Medline: 11107156

Medical and Pediatric Oncology 35(6): 724-726, 2000.

Results of the cooperative protocol (N-III-95) for metastatic relapses and refractory neuroblastoma.

Castel V, Canete A, Melero C, et al.


Prognosis of relapsed and refractory neuroblastoma is uniformly fatal; new therapeutic approaches are needed. PROCEDURE: Relapsed and refractory neuroblastoma patients were treated with continuous infusion chemotherapy combined with MIBG.

Over 4 years, 35 heavily pretreated patients were registered, 29 with bone or/and bone marrow metastases. Grade 3 or 4 hematologic toxicity was frequent, without toxic deaths. Sixteen patients responded. The probability of 5-year overall survival was 0.19.

This approach is feasible and toxicity manageable; it rescued some patients and prolonged their survival. It merits assay in newly diagnosed high-risk neuroblastoma patients. Copyright 2000 Wiley-Liss, Inc.

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