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http://www.ukb.uni-bonn.de

 

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2012


Alvarez-Baron, E., Michel, K., Mittelstaedt, T., Opitz, T., Schmitz, F., Beck, H., Becker, A.J., Schoch, S. (2012) Role of short Rim isoforms in regulating dendritic morphogenesis. J. Neurosci., im Druck. 


Uebachs, M., Albus, C., Opitz, T., Isom, L., Niespodziany, I., Wolff, C., Beck, H. Loss of b1 accessory Na+ channel subunits leads to failure of carbamazepine, but not of lacosamide in blocking high-frequency firing via differential effects on persistent Na+ currents. Epilepsia, im [PDF].

 

Pitsch, J., Opitz, T., Woitecki, A., Staniek, M., Beck, H., Becker, A.J., Schoch, S. (2012) The presynaptic active zone protein RIM1α controls epileptogenesis following status epilepticus. J. Neurosci., 32: 12384-95. [PDF]


Müller, C., Beck, H., Coulter D.A., and Remy, S. (2012) Inhibitory control of linear and supralinear dendritic excitation in CA1 pyramidal neurons. Neuron, 75: 851-64. [PDF]

 

Surges, R., Kukley, M., Brewster, A., Rüschenschmidt, C., Baram, T.Z., Beck, H., Dietrich, D. (2012) Hyperpolarization-activated cation current Ih of dentate gyrus granule cells is up-regulated in human and rat temporal lobe epilepsy. Biochem Biophys Res. Comm., 420:156-60 (2.548). [PDF]

 

Van Loo, K., Schaub, C., Pernhorst, K., Yaari, Y., Beck, H., Schoch, S., and Becker, A.J. (2012) Egr1 and REST bi-directionally regulate the activity of the T-type Ca2+ channel CaV3.2 promoter. JBC, 287:15489-501 (5.328).

 

2011

 

Jeub, M., Emrich, M., Pradier, B., Huylebroeck, D., Zimmer, A., Beck, H. , Racz, I. (2011) The transcription factor Smad-interacting protein 1 controls pain sensitivity via modulation of DRG neuron excitability. Pain, im Druck. [PDF]
        
Krüppel, R., Remy, S., Beck, H. (2011) Dendritic integration in hippocampal dentate granule cells. Neuron, 71:512-528 (14.027). [PDF]
        
Otte, D.M., Sommersberg, B., Kudin, A., Guerrero, C., Albayram, Ö., Filiou, M.D., Frisch, P. Yilmaz, Ö, Drews, E., Turck, C.W., Bilkei-Gorzó, A., Kunz, W.S., Beck, H., Zimmer, A. (2011) N-acetyl cysteine treatment rescues cognitive deficits induced by mitochondrial dysfunction in G72/G30 transgenic mice. Neuropsychopharmacology, 6.993 [PDF]. 
        
Chen, S., Su, H., Remy, S., Yue, C., Sochivko, D., Beck, H. and Yaari, Y. (2011) Two distinct mechanisms generating aberrant intrinsic bursting in acquired temporal lobe epilepsy. J. Neurophysiol., 105:117-29 (3.790). [PDF]

 

2010


Barnes, S., Opitz, T., Merkens, M., Kelly, T., von der Brelie, C., Krüppel, R., Beck, H.  (2010) Mossy fiber long-term potentiation requires Ca2+ influx at both the soma and the axon terminals of dentate granule cells. J. Neurosci., 30: 12996-13004 (7.490). [PDF]
        
Coras, R., Siebzehnrubl, F.A., Pauli, Huttner, H.B., Njunting, M., Kobow, K., Villmann, C., Hahnen, E., Neuhuber, W., Weigel, D., Buchfelder, M., Stefan, H., Beck, H., Steindler, D.A., Blümcke, I. (2010) Low proliferation and differentiation capacities of adult hippocampal stem cells correlate with memory dysfunction in humans. Brain, 133: 3359-72 (9.490). [PDF]
        
Wimmer, V.C., Reid, C.A., Mitchell, S., Richards, K.L., Scaf, B.,  Hill, E.L., Royeck, M., Horstmann, M.-T., Cromer, B, Davies, P.J., Xu, R., Lerche, H., Berkovic, S.F., Beck, H.,  Petrou, S. (2010) A human sodium channel accessory subunit mutation causes epilepsy via an axonal channelopathy. JCI, 120: 2661-71 (16.56). [PDF]

