Medline: 6227249

American Journal of Nephrology 3(5): 277-278, 1983.

Nephrotoxicity following single dose mithramycin therapy.

Benedetti RG, Heilman KJ, Gabow PA


Mithramycin given as a single dose for the treatment of hypercalcemia has not been reported to cause renal dysfunction. A case is presented of nephrotoxicity following a single 25 micrograms/kg dose in a patient with underlying squamous cell carcinoma, obstructive uropathy, and hypercalcemia. Underlying renal impairment may magnify the nephrotoxicity of mithramycin.

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