Medline: 10931059

British Journal of Surgery 87(8): 1106-1110, 2000.

Preoperative risk analysis in patients with adenocarcinoma or squamous cell carcinoma of the oesophagus.

Bollschweiler E, Schroder W, Holscher AH, et al.


The outcome after oesophagectomy depends not only on the surgical procedure itself but can be improved by the selection of patients based on a preoperative risk score.

In order to compare the preoperative risk for different histological subtypes of oesophageal carcinoma, 221 patients with a squamous cell carcinoma (SCC) and 104 patients with an adenocarcinoma (AC) were enrolled in a prospective study. The preoperative assessment included socioeconomic status, alcohol and tobacco consumption, general and nutritional status, and pulmonary, cardiovascular, hepatic and renal function.

More patients with an SCC were 'blue collar' and with an AC were 'white collar' workers (P < 0.001). Alcohol and tobacco consumption was higher in patients with an SCC (P < 0.01 and P < 0.05 respectively). The preoperative forced expiratory volume, arterial partial pressure of oxygen and the aminopyrine breath test showed more severely compromised pulmonary and hepatic function in patients with an SCC (P < 0.05 for all variables). Some 50 per cent of patients with an AC were overweight with a higher body mass index (P < 0.001). More patients with an AC had severely impaired cardiac function (P < 0.01).

Patients with SCC and AC of the oesophagus differed regarding their socioeconomic and preoperative risk factors for surgery.

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