Uebachs, M., Opitz, T., Royeck, M., Dickhof, G., Horstmann, M.-T., Isom, L., Beck, H. (2010) Efficacy loss of the anticonvulsant carbamazepine in mice lacking sodium channel accessory subunits via paradoxical effects on persistent sodium currents. J. Neurosci., 30: 8489-501 (7.490). [PDF]

 

2009


Remy, S., Csicsvari, J. and Beck H. (2009) Activity-dependent control of neuronal output by local and global dendritic spike attenuation. Neuron, 61: 906-916 (13.41). [PDF] Comment in 'Neuron Previews' by Tiago Branco and Michael Häusser [PDF]

 

2008


Beck, H. and Yaari, Y. (2008) Plasticity of intrinsic neuronal properties in CNS disorders. Nature Reviews Neuroscience. 9: 357-369. [PDF]

Royeck, M., Remy, S., Reitze, M., Yaari, Y., and Beck, H. (2008) The role of axonal Nav1.6 in action potential initiation of CA1 neurons. J. Neurophysiol., in press. [PDF]

Eckhardt, M., Hedayati, K.K., Lüllmann-Rauch, R., Pitsch, J., Beck, H., Ngamli Fewou, S. and Gieselmann, V. (2007) Neurological symptoms and nerve fiber degeneration in arylsulfatase A-deficient mice with increased sulfatide storage in neurons. J. Neurosci., 27:9009-9021. [PDF]

Kirschstein, T., Bauer, M., Rüschenschmidt, C., Schoch, S., Becker, A., and Beck, H. Loss of metabotropic glutamate receptor-dependent LTD via down-regulation of metabotropic glutamate receptor 5 following status epilepticus. J. Neurosci., 27: 7696-704. [PDF]

 

2007


Bender, R.A., Kirschstein T., Kretz, O., Brewster, A.L., Richichi, C., Rüschenschmidt, C., Shigemoto, R., Beck, H., Frotscher, M., Baram T.Z. (2007) Transient axonal trafficking of HCN1 channels during hippocampal development is regulated by neuronal activity. J. Neurosci., 27:4697-706. [PDF]

Schaub, C., Uebachs, M., Beck, H. (2007) Attenuated effects of carbamazepine on CA1 neurons in chronic experimental epilepsy. Epilepsia, 48: 1339-1350. [PDF]

Müller, A., Kukley, M., Uebachs, M., Beck, H., and Dietrich, D. (2007) Nanodomains of single Ca2+ channels mediate action potential repolarization in cortical neurons. J. Neurosci. 27:483-95. [PDF]

 

2006

Wiese, C., Rolletschek, A., Kania, G., Navarrete-Santos, A., Anisimov, S.V., Steinfarz, B., Tarasov, K.V., Brugh, S.A., Zahanich, I., Rüschenschmidt, C., Beck, H., Blyszczuk, P., Czyz, J., Heubach, J.F. Ravens, U., Horstmann, O., St-Onge, L., Braun, T., Brüstle, O., Boheler, K.R. and Wobus, A. (2006) Signals from embryonic fibroblasts induce adult intestinal epithelial cells to form nestin positive cells with proliferation and multilineage differentiation capacity in vitro. Stem Cells,24: 2085-97. [PDF]

Surges, R., Brewster, A.L., Bender, R.A., Beck, H., Feuerstein, T.J., and Baram, T.Z. (2006) Regulated expression of HCN channels and cAMP levels shape the properties of the h current in developing rat hippocampus. European J. Neurosci., 24: 94-104. [PDF]

Übachs, M., Schaub, C., Perez-Reyes, E. and Beck, H. (2006) Slow recovery from inactivation of cloned and native T-type Ca2+ channels. J. Physiol., 571: 519-536. [PDF]

Rüschenschmidt, C., Riazanski, V., Chen, J., Becker, A. and Beck, H. (2006) Functional properties and oxidative modulation of A-type potassium currents in hippocampal granule cells of control and chronically epileptic rats. European J. Neurosci., 23: 675-685.  [PDF]

Von der Brelie, C., Waltereit, R., Zhang, L., Weller, M., Beck, H. and Kirschstein, T. (2006) Impaired synaptic plasticity in a rat model of tuberous sclerosis. European J. Neurosci. 23:686-692. [PDF]

