Medline: 87555

Lancet 1(8056): 125-126, 1978.

Early detection of cancer of oesophagus along Caspian Littoral. Report of a pilot project.

Dowlatshahi K, Daneshbod A, Mobarhan S


Endoscopic brush cytology for exfoliated cells in the esophagus was performed as part of a screening program for esophageal cancer in 280 adults from three villages with a total population of 10,000 in the Gorgon region of Iran, an area with a known high incidence of esophageal cancer. People with atypical cells in the cytology specimen were later examined with a fiberoptic esophagoscope. Of the patients examined, 20 had atypical exfoliated cells on cytological examination. Of these, six did not submit to further examination and two developed frank carcinoma. The remaining 12 patients were re-examined and biopsies taken from the upper, middle and lower zones of the esophagus. One 71-yr-old man was found to have a tumor at the cardia. No definite leson could be pinpointed in the remaining patients, and biopsy material was negative. However, at a repeat study four patients were found to have atypical cells, and these people are being kept under observation. Early diagnosis of esophageal cancer using exfoliate cytology may improve the prognosis of this disease. Results of other screening programs for esophageal cancer are discussed. (14 Refs)

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