesions resembling Kaposi's sarcoma in transgenic mice.

Vogel J, Hinrichs SH, Reynolds RK, et al.

Abstract:

When the human immunodeficiency virus transactivating gene under the control of the viral regulatory region is introduced into the germline of mice, skin lesions are induced that resemble Kaposi's sarcoma seen in AIDS. Our findings indicate that HIV could play a direct part in causing cancer.


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