 

2005

Yue, C., Remy, S., Beck, H., and Yaari, Y. (2005) Proximal persistent Na+ channels underlie spike depolarizing afterpotentials in adult rat CA1 pyramidal cells. J. Neurosci., 25: 9704-20. [PDF]

Zhang, L., Kirschstein, T., Manahan-Vaughan, D., Elgersma, Y., und Beck, H. (2005) Pathway-specific metaplasticity requires inhibitory autophosphorylation of CaMKII. J. Neurosci.,25: 7697-707. [PDF]

Müller, A., Kukley, M., Stausberg, P., Beck, H. Müller, W. and Dietrich, D. (2005) Endogenous Ca2+ buffer concentration in hippocampal neurons. J. Neurosci., 25: 558-65. [PDF]

Rüschenschmidt, C., Koch, P., Brüstle, O.B. und Beck, H. (2005) Functional properties of ES-cell derived neurons in the pilocarpine model of epilepsy. Epilepsia, 46 Suppl 5: 174-83. [PDF]

 

2004

Remy, C., Beck, H., Swandulla, D. und Hans, M. (2004) Modulation of voltage-dependent sodium channels by the d-agonist SNC80 in acutely isolated rat hippocampal neurons. Neuropharmacology, 47: 1102-12. [PDF]

Bernard, C., Anderson, A., Becker, A., Poolos, N., Beck, H., and Johnston, D. (2004) Acquired dendritic channelopathy in temporal lobe epilepsy. Science, 305: 532-535. [PDF], [supplemental data], [commentary]

Wernig, M., Benninger, F., Tucker, K.L., Beck, H. und Brüstle, O. (2004) Functional Integration of ES Cell-Derived Neurons In Vivo. J. Neurosci, 24: 5258-68. [PDF]

Kirschstein, T., von der Brelie, C., Steinhäuser, M., Vincon, A., Beck, H. und Dietrich, D. (2004) L-CCG-I inhibits group III metabotropic glutamate receptors in the rat hippocampal CA1 region. Neuropharmacology, 47: 157-162. [PDF]

 

2003

Scheffler, B., Schmandt, T., Schröder, W., Steinfarz, B., Wellmer, J., Beck, H., Steinhäuser, C., Wiestler, O.D., Blümcke, I. and Brüstle, O. (2003) Functional network integration of transplanted ES cell-derived glial precursors. Development, 130: 5533-41. [PDF]

Bender, R.A., Soleymani, S.V., Brewster, A.L., Nguyen, S.T., Beck, H., Mathern, G.W., Baram, T.Z. (2003) Enhanced expression of a specific hyperpolarization-activated cyclic nucleotide-gated cation channel (HCN) in surviving dentate gyrus granule cells of human epileptic hippocampus. J. Neurosci., 23(17):6826-36. [PDF]

Benninger, F., Beck, H., Wernig, M., Brüstle, O., and Scheffler B. (2003) Functional Integration of Embryonic Stem Cell-Derived Neurons. J. Neurosci. 23: 7075-83. [PDF]

Dietrich, D., Kirschstein, T., Kukley, M., Pereverzev, A., von der Brelie, C., Schneider, T., and Beck, H. (2003) Functional specialization of presynaptic Cav2.3 Ca2+ channels. Neuron, 39: 483-96. [PDF]

Remy, S., Urban, B.W., Elger, C.E. and Beck, H. (2003) Anticonvulsant pharmacology of voltage-dependent Na+ channels in hippocampal dentate granule neurons in chronic epilepsy. Eur. J. Neurosci., 17: 1-11. [PDF]

Ellerkmann, R., Remy, S., Chen, J., Sochivko, D., Elger, C.E., Urban, B.W. Becker, A. and Beck, H. (2003) Molecular and functional changes in voltage-dependent Na+ channels following status epilepticus in hippocampal dentate granule neurons. Neuroscience, 119: 323-333. [PDF]

Remy, S., Gabriel, S., Urban, B.W., Lehmann, T.-N., Elger, C.E., Heinemann, U. and Beck, H. (2003) A novel mechanism underlying pharmaco-resistance in chronic epilepsy: reduced pharmacosensitivity of voltage-dependent sodium channels. Ann. Neurol., 53: 469-79. [PDF]

