heteroduplex analysis

Pronunciation:(HEH-teh-roh-DOO-plex uh-NA-lih-sis)

Definition: A method of detecting sequence differences between normal DNA and the DNA to be tested. It is commonly used as a screening method to detect potential mutations in a gene.GeneticsHealth professional

DNA duplexes. Homoduplex DNA shows the normal binding of wild-type DNA sequences. Heteroduplex DNA shows unpaired regions, which are sites of possible mutations.2010-04-19