predisposing mutation

Pronunciation:(PREE-dih-SPOH-zing myoo-TAY-shun)

Definition: A genetic alteration that increases an individual’s susceptibility or predisposition to a certain disease or disorder. When such a variant (or mutation) is inherited, development of symptoms is more likely, but not certain. Also called deleterious mutation, disease-causing mutation, pathogenic variant, and susceptibility gene.GeneticsHealth professional