Sochivko, D., Becker, A., Chen, J. and Beck, H. (2003) R-type Ca2+ channels in hippocampal CA1 neurons. Neuroscience, 116: 629-38. [PDF]

Fasen, K., Beck, H., Elger, C.E. and Lie, A.A. (2003) Differential regulation of cadherins and catenins during axonal reorganization in the adult rat CNS. JNEN, 61: 903-913. [PDF]

 

2002

Wellmer, J., Su, H., Beck, H. and Yaari, Y. (2002) Long-lasting modification of intrinsic discharge properties in subicular neurons following status epilepticus. European J. Neurosci.,16: 259-266. [PDF]

Becker, A.J., Chen, J., Paus, S., Normann, S., Beck, H., Elger, C.E., Schramm, J., Wiestler, O.D., Blümcke, I. (2002) Transcriptional profiling in human epilepsy: expression array and single cell real-time qRT-PCR analysis reveal distinct cellular gene regulation. Neuroreport,13: 1327-1333. 

Sochivko, D., Pereverzev, A., Smyth, N., Gissel, C., Schneider, T. and Beck, H. (2002) The Cav2.3 Ca2+ channel subunit contributes to R-type Ca2+ currents in hippocampal and neocortical pyramidal neurons. J. Physiol., 542: 699-710. [PDF]

Su, H., Sochivko, D., Becker, A., Chen, J., Jiang, Y., Yaari, Y. und Beck, H. (2002) Up-regulation of a T-type Ca2+ channel causes a long-lasting modification of neuronal firing mode following status epilepticus. J. Neurosci., 22: 3645-3655. [PDF]

Kudin, A.P., Kudina, T., Vielhaber, S., Beck, H., Elger, C.E. und Kunz, W.S. (2002) Seizure-dependent modulation of mitochondrial oxidative phosphorylation in rat hippocampus. J. Neurosci., 15: 1105-1115. [PDF]

Jeub, M., Beck, H., Siep, E., Rüschenschmidt, C., Speckmann, E.-J., Ebert, U., Potschka, H., Freichel, C., Reissmüller, E., Löscher, W. (2002) Effect of phenytoin on sodium and calcium currents in hippocampal CA1 neurons of phenytoin-resistant kindled rats. Neuropharmacology, 42: 107-16. [PDF]

 

2001

Riazanski, V., Becker, A., Chen, J., Sochivko, D., Wiestler, O.D., Elger, C.E. and Beck, H. (2001) Functional and molecular changes in A-type potassium channels during ontogenesis in hippocampal neurons. J. Physiol., 537:391-406. [PDF]

Chen, J., Sochivko, D., Beck, H., Cuzange, A., Wiestler, O.D., and Becker, A. Activity-induced expression changes in common reference genes in individual CNS neurons. Lab. Invest., 81: 913-916. [PDF]

Ellerkmann, R., Riazanski, V., Elger, C.E., Urban, B.W. and Beck, H. (2001) Slow recovery from inactivation regulates the availability of voltage-dependent Na+ channels in hippocampal granule cells, hilar neurons and basket cells. J. Physiol., 532.2: 385-397. [PDF]

 

2000

Kunz, W.S., Kudin, A.P., Vielhaber, S., Blümcke, I., Zuschratter, W., Schramm, J., Beck, H. and Elger, C.E. (2000) Mitochondrial complex I deficiency in the epileptic focus of patients with temporal lobe epilepsy. Ann. Neurol., 48: 766-773. [PDF]

Söhl, G., Güldenagel, M., Beck, H., Kunzelmann, P., Traub, O., Gutiérrez, R., Heinemann, U. and Willecke, K. (2000) Gap junction expression in the kainic acid and kindling models of human temporal lobe epilepsy. Brain Res. Mol. Brain Res. 83: 44-51. [PDF]

Schumacher, T., Beck, H., Steffens, R., Wiestler, O.D., Schramm, J., Elger, C.E. and Steinhäuser, C. (2000) Modulation of calcium channels by group I and group II metabotropic glutamate receptors in dentate gyrus neurons from patients with temporal lobe epilepsies. Epilepsia, 41: 1249-1258. [PDF]

Beck, H., Goussakov, I.V., Lie, A., Helmstaedter, C., and Elger, C.E. (2000) Synaptic plasticity in the human dentate gyrus. J. Neurosci., 20: 7080-7086. [PDF]

