Urology 4(4): 414-420, 1974.
Varkarakis MJ, Gaeta J, Moore RH, et al.
The course of 238 patient (195 men, 43 women) with superficial bladder tumors (1939-1967) was followed until death or the end of the study in 1972. The age range of patient was 32-86 yr, 75% were 69-75 yr old. Only tumors which had infiltrated no more than half of the muscular layer of the bladder (Stage 0, A, B1) were considered. At diagnosis most lesions ranged between 1-4 cm in size, and were associated with clinical stage A and histological grade II. Transitional cell carcinomas comprised 95.7% of the tumors. Surgical treatment alone, admin to 73.1% of the patient, resulted in better 5 yr survivals than any other form of treatment which included surgery + chemotherapy, +/or radiotherapy (4-4, 500 R). The ten year survival rate showed no difference between these groups. The disease progressed in 31% of the patient to more advanced clinicopathological stages. Recurrences were seen in 2/3 of the cases. One third of the patient with this disease died of bladder cancer. At the end of the study 1/2 of the patient were alive without tumor. Significant correlations were made between initial clinical staging and other factors, such as histological grading, size of initial lesions, degree of progression and survival rates. (23 refs)
Rheinische Friedrich- Wilhelms- Universität Bonn