Goussakov, I.V., Fink, K., Elger, C.E. and Beck, H. (2000) Metaplasticity of mossy fiber synaptic transmission involves altered release probability. J. Neurosci., 20: 3434-3441. [PDF]

Naegerl, V., Mody, I., Jeub, M., Lie, A.A., Elger, C.E. and Beck, H. (2000) Surviving granule cells of the sclerotic human hippocampus have reduced Ca2+ influx because of a loss of Calbindin-D28k in temporal lobe epilepsy. J. Neurosci., 20: 1831-1836. [PDF]

Blümcke, I., Becker, A.J., Klein, C., Scheiwe, C., Lie, A.A., Beck, H., Waha, A., Friedl, M., Kuhn, R., Schramm, J., Elger, C.E. and Wiestler, O.D. (2000) Temporal lobe epilepsy associated up-regulation of metabotropic glutamate receptors: correlated changes in mGluR1 mRNA and protein expression in experimental animals and human patients. J. Neuropathol. Exp. Neurol., 59: 1-10.  

Lie, A.A., Becker, A., Behle, K., Beck, H., Malitschek, B., Conn, P.J., Kuhn, R., Nitsch, R., Plaschke, M., Schramm, J., Elger, C.E., Wiestler, O.D. and Blümcke, I. (2000) Up-regulation of the metabotropic glutamate receptor mGluR4 in hippocampal neurons with reduced seizure vulnerability. Ann. Neurol., 47: 26-35. [PDF]

 

1999

Grunwald, T., Beck, H., Lehnertz, K., Blümcke, I., Pezer, N., Kurthen, M., Fernandez, G., Van Roost, D., Heinze, H.J., Kutas, M. and Elger, C.E. (1999) Evidence relating human verbal memory to hippocampal N-methyl-D-aspartate receptors. Proc. Natl. Acad. Sci. 96:12085-9. [PDF]

Kudin, A., Vielhaber, S., Beck, H., Elger, C.E. and Kunz, W. (1999) Quantitative investigation of mitochondrial function in single rat hippocampal slices: a novel application of high-resolution respirometry and laser-excited fluorescence spectroscopy. Brain Res. Protocols 4, 93-98. [PDF]

Blümcke, I, Beck, H., Lie, A.A., and Wiestler, O.D. (1999) Molecular neuropathology of human mesial temporal lobe epilepsy. Epilepsy Res. 36: 205-223. [PDF]

Jeub, M., Lie, A., Blümcke, I., Elger, C.E. and Beck, H. (1999) Loss of dynorphin-mediated inhibition of voltage-dependent Ca2+ currents in hippocampal granule cells isolated from epilepsy patients is associated with mossy fiber sprouting. Neuroscience, 94: 465-471. [PDF]

Beck, H.,. Steffens, R., Heinemann, U. and Elger, C.E. (1999) Ca2+-dependent inactivation of high-threshold Ca2+ currents in hippocampal granule cells of patients with chronic temporal lobe epilepsy. J. Neurophysiol., 82: 946-957. [PDF]

Lie, A., Blümcke, I., Volsen, S.G., Wiestler, O.D., Elger, C.E. and Beck, H. (1999) Distribution of voltage-dependent Ca2+ channel b subunits in the hippocampus of patients with temporal lobe epilepsy. Neuroscience, 93(2): 449-456. [PDF]

Grunwald, T., Beck, H., Lehnertz, K., Blümcke, I., Pezer, N., Kutas, M., Kurthen, M., Karakas, H., Van Roost, D., Wiestler, O.D. and Elger, C.E. (1999) Limbic P300s in temporal lobe epilepsy with and without Ammon’s horn sclerosis. Eur. J. Neurosci., 11:1899-1906. [PDF]

Lie, A.A., Blümcke, I., Beck, H., Wiestler, O.D., Elger, C.E. and Schoen, S.W. (1999) 5’-Nucleotidase activity indicates sites of synaptic plasticity and reactive synaptogenesis in the human brain. J. Neuropathol. Exp. Neurol., 58: 451-458. 

Becker, A.J., Gillardon, F., Blümcke, I., Langendörfer, D., Beck, H. and Wiestler, O.D. (1999) Differential regulation of apoptosis-related genes in resistant and vulnerable subfields of the rat epileptic hippocampus. Mol. Brain Res. 67:172-176. [PDF]

Reckziegel, G.; Beck, H.; Schramm, J., Urban, B.W. and Elger, C.E. (1999) Carbamazepine effects on Na+ currents in human dentate granule cells from epileptogenic tissue. Epilepsia40: 401-407. [PDF]

Kunz, W.S., Goussakov, I.V., Beck, H. and Elger, C.E. (1999) Altered mitochondrial oxidative phosphorylation in hippocampal slices of kainate-treated rats. Brain Res., 826: 236-242. [PDF]

Blümcke, I.; Beck, H.; Suter, B.; Hoffmann, D.; Födisch, J.; Wolf, H.K.; Schramm, J., Elger, C.E. and Wiestler, O.D. (1999) An increase of hippocampal calretinin-immunoreactive neurons correlates with early febrile seizures in temporal lobe epilepsy. Acta neuropathologica 97: 31-39. [PDF] 

 

1998

Lie, A., Blümcke, I., Beck, H., Schramm, J., Wiestler, O.D. and Elger, C.E. (1998) Altered patterns of Ca2+/calmodulin-dependent protein kinase II and calcineurin immunoreactivity in the hippocampus of patients with temporal lobe epilepsy. J. Neuropathol. Exp. Neurol.57:1078-88. [PDF] 

Beck, H.; Steffens, R.; Heinemann, U. and Elger, C.E. (1998) Voltage-dependent Ca2+ currents in epilepsy. Epilepsy Res. 32: 321-332. [PDF]

Schumacher, T.B., Beck, H., Steinhäuser, C., Schramm, J. and Elger, C.E. (1998) Effects of phenytoin, carbamazepine, and gabapentin on calcium channels in hippocampal granule cells from patients with temporal lobe epilepsy. Epilepsia 39: 355-363. [PDF]

Reckziegel, G.; Beck, H.; Schramm, J.; Elger, C.E. and Urban, B.W. (1998) Electrophysiological characterization of Na+ currents in acutely isolated human hippocampal dentate granule cells. J. Physiol. 509: 139-151. [PDF]

 

1997

Dietrich, D.; Beck, H.; Kral, T.; Clusmann, Elger, C.E. and Schramm, J. (1997) Metabotropic glutamate receptors modulate synaptic transmission in the perforant path: pharmacology and localization of two distinct receptors. Brain Res., 767: 220-227.[PDF]

Scheffler, B.; Faissner, A.; Beck, H.; Behle, K.; Wolf, H.K.; Wiestler, O.D. and Blümcke, I. (1997) Hippocampal loss of tenascin boundaries in Ammon’s horn sclerosis. Glia, 19: 35-46. [PDF]

Beck, H.; Steffens, R.; Heinemann, U. and Elger, C.E. (1997) Properties of voltage-activated Ca2+ currents in acutely isolated human hippocampal granule cells. J. Neurophysiol. 77: 1526-1537. [PDF]

Beck, H.; Clusmann, H.; Kral, T.; Schramm, J.; Heinemann, U. and Elger, C.E. (1997) Potassium currents in acutely isolated human hippocampal granule cells. J. Physiol. 498(1): 73-85. [PDF]

 

1996

Blümcke, I.; Beck, H.; Scheffler, B.; Hof, P.R.; Morrison, J.H.; Wolf, H.K.; Schramm, J.; Elger, C.E. and Wiestler, O.D. (1996) Altered distribution of the a-amino-3-hydroxy-5-methyl-4-isoxazole propionate receptor subunit GluR2(4) and the N-methyl-D-aspartate receptor subunit NMDAR1 in the hippocampus of patients with temporal lobe epilepsy. Acta neuropathologica,92: 576-587. 

Blümcke, I.; Beck, H.; Nitsch, R.; Eickhoff, C.; Scheffler, B.; Celio, M.R.; Schramm, J.; Elger, C.E.; Wolf, H.K. and Wiestler, O.D. (1996) Preservation of calretinin-immunoreactive neurons in the hippocampus of epilepsy patients with Ammon's horn sclerosis. J. Neuropathol. Exp. Neurol. 55: 329-341. 

Beck, H.; Heinemann, U.; Blümcke, I.; Kral, T.; Clusmann, H.; Schramm, J.; Wiestler, O.D. and Elger, C.E. (1996) Properties of a delayed rectifier potassium current in dentate granule cells isolated from the hippocampus of patients with chronic temporal lobe epilepsy. Epilepsia, 37: 892-901. [PDF]

Wieser, H.G. and Beck, H. Improvement of medically refractory temporal lobe complex partial epilepsy with dextromethorphan. J. Epilepsy 5: 246-247, 1992.

 

1992

Beck, H.; Ficker, E. and Heinemann, U. (1992) Properties of two voltage dependent potassium currents in acutely isolated juvenile rat dentate gyrus granule cells. J. Neurophysiol.68: 2086-2099.

 

Book chapters, Reviews:

  1. Beck, H. and Elger, C.E. (2008) Epilepsy research: a window onto function to and dysfunction of the human brain. Dialogues Clin Neurosci. 10: 7-15.
  2. Beck, H. and Yaari, Y. (2008) Plasticity of intrinsic neuronal properties in CNS disorders. Nature Reviews Neuroscience. 9: 357-369. [PDF]
  3. Sisodiya, S., Beck, H., Löscher, W., and Vezzani, A. Mechanisms of Drug Resistance In: Epilepsy: A Comprehensive Textbook, edited by J. Engel, Jr. and T. A. Pedley, 2008.
  4. Mathern, G.W., Wilson, C.L., Beck, H. Hippocampal Sclerosis. In: Epilepsy: A Comprehensive Textbook, edited by J. Engel, Jr. and T. A. Pedley, 2008.
  5. Beck, H. Plasticity of antiepileptic drug targets. Epilepsia 48 (Suppl 1): 14-18, 2007.
  6. Beck, H. and Remy, S. Molecular and cellular mechanisms of pharmacoresistance in chronic epilepsy. Brain 129: 18-35, 2006. [PDF]
  7. Heinemann, U., Kann, O., Remy, S. and Beck, H. Novel mechanisms underlying drug resistance in temporal lobe epilepsy. Adv. Neurol. 97: 85-95, 2006.
  8. Heinemann, U., Beck, H. and Draguhn, A. Antiepileptic Drugs. Neuropharmacology, in press.
  9. Yaari, Y. and Beck, H. Plasticity of intrinsic neuronal properties in temporal lobe epilepsy. Brain Pathology, 12: 234-239, 2002.
  10. Grunwald, T., Beck, H. and Elger, C.E. Bausteine des Gedächtnisses: Untersuchungen der menschlichen Hippokampusfunktion in-vivo und in-vitro. Neuroforum, 3: 114-121, 2001.
  11. Beck, H. and Elger, C.E. Anfallserkrankungen. In: Lehrbuch der Pathophysiologie, Fölsch, U.R.; Kochsieck, K. and Schmidt, R.F. Hrsg., Springer Verlag, Heidelberg.
  12. Spenger, C., Beck, H., Studer, L., Evtouchenko, L. and Seiler, W. Transplantation fötalen mesenzephalen Gewebes. Therapiewoche Schweiz 11,2, 80-84, 1995.
  13. Heinemann, U.; Beck, H.; Dreier, J.; Ficker, E.; Stabel, J. and Zhang, C.L. The dentate gyrus as a regulated gate for propagation of epileptiform activity. In: The dentate gyrus and its role in seizures, Eds. C.E. Ribak, C.M. Gall and I. Mody, Epilepsy Res. Suppl. 7: 273-280, 1992.
  14. Heinemann, U.; Albrecht, D.; Beck, H.; Ficker, E.; von Haebler, D.; Nixdorf, B.; and Stabel, J. Potassium homeostasis and epileptogenesis in the immature hippocampus. In: Epileptogenic and exitotoxic mechanisms, Eds. G. Avanzini, R. Fariello, U. Heinemann and R. Mutani. J. Libbey and Company Ltd. pp. 99-106, 1993.
  15. Heinemann, U.; Albrecht, D.; Beck, H.; Ficker, E.; von Haebler, D. and Stabel, J. (1992) Delayed potassium regulation and potassium current maturation as factors of enhanced epileptogenicity during ontogenesis of the hippocampus of rats. In: Molecular Neurobiology of Epilepsy, Eds. J. Engel, Jr, C. Wasterlain, E.A. Cavalheiro, U. Heinemann und G. Avanzini, Epilepsy Res. Suppl. 9: 